• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.17-29
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• 1988

The author examined the effects of lidocaine on the veratrine-or potassium-induced release of neurotransmitters to determine the possible role of amino acid neurotransmitters in lidocaine-induced convulsion. The examined transmitters were gamma-aminobutyric acid (GABA), aspartic acid, glutamic acid and norepinephrine which are released from the synaptosomes. Furthermore, the effects of lidocaine on the binding to receptors and synaptosomal uptake of the two transmitters, GABA and glutamic acid, were determined in crude synaptic membranes and synaptosomes. In addition, the effects of propranolol, norepinephrine and serotonin on the release of amino acid neurotransmitters were also examined. The veratrine-induced release of GABA was most severely inhibited by lidocaine and propranolol, while norepinephrine and serotonin reduced the release of aspartic acid and glutamic acid more than the GABA release. Generally the potassium-induced release was much more resistant to the lidocaine action than the veratrine-induced release. Among the neurotransmitters examined, the aspartic acid release was most prone to the lidocaine action, while the GABA release was most resistant. Concentrations of lidocaine below 1 mM did not significantly change the GABA and glutamic acid receptor binding and uptake. These results indicate that the blocking of sodium channels by lidocaine can result in the selective depression of the GABA release. This may result in unlimited excitation of the central nervous system.

• Radiation Oncology Journal
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• v.5 no.1
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• pp.1-11
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• 1987

Total 390 mice were irradiated with $2{\times}3cm$ abdominal field and $200{\times}5/wk$ regimen with orthovoltage x-ray machine. All animals were divided into 2 large groups, damage and recovery, and histopathologic changes were analyzed at various total dose level (1,000 cCy-5,000 cCy) and intervals (1 week-15 weeks). Almost acute changes such as decreased mitotic activity, villi shortening and focal erosion of mucosa recovered within 1-2 weeks in 1,000-3,000 cGy irradiated group but mild changes persisted in 4,000 and 5,000 cCy irradiated groups. Chronic delayed changes such as thickening of vessel wall with focal thrombosis, submucosal fibrosis, mucosal atrophy and chronic ulcer were observed from 2-3 week specimens in 4,000 and 5,000 cGy groups, These late changes recovered slightly, as increasing time intervals after irradiation but mild, persistant changes were observed throught all follow up period. These data suggest hat even 4,000 cCy is not completely safe for possible permanent damage and judicious modificiation of total dose, dose rate, fraction size, and field size should be considered for better results.

• Journal of Radiation Protection and Research
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• v.22 no.3
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• pp.161-170
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• 1997

Theoretical and experimental determination of the lower limits of detection (LLD) of C-300-A $CaSO_4$:Dy TL dosimeters which are currently used for the personnel monitoring in Korea Atomic Energy Research Institute(KAERI) are described with a critical level which is defined as the signal level above which a result has a probability of being due to a fluctuation of the background. The personnel monitoring processors can derived easily the LLD of their system using this method with the background readings of their service interval and the irradiation readings of the known doses. Experimental studies were also conducted for the fading rates of the dosimeters with the temperatures and humidities for 3 months. Finally sensitivity changes in repeat uses were measured for 40 times consecutive uses of the dosimeters. The applications of the experimental results of fading rates and sensitivity changes in real personnel monitoring services are discussed briefly.

• Tunnel and Underground Space
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• v.16 no.2 s.61
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• pp.166-178
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• 2006

Recently, the frequency of occurring dynamic events such as earthquakes, explosives blasting and other types of vibration has been increasing. Besides, the chances of exposure for rock discontinuities to free faces get higher as the scale of rock mass structures become larger. For that reason, the frictional behavior of rock joints under dynamic conditions needs to be investigated. In this study, artificially fractured rock joint specimens were prepared in order to examine the dynamic frictional behavior of rough rock joint. Roughness of each specimen was characterized by measuring surface topography using a laser profilometer and a series of shaking table tests was carried out. For mated joints, the static friction angle back-calculated ken the yield acceleration was $2.7^{\circ}$ lower than the tilt angle on average. The averaged dynamic friction angle for unmated joints was $1.8^{\circ}$ lower than the tilt angle. Displacement patterns of sliding block were classified into 4 types and proved to be related to the first order asperity of rock joint. The tilt angle and the static friction angle for mated joints seem to be correlated to micro average inclination angle which represents the second order asperity. The tilt angle and the dynamic friction angle for unmated Joints, however, have no correlation with roughness parameters. Friction angles obtained by shaking table test were lower than those by direct shear test.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.2
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• pp.121-131
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• 2007

Recently, the probability of rock joints being exposed to free faces is getting higher for the scale of rock mass structures gets larger. Also, the frequency of occurring dynamic events such as earthquakes and blasting has been increasing. Thus, the shear behavior of rock joints under different conditions needs to be investigated. In this study, a series of direct shear tests were carried out under various conditions to examine the velocity-dependent shear behavior of saw-cut rock joints. Two types of direct shear test were carried out. The first was to examine the velocity-dependent shear behavior of saw-cut rock joints at seven different shear velocities, each with three different normal stresses. The second was to examine the shear behavior of saw-cut rock joints when three different instantaneous shear velocities changed. As a result, the coefficient of friction was affected by normal stress. The breakpoint velocity, the point when the change of shear velocity starts to affect the frictional behavior, became lower as normal stress increased. Also, as the shear velocity became lower, the degree of stress-drop on stick-slip behavior became larger. As a result of examining the changes of friction coefficient, velocity weakening (decrease of friction coefficient) was observed. The decrement of friction coefficient due to the changes of shear velocity under slow shear velocity was larger than that under fast shear velocity.

• Journal of the Mineralogical Society of Korea
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• v.19 no.2 s.48
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• pp.81-88
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• 2006

The Yttria Partially Stabilized Zirconia powder was prepared by spontaneous precipitation method using $ZrOCl_2{\cdot}8H_O-YCl_33{\cdot}6H_2O$ solution as a starting materials. The optimal experimental conditions such as concentration and pH of starting solutions, the amounts of stabilizer $Y_2O_3$ used, and sintered temperature were carefully studied. The best condition for synthesizing $ZrO_2$ was experimentally selected and applied throughout this study for the preparation of the 3 mole% $Y_2O_3$ partially stabilized zirconia, 3YSZ. The physical properties of 3YSZ was examined by XRD, Raman, DT A, and SEM. The structural transition from pure monoclinic high temperature $ZrO_2$ to tetragonal room temperature 3YSZ was made possible by the added amount of $Y_2O_3$ in the $ZrO_2+Y_2O_3$ system. All Raman Spectrum band appeared in the lower wave numbers rather than in higher wave numbers as structure changes from monoclinic to tetragonal.

• Journal of Plant Biotechnology
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• v.39 no.3
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• pp.127-132
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• 2012

We analysed the current status of development of GM crops and national biosafety framework including legislation-related agricultural GMO in China to provide the policy for the development of global GM crops in Korea. In China, several GM crops including cotton, petunia, tomato, sweet pepper, poplar, and papaya have been approved for commercialization and they have been cultivated at more than 4 million ha. In addition, GM rice and GM maize have also obtained approval for productive testing in 2009. China will be the first country to approve GM rice for commercialization. Prior to commercialization in China, all GM crops must be approved by government authority for biosafety assessment specified by national legislation including restricted field testing, enlarged field testing, productive testing and safety certificate. According to China's legislation, agricultural GMOs have been classified by research and testing, production and processing. All GMOs must go through 3 steps of field testing (restricted, enlarged and productive). Prior to conducting each field testing, it has to be approved by government authority. It is assumed that at least one to two years will be taken for each step of field testing (total 4 to 8 years to obtain the final safety certificate) along with a large amount of budget.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1711-1715
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• 2007

하천에서는 나라마다 하천마다 구간마다 독특한 하도특성을 지니고 있다. 우리나라는 전 국토의 70 %가 산지로 이루어져 있으며, 이로 인하여 특이한 하도형태의 모습을 보이는 구간이 산재하고 있다. 그 대표적인 모습이 충적하도와 침식하도가 연속해 발생하는 과정에서 나타나는 것이 하천 협착부 구간이다. 이러한 하천협착부 주변지역은 전형적인 수해상습 구간이 되는 경우가 많다. 이러한 상황임에도 불구하고 현재까지 우리 나라에서는 이러한 협착부 구간에서 하도특성을 반영한 연구 및 설계 사례가 전무한 실정이다. 따라서, 본 연구에서는 낙동강 선산지역의 하천 협착부에서의 하도 수리학적 의미와 하도형태에 대하여 조사하고 분석하였다. 연구 결과, 모래하천인 조사구간의 저수로 하상에서 아주 미세한 유사분급 현상은 확인할 수 있었지만, 명쾌한 자연 영력에 의한 유사분급 현상이라 판단하기에는 어려운 부분이 있었다. 이는 완만한 하상경사, 균일성에 가까운 하상재료의 공급에 기인한다고 추정할 수 있었다. 그러나 이와 같은 자연적인 현상보다는 골재채취 등의 원인에 따른 유사분급이 확연하다고 추정되었다. 그리고 협착부의 배수구역에서 과거 활발했던 이동상 단단면 하도형태가 유심부의 이동과 더불어 최근 급격하게 복단면화가 진행되고 있음을 확인하였다. 이와 더불어 저수로의 하폭이 크게 줄어드는 현상을 확인할 수 있었다. 이와 같은 현상은 궁극적으로 이상홍수 발생시의 복단면 가중 또는 홍수단면적 축소, 저수로에서의 호안 또는 제방 아래부분의 국소세굴이 야기될 수 있음을 시사한다.원주교각에 대한 국부세굴 특성을 검토하였다. 또한 원주형의 교각에서는 단일원주보다는 원주군으로 설치되는 경우가 대부분이며 이때 교각의 직경(D)에 대한 교각 사이 간격$(L_d)$의 비$(L_d/D)$에 따른 전면교각에서의 수류변화의 영향이 후면교각에 작용하여 상호 복합적인 흐름 및 세굴특성을 나타내므로 이와 같은 복렬형 원주군의 세굴특성을 파상형 원주교각에 적용하여 국부세굴의 크기 변화를 해석하였다. 따라서, 교각주위에서의 수류특성 및 세굴의 변동은 원주군 및 교각파상의 크기와 간격 등과 같은 구조물의 배열조건과 Froude 수, 수심 등의 수리학적 조건에 따라 달라지므로 이의 조건을 체계적으로 변화시켜 가면서 교각주위에서의 국부세굴 및 세굴 감소특성을 검토하였다. 실험결과 오목 및 볼록 파상형 원주 주위에서의 세굴크기는 원형원주와 비교하여 전체적으로 감소하는 것으로 확인되었으며 특히 오목형 $B/\acute{h}=3$에서는 세굴경감효과가 탁월하여 70%이상 감소하는 것으로 확인되었으나 볼록형 $B/\acute{h}=5$에서는 세굴촉진특성이 나타나고 있는 것으로 나타났다. 따라서, 파상형 원주에서는 하강류나 와류를 파상형의 내부로 유도하여 세굴의 크기를 조절할 수 있는 최적의 파상이 존재하고 있는 것으로 예측되었다.원 분야 소프트웨어의 개발에 기본 토대를 제공할 것으로 판단된다.았다. 또한 저자들의 임상병리학적 연구결과가 다른 문헌에서 보고된 소아 신증후군의 연구결과와 큰 차이

• Journal of Life Science
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• v.23 no.3
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• pp.448-461
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• 2013

Inflammatory bowel disease, known as Crohn's disease and ulcerative colitis, is an unexplained disease characterized by chronic inflammation that repeats a cycle of relapse, improvement, and complications. The cause of inflammatory bowel disease is not clearly known, but it is predicted that a complex of various factors precipitate its occurrence. In particular, inflammatory mediators, such as cytokine, induce an increase in cell-mediated inflammatory responses. Focal tissue damage then occurs in the intestinal mucosa because of the weakening of the immune-modulating functions of cotton. Immune and inflammatory responses do not decrease appropriately but continue until they lead to chronic inflammation. Current research has focused on the cytokine genes, which have important roles in these inflammatory responses. Cytokine is a glycoprotein that is produced mostly in activated immune cells. It connects the activation, multiplication, and differentiation between immune cells, which causes focal tissue damage and inflammatory response. Moreover, butyrate, which originates in dietary fiber and plays an important role in the structure and function of the intestinal area, shows control functions in the intestinal immune system by decreasing the proinflammatory cytokine and increasing the anti-inflammatory cytokine. Therefore, this research investigated the molecular mechanism of the anti-inflammatory effects of butyrate to comprehend the cytokine controlling abilities of butyrate in the immune cells. Butyrate is expected to have potential in new treatment strategies for inflammatory bowel disease.

• Korean Journal of Optics and Photonics
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• v.19 no.5
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• pp.349-359
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• 2008

For an inner-focusing 3-groups zoom lens system, this study suggests a new initial design method which applies the process that changes thin lenses into thick ones effectively and quickly, using the hybrid lens system(thin lens+thick lens). In other words, the hybrid lens system is the semi-automatic design process that makes the thin lens of one group change into a thick one while the other groups are composed of thin lenses. Keeping the total power of the system fixed, the power of each group and the distance between principal planes can be fixed. Of course, the other groups composed of thin lenses could be changed into thick lenses sequentially by this process. This design conception results in the 1/4" 5 M inner-focusing 3-groups 2x zoom lens system satisfying the specifications and performances of zoom lens for phone cameras. Also aspherization on lens elements of glass and plastic material enhanced the resolution and reduced the lens size. As a result, we have an ultra-compact inner-focusing 3-groups 2x zoom lens system for a phone camera, with a slim size with TTL of 9.8 mm.