• Annual Conference on Human and Language Technology
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• 2005.10a
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• pp.21-27
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• 2005

본 논문에서는 국가에서 추진하는 차세대신성장동력산업과 관련된 특정 분야('바이오 신약/장기' 분야 중 '면역 기능 제어')를 선택하여, 기구축된 면역학 전문용어사전을 비롯하여 의학용어사전, 표준국어대사전 등을 참조하여 핵심 용어와 관련 용어를 중심으로 면역학 시소러스(어휘 3,462개) 및 온톨로지(개념 노드 4,703개)를 구축하였다. 이것은 전문용어사전부터 온톨로지에 이르기까지 통일화된 표준 체계를 가지고 있으며, 도메인 온톨로지를 구축하여 향후 온톨로지 개발 방향을 설정할 수 있는 계기가 되었다고 할 수 있다. 또한 면역학 시소러스는 검색의 성능을 향상시킬 수 있도록 충분한 양의 데이터를 구축하였고 면역학 온톨로지는 언어처리적 관점에서의 온톨로지를 표현하였다. 이는 정보검색에서의 효율성을 비롯하여, 특정 웹 온톨로지 언어를 이용한 웹 온톨로지로의 변환성, 대규모 도메인 온톨로지라는 점에서 의미를 가진다고 할 수 있다.

• Journal of Korean Philosophical Society
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• no.95
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• pp.59-93
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• 2011

Die vorliegende Abhandlung beschäftigt sich mit der Frage, ob Jacque Derrida das Problem des Global-Terrorismus im politisch-theologischen Sinne mit seiner Philosophie der Gastfreundschaft lösen kann. Fur Derrida ist der '11. September' das 'Ereignis', und das Symptom einer autoimmunitären Erkrakung der westlichen Welt. Derrida findet im '11. September Ereignis' die Struktur der Aneignung des Eignen und der Enteignung im Heideggerschen Sinne. Das 'major event' wird nicht in einer vergangenen Aggression bestanden haben, die präsent und wirksam ist und noch schlimmer in der Futur sein wird. Derrida versucht einen philosophischen, politisch-theologischen Ansatz zur Bedingungen der Möglichkeit der absoluten, vollkommenen Auflösung des Globalen Terrorismus zu programmieren. Dafür fordert er das Postulat Verwirklichung des 'Messianischen ohne Messianismus'. Die Gegenüberstellung zwei politischer Theologien zwischen der Europäischen Demokratie und der Islamischen Vereinigten Staaten kann erlöst werden, wenn die 'neue religiöse Spiritualität', die gegenüber der dogmatischen Religionswahrheit frei ist, mit der 'Wiederkehr der Religion' im echten Sinne vorkommt. In der 'Neuen Religion' Derridas ist der Begriff der 'Gastfreundschaft' wichtiger als der der 'Toleranz', den er als 'abrahamitisch' definiert. Die von Derrida postulierte neue Religion ist eine offene Religion, in der das Unvergebbare unbedingt zu vergeben ist. Ihre politische Transformation ist der Begriff der 'Neuen Europäischen Gemeinschaft' und des 'Anderen Kaps'. Derrida postuliert diese neue Idee des Kosmopolitismus als die notwendige Bedingung der vollkommenen Auflösung des autoimmunitären Global-Terrorismus.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.42 no.5
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• pp.59-68
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• 2005

A novel immunotronic approach to fault detection in hardware based on symbiotic evolution is proposed in this paper. In the immunotronic system, the generation of tolerance conditions corresponds to the generation of antibodies in the biological immune system. In this paper, the principle of antibody diversity, one of the most important concepts in the biological immune system, is employed and it is realized through symbiotic evolution. Symbiotic evolution imitates the generation of antibodies in the biological immune system morethan the traditional GA does. It is demonstrated that the suggested method outperforms the previous immunotronic methods with less running time. The suggested method is applied to fault detection in a decade counter (typical example of finite state machines) and MCNC finite state machines and its effectiveness is demonstrated by the computer simulation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.8 no.2
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• pp.3-12
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• 1998

블럭암호의 비도는 S-box의 비도와 운영방식에 의존된다. S-box 의 비도는 이 한수의 성분함수인 Book함수의 비선형성, 상관면역위수, SAS, 균형성 등에 의존되며, S-box자체의 비선형성, 입력성부(또는 입력비트)에 대한 출력성분(또는 출력비트)의 독립성 등에 의존된다. 이와 같은 출력 성분의 독립성에 관한 개념의 하나가 완비성이다. 본 논문에서는 Galois 체 GF(2)위해 n차원 벡터공간 GF(2)$^{n}$ 에서 완비함수의 존재성에 관한 몇 가지 알고리즘과 완비함수가 만족하는 성질들을 조사하였다.

• Research in Plant Disease
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• v.21 no.3
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• pp.161-179
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• 2015

Plant have developed sophisticated defence mechanisms against microbial pathogens. The recent accumulated information allow us to understand the nature of plant immune responses followed by recognition of microbial factors/determinants through cutting-edge genomics and multi-omics techniques. However, the practical approaches to sustain plant health using enhancement of plant immunity is yet to be fully appreciated. Here, we overviewed the general concept and representative examples on the plant immunity. The fungal, bacterial, and viral determinants that was previously reported as the triggers of plant immune responses are introduced and described as the potential protocol of biological control. Specifically, the role of chitin, glucan, lipopolysaccharides/extracellular polysaccharides, microbe/pathogen-associated molecular pattern, antibiotics, mimic-phytohormones, N-acyl homoserine lactone, harpin, vitamins, and volatile organic compounds are considered. We hope that this review stimulates scientific community and farmers to broaden their knowledge on the microbial determinant-based biological control and to apply the technology on the integrated pest management program.

• The Korean Journal of Cytopathology
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• v.7 no.1
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• pp.1-11
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• 1996

From the concepts of cellular pathology and of exfoliative cytology, as elucidated by Virchow and Papanicolaou respectively in the late 19th and early 20th century, have evolved the primary methods for the diagnosis of cancer today. From Papanicolaou's concept of exfoliative cytology developed fine needle aspiration biopsy in the early 1960's, this has become a major diagnostic procedure and has contributed to a significant reduction in open biopsies and, therefore, to medical cost-effectiveness immunobiochemical techniques provided us with a supplement to cancer diagnosis in the 1980's. The immunoperoxidase method, using monoclonal antibodies, is applied primarily as an ancillary measure to elucidate the nature of cancers The availability of specific monoclonal antibodies has greatly facilitated the identification of cell products or surface markers. For example, antibodies directed against intermediate filaments have proved to be of value in determining the histogenesis oi poorly differentiated neoplasms. Tumor markers may serve as biochemical indicators of the presence of a neoplasm. They can be detected In plasma and other body fluids. Their concentration can be applied as a diagnostic test, for monitoring the clinical course of known cancer, and as a screening measure to detect certain cancers in a population at risk. Flow cytometry is a useful tool for distinguishing several cell characteristics, such as the immunophenotype of leukemia-lymphoma cells, the DNA content of neoplastic cells, and cell proliferation rate. Molecular biologic techniques provided a giant step for the management of cancer patients encompassing diagnosis, prognostic evaluation, and therapy. Nucleic acid hybridization techniques are utilized as Southern, Northern, and dot blots and in situ hybridization. Molecular biology and its techniques may bring a blight new horizon for understanding cancer biology and in designing therapy on the basis of gene manipulation.

• Journal of Korean Biological Nursing Science
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• v.22 no.1
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• pp.23-35
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• 2020

Purpose: Compliance in kidney transplant recipients is critical for a positive prognosis. Especially compliance with medications after kidney transplantation is a major health care issue with implications for graft rejection and graft loss. But the definition of compliance in transplantation varies among centers. The purpose of this study was to clarify the concept of compliance in kidney transplant recipients. Methods: A literature search was conducted using RISS, MEDLINE, CINAHL. The concept analysis was guided by the methodology posited by Walker and Avant. Results: In this study, we found the attributes of the concept: 'compliance with immunosuppressive medication', 'compliance with follow-up', 'compliance with early detection of graft rejection and complication', and 'compliance with prevention of complication'. The antecedents of 'compliance in kidney transplant recipients' included 'having a kidney transplant surgery' and 'normal function of transplanted kidney'. The consequences of 'compliance in kidney transplant recipients' included 'affecting the function of the transplanted kidney' and 'affecting the health of kidney transplant recipients. Conclusion: This study may contribute to the development of tools for measuring compliance in kidney transplant recipients, as well as benefit nursing interventions research to increase compliance in kidney transplant recipients.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.227-228
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• 2015

질병 치료에 대한 패러다임이 과거 치료 위주에서 조기진단 및 예방의 개념으로 전환되고 있으며 진단용 마커와 단클론 항체 제작은 핵심 기술로 부각되고 있다. 현재까지의 항원결정부위(epitope) 예측은 단백질의 1차구조인 아미노산 배열 순서를 바탕으로 추출되어 진다. 하지만 항원결정부위는 수용성의 항체와 직접 결합하기 때문에 친수성 잔기가 차지하는 비율이 높아야 하며, 면역계가 쉽게 인지할 수 있도록 노출되어 있어야하고, 긴 선상의 폴리펩티드 단백질이 3차원 구조를 형성하기 위해 회전, 유연성 등이 요구된다. 따라서 한 가지 성질 중심으로 할 경우 오류가 나올 가능성이 있다. 이를 보완하기 위하여 본 연구에서는 친수성(hydrophilicity), 극성(polarity), 파묻힘성(buried residues), 접근성(accessibility), 회전성(${\beta}-turns$), 유연성(flexibility), 굴절성(refractivity) 등을 분석한 후 통합 예측시스템을 개발하였다. 이를 검증하기 위해 고양이 백혈병 바이러스의 항원결정부위를 예측해보았다.

• Journal of Oral Medicine and Pain
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• v.33 no.2
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• pp.187-194
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• 2008

Recurrent aphthous stomatitis is common oral disease in the world. It is characterized by multiple, recurrent, painful ulcer with circumscribed margins, erythematous haloes and yellow or grey floors. Patients with recurrent aphthous stomatitis suffer from its painful ulcer. But unfortunately, its etiology and pathogenesis is not clear and still unknown. So we review etiology and pathogenesis of recurrent aphthous ulcer and wish to propose direction of the future study.

• KOREAN POULTRY JOURNAL
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• v.33 no.3 s.377
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• pp.104-106
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• 2001

작년 6월에 인간 유전자 지도의 초안이 작성된 이후 지난 2월 11일에 신문과 방송은 사람이 게놈지도가 완성되었다고 주요뉴스로 보도하였다. 1990년 8월에 인간게놈 연구계획이 발표된지 11년여간의 연구 끝에 이룩한 연구결과이다. 최근, 학문의 급속한 발전으로 질병의 진단과 치료에 새로운 지평이 열리고 있다 수의분야에서도 예외는 아니다. 특히 질병예방에 있어 중요한 백신의 연구개발에 있어서도 괄목할 만한 발전이 있었다. 유전공학의 발전과 여러 병원체의 병원성 인자와 체내의 면역기능과의 관련성 연구결과로 여러질병이 백신으로 예방이 가능하게 되었으며 보다 안전하고 효과적인 새로운 개념의 백신도 개발되고 있다. 새로운 백신, 즉 신백신은 유전자 조작(재조합)에 의한 병원성이 약해진 백신에서부터 여러 질병을 동시에 예방하려고 공안된 벡터백신, 그리고 유전자를 접종하는 DNA 백신 등이 대표적이다. 이들 백신은 기존백신에 사용되고 있는 백신보다 안전하고 경제적이며 우수한 효능을 발휘하도록 고안되고 있다.