• Proceedings of the Korean Nutrition Society Conference
• /
• 2003.05a
• /
• pp.144.2-144.2
• /
• 2003

• Proceedings of the Korea Information Processing Society Conference
• /
• 2001.10a
• /
• pp.523-526
• /
• 2001

최근 컴퓨터와 인터넷의 급속한 발전과 더불어 컴퓨터의 데이터를 파괴하거나 바이러스를 이용해 정보를 빼내기 위한 해킹 등이 만연하고 있다. 이에 컴퓨터의 데이터를 외부 침입물질에 대해 자체적인 보호와 제거 기능을 가진 생체 면역시스템을 이용한 연구가 활발히 진행되고 있다. 생체 면역 시스템은 바이러스나 병원균 등의 낮선 외부의 침입자로부터 자신을 보호하기 위해 크게 선천성 면역과 후천성 면역을 제공한다. 본 논문은 선천성 면역에는 오용탐지기법과 후천성 면역에는 비정상행위 탐지 기법을 이용한 하이브리드 침입탐지 시스템을 제안한다. 감사 자료 수집은 멀티레벨 파라미터 모니터링을 통해 감사 자료를 수집한다. 선천성 면역에서는 피부와 여러 가지 감각 기관의 분비물을 이용하듯이 방화벽과 같은 비슷한 기능을 하는 서비스 제한 에이전트와 기존에 알려진 버그와 해킹 기법을 시나리오 지식베이스를 이용하는 오용탐지 기법을 사용한다. 그리고, 후천성 면역에서는 유전자 알고리즘을 이용해 침입을 탐지하고 대응한다.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.41 no.11
• /
• pp.1521-1527
• /
• 2012

Medicinal herbs have long been used as a remedy for diverse diseases in Asia owing to their various pharmacological effect. In this study, the immuno-enhancing activity of medicinal herbs was investigated using macrophage cell lines. Specifically, we examined the effects of extracts of twelve medicinal herbs on nitric oxide (NO) production in RAW 264.7 cells, and selected five that were highly effective (Glycyrrhiza glabra, Rehmannia glutinosa, Angelica gigas, Platycodon grandflorum, and Actinidia polygama) for further immune related studies. The effects of extracts from five theses medicinal herbs, which were mainly composed of polysaccharides and proteins on the production of immune-related cytokines in the RAW 264.7 macrophage cell line and the Molt-4 T cell line were investigated. The extracts of all investigated medicinal herbs increased the production of NO and cytokines such as tumor necrosis factor-alpha (TNF-${\alpha}$), interleukin-1beta (IL-$1{\beta}$), interleukin-6 (IL-6) and interleukin-10 (IL-10). Additionally, they slightly increased the proliferation of T-cells when compared to the control. Overall, the result of this study suggests that the five medicinal herb extracts investigated herein are useful natural immune enhancing agents.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2001.05a
• /
• pp.183-186
• /
• 2001

최근 컴퓨터와 인터넷의 급속한 발전과 더불어 컴퓨터의 데이터를 파괴하는 바이러스나 정보를 빼내기 위한 해킹 등이 만연하고 있다. 이에 컴퓨터의 데이터를 보호하기 위한 방법들이 연구중에 있는데 이 중 외부의 침입물질에 대해 자체적인 보호와 제거기능을 가지는 생체면역시스템을 이용한 컴퓨터면역시스템 구축에 대해 활발히 연구가 진행되고 있다. 생체 면역시스템은 바이러스나 병원균 등의 낮선 외부 침입자로부터 자신을 보호하고 침입자를 제거한다. 본 논문에서는 생체면역시스템의 면역세포 중 하나인 세포독성 T세포의 자기(Self)와 비자기(Nonself)를 구분하는 기능을 이용해 자기변경 검사 알고리즘을 구현하였다. 구현한 알고리즘은 자기로 인식하는 자기파일에서 자기를 구분하는 MHC 인식부를 구성한다. 이렇게 구성한 MHC 인식부는 자기파일을 대표하는 값을 이용하여 변경된 파일을 구분한다. 이 알고리즘을 변경된 자기파일에 적용함으로써 컴퓨터 해킹이나 바이러스에 의한 자기파일의 변경 검사의 유효성을 검증한다.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.11 no.9
• /
• pp.801-806
• /
• 2001

According as many people use a computer newly, damage of computer virus and hacking is rapidly increasing by the crucial users A computer virus is one of program in computer and has abilities of self reproduction ad destruction like a virus of biology. And hacking is to rob a person's data in a intruded computer and to delete data in a person s computer from the outside. To block hacking that is intrusion of a person s computer and the computer virus that destroys data, a study for intrusion-detection of system and virus detection using a biological immune system is in progress. In this paper, we make a model of positive selection and negative selection of self-recognition process that is ability of T-cytotoxic cell that plays an important part in biological immune system. So we embody a self-nonself distinction algorithm in computer, which is an important part when we detect an infected data by computer virus and a modified data by intrusion from the outside. The composed self-recognition process distinguishes self-file from the changed files. To prove the efficacy of self-recognition algorithm, we use simulation by a cell change and a string change of self file.

• Feed Journal
• /
• v.4 no.7 s.35
• /
• pp.83-87
• /
• 2006

• Feed Journal
• /
• v.5 no.10 s.50
• /
• pp.82-87
• /
• 2007

• Parasites, Hosts and Diseases
• /
• v.29 no.1
• /
• pp.31-42
• /
• 1991

In order to observe the antigenic localization in the tissues of the young adult Paragenimus westermani, immunogold labeling method was applied using serum immunoglobulins (IgG) of the dog which infected with isolated metacercariae from Cambaroides similis. The sectioned worm tissue was embedded in Lowicryl HM 20 medium and stained with infected serum IgG and protein A gold complex(particle size; 12 nm) It was observed by electron microscopy at each tissues of the worm. The gold particles were not observed on the basal lamina of the tegument, interstitial matrix of the parenchyma, the muscle tissue and mitochondria of the tegument. The gold particles were specifically labeled in the secretory granules in the vitelline cells. They were predominantly labeling on the epithelial lamela and lumen of caecum. The above finding showed that antigenic materials in young adult worm tissue were specifically concentrated on the tegumental syncytium as well as cytoplasm of tegumental cells.

• Journal of the Korean Electrochemical Society
• /
• v.17 no.3
• /
• pp.172-178
• /
• 2014

In this work, we describe an electrochemical immunosensor for simple, fast and quantitative detection of a urinary hippuric acid (HA). Urinary HA, of molecular weight 180 DA, is one of the major metabolites and biological indicators in toluene-exposed humans. Simple and ubiquitous monitoring of exposure to toluene is very important in occupational health care. We propose the electrochemical immunoassay based on the dopamine-antigen conjugate for detecting hippuric acid. Our electrochemical immunoassay system employs a conjugate of dopamine (DA) as an electrochemical active molecule and hippuric acid (HA) as an antigen. As an electrochemical aspect, dopamine (DA) containing two hydroxyl group can show excellent redox signal. Also, dopamine-tethered hippuric acid (DA-HA) shows the reversible redox signal in the immunoassay. The competition between HA and DA-HA generated electric signals proportional to HA concentration. The electrochemical immunoassay was performed with DA-HA on the screen printed carbon electrodes (SPCEs), and then applies the mixture antigen (HA) and HA-antibody. The electrical signals were proportional to HA in the range of 0.010~2.500 mg/mL which is enough range to be used for the point-of-care.

• Parasites, Hosts and Diseases
• /
• v.30 no.1
• /
• pp.1-14
• /
• 1992

In order to observe the antigenic localization in the tissues of Paragonimus westermani of deve- lopmental stages, immunogoldlabeling method was applied using serum of the cats which were infected with isolated metacercariae from Cambaroides similis. The sectioned worm tissues from orch developmental stage were embedded in Lowicryl HM20 medium, stained with infected semi IgG and protein A gold complex(particle size: 12 nm) and observed by electron microscopy. In the young adult worm tissue of 4 weeks after infection with metacercariae, the gold particles were specifically concentrated on the tegumental syncytium and cytoplasm of the tegumental cells as well as the secretory granules in the parenchymal tissue. The antigenic materials in the adult worm tissue were specifically concentrated on the secretory granules in the parenchymal tissue, the cytoplasm between granules in the vitelline gland and the epithelial lamella in the lumen of the caecum.