• Korean Journal of Oriental Medicine
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• v.13 no.3
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• pp.151-156
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• 2007

Sagunja-tang(Sijunzi-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Sagunja-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Sagunja-tang(Sijunzi-tang) on SD rats. Twenty rats were orally adiministered Sagunja-tang for 28 days at a dose of 0 mg/kg(control group) or 1500mg/kg(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (1500mg/kg) for 28 days. This result suggests that Sagunja-tang(Sijunzi-tang). a herbal medicine prescription, is a safe prescription to body.

• Herbal Formula Science
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• v.16 no.2
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• pp.145-153
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• 2008

Objectives : This study was to assessment the toxicity of Sipjeondaebo-tang(Shiquan dabu-decoction) by Chromosomalanomaly test. Methods : Sipjeondaebo-tang(Shiquan dabu-decoction) water-extract in vivo Chromosomalanomaly test was performed using chiness hamster lung cell line. Results : Sipjeondaebo-tang water extract was negative in Chromosomalanomaly test at the doses of 0, 625, 1250 and $2500{\mu}g/m\ell$ at 6h and 24h.(S9- fraction). Chromosomalanomaly test(S+fraction) was also negative at the doses of 0, 1250, 2500 and $5000{\mu}g/m\ell$. Conclusions : It was concluded that Sipjeondaebo-tang extract did not induce Chromosomalanomaly in the chiness hamster lung cell.

• The KSFM Journal of Fluid Machinery
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• v.15 no.6
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• pp.18-24
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• 2012

This study simulated the operation of a steam injected gas turbine combined heat and power (CHP) system. A full off-design analysis was carried out to examine the change in the turbine blade temperature caused by steam injection. The prediction of turbine blade temperature was performed for the operating modes suggested in the previous study where the limitation of compressor surge margin reduction was analyzed in the steam injected gas turbine. It was found that both the fully injected and partially injected operations suggested in the previous study would cause the blade temperature to exceed that of the pure CHP operation and the under-firing operation would provide too low blade temperature. An optimal operation was proposed where both the turbine inlet temperature and the injection amount were modulated to keep both the reference turbine blade temperature and the minimum compressor surge margin. The modulation was intended to maintain a stable compressor operation and turbine life. It was shown that the optimal operation would provide a larger power output than the under-firing operation and a higher efficiency than the original partially injected operation.

• Journal of Satellite, Information and Communications
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• v.3 no.2
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• pp.38-42
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• 2008

In 2005, DVB-S2 spec. was finalized. But with a large number of DVB-S receivers already installed, backwards compatibility may be required for a period of time, where old receivers continue to receive the same capacity as before, while the new DVB-S2 receivers could receive additional capacity broadcasts. To facilitate the reception of DVB-S serviced by DVB-S2 receivers, implementation of DVB-S in DVB-S2 chips is highly recommended. For the backward compatibility the system adapt the hierarchical modulation scheme. And the system has to meet system margin, so in this paper analyzes the effect according to the deviation angle and shows the BER performance. And finally this paper shows the result of the system implement using FPGA chip.

• Journal of Sensor Science and Technology
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• v.7 no.1
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• pp.23-30
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• 1998

In this paper, we analyzed the effect of the time delay of the image sensor in the tracking loop of Electro-Optical Tracking System(EOTS). we showed that Smith predictor can greatly improve the stability and various performances of EOTS with time delay. And also, to verify the realistic validity, we executed the experiment in EOTS recently developed, and confirmed the effectiveness in EOTS.

• Journal of Society of Preventive Korean Medicine
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• v.17 no.1
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• pp.117-124
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• 2013

Objectives : This study was carried out to investigate the acute toxicity and safety of Palmultang and Fermented Palmultang Extract in Mice. Methods : To evaluate their acute toxicity and safety, 0 (control group), 2000 mg/kg of Palmultang and Fermented Palmultang Extracts were orally administered to 15 male and 15 female ICR mice. After a single administration, we observed survival rates, behavioral pattern, clinical sign, body weight. The results of biochemical analysis and hematological analysis were no any significant change. Results : Compared with the control group, we could not find any toxic alteration in all treated mice. Conclusions : Overall, the results suggest that, the oral administration of Palmultang and Fermented Palmultang extracts did not produce significant toxic effect in mice. Hence, the fermented extract can be utilized for herbal therapy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1192-1195
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• 2008

Sipjeondaebo-tang has been traditionally prescribed a medicine as a restorative. In this study, we investigated the acute toxicity about water-extracted Sipjeondaebo-tang. Thirty rats completed 14 days of oral Sipjeondaebo-tang at the respective doses of 0(control group), 2000 and 5000 mg/kg. We observed survival rates, general toxicity, change of body weight and autopsy. To be confirmed the data for the toxicity and safety problems of oriental medicine prescription. Compared with the control group, we could not find any toxic alteration in all treated groups (2000 and 5000 mg/kg). LD50 of Sipjeondaebo-tang was over 5000 mg/kg and it is very safe to SD rats.

• Korean Journal of Pharmacognosy
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• v.43 no.3
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• pp.250-256
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• 2012

In order to extract the curcuminoid such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) in turmeric (Curcuma longa), solvent extraction methods (dipping and ultrasonic extraction method) and solid-phase extraction (SPE) were used. RP-HPLC (reverse-phase high-performance liquid chromatography) and TLC (thin-layer chromatography) were used for identification and analysis the three curcuminoid. From the experimental results, it is evident that the percentage of curcuminoid extracted from turmeric by ultrasonic extraction method was higher than dipping method. The percentage of curcumin extracted from turmeric by pure methanol was higher than any aqueous methanolic composition. Moreover, the total peak area of three curcuminoid was above 92% in RP-HPLC using solid-phase extraction. These results will form a database for investigating the constituents of natural products and the resources of pharmaceutical, nutrition, and cosmetic products.

• Korean Journal of Pharmacognosy
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• v.49 no.1
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• pp.70-75
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• 2018

Acer tegmentosum Maxim (ATM) has been used to treat hepatic disorders in traditional oriental medicine. However, there is little information about phytochemical constituents for quality control of ATM. In this study, we developed and established a simultaneous analytical method of the 10 marker compounds (three coumarins, 3 flavonoids, 1 lignan, 3 phenolics) in ATM using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Chromatographic separation of ten target analytes was achieved with a Waters Acquity UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}m$), using a mobile phase of 0.1% (v/v) formic acid in water and acetonitrile with gradient elution. Identifications and quantitation of all analytes were performed using a Q-Exactive UPLC-MS/MS system. Correlation coefficients of the calibration curve for all analytes were ${\geq}0.9986$. The values of limits of detection and quantification of all analytes were 0.5-10.0 and 5.0-50.0 ng/mL, respectively. The established UPLC-MS/MS method successfully identified all target analytes in ATM, and the phytochemicals were 0.01-67.98 mg/g in its lyophilized water extract.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.137-141
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• 2008

Samul-tang(Siwu-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Samul-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Samul-tang(Siwu-tang) on SD rats. Twenty rats were orally adiministered Samul-tang for 28 days at a dose of 0 mg/kg(control group) or 1500 mg/kg(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (1500 mg/kg) for 28 days. This result suggests that Samul-tang(Siwu-tang), a herbal medicine prescription, is a safe prescription to body.