• Proceedings of the KSME Conference
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• 2005.11a
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• pp.71.2-71.2
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• 2005

• 전기의세계
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• v.51 no.5
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• pp.30-35
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• 2002

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.305-308
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• 2006

For controlling micro-flows inside a LOC (lab-on-a-chip) a syringe pump or an electronic device for EOF(electro-osmotic flow) have been used in general. However, these devices are so large and heavy that they are burdensome in the development of a portable micro-TAS (total analysis system). In this study, a new flow control system employing pressure chambers, digital switches and speed controllers was developed. This system could effectively control the micro-scale flows inside a LOC without any mechanical actuators or electronic devices We also checked the feasibility of this new control system by applying it to a LOC of micro-mixer type. Performance tests show that the developed control system has very good performance. Because the flow rate in LOC is controlled easily by throttling the speed controller, the flows in complicate microchannels network can be also controlled precisely.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.05a
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• pp.6-6
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• 2004

마이크로 / 나노 바이오 기술은 생명공학 및 의약기술의 발전을 가능하게 하고 생체시스템 관련 연구를 위한 마이크로 및 나노 기기를 제작할 수 있게 함으로써 새로운 기술적 영역으로 부각되고 있다. 이러한 기술은 1990년대 초에 랩온어칩(Lab-on-a-chip)의 개발을 가능하게 하였다. 랩온어칩은 실험실(Lab)을 하나의 소자(Chip)에 올려놓는다(On)는 말로 쉽게 설명된다. 즉, 생물학이나 생화학 실험실에서 주로 연구되는 단백질, 세포 등 인체에 영향을 주는 다양한 물질들이 체내외에서 나타내는 반응을 쉽게 검출, 분석하는 일련의 과정들을 빠르고 정확하게 수행할 수 있도록 도와주는 도구인셈이다.(중략)

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1546-1547
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• 2007

휴대용 면역진단 시스템을 구현하기 위하여 설계된 공기주입기로 구동되는 랩온어칩 내의 유체 유동을 컴퓨터 시뮬레이션을 통하여 해석하고, 문제점을 보완할 수 있는 구조로 랩온어칩을 재설계하였다. 공기주입기에서 흘러나오는 공기를 이용해 완충액 저장고 내에 있는 완충액을 토출시킬 때 다량의 기포가 발생함을 시뮬레이션 결과를 통해 알 수 있었다. 완충액 저장고의 내부에 계단형 구조를 삽입함으로서 완충액 이송 시 형성되는 기포를 상당히 억제할 수 있었다. 또한 계단형 구조는 유선을 역행 방지판 쪽으로 분산시켜 역행 방지판의 효율을 높일 것이다.

• The Magazine of the IEIE
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• v.31 no.1
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• pp.58-72
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• 2004

Smart sensors and biochip technologies have received a great deal of attention in recent years not only because of the enormous potential markets in the healthcare expenditures but more importantly because of its great impact on the quality of human life in the future. Collaborative research among BT (Bio Technologies), IT (Information Technologies) and NT (Nano Technologies) will bring us a new paradigm of the healthcare services. Examples include disease prediction based on the genetic tests, personal medicines, point-of-care analysis, rapid and sensitive infectious disease diagnostics, environmental monitoring for chemical or biological warfares, intelligent drug delivery systems etc. In this report, recent accomplishment in the research area on biosensors, DNA chips, Protein Chips and Lab-on-a-chips are reviewed.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.10
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• pp.188-195
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• 2004

In this paper, we fabricated fluidic devices like micro-channel, pump, mixer and particular gas separator with the technology of stereolithouaphy using RP(rapid-prototyping). The fabricated fluidic devices are expected to be applied to develop Lab-on-a chip type liquid analyzer. Stereolithography technology seems effective for fabricating MEMS(Micro Electro Mechanical System) with complicated structure because it makes three dimensional fabrication possible but, exclusive devices are needed to be developed fur fabricating even more microscopic MEMS structure.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.05a
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• pp.245-245
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• 2004

최근 급속히 성장하는 제약산업 분야에서 신약개발, 약물 투여, 유전자 분석에 필요한 비용과 시간을 줄이기 위하여 랩온어칩(Lab-on-a-chip) 기술이 부상하고 있다. 이러한 랩온어칩에서는 원하는 소량의 시료를 정밀하게 이송시켜 혼합, 반응, 분리, 검출 등이 하나의 칩 위에서 일련의 과정으로 수행 가능하게 하여 고속, 고효율, 저비용의 자동화를 시킬 수 있는 장점이 있다. 즉, 이는 하나의 칩 위에 분석에 필요한 여러 가지 장치들을 마이크로 머시닝 기술로 초소형 집적화 시킨 마이크로 프로세서이다.(중략)

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.2 s.245
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• pp.110-116
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• 2006

A syringe pump or a device using high electric voltage has been used for controlling flows inside a LOC (lab-on-a-chip). Compared to LOC, however, these microfluidic devices are large and heavy that they are burdensome for a portable ${\mu}-TAS$ (micro total analysis system). In this study, a new flow control technique employing pressure regulators and pressure chambers was developed. This technique utilizes compressed air to control the micro-scale flow inside a LOC, instead of a mechanical actuator or an electric power supply. The pressure regulator controls the output air pressure by adjusting the variable resistor attached. We checked the feasibility of this system by measuring the flow rate inside a capillary tube of $100{\mu}m$ diameter in the Re numbers ranged from 0.5 to 50. In addition, the performance of this flow control system was compared with that of a conventional syringe pump. The developed flow control system was found to show superior performance, compared with the syringe pump. It maintains automatically the: air pressure inside a pressure chamber whether the flow inside the capillary tube is on or off. Since the flow rate is nearly proportional to the resistance, we can control flow in multiple microchannels precisely. However, the syringe pump shows large variation of flow rate when the fluid flow is blocked in the microchannel.

• KSBB Journal
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• v.20 no.3
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• pp.197-204
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• 2005

Lab-on-a-chip is a miniaturized analytical device in which all of the procedures for the analysis of molecules are carried out, such as pretreatment, reaction, separation, detection, etc. Lab-on-a-chip has increasing concern as a device not only for rapid detection of molecules but also for high throughput screening and point of care, because conventional laborious and time consuming analytical procedures can be substituted. Thus, a lot of microfabrication and analytical techniques for lab-on-a-chip have been developed with microstructures smaller than a few hundreds of micrometers. Separation of the molecules is one of the most important components of lab-on-a-chip, because effective separation method can simplify the design and can provide better sensitivity. The electrokinetic separation based on capillary electrophoresis is most widely employed technique in lab-on-a-chip for the control of fluids and the separation of molecules. In this article, bioseparation techniques and its applications realized in lab-on-a-chip are reviewed.