• Journal of the Society of Cosmetic Scientists of Korea
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• v.38 no.3
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• pp.247-254
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• 2012

Ramalin (${\gamma}$-glutamyl-N'-(2-hydroxyphenyl)hydrazide) isolated from the Antarctic lichen Ramalina terebrata has been shown to have strong antioxidant activities in the previous study. To investigate additional activities of ramalin, we studied the effects of ramalin on melanogenesis in melan-a cells, a non-tumorigenic melanocyte cell line. At a non-cytotoxic concentration, ramalin dramatically decreased melanin synthesis in melan-a cells in a dose-dependent manner, which was more potent than arbutin, a well-known tyrosinase inhibitor. Ramalin inhibited cell-free tyrosinase activity directly and intracellular tyrosinase activity as well. Its inhibitory mechanisms on melanin production were further assessed, and we found that ramalin significantly decreased the protein levels of melanogenic enzymes such as tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). However, the mRNA levels of these enzymes were not altered. In a clinical study, application of 0.2 % ramalin on human skin significantly improved the degree of skin brightness after 3 weeks. In conclusion, ramalin has strong anti-melanogenic activity that is exerted both by the direct inhibition of tyrosinase activity and by down-regulation of melanogenic proteins. Furthermore, ramalin showed skin brightening effect in a clinical study. Collectively, these results suggest that ramalin may be a useful inhibitor for melanogenesis in skin.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5389-5396
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• 2012

In this paper, an optimized residual data decoder architecture is proposed to improve the performance in H.264/AVC. The proposed architecture is an integrated architecture that combined parallel inverse transform architecture and parallel inverse quantization architecture with common operation units applied new inverse quantization equations. The equations without division operation can reduce execution time and quantity of operation for inverse quantization process. The common operation unit uses multiplier and left shifter for the equations. The inverse quantization architecture with four common operation units can reduce execution cycle of inverse quantization to one cycle. The inverse transform architecture consists of eight inverse transform operation units. Therefore, the architecture can reduce the execution cycle of inverse transform to one cycle. Because inverse quantization operation and inverse transform operation are concurrency, the execution cycle of inverse transform and inverse quantization operation for one $4{\times}4$ block is one cycle. The proposed architecture is synthesized using Magnachip 0.18um CMOS technology. The gate count and the critical path delay of the architecture are 21.9k and 5.5ns, respectively. The throughput of the architecture can achieve 2.89Gpixels/sec at the maximum clock frequency of 181MHz. As the result of measuring the performance of the proposed architecture using the extracted data from JM 9.4, the execution cycle of the proposed architecture is about 88.5% less than that of the existing designs.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.140-140
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• 2010

최근 정부가 저탄소 녹색성장을 새로운 국정비전으로 제시하고 혁신적 그린에너지 기술개발을 위해 연평균 20%이상의 R&D 예산을 증액하고 있는 상황에서 연구개발결과의 상용화율 제고를 위한 연구기획, 평가, 관리시스템의 개선이 시급한 실정이다. 특히 선진국의 경우 최근 3년간 에너지분야 R&D의 상용화율이 미국 35.9%, 유럽 46.8%로서 24.2%인 한국에 비해 매우 높다고 할 수 있다. 이와같은 격차가 존재하는 것에 대해서 다양한 요인을 생각해볼 수 있겠지만, 크게 시장적인 또는 산업적인 측면에서의 중요도를 기준으로 연구과제를 선정하지 못하고 있다는 점과 연구개발결과를 효율적으로 사업화하고 있지 못하고 있다는 점을 생각해볼 수 있다. 특히 에너지 분야는 대규모 자금의 초기소요 및 개발기술 상용화기간의 장기화등으로 인해 사업화 실적이 타산업대비 매우 저조한 편이다. 이와같은 연구결과의 사업화와 관련된 문제점을 극복하기 위한 노력으로 국내에서 다양한 형태의 기술사업화 지원프로그램이 운영괴고 있으나, 에너지 분야에 특화된 프로그램은 부족한 상황이다. 반면에 미국의 경우, 재생에너지 R&D분야 전문투자자 그룹인 클린테크그룹 등을 중심으로 2002년부터 현재까지 다수의 녹색기술분야에 특화된 기술사업화 지원 프로그램을 운영하고 있다. 그 결과 현재까지 약 9년간 총 16억$의 투자유치에 성공함으로써 민간투자 활성화 역할을 담당하고 있다. 따라서 국내의 경우에도 이와같은 에너지 R&D 결과를 효과적으로 사업화로 연계시킬 수 있는 관련 프로그램 등이 시급히 도입되어야 할 것이다. 본 논문에서는 국내의 사업화 부진문제를 해결하기 위한 하나의 방안으로서 올해부터 정부주관으로 시행되고 있는 녹색인증사업을 활용하여 사업화가 유망한 기술 및 기업을 선별하고, 이에 대해 사업화 지원을 위한 후속프로그램을 적극 지원함으로써 연구개발결과의 경제적 활용도를 획기적으로 개선하는 방안을 제시하고자 한다. 또한 사업화 지원프로그램의 효율성을 높이기 위해 수도권, 영남권, 호남권 등 지역별 TP 등을 중심으로 기술사업화 협력 네트워크를 구축하고, 이를 기반으로 한 수요기술조사, 기술마케팅, 투자자유치 등의 관련프로그램을 개발하여 전단의 시스템과 융합시킴으로써 향후의 정부주도 R&D결과의 상용화율을 제고할 수 있는 시스템을 제안하고자 한다. 이에는 에너지 R&D분야별 기술적 시장적 특징분석, 지역별 산업특성과 기술공급 서플라이 체인분석을 토대로 한 기술이전 잠재수요기업 투자자를 대상으로 한 맞춤형 기술사업화 프로그램 등이 포함된다. 마지막으로 제안된 시스템에 대한 타당성 검증을 위해 올해년도에 시행한 녹색인증 기술사업화 연계프로그램 및 기술사업화 협력네트워크 활용사례 등을 분석하고, 향후 발전방향으로서 기술사업화 유관기관간간 기술사업화 정보교환 및 사업화 유망기술 기업 마케팅 등을 기본내용으로 한 시장지향적 녹색에너지 R&D 관리 시스템 구축방안을 제시하고자 한다.

• Spatial Information Research
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• v.20 no.2
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• pp.1-11
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• 2012

In the current construction planning and designing process, an architectural miniature model was designed to verify the interior or exterior spatial sense of a building structure, but building of the miniature model is demand much more effort and time; in addition to this it has limitation to identify interior information of the building. For a complement of it, CAD would be used in the existing planning and designing process to visualize the building information, but its visualization is not satisfactory for the 3D volume which could be easily verified with the miniature model. CAD is the specific software for designing building structures and the 3D results are usually rendered on 2D monitor screen. Therefore, there is a shortage of cognitive immersion for the 3D space. In this paper, we introduce the conversion process of BIM shape data into the Augmented Reality contents by using a series of softwares. As a result of modification on construction plan or design we reduced the cost and time to reconstruct the final visualization. We have shown that the interior or exterior information of the building structures are easily visualized with BIM shape data on augmented reality environment. Several proposed interaction methods, such as rem oval of building components, and slice-cut operation, provide the user for the effective manipulation of models on the augmented reality environment.

• Spatial Information Research
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• v.22 no.4
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• pp.77-87
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• 2014

Recently there are many disasters caused by volcanic activities such as the eruptions in Tungurahua, Ecuador(2014) and $Eyjafjallaj\ddot{o}kull$, Iceland(2010). Therefore, it is required to prepare countermeasures for the disasters. This study analyzes the Baekdu Mountain area, where is the risky area because it is active volcano, based on the observed data and scientific methods in order to assess a risk, produce a hazard map and analyze a degree of risk caused by the volcano. Firstly, it is reviewed for the research about the Baekdu mountain volcanic eruption in 1215(${\pm}15$ years) done by Liu Ruoxin. And the factors causing volcanic disaster, environmental effects, and vulnerability of Baekdu Mountain are assessed by the dataset, which includes the earthquake monitoring data, the volcanic deformation monitoring data, the volcanic fluid geochemical monitoring data, and the socio-economic statistics data. A hazard, especially caused by a volcano, distribution map for the Baekdu Mountain Area is produced by using the assessment results, and the map is used to establish the disaster risk index system which has the four phases. The first and second phases are very high risky area when the Baekdu Mountain erupts, and the third and fourth phases are less dangerous area. The map shows that the center of mountain has the first phase and the farther area from the center has the lower phase. Also, the western of Baekdu Mountain is more vulnerable to get the risk than the eastern when the factors causing volcanic disasters are equally applied. It seems to be caused by the lower stability of the environment and the higher vulnerability.

• Journal of the Korean Association of Geographic Information Studies
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• v.14 no.4
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• pp.63-76
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• 2011

This study purposes to develop a model to analyze soil loss in estimating prior disaster influence. The model of analyzing soil loss develops the soil loss analysis system on the basis of Internet by introducing cloud computing system, and also develops a standalone type in connection with HyGIS. The soil loss analysis system is developed to draw a distribution chart without requiring a S/W license as well as without preparing basic data such as DEM, soil map and land cover map. Besides, it can help users to draw a soil loss distribution chart by applying various factors like direct rain factors. The tools of Soil Loss Anaysis Model in connection with HyGiS are developed as add-on type of GMMap2009 in GEOMania, and also are developed to draw Soil Loss Hazard Map suggested by OECD. As a result of using both models, they are developed very conveniently to analyze soil loss. Hereafter, these models will be able to be improved continuously through researches to analyze sediment a watershed outlet and to calculate R value using data of many rain stations.

• Clean Technology
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• v.12 no.2
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• pp.53-61
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• 2006

A PGSS (Particles from Gas Saturated Solutions) process designed to generate nano-particles using supercritical fluids has been conducted for the fabrication of Poly(lactide-co-glycolide) (PLGA) microparticles that encapsulate a protein drug. It is demonstrated that the polymer and the dry powder of a protein can be mixed under supercritical carbon dioxide conditions and that the protein component retains its biological activity. In this experiment, the mixture of polymer which is plasticized and dry powder protein was sprayed to form solid polymer that encapsulate the protein. It is found that supercritical fluid process give fine tuning of particle size and particle size distribution by simple manipulations of the process parameters. Porous particles were formed with irregular shape. Protein encapsulated in the polymer was found to have enzymatic activity without significant loss of its initial value.

• Journal of Haehwa Medicine
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• v.21 no.1
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• pp.125-133
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• 2012

본 논문은 피부미백에 관한 실험적 연구로서, 봉선화(Impatiens balsamina Linne)의 성분 중에서 하이드록시-나프타-퀴논(hydroxynaphthoquinone)이 멜라닌 생성억제 효능, 색소침착 저해 효과 등의 미백 활성이 있는 것으로 밝혀졌다. 피부흑화(melanogenesis)는 멜라닌 색소생성세포(melanocyte)에서 자외선 등의 자극에 대한 방어기작으로 멜라닌 생성 활동이 증가되고 이로 말미암아 만들어진 다량의 멜라닌이 각질형성세포(keratinocyte)로 전이되어 피부 표피층에 축척된 결과이다. 비록 멜라닌이 피부에 보호작용을 하나 피부의 과색소 침착은 기미, 주근깨, 피부염증 후의 피부흑화, 노인성 색소반점 등을 일으키며 이로 인해 피부미용 상의 불편뿐만 아니라 정신적으로 부정적인 영향을 미쳐 사회활동에 불편을 초래하기도 한다. 멜라닌 생성 과정은 아미노산의 일종인 티로신(tyrosine)에 티로시나제(tyrosinase)라는 효소가 작용하여 도파(DOPA), 도파퀴논(dopaquinone)으로 바뀐 후 비효소적인 산화 반응을 거쳐 만들어 지며, 이것이 피부 내에 이상 침착하여 기미, 검버섯 등이 생기는 것이라고 알려져 있다. 이와 같은 색소침착, 기미, 반점 등의 완화, 예방 및 치료에는 멜라닌 생성을 억제하는 물질, 예를 들면 하이드로퀴논(hydroquinone), 알부틴, 비타민 C 및 그 유도체 등이 개발되어 사용되고 있으나 이 중, 하이드로퀴논은 일단 효과가 인정되고 있지만 감작성이 있기 때문에 일반적으로 사용이 제한되고 있다. 아스콜빈산은 쉽게 산화되어, 이를 배합한 제품에는 변색, 변취가 되는 문제를 야기하고, 식물추출물 유래의 물질들은 식물의 산지에 따라 효능의 차이가 심하여 제품의 균질성이 유지되기 어렵다. 이러한 이유로 많은 멜라닌 생성을 억제하는 물질을 개발하기 위한 연구들이 계속 진행하고 있다. 2-히드록시-[1,4]나프토퀴논 유도체는 다음과 같은 구조를 나타낸다. 상기 구조에서 R은 포화 혹은 불포화된 직쇄 또는 분지쇄의 알킬로서, 바람직하게는 C1 내지 C10의 포화 혹은 불포화된 직쇄 또는 분지쇄의 알킬이고, 보다 바람직하게는 C1 내지 C5의 포화 혹은 불포화된 직쇄 또는 분지쇄의 알킬이다. 실험에 활용된 화합물은 다음과 같은 반응식으로 얻어졌다. 2-히드록시-[1,4]나프토퀴논과 포타슘카보네이트(K2CO3)를 아세토니트릴에 용해한 후, 저온수조로 냉각하고 알킬할라이드를 적당한 당량비로 천천히 적하하여 히드록시기와 에테르(ether) 반응을 통하여 얻어질 수 있다. 상기 반응식에서 R은 C1~10의 포화 또는 불포화된 알킬기로서 직쇄형 또는 분지쇄형 모두 가능하다. 상기 화합물인 2-히드록시-[1,4]나프토퀴논(2-hydroxynaphthoquinone)은 배양된 쥐의 멜라노마 세포에 대하여 하이드로퀴논과 대등한 멜라닌 생성 억제효과를 보였다. 하이드로퀴논은 저농도에서 강력한 멜라닌 생성 억제효과를 보이지만 상기 화합물들은 보다 낮은 농도에서도 세포독성을 나타내지 않으며 하이드로퀴논보다 높은 멜라닌 생성 억제 효과를 보였다.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.5 s.335
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• pp.55-62
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• 2005

In this paper, we propose an efficient symbol detection algorithm for space-frequency OFDM (SF-OFDM) transmit diversity scheme and present the implementation results of the SF-OFDM WLAN baseband processor with the proposed algorithm. When the number of sub-carriers in SF-OFDM scheme is small, the interference between adjacent sub-carriers may be generated. The proposed algorithm eliminates this interference in a parallel manner and obtains a considerable performance improvement over the conventional detection algorithm. The bit error rate (BER) performance of the proposed detection algorithm is evaluated by the simulation. In the case of 2 transmit and 2 receive antennas, at $BER=10^{-4}$ the proposed algorithm obtains about 3 dB gain over the conventional detection algorithm. The packet error rate (PER), link throughput, and coverage performance of the SF-OFDM WLAN with the proposed detection algorithm are also estimated. For the target throughput at $80\%$ of the peak data rate, the SF-OFDM WLAN achieves the average SNR gain of about 5.95 dB and the average coverage gain of 3.98 meter. The SF-OFDM WLAN baseband processor with the proposed algorithm was designed in a hardware description language and synthesized to gate-level circuits using 0.18um 1.8V CMOS standard cell library. With the division-free architecture, the total logic gate count for the processor is 945K. The real-time operation is verified and evaluated using a FPGA test system.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.12
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• pp.45-52
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• 2005

A systolic array formed by interconnecting a set of identical data-processing cells in a uniform manner is a combination of an algorithm and a circuit that implements it, and is closely related conceptually to arithmetic pipeline. High-performance computation on a large array of cells has been an important feature of systolic array. To achieve even higher degree of concurrency, it is desirable to make cells of systolic array themselves systolic array as well. The structure of systolic array with its cells consisting of another systolic array is to be called super-systolic array. This paper proposes a scalable bit-level super-systolic amy which can be adopted in the VLSI design including regular interconnection and functional primitives that are typical for a systolic architecture. This architecture is focused on highly regular computational structures that avoids the need for a large number of global interconnection required in general VLSI implementation. A bit-level super-systolic FIR filter is selected as an example of bit-level super-systolic array. The derived bit-level super-systolic FIR filter has been modeled and simulated in RT level using VHDL, then synthesized using Synopsys Design Compiler based on Hynix $0.35{\mu}m$ cell library. Compared conventional word-level systolic array, the newly proposed bit-level super-systolic arrays are efficient when it comes to area and throughput.