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SEREX; discovery of tumor antigens (종양 항원의 발견: SEREX)

  • Lee, Sang-Yull
    • Journal of Life Science
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    • v.17 no.6 s.86
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    • pp.841-846
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    • 2007
  • The identification of tumor antigens is essential for the development of anticancer therapeutic vaccines and clinical diagnosis of cancer. SEREX (serological analysis of recombinant cDNA expression library)has been used to identify such tumor antigens by screening sera of cancer patients with cDNA ex-pression libraries. SEREX-defined antigens provide markers for the diagnosis of cancers. SEREX is also a powerful method for the development of anticancer therapeutics. The development of anticancer vaccines requires that tumor antigens can elicit antigen-specific antibodies or T lymphocytes. This re-view provides information on the application of SEREX for discovery of tumor antigens.

Genetic Optimization of IG-based Fuzzy Model by Means of Improved Consecutive Tuning Method (개선된 연속적 동조 방법에 의한 정보 입자 퍼지 모델의 최적화)

  • Park, Geon-Jun;O, Seong-Gwon
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2006.11a
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    • pp.370-373
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    • 2006
  • 본 논문에서는 복잡하고 비선형적인 시스템에 대하여 구체적이고 체계적인 방법에 의한 퍼지 모델을 설계하기 위해 유전자알고리즘을 이용하여 전반부 및 후반부의 구조와 파라미터 동정한다. 정보 입자 기반 퍼지 모델의 구조를 동정하기 위하여 유전자 알고리즘을 이용하여 입력 변수의 수, 선택될 입력 변수, 멤버쉽함수의 수, 그리고 후반부 형태를 결정하고, 파라미터를 동정하기 위하여 전반부 멤버쉽 파라미터를 동조하여 최적의 퍼지 모델을 설계한다. 또한 구조 동정 및 파라미터 동정에 있어서 개선된 연속적 동조 방법으로 접근하여 정보 입자 기반 퍼지 모델의 최적 동정을 도모한다. 마지막으로 제안된 퍼지 모델은 표준 모델로서 널리 사용되는 수치적인 예를 통하여 평가한다.

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Study of Aspergillus Species from Clinical Specimen Isolate (임상검체에서 분리된 Aspergillus Species의 연구)

  • Lee, Jang Ho;Koo, Bon-Kyung
    • Korean Journal of Clinical Laboratory Science
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    • v.48 no.1
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    • pp.15-21
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    • 2016
  • Aspergillus is the most common opportunistic fungus causing infection. Aspergillus is the most morphologically identified in the laboratory. Recently, molecular genetic methods have been proposed for identification of fungi that unidentified morphologically or identified genus level. Of 475 cases of Aspergillus isolated from clinical specimens, there were Aspergillus fumigatus 257 (54.1%), A. niger 101 (21.3%), A. flavus 43 (9.1%), A. terreus 29 (6.1%), Aspergillus nidulans 2 (0.4%), Aspergillus clavatus 1 (0.2%), and the Aspergillus species 42 (8.8%). Eleven cases of unidentified or identified at the genus level included Aspergillus fumigatus 5, Aspergillus falvus 1, Aspergillus terreus 1, and Aspergillus lentulus 1 was identified in the sequencing of the strain level. It was identified as Aspergillus versicolor 2, and Emericella parvathecia 1. 92.2% of Aspergillus was identified as a possible morphological, 8.8% could not be identified at the species level. Sequence-based molecular analysis using the ITS and D1D2 is considered useful for identification of the species level.

Identification and Tolerance-Test to Digestive Fluids of Lactobacilli Isolated from Korean Liquid Yogurts (국내 액상발효유에서 분리한 유산균의 동정 및 소화관액 내성조사)

  • So, Myeong-Hwan
    • Korean Journal of Food Science and Technology
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    • v.17 no.3
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    • pp.192-196
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    • 1985
  • Eight strains of Lactobacilli(a, b, b', c, d, e, f and g) were isolated from seven Korean liquid-yogurts(A, B, C, D, E, F and G), and identification and tolerance-test to digestive fluids were carried out. Isolate a from yogurt A and isolate a from yogurt E were identified as L. casei, isolate b from yogurt B as L. acidophilus, isolate d from yogurt D as L. bulgaricus, isolate f from yogurt F as L. helveticus, and isolate b' from yogurt B, isolate c from yogurt C and isolate g from yogurt G as L. jugurti, respectively. Isolate f(L. helveticus) and c(L. jugurti) showed high tolerance to artificial gastric juice but didn't to bile acid. Isolate b(L. acidophilus), a(L. casei), and e(L. casei) showed high tolerance to both artificial gastric juice and bile acid, but isolate d(L. bulgaricus), b'(L. jurgurti) and g(L. jugurti) did not.

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Development of a Hypertext-based Polychotomous Key for the Identification of Planthoppers Caught by Light Trap in Paddy Fields (논에 설치한 유아등에 채집되는 멸구류 동정을 위한 하이퍼텍스트 기반 검색표 개발)

  • 김황용;박창규;한만위;엄기백;우건석
    • Korean journal of applied entomology
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    • v.41 no.2
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    • pp.75-83
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    • 2002
  • The hypertext-based polychotomous key in m (World Wide Web) was developed to improve the identification accuracy of planthoppers caught by the light trap in Korean paddy fields. The effects of it were tested by 12 students who are not familiar at the identification of insects. When they used the hypertext, it was improved that the ability of them to recognize Sogatella furcifera (Horvath) and Laodelphax striatellus (Fallen). Identification accuracy of the former was increased significantly from 56% to 83% and that of the latter was also increased significantly from 47% to 80%. However, many students still have difficulty in the recognition of Nilaparvata lugens (Stal).

Separation and Identification of Volatile Components of Apple Fruits after Harvest (수획후(收獲後) 사과과실(果實)의 향기성분(香氣成分)의 분리(分離) 및 동정(同定))

  • Kim, Sung-Dal;Odagiri, Satoshi;Ito, Tetsuo
    • Applied Biological Chemistry
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    • v.32 no.2
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    • pp.143-147
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    • 1989
  • The volatile compounds of McIntosh apples were separated and identified at the stage of climacteric maximum. 21 compounds were identified from head space method and classes of that were 13 kinds of esters, 6 of alcohols, an aldehyde and a ketone. From simultaneous steam distillation-extraction method, 37 compounds were identified and classes of that were 20 kinds of esters, 14 of alcohols, 2 of aldehydes and a ketone. Esters were the most abundant flavor component in the both methods and next was alcohols.

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Giant Venous Aneurysm after Brachiocephalic Arteriovenous Shunt for Hemodyalisis Access -A case report- (혈액투석을 위한 상완동맥-두정맥단락 수술 후 발생한 거대한 정맥의 동맥류 -1예 보고-)

  • Chon, Soon-Ho;Lee, Chul-Burm
    • Journal of Chest Surgery
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    • v.39 no.11 s.268
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    • pp.861-863
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    • 2006
  • We report a case of a 46-year-old man with end-stage renal failure who developed a giant aneurysm after a brachiocephalic arteriovenous shunt. The patient had complaints of pulsating pain and swelling of his left upper extremity The patient had abandoned use of the arteriovenous shunt and had a second arteriovenous shunt procedure over his right extremity. The giant venous aneurysm was removed just distal to his anastomosis. The patient's postoperative course was uneventful.

Streptomyces 속 균주가 생산한 항생물질에 관한 연구 (제2보) 생산균주의 미생물학적인 동정

  • Ko, Young-Hee;Bae, Moo
    • Proceedings of the Korean Society for Applied Microbiology Conference
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    • 1978.10a
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    • pp.205.4-206
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    • 1978
  • 벼 문길병균 Pellicularia sasakii에 대하여 강한 항균력을 나타내는 항생물질 생산균의 배양상의 특성과 형태적, 생리적 특성을 종합적으로 조사하여 항생물질 생산균을 동정하였다. 동정 결과 본 생산균은 Streptomyces griseorubi-ginosus로 동정되었고 배양상의 조건에 근소한 차이를 나타내므로 상기균주의 새로운 변종으로서 Streptomyces griseorubiginosus var. kyungiensis 명명하였다.

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