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http://dx.doi.org/10.5352/JLS.2007.17.6.841

SEREX; discovery of tumor antigens  

Lee, Sang-Yull (Department of Biochemistry, School of Medicine, Pusan national University)
Publication Information
Journal of Life Science / v.17, no.6, 2007 , pp. 841-846 More about this Journal
Abstract
The identification of tumor antigens is essential for the development of anticancer therapeutic vaccines and clinical diagnosis of cancer. SEREX (serological analysis of recombinant cDNA expression library)has been used to identify such tumor antigens by screening sera of cancer patients with cDNA ex-pression libraries. SEREX-defined antigens provide markers for the diagnosis of cancers. SEREX is also a powerful method for the development of anticancer therapeutics. The development of anticancer vaccines requires that tumor antigens can elicit antigen-specific antibodies or T lymphocytes. This re-view provides information on the application of SEREX for discovery of tumor antigens.
Keywords
SEREX; tumor antigen; cancer/testis(CT) antigen; SADA;
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