• Journal of Veterinary Clinics
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• v.15 no.1
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• pp.110-115
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• 1998

인삼 PD saponin(GPD)으로 배양한 고양이 말초혈액 단핵구세포(afNC) 배양상충 액에서 말초혈액 다형핵백혈구(PMNC)에 대한 interleukin(IL) 8 양 유주활성에 잔하여 검토 하였다. PMNC의 유주활성은 Hoyden chamber 변법으로 측정하였다. GPD를 첨가하여 배양 한 MNC배양상층액중에는 rMNC에 대한유주활성이 인정되었다. PMNC에 대하여 GPD 로 배양한 MNC 배양상층액중에 존재하는 유주활성이 IL 8 양 물질인지를 알아보기 위해 human recombinant IL 8을 이용하여 고양이 PMNC에 대해 유주팔성을 측정한 결과, GPD 로 배양한 MNC 배양상층액의 경우와 동등한 활성이 나타났다. Human IL 8 mAb를 사용하 여 GPD로 배양한 MNC 배양상층액중의 유주활성에 대한 중화반응을 살펴본 결과, GPD로 배양잔 MNC 배양상충액 및 human IL 8에 의해 증가되었던 PMNC의 유주활성은 IL 8 cAb의 첨가농토가 증가함에 따라 활성이 완전히 억제되었다. 또한 GPD로 배양한 고양이 MNC 배양상충액중의 유주활성은 열처리(4, 30, 37, 60 및 $100{\circ}C$) 및 산(pH 3.0)과 알카리 (pH 9.0)처리에도 안정성을 보여 human IL 8의 물리화학적 성상과 매우 유사하였다. 따라서 GPD로 배양한 MNC 배양상충액중에 존재하는 고양이 PMNC에 대한 유주활성은 feline IL 8 양 물질임을 강하게 시사하였다.

• The Korean Society of Law and Medicine
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• v.22 no.1
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• pp.91-124
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• 2021

In May 2019, the Ministry of Food and Drug Safety revised the "Pharmaceutical Determination and Adjustment Criteria" with the content of differentially calculating the price of generic drugs according to the registration of the drug substance and meeting the requirements for their own bioequivalence test. According to this revised rule, if their own bioequivalence test is not conducted, even the generic drugs that have already been approved would be lowered in price. I wondered whether this system was introduced with sufficient public legal considerations regarding its legislative purposes and means. Therefore, I reviewed the contents of the revised notice based on whether or not it is valid to determine and adjust the price of generic drugs in terms of the legitimacy of legislative purposes and the proportionality principle after introducing the history and background of the rule. First, I raised a question as to whether the purpose of preventing the overrun of generic drugs is indeed legitimate in terms of the legitimacy of the purpose. In order for the revised notice of "reduction of drug prices when the test requirements are not met," to meet the conformity principle, the premise that it is difficult to recognize safety and effectiveness through consignment (joint) bioequivalence test or that these tests are insufficient in safety and efficacy verification than their own test must be established. Nevertheless, it seems that suffficient review has not been carried out. In order to achieve the purpose of securing safety and effectiveness, the focus should be on 'reinforcement of the standards for bioequivalence test and the management of the bioequivalence test itself' rather than whether it is a their own test or a consignment (joint) test. Third, it is contrary to the necessity and substantiality principle that strict standards are uniformly applied to the products that can be considered to have been sufficiently verified for safety and effectiveness after a considerable period of time has passed after the product approval. In many cases, revised administrative legislations quickly enacted and amended in the state of lack of legal review or consensus, while the regulatory effects resulting from it are quite direct and specific to the regulated person. In this respect, I emphasized that the administrative legislative process also requires substantial review and prior control of the regulatory purposes and means, and that the participation of stakeholders in the legislative procedure is to be strengthened.

• 한국가스학회:학술대회논문집
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• 2003.10a
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• pp.65-72
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• 2003

현행 가스법상 지상식 LNG 저장탱크에 있어서 일정 용량의 저장탱크 주위에는 액상의 가스가 누출된 경우에 그 유출을 방지할 수 있는 방류둑(Dike) 또는 이와 동등 이상의 효과가 있는 시설을 설치하도록 규정하고 있어, 실제로 모든 지상식 LNG 저장탱크에 대해서 별도의 방류둑 설치를 의무화하고 있다. 또한, 예외규정으로 국제기준(international codes and standards)에 의해 설계되는 저장탱크는 심의를 통해 방류둑 기능을 인정할 수 있도록 하고 있다. 외국의 경우 LNG 저장탱크는 일반적으로 자국내 법령보다는 국제기준에 의해 건설됨으로써 1차 탱크로부터 일정거리의 둘레에 방류둑이 필요한 단일방호식 저장탱크 이외에 이중방호식, 완전방호식(full-containment) 및 멤브레인식(membrane) 저장탱크의 경우 외부(콘크리트, 강재)탱크가 방류둑 기능을 가지고 있어 별도의 방류둑이 필요없는 구조로 규정하고 있다. 멤브레인 LNG 저장탱크의 경우 프랑스, 일본 및 한국이 설계기술을 보유하고 있고, 최근 프랑스 및 한국에서 별도의 방류둑 없는 지상식 멤브레인 저장탱크 건설이 추진되고 있으나 양국 모두 자국법의 방류둑 규정에 의해 건설의 장애요소로 작용하고 있다. 따라서 지상식 멤브레인 LNG 저장탱크의 방류둑 기능에 대한 각 국의 법령 및 기준을 조사하고, 방류둑 일체형 저장탱크(완전방호식 및 멤브레인 저장탱크)의 형식별 안전성 평가 자료를 비교 검토함으로써 방류둑 일체형 멤브레인 저장탱크의 국내 도입의 타당성을 검토하고자 하였다. 조사결과 유럽, 미국 및 일본에서는 이중벽 LNG 저장탱크의 경우 콘크리트 외부탱크가 방류둑 기능을 가지는 것으로 규정하고 있으며, 특히 EN 1473과 제정중인 prEN 265002에서는 멤브레인 저장탱크의 경우 내부 멤브레인 탱크 누출시 단열시스템과 함께 외부 콘크리트 탱크가 액밀성 및 기밀성을 동시에 가지는 것으로 별도의 방류둑이 불필요함을 규정하고 있다. 프랑스 및 일본의 방류둑 일체형 LNG 저장탱크에 대한 위험성 평가 결과를 검토한 결과 멤브레인 저장탱크와 완정방호식 저장탱크는 안전성 차원에서 거의 동일한 것으로 나타났다. 따라서 국내에서 개발한 지상식 멤브레인 LNG 저장탱크 설계모델에 대한 안전성 제고 및 안전성 평가 등을 통해 객관적인 안전성 근거가 확보된다면 동 탱크의 경우에도 완전방호식 LNG 저장탱크와 같이 외부콘크리트 저장탱크의 방류둑 기능인정이 가능할 것으로 판단된다.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.134-139
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• 2021

This paper discusses the types and functions of English subordinate clauses, whether English subordinate clauses (SC) are headed by a Complementizer (CP) or headed by a lexical (but not functional) Preposition (PP). Furthermore, unlike the standard classification, the current paper provides a finer-grained analysis and classification of English SCs. The traditional or prescriptive view on the functions of English SCs includes Noun SC such as complement clauses, Adjectival SC including relative clauses, and Adverbial SCs that cover a garden variety of subordinators. Added to the existing classification of subordination in English is what I notate as Verbless subordinate clause (V-less SC). Of these 4 different types of subordinate clauses with different functions, properties, and distributions, Subjectless Verbless subordinate clause is further divided into Smallest small clause (SSC) which accounts for English subordination mechanism more uniformly and consistently with respect to their clausal architecture, especially when the subordinate clause is neither PP nor CP.

• Journal of the Korean Society for Library and Information Science
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• v.40 no.3
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• pp.369-389
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• 2006

Grey literature is a non-Public data only for nonprofit users. Some of the major grey literatures are technical report, Proceeding, and thesis. For their Promptitude, these sources are core of research and development. According to a research on the academic qualify. grey literatures have higher usage rates than books-articles excluded. Also, the usage of foreign grey literature by librarians of research organization was investigated. The result was that over 90 percent of the researchers were demanding the original text of the foreign grey literature. In addition, librarians pointed out that the time-consuming problem and the lack of published information was a hindrance to using grey literature. For the centralized management of grey literature. they wanted an alliance structure.

• The Korean Journal of Financial Management
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• v.6 no.1
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• pp.31-62
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• 1989

By using deterministic dynamic models, we observe the behavior of the foreign exchange rate of a small open economy with rational expectation formation and different restrictions on the international economic integrations. First, an economy connected to the world by purchasing power parity and uncovered interest parity is studied in the next section. In both sections, financial assets available in the economy are domestic money and bonds. Stocks are added as a financial instrument in the next section, and real capital accumulation is also taken into account. Furthermore, the economy concerned there is fairly autonomous, and not directly governed by either purchasing power parity or uncovered interest parity. The expectation formation used throughout the whole paper is complete perfect foresight, which is the certainty version of rational expectation and free from any forecast errors. It is found that upon monetary expansion the short run depreciation of the foreign exchange rate is a fairly robust result regardless of the degree of the international economic integration, while it is not true for fiscal expansion. The expectation on the long run state significantly affects the short run response of the exchange rate. All of our models postulate that the current account should be balanced eventually. As the result, the short run behavior of the exchange rate is affected by the expectation on the long run balance and may well be a blend of the traditional flow view and modem asset view. The initial overshooting of the exchange rate is easily observed even in the fairly autonomous economy Furthermore, the initial overshooting is not reduced over time, but augmented for some time before it is eventually eliminated. As long as we maintain rational expectaion, introducing time delay in the adjustment of the foreign goods price to the foreign exchange rate does not make much difference.

• Applied Biological Chemistry
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• v.40 no.1
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• pp.23-29
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• 1997

To develop novel cephem antibiotics, We have synthesized a new compound, named YH-487, by attaching the thiol and aminothiazole residue to $C_3$ and $C_7$ position of 7-ACA, respectively. Several characteristics such as structure, antibiotic spectrum, action mechanism, stability against ${\beta}-lactamase$ and synergistic effect were investigated. Anti-bactericidal activity of YH-487 against gram-positive and gram-negative bacteria were superior to that of the other cephem antibiotics. We have examined the action mechanisms of YH-487 using penicillin binding protein (PBP) assay, and found that the bactericidal activity was obtained by inhibiting PBP-1A, PBP-1B and PBP-3. YH-487 showed synergistic effect with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa. In addition, YH-487 was effective against Enterobacter cloacae in combination with amikacin. Based on the above observations, YH-487 was classified as a novel third-generation ${\beta}-lactam$ antibiotics.

• The Journal of the Convergence on Culture Technology
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• v.6 no.1
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• pp.381-388
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• 2020

This paper discusses English Hedges or Hedging Expressions on the basis of their morphosyntactic-pragramatic properties within the perspective of sociolinguistics. The term, 'Hedges' for the past decades since Lakoff(1973), has received little attention from the English grammar circles such as morphosyntax and the generative grammar theories. This paper presents a more comprehensive approach to the identification, distributions, functions, and the morphosyntactic properties of English Hedges. The earlier research on English Hedges in the 70's show that hedges are metalinguistic or mitadiscourse expressions which constitute a means for executing Politeness strategy in pragmatics. Nonetheless, research from the interface of syntactic-pragmatics has been scarce. This article suggests a more complex body of English hedges that have not been extensively discussed in the literature. Additionally, their configurational domain is to be proposed as part of the PolP with [±hedged] above CP⁺ (or CP beyond). The ramifications of the current study are suggested in terms of comparative linguistics, EFL/ESL studies of English for global communication, and pragmatics-sensitive machine translation studies in the forseeable future.

• Journal of Korean Society of Forest Science
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• v.54 no.1
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• pp.68-75
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• 1981

The genetic structures at one leucine aminopeptidase locus (LAP-A) of acorns, seedling raised in greenhouse and forest form the two beech provenances. West Germany and Rumania, were investigated and compared with each other. In many pair wise comparisons significant differences in genotypic structure as well as genic structure were ascertained between different developmental stages. In both the provenances, the allele $A_2$ seems to have advantage at both seedling stages raised under two different conditions. Homozygous carriers of $A_2$ allele survived best in greenhouse, while heterozygous carriers especially with $A_2$ allele possessed great viability under more variable environmental conditions. Since a distinct different genetic background was present in two base populations, the identical effect of the allele $A_2$ confirms the adaptiveness of this locus. With aid of some measures such as viability parameter and genetic distance, the character of occurred viability selection of further explained. The possible significance of this locus at this early stage is discussed in relation to adaptation of this long lived tree species to heterogeneous environment.

• The Korean Society of Law and Medicine
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• v.24 no.3
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• pp.27-55
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• 2023

The term "Collaborative medical care" commonly used in South Korea refers to the case where doctors from different medical departments work together to treat a patient within the same medical institution. Therefore, "Collaborative medical care" represents the aspect of a medical team where various medical professionals collaborate based on their expertise to treat patients. Additionally, doctors from different specialties within the medical team engage in horizontal division of labor at an equal status, distributing legal responsibilities according to the principles of division of labor. The Supreme Court also acknowledges cases where multiple doctors collectively provide medical treatment through division of labor or collaboration and states that the doctor who initially attended to the patient must accurately inform the subsequent attending doctor about the patient's condition to enable appropriate measures. In medical institutions with multiple specialties, when doctors from different specialties collaborate to provide medical treatment, the doctor who attended to the patient initially must decide whether collaboration is necessary based on the patient's condition. Subsequently, they must inform the doctor from the relevant specialty about the patient's condition accurately to facilitate appropriate actions. The successor doctor who participates in collaborative medical care must actively communicate relevant treatment information related to the patient's condition with the predecessor doctor who requested collaboration, exchange opinions, and do so until the patient's treatment concludes. However, the determination of the necessity of collaborative medical care should be based on the patient's condition at the time, and it cannot be asserted that collaborative medical care is mandatory in all cases. Whether there is negligence in the decision about the necessity of collaboration will be assessed based on the legal principles of a doctor's duty of medical care.