• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.320-324
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• 2007

This study was undertaken to assess the antinociceptive effect of Korean bee venom (BV) in mice. Korean BV was collected using BV collector devices in which an electrical impulse is used to stimulate the worker bee (Apis mellifera L.) to sting and release venom. After collection, whole BV was evaporated until dry using the BV collector. Experiments were performed on male ICR mice (weighing $30{\sim}35g$, 6 weeks old). Mice were divided into 4 groups, each comprising 8 mice. BV was diluted and amounts of 6 mg/kg body weight (BW), 0.6 mg/kg BW and 0.06 mg/kg BW were tested. BV was subcutaneously injected to produce an antinociceptive effect and the antinociceptive efficacy was evaluated using a writhing test in mice. Intraperitoneal injection of acetic acid produced a tonic pain behavior, first observed at 3 to 9 min post-injection. This writhing response peaked at 20 min post-acetic acid injection, and then declined until it was undetectable at 60 min post-injection. The time elapse between the administration of acetic acid and the first observed pain behaviors indicated a dose-dependent suppressive effect. These results suggest that Korean BV may be used to achieve an antinociceptive effect for use in medical therapies.

• Proceedings of the KSCN Conference
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• 2003.11a
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• pp.1087-1088
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• 2003

영양사들이 영양서비스에 대한 중요성을 인지하고 있으나 과중한 급식업무에 많은 시간을 할애하고 있으며, 또한 영양사 인력부족으로 인하여 환자에 대한 영양상담이나 영양교육이 제대로 이루어지지 않은 병원도 있어 간호사들이 영양교육을 실시하는 병원도 있는 형편이다. 따라서 영양사의 원활한 업무수행 및 역할 확대를 위하여서는 이에 영향을 미칠 수 있는 의사, 간호사 등 타 의료진의 영양관리에 대한 인식파악이 필요하다고 생각되어 마산시와 창원시 및 경남 함안군에 위치한 2-3차 의료기관에 종사하는 보건의료인 중 간호사(197명)와 간호조무사(94명) 291명을 대상으로 영양관리 중 영양교육에 대한 인식 및 영양지식을 조사하였다. 환자에 대한 영양교육이 ‘매우 필요하다’에 74.2%, ‘약간 필요하다’에 32.8%를 보였으며, 간호사와 전문대 졸업이상에서 간호조무사와 고졸자에 비하여 영양교육의 필요성에 대한 인식이 높게 나타났다(P < 0.001). 영양관련 과목을 이수하지 않은 자는 47.9%, 이수한 자는 52.1%이였으며, 간호조무사(60.4%)가 간호사(42.1%)에 비하여 (P < 0.01), 그리고 근무경력 2년 이상(51.5-59.4%)에서 2년 미만(34.4%)에 비하여(p < 0.05) 영양관련 과목을 이수하지 않은 율이 높게 나타났다. 영양관련 과목 이수자 중 영양지식 습득정도는58.7%가 ‘부족’한 것으로, 40.6%가 ‘보통’인 것으로 답하여 대체적으로 부족하다고 인정하고 있었으며, 학력이 낮을수록 ‘부족’하다고 답하여 학력에 따른 유의적인 차이가 있었다(P <0.05). 영양교육 연수경험이 있는 대상자는 8.6%, 없는 자는 91.4%로 간호사에게 영양교육 연수가 거의 없는 것으로 나타났다. 영양교육 담당자의 적임자로는 영양사 69.3%, 간호사 21.3%로 답하였으며, 간호조무사는 영양교육 적임자로 영양사 82.7%, 간호사 5.8%로 답한 반면 간호사는 영양사 63.5%, 간호사 27.9%로 답하여 유의적인 차이가 있었다(p<0.001). 기회가 주어지면 영양교육에 참여하겠다는 대상자가 47.2%, 참여하지 않겠다는 자가 52.8%로 약1/2정도는 기회가 온다면 참여하겠다는 의지를 보였다. 영양교육에 참여하지 않겠다는 대상자의 43.4%가 ‘전문지식 부족’, 40.5%가 ‘전문가가 담당하는 것이 바람직하다’, 11.9%가 ‘업무량 과중’을 이유로 들었다. 환자치료 시에 영양에 대한 내용을 지도한 경험이 있는 대상자는 48.8%, 지도경험이 없는 자는 51.2%로 나타났으며, 간호사(60.9%)가 간호조무사(23.4%)에 비하여 지도경험율이 높고(p <0.001), 기혼자(57.4%)가 미혼자(44.2%)에 비하여 높으며(p < 0.05), 근무경력 2년 이상이 2년 미만에 비하여(P <0.05), 그리고 전문대 졸업 이상이 고졸에 비하여 유의적으로 높게 나타났다(p<0.001). 영양지식점수의 분포는 good group 55.3%, fair group 41.2%, Poor group이 3.4%이었으며, good group의 평균 점수는 16.1 $\pm$ 1.1점, fair group은 12.7 $\pm$ 1.4점, poor group은 6.6 $\pm$ 2.8점으로 세 군간에 유의적인 차이가 있었다(p < 0.001). 영양지식 점수의 전체평균은 20점 만점에 14.3 $\pm$ 2.5점이였다. 이상의 결과에서 환자의 영양교육 및 상담업무를 원활하게 수행하기 위하여 영양과 내에 급식관리와는 별도로 임상영양 및 영양교육을 담당하는 부서가 설치되어야 하며 영양사의 인력확보가 필요하다고 사료된다. 이상의 연구결과에서 간호사들은 영양교육이 필요하다고 인식하고 있었으나 간호사를 영양교육의 적임자로 보는 시각이 비교적 높았고 약 1/2정도는 영양교육에 참여하겠다는 의지를 가지고 있을 뿐만 아니라 실제로 영양지도를 한 경험이 있는 것으로 나타났다. 그러나 1/2 정도가 영양관련과목을 이수하지 않았으며, 91.4%가 영양교육 연수경험이 없는 것으로 나타났다.

• Journal of Oral Medicine and Pain
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• v.31 no.1
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• pp.101-111
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• 2006

Temporomandibular disorders (TMD) is a collective term embrassing a number of clinical problems that involve the masticatory musculature, the Temporomandibular joint and associated structures, or both. The prevalence of signs and symptoms associated with TMD can be best appreciated by examining epidemiologic studies. But domestic epidemiologic studies about sex, history, chief complaint, diagnosis were not sufficient comparing with foreign countries. The results obtained as follow. 1. The number of visiting patients were 6500 and mean age was 34.06 year (Male's mean age was 33.15, Female's 34.62). In the age of patients, there was no significant difference between sex. 2. There are most patients who were referred by dentist (80.07%). Most diagnostic group was arthrogenous TMD group and followed by myogenous TMD, soft tissue disease. 3. There was strong interaction between diagnostic groups and chief complaint. 4. There was little pain difference between right and left sides. Male mainly had pain onset under 6 month, but female had pain onset more than 6 month. 5. The number of patients who had joint sound history were 3445 (53.15%). There was no significant difference of pain onset between sex. Clicking sound was most among joint sounds which happened to patients. 6. In analyzing the parafunctional habit, male mainly had bruxism, but female had clenching habit.

• Journal of Life Science
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• v.29 no.6
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• pp.735-739
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• 2019

The dried rhizomes and roots of Gentiana scabra (GS) have been frequently prescribed as a traditional folk medicine in East Asia (including China, Japan, and Korea) for the treatment of various pathophy-siological conditions, such as inflammatory skin diseases, anorexia, indigestion, gastric infections, and diabetes mellitus. In the present study, the effects of aqueous (GS-W) and ethanolic (GS-E) extracts of GS on gastrointestinal (GI) motor function were investigated by measuring the in vivo gastric emptying rate (GER) and the intestinal transit rate (ITR) in mice. The GER was significantly increased by GS-W at a dose of 1 g/kg. The ITR was significantly increased by GS-W (at doses of 0.1 and 1 g/kg) or GS-E (at a dose of 1 g/kg) in a dose-dependent manner. Furthermore, the ITR value of GS-W (at a dose of 1 g/kg) appeared to be higher than that of cisapride, which was the most prominent prokinetic agent in the 1900s but was removed from the market in 2000 due to its fatal side effects. The above results suggest that GS-W might be a potential prokinetic agent to replace cisapride.

• Journal of Life Science
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• v.29 no.6
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• pp.712-723
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• 2019

Chemically synthesized compounds are widely used in oral hygiene products. However, excessively long-term use of these chemicals can cause undesirable side effects such as bacterial tolerance, allergy, and tooth discoloration. To solve these issues, significant effort is put into the search for natural antibacterial agents. The aim of this study was to assess the extracts of foreign native plants that inhibit the growth and biofilm formation of Streptococcus mutans. Among the 300 foreign plant extracts used in this study, Chesneya nubigena (D. Don) Ali extract had the highest antimicrobial activity relatively against S. mutans with a clear zone of 9 mm when compared to others. This plant extract also showed anti-biofilm activity and bacteriostatic effect (minimal bactericidal concentration [MBC], 1.5 mg/ml). In addition, the plant extracts of 19 species decreased the ability of S. mutans to form biofilm at least a 6-fold in proportion to the tested concentrations. Of particular note, C. nubigena (D. Don) Ali extract was found to inhibit biofilm formation at the lowest concentration tested effectively. Therefore, our results reveal that C. nubigena (D. Don) Ali extract is a potential candidate for the development of antimicrobial substitutes, which might be effective for caries control as well, as demonstrated by its inhibitory effect on the persistence and pathogenesis of S. mutans.

• Journal of Digital Convergence
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• v.17 no.8
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• pp.265-270
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• 2019

Growing evidence suggests that mediating apoptotic cell death of ER stress plays an important role in pathological development of neurodegenerative diseases including Alzheimer's disease. The ethanol extract of Rodiola sacra (ERS) investigates whether ER stress protects neuroinvasive neuro-2A cells from homocysteine (Hcy) cell death and ER stress. In neuronal cells, Hcy markedly decreased the viability of the cells and induced the death of Annexin V-positive cells as confirmed by MTT assay. The Hcy cell viability and apoptotic loss pretreated with ERS were attenuated, and Hcy showed stress in the expression of C / EBP homologous protein, 78-kDa glucose regulatory protein and the junction of X-box binding protein-1 (xbp1) mRNA. ESR decreased Hcy-induced mRNA binding, GRP78 and CHOP cells induced Hcy-induced ER stress and apoptosis, and Western blotting revealed expression of heme oxygenase-1 and HO-1 enzyme activity Inhibition is indicative of therapeutic value for neurodegenerative diseases such as decreased cell death by hemin.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.27 no.2
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• pp.82-96
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• 2018

3D printing is a process of producing 3d object from a digital file in STL format by joining, bonding, sintering or polymerizing small volume elements by layer. The various type of 3d printing is classified according to the additive manufacturing strategies. Among the types of 3D printer, SLA(StereoLithography Apparatus) and DLP(Digital Light Processing) 3D printer which use polymerization by light source are widely used in dental office. In the previous study, a full-arch scale 3d printed model is less precise than a conventional stone model. However, in scale of quadrant arch, a 3d printed model is significantly precise than a five-axis milled model. Using $3^{rd}$ Party dental CAD program, full denture, provisional crowns and diagnostic wax-up model are fabricated by 3d printer in dental office. In Orthodontics, based on virtual setup model, indirect bracket bonding tray can be generated by 3d printer. And thermoforming clear aligner can be fabricated on the 3d printed model. 3D printed individual drilling guide enable the clinician to place the dental implant on the proper position. The development of layer additive technology enhance the quality of 3d printing object and shorten the operating time of 3D printing. In the near future, traditional dental laboratory process such as casting, denture curing will be replaced by digital 3D printing.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.36-44
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• 2019

Swallowing impairment is a frequent complication following stroke. The characteristics of swallowing impairment with stork patient can facilitate identification of individuals at risk of dysphagia would be of great helpful. The present study examined oropharyngeal swallowing impairment with subacute stroke patients using the Modified Barium Swallowing Impairment Profile(MBSImP). The 49 consecutive patients with the supratentorial stroke met inclusion criteria for the present study. A retrospective review was performed of patients who underwent the videofluoroscopic swallowing study(VFSS). Of Stroke patients, 95.9% exhibited abnormal function of lip closure. 98% and 57.1 % shown abnormal tongue function and lingual motion, respectively. Oral residue was present in 51% and delayed pharyngeal response was present in 89.9%. In addition, abnormal laryngeal and hyoid excursion was seen in 42.9% and 87.8%, respectively. Abnormal function of soft palate elevation was present in 18.4% and abnormal epiglottic movement was seen in 4.1%. 30.6% of 30.6% of these patients exhibited abnormal laryngeal closure. All of the stroke patients(100%) in this study exhibited abnormal pharyngeal stripping wave and pharyngoesophageal segment opening. Abnormal tongue base retraction and oral reside were present 91.8%, respectively. The results suggest that stroke patient is more likely to exhibit reduced swallowing functions including lip closure, tongue control, initiation of pharyngeal swallow, anterior hyoid motion, tongue base retraction, pharyngeal residue and pharyngoesophageal contraction. Therefore, these data could provide valid and precise information regarding physiological evidence to delineate symptoms of dysphagia in this stroke cohort. Future studies should explore the bolus effect in the swallowing impairment.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.163-171
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• 2021

Various records on health, food and treatment are written in ancient documents of Korea such as old recipe books, Korean medical books and history books, through these records, the principle of Sikchi can be discovered. Sikchi includes the meaning of medicine and food work on the same principle, and it is not only as traditional knowledge but also affecting modern food culture. Based on this principle of Sikchi, this study tried to lay a foundation that can be used as a modern health food material through scientific verification of foods recorded in the ancient literature. For this purpose, Omigalsu, a traditional drink made from omija, soybean, and honey, which is related to blood glucose control, which is one of the representative metabolic diseases of modern people, was selected as the subject of this study. In order to compensate for the agglomeration of beverages caused by honey or the rise in postprandial blood glucose, which occurs when the traditional Omigalsu recorded in the ancient literature is reproduced, the raw material that can be substituted for honey was discovered. The health promotion and quality improvement effects of newly prepared Omigalsu using honey substitutive raw material were confirmed through a comparative test with traditional Omigalsu. Based on this study, through scientific research using the principle of Sikchi, we intend to lay a foundation that can be used as various contents in the medical and food fields such as food bio and healthcare in modern society.

• Korean Journal of Food Science and Technology
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• v.53 no.2
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• pp.139-148
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• 2021

Atopic dermatitis is a chronic, recurrent, inflammatory skin disease that is a well-known allergic disease with severe itching, making daily life difficult. Since the immunomodulatory action of vitamin D has been reported, several researchers have attempted to determine the correlation between vitamin D and atopic dermatitis. In this review, 41 articles meeting the inclusion criteria were selected and reviewed from the articles published to date. Several studies have reported that low vitamin D levels are associated with the onset of atopic dermatitis and severe atopic dermatitis, but the opinions remain conflicting. Similarly, there are conflicting opinions on the improvement effect of oral vitamin D supplementation on atopic dermatitis, but some possibilities have been suggested. To apply vitamin D as a therapeutic agent for atopic dermatitis, a more systematically designed experiment should be conducted, and an appropriate intake dose for an immunomodulatory function should be obtained.