• Title/Summary/Keyword: 단일주기가진

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The Effect of Light Stimulation on the Reduction of Unilateral Neglect of Stroke Patients: Single Subject Research Design (뇌졸중 환자에게 불빛 자극이 편측무시 감소에 미치는 영향: 단일 사례 연구)

  • Lee, Ho-Seung
    • The Journal of Korean society of community based occupational therapy
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    • v.2 no.2
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    • pp.61-69
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    • 2012
  • Objective : The purpose of this study was to investigate the effect of left visual stimuli for reducing the severity of unilateral neglect. Method : This research used a reversal design(ABAB) of single case study. The subject was a 60-year-old male patient who had left unilateral neglect. Remedial approach is more valuable method than compensatory approach in term of reducing the unilateral neglect. One of the method of remedial approach is controlled sensory stimulation. Result : I performed the line bisection test before and after the stimulation, and while doing that, put blinking lights to the patient from the left side. The average errors in the line bisection test decreased in B B', the intervention period, compared with A A'. The MVPT left response behavior score increased from 13 to 18. Conclusion : This shows that the light stimulation is effective in the reduction of unilateral neglect.

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Establishment and Application of Molecular Genetic Techniques for Preimplantation Genetic Diagnosis of Osteogenesis Imperfecta (골형성부전증의 착상전 유전진단을 위한 분자유전학적 방법의 조건 확립과 적용)

  • Kim, Min-Jee;Lee, Hyoung-Song;Choi, Hye-Won;Lim, Chun-Kyu;Cho, Jae-Won;Kim, Jin-Young;Song, In-Ok;Kang, Inn-Soo
    • Clinical and Experimental Reproductive Medicine
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    • v.35 no.2
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    • pp.99-110
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    • 2008
  • Objectives: Preimplantation genetic diagnosis (PGD) has become an assisted reproductive technique for couples carrying genetic conditions that may affect their offspring. Osteogenesis imperfecta (OI) is an autosomal dominant disorder of connective tissue characterized by bone fragility and low bone mass. At least 95% of cases are caused by dominant mutations in the COL1A1 or COL1A2. In this study, we report on our experience clinical outcomes with 5 PGD cycles for OI in two couples. Methods: Before clinical PGD, we assessed the amplification rate and allele drop-out (ADO) rate of alkaline lysis and nested PCR protocol using heterozygous patient's single lymphocytes in the pre-clinical diagnostic tests for OI. We performed 5 cycles of PGD for OI by nested PCR for the causative mutation loci, COL1A1 c.2452G>A and c.3226G>A, in case 1 and case 2, respectively. The PCR products were analyzed by agarose gel electrophoresis, restriction fragment length polymorphism (RFLP) analysis with HaeIII restriction enzyme in the case 1 and direct DNA sequencing. Results: We confirmed the causative mutation loci, COL1A1 c.2452G>A in case 1 and c.3226G>A in case 2. In the pre-clinical tests, the amplification rate was 94.2% and ADO rate was 22.5% in case 1, while 98.1% and 1.9% in case 2, respectively. In case 1, a total of 34 embryos were analyzed and 31 embryos (91.2%) were successfully diagnosed in 3 PGD cycles. Eight out of 19 embryos diagnosed as unaffected embryos were transferred in all 3 cycles, and in the third cycle, pregnancy was achieved and a healthy baby was delivered without any complications in July, 2005. In case 2, all 19 embryos (100.0%) were successfully diagnosed and 4 out of 11 unaffected embryos were transferred in 2 cycles. Pregnancy was achieved in the second cycle and the healthy baby was delivered in March, 2008. The causative locus was confirmed as a normal by amniocentesis and postnatal diagnosis. Conclusions: To our knowledge, these two cases are the first successful PGD for OI in Korea. Our experience provides a further demonstration that PGD is a reliable and effective clinical techniques and a useful option for many couples with a high risk of transmitting a genetic disease.

A Case Report on Bee Venom Acupuncture for Patient with Osteo-Arthritis of Knee Joint, Diabetic Mellitus, and No Response for Steroid Injection (관절강내 Steroid injection에 호전되지 않은 DM을 가진 OA환자에 대한 봉독요법 치험1례)

  • Han, Soon-Hyun;Youn, You-Suk;Kim, Sung-Soo;Chung, Won-Suk
    • The Journal of Korea CHUNA Manual Medicine
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    • v.4 no.1
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    • pp.17-28
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    • 2003
  • We experienced a patient(53-year-old female) with knee joint effusion, pain and stiffness who had not responded to steroid injection therapy, significantly improved by bee venom acupuncture in clinical symptom. And for a opinion that prohibited bee venom acupuncture on DM because of increasing serum glucose level by increasing serum cortisol level, we also experienced that serum glucose level of DM patient stabilized by bee Venom acupuncture treatments, so we report this case with literature review of articles.

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Study on the Dynamic Characteristics of a Manual Transmission Using Linear Models (선형모델을 이용한 수동변속기의 동적 특성 연구)

  • Yoon, Jong-Yun;Lee, Iljae
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.23 no.3
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    • pp.240-248
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    • 2013
  • Torsional vibrations, such as the gear rattle of the manual transmission in vehicle systems, are correlated with the firing stroke from the engine. These vibro-impacts can be examined based upon linear time-invariant analysis. In order to understand the gear dynamics, a specific manual transmission with a front-engine front-wheel drive configuration is investigated. A method to reduce the degrees of freedom is suggested based upon the eigensolutions and frequency response functions, which will lead to the development of an efficient matrix size. The dynamic characteristics of single- and dual-mass flywheels are then compared. The effect of the dual-mass flywheel is investigated based upon the mobility analysis, which will lead to understanding of the concepts for avoiding vibro-impacts. A linear time-invariant system model is examined by employing the effective clutch stiffness from a two-stage clutch damper. Thus, the relationship between the dynamic characteristics and the clutch damper can be predicted by assuming a combination of different stage stiffness levels.

Differential Display of mRNA in the Preimplantation Mouse Embryos by Reverse Transcriptase Polymerase Chain Reaction (역전사 연쇄중합반응에 의한 착상전 생쥐난자에서의 상이한 mRNA의 발현조사에 의한 새로운 유전자의 크로닝법)

  • 김진회;박흠대;이훈택;정길생
    • Korean Journal of Animal Reproduction
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    • v.18 no.3
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    • pp.199-206
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    • 1994
  • We present here a new PCR-based cloning technique that allows the different PCR products during mouse embryogenesis. Recently, mRNA differential display described by Liang & Pardee (Science 257, 1992) and re-confirmed by Zimermann & Schultz (PNAS 91,1994). This method will detect the appropriate changes in the temporal patterns of expression or in the transition from maternal control to zygotic control as well as the functional difference of embryo with polyspermy or monospermy, the difference of expression between successfully hatched blastocyst and blastocyst failed to hatching, response to agents, and cell cycle regulation. By this methods, we have cloned an eDNA, which showed mouse 2 cell specific expression. Genomic DNA digested with EcoRI showed approximately 15 kb and then showed higher expression in fetal liver rather than adult liver. Furthermore, this gene is likely to have 2 mRNA by alternative splicing.

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Removal Characteristics of Toluene in Biofilters Packed with Reticulated-PU-Foams of Different Porosities (서로 다른 공극률의 망상형 폴리우레탄들이 충전된 바이오필터에서 톨루엔 제거 특성)

  • 명성운;남윤수;이용우;최호석
    • KSBB Journal
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    • v.18 no.6
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    • pp.448-454
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    • 2003
  • We studied on the removal of toluene vapors in a lab-scale biofilter. There are three biofilters packed with reticulated polyurethane foams of different porosities of 15, 25, 45 PPI (Pore Per Inch) as media. A toluene-degrading strain (Pseudomonas Putida KCCM 11348, ATCC 12633) was naturally immobilized on the filter media by circulating the culture media. Three biofilters were operated under different sets of continuous experiments, varying both the design and operation parameters such as the inlet toluene concentration and the flow rate. Maximum elimination capacity of 115.5g/㎥hr of biofilter packed with foams of 25 PPI was obtained for toluene degradation. The effect of operating conditions such as flow rate, inlet toluene concentration and porosity on the performance of the biofilter was investigated.

Digital Watermark Generation Algorithm Embedding Hangul Text (한글 텍스트가 내장된 디지털 워터마크 생성 알고리즘)

  • Cho, Dae-Jea;Kim, Hyun-ki
    • The KIPS Transactions:PartB
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    • v.10B no.5
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    • pp.485-490
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    • 2003
  • In this paper, we propose the possibility of introducing chaotic sequences into digital watermarking systems as potential substitutes to commonly used pseudo noise sequences. Chaotic sequences have several good properties including the availability of a great number of them, the ease of their generation, as well as their sensitive dependence on their initial conditions. And the quantization does not destroy the good property. So this paper proposes a method that transforms Hangul text to chaotic sequence. And we presents how the Hangul text is expressed by an implied data and the implied data is regenerated into the original text. In this paper, we use this implied Hangul text for watermarking.

Optical and Electrical Properties of InAs Sub-Monolayer Quantum Dot Solar Cell

  • Han, Im-Sik;Park, Dong-U;No, Sam-Gyu;Kim, Jong-Su;Kim, Jin-Su;Kim, Jun-O
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.196.2-196.2
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    • 2013
  • 본 연구에서는 분자선 에피택시 (MBE)법으로 성장된 InAs submonolayer quantum dot (SML-QD)을 태양전지에 응용하여 광학 및 전기적 특성을 평가하였다. 본 연구에서 사용된 양자점 태양전지(quantum dot solar cell, QDSC)의 구조는 n+-GaAs 기판 위에 n+-GaAs buffer와 n-GaAs base layer를 차례로 성장 한 후, 활성영역에 InAs/InGaAs SML-QD와 n-GaAs spacer layer를 8주기 형성하였다. 그 위에 p+-GaAs emitter, p+-AlGaAs window layer를 성장하고 ohmic contact을 위하여 p+-GaAs 를 성장하였다. SML-QD 구조의 두께는 0.3 ML 이며, 이때 SML-QD의 적층수를 4 stacks 으로 고정하였다. SML-QD 와의 비교를 위하여 2.0 ML크기의 InAs자발 형성 양자점 태양전지(SK-QDSC)과 GaAs 단일 접합 태양전지 (reference-SC)를 동일한 성장조건에서 제작하였다. PL 측정 결과, 300 K에서 SML-QD의 발광 피크는 SK-QD 보다 고에너지에서 나타나는데(1.349 eV), 이것은 SML-QD가 SK-QD보다 작은 크기를 가지기 때문으로 사료된다. SML-QD는 single peak를 보이는 반면, SK-QD는 dual peaks (1.112 / 1.056 eV)을 확인하였다. SML-QD의 반치폭(full width at half maximum, FWHM)이 SK-QD에 비하여 작은 것으로 보아 SML-QD가 SK-QD보다 양자점 크기 분포의 균일도가 높은 것으로 해석된다. Illumination I-V 측정 결과, SML-QDSC의 개방 전압(VOC) 과 단락전류밀도(JSC)는 SK-QDSC의 값과 비교해 보면, 각각 47 mV와 0.88 mA/cm2만큼 증가하였다. 이는 SK-QD보다 상대적으로 작은 크기를 가진 SML-QD로 인해 VOC가 증가되었으며, SML-QD가 SK-QD 보다 태양광을 흡수할 수 있는 영역이 비교적 적지만, QD내에 존재하는 energy level에서 탈출 할 수 있는 확률이 더 높음으로써 JSC가 증가한 것으로 분석 된다.

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Analysis of Magnetic Multi-layers by RBS and PIXE (후방산란법(RBS)/양성자 여기 X-선 방출법(PIXE)을 이용한 다층자성박막의 두께 및 조성 정량분석)

  • 송종한;김태곤;전기영;황정남;신윤하;김영만;장성호;김광윤
    • Journal of the Korean Magnetics Society
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    • v.11 no.6
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    • pp.272-277
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    • 2001
  • A spin valve structure of Ta/NiFe/CoFe/Cu/CoFe/Ru/CoFe/FeMn/Ta which has a synthetic antiferromagnet (CoFe/Ru/CoFe), was fabricated by using a magnetron sputtering system. The thickness and composition of magnetic free and pinned layers affect the magnetic properties such as exchange interaction strength of each layer and so on. Even though Rutherford Backscattering Spectrometry (RBS) has advantages of quantitative and non-destructive analysis, it is almost impossible to determine the thickness and composition of magnetic thin films using lBS because of its poor mass resolution for a higher atom number (Z>20). In this study, quantitative analysis of the element composition and thickness for the spin valve sample was performed by combining both Proton Induced X-ray Emission Spectrometry (PIXE), which is one of element specific analysis techniques, and grazing-exit RBS with a highly improved depth resolution and absolute quantitative analysis. For the quantitative analysis, standardization of PIXE was carried out with NiFe, CoFe, and FeMn layers, which are one of constituent layers of spin valve films. Through PIXE standardization and the aid of PHE experimental results of the spin valve sample, ire overlapped signal in a grazing-exit RBS spectrum were successfully resolved and the thickness of the Ru layer was determined with a resolution of ∼1 .

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The Viscosity and Rheology of the Silica Dispersion System with UV Curable Monomers (UV 경화형 단량체계 실리카 분산체의 점도 특성 및 유변학적 거동)

  • Ahn, Jae-Beom;Cho, Bong-Sang;Yoo, Eui-Sang;Noh, Si-Tae
    • Korean Chemical Engineering Research
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    • v.50 no.2
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    • pp.292-299
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    • 2012
  • We made 8 wt% silica dispersion system with fumed silica and photo curable acrylic monomer by beads mill process. These dispersions could be applied in organic/inorganic hybrid coating systems. These dispersions could be applied in organic/inorganic hybrid coating systems. The 4 species of photo curable acrylic monomer which was presence of hydroxyl group, different solubility parameter, and different molecular size were used in the silica dispersions. Stability of polar solvent, isopropyl alcohol, in silica dispersions was investigated. We investigated the stability of silica dispersions by using steady-state and dynamic rheology. As the monomer has hydroxyl group increased in mono and binary monomer silica dispersions, they showed non flocculated stable sol (loss modulus (G")> storage modulus (G')). When polar solvent IPA was added into slightly flocculated silica dispersions, they changed to non flocculated stable sol.