• Explosives and Blasting
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• v.12 no.4
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• pp.64-65
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• 1994

우리나라는 수도 서울에서 전국 인구의 25% 이상이 모여있다. 서울이라는 하나의 핵에 인구 뿐만 아니라 정치, 경제, 문화, 정보, 교육기능 등이 몰려있다. 다른 선진국의 경우 인구순위 1위인 도시의 비율이 일본은 6.6%, 프랑스는 4.0% 독일은 5.5%, 미국은 2.9%, 이태리는 5.0%에 불과하다. 이는 이들 나라에서는 도시가 균형있게 발달해 국토상의 도시배치가 다핵화 상태로 되어 있음을 입증하고 있다. 서울이라는 하나의 핵에 인구뿐만 아니라 모든 기능이 집중화돼 있는 우리나라 선진국의 균형있는 도시발전과 도시 다핵화 사례들은 우리에게 많은 것을 던져준다. 그들의 치밀한 도시계획과 노력, 중장기적 안목의 산물인 도시 다핵화는 국가경제를 이끌어 가는 또 하나의 원동력이다.

• Product Safety
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• s.39
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• pp.24-27
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• 1995

• Spatial Information Research
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• v.20 no.2
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• pp.93-103
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• 2012

Recently metropolitan cities pursue multi centric urban spatial structure for sustainable development and efficient urban management. Thus, this study calculated population potential using data on population distributed among road nodes for the last 50 years, and based on the results. We measured the spatial variability of the multi centric structure of Busan Metropolitan City. According to the results, the multi centralization process has been continued up to recently in Busan Metropolitan City. As population potential is concentrated on sub centers, Hadan, Gupo and Haeundae areas were playing an increasingly powerful role as the center of the respective district, and Sasang and Dongrae had been losing their role as the center of their respective districts since 2000 and 1990, respectively. Additionally, in all the multi centric districts except Haeundae was observed the increase of oblongity, which is the change of spatial structure in an unbalanced way toward a specific area or direction.

• The Korean Journal of Zoology
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• v.37 no.2
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• pp.240-248
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• 1994

골격근 세포는 미분화 단핵 근원세포로부터 신장과 융합을 거쳐 다핵 횡문근섬유로 분화되어 가며 동시에 근특이 유전자의 발현이 선택적으로 일어난다. 본 연구에서는 계배 배양 근원세포의 분화동안 유전자 발현 조절 양상에 대한 연구를 위해, 계배 근원세포를 72시간 배양한 근섬유로부터 CDNA 라이브러리를 제작하였다. 이 cDNA 라이브러리를 미분화 단핵 근원세포(배양 36시간)와 분화된 다핵 근섬유(배양 72시간)의 poly(A)+ RNA 주형에서 합성된 [32P〕cDNA를 Probe로 사용한 differential plaque hybridization 방법으로 스크리닝하였다 분화된 다핵 근섬유 CDNA probe에 강한게 흔성화되는 CDNA clone을 선별하여 클로닝하였다. 선별한 CDNA clone 들 중 하나는 약 1.3 Kb 크기의 삽입절편을 갖고 있는 것으로 나타났고, 이 CDNA를 probe로 사용하여 northern blotting 한 결과, 이 CDNA엑 대한 유전자는 미분화 단핵 근원세포에서 분화된 다핵 근섬유로 분화가 진행됨에 따라 유전자 산물인 RNA 양이 증가되는 것으로 나타났다 또한 이 1.3 Kb CDNA에 대한 RNA의 크기는 약 2 7 Kb로 확인되었다.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.33 no.12
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• pp.65-72
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• 2017

Three decades after its establishment in 1946, Seoul National University was transferred to its current location in Gwan-ak District in accordance with the Seoul National University Integration Plan. In the 40 years since Seoul National University transferred to the Gwan-ak area, much quantitative and qualitative growth has taken place, and the university has grown into a world-class research institution. In this process, the campus was expanded externally and internally, and many changes have been made to the campus life bases and facilities which were planned at the beginning of the campus' construction. This study examines the expansion of the facilities at Seoul National University's Gwan-ak campus, as well as the expansion of the campus' boundaries. In addition, through quantitative analysis (Space Syntax), we predicted the location of campus life bases of the present multi-centralized campus and suggested a future developmental direction for the campus.

• Journal of the Korean Geographical Society
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• v.37 no.1
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• pp.61-74
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• 2002

In late 1980s, many suburban cities in Tokyo metropolitan area have tried to construct office parks, such as Makuhari New Town, Minato Mirai 21 to promote knowledge based economy. As the most important player of this mesa project, the local government mobilized local resources from various private sectors. The local government adopted place marketing strategy to attract companies and consumers with thick pocket. The composition of this strategy embraces publicity, uniqueness, centrality of function and information and comfortability for formation of the office park. Headquarters and producer service offices were relocated in the suburban office parks for the first time in the history of modem Tokyo since 1920s. Although it is the ongoing project that encounters some financial difficulties, the office park Project will be a sound foundation for future growth of knowledge-based economy.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.2
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• pp.1-14
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• 2014

In this study, the change characteristics of urban spatial structure in Daegu were analyzed connecting with urban planning for efficient urban management. Urban development process from 1970 to 2010 in Daegu was analyzed utilizing Getis-Ord $G_i^*$ methodology, a spatial statistical method, and it was identified that Daegu was in the stage of disurbanization. However, as Daegu orients multi-nuclei city, it was difficult to explain the stage of urban development after disurbanization in 2000. Accordingly, to analyze detailed changes in spatial structure in multi-centric areas after 2000, population, land price and employment factor changes were analyzed using Bachi Measurement. According to analytical results, multi-centralization process has been continued in Daegu. Urban core area and Chilgok area showed spatial structure change into distribution process, Ansim area into concentration process, and Seongseo and Talseo area into concentration and distribution process. Therefore, urban planning considering the regional characteristics are needed for efficient urban management.

• Journal of Veterinary Clinics
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• v.31 no.3
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• pp.258-261
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• 2014

A 4-week-old male piglet being maintained in a research facility was found dead without any previous clinical signs. The piglet had been born from a surrogate mother after somatic nuclear transfer as part of a xenotransplantation study. Ovaries for nuclear transfer were obtained from a private farm outside the research facility. Histopathologically, multifocal to coalescing granulomatous myocarditis was observed in the heart, characterized by infiltration of lymphocytes, macrophages and multinucleated giant cells, and by myocardial necrosis and fibrosis. Lymphoid tissues showed marked lymphoid depletion with infiltration by histiocytes or giant cells. Immunohistochemistry showed PCV-2 antigens in necrotic myocytes, macrophages and multinucleated giant cells in the heart, as well as in macrophages and giant cells in lymphoid depleted areas of lymphoid tissues. Reproductive failure associated with PCV-2 in aborted or stillborn piglets is frequently characterized by myocarditis, and similar lesions were observed in this 4-week-old piglet with PCV-2 infection. The PCV-2 infection in this piglet may have been due to contamination or infection of an ovary from the pig farm.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.4
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• pp.532-539
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• 2015

Inhibition of osteoclast differentiation is the most important target for prevention of inflammatory bone resorption and bone diseases. Here, we investigated the effect of spinach ethanol extract on osteoclast differentiation in RAW264.7 cells. Spinach was extracted with ethanol at a concentration ranging from 0 to 100% (0, 25, 50, 75, and 100% ethanol). Inhibitory effects of receptor activator of NF-${\kappa}B$ ligan (RANKL)-induced osteoclast differentiation were evaluated using tartrate-resistant acid phosphatase (TRAP) stain assay. The most effective eanol concentration for osteoclast differentiation was 100%. Spinach extract (100% ethanol) suppressed RANKL-induced osteoclast differentiation and TRAP activity. Spinach extract (100% ethanol) also suppressed expression of osteoclast differentiation-related marker genes (NFATc1, c-FOS, cathepsin K, and TRAP) and down-regulated RANKL-induced NF-${\kappa}B$ and ERK phosphorylation during osteoclast differentiation. Taken together, our results suggest that spinach extract is effective against reducing osteoclast differentiation through the NF-${\kappa}B$-mediated pathway.

• Journal of the Korean association of regional geographers
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• v.18 no.4
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• pp.414-432
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• 2012

Land price is a kind of text to read urban spatial structure. The purpose of this paper is to inquire into the characteristics of Daegu's urban structure and its change in time through exploring spatio-temporal variations of land price with a detailed spatial and temporal resolution. To achieve this, land value surfaces were represented using the officially assessed land price every other year from 1995 to 2011. Through mapping and exploring spatio-temporal patterns and fluctuation rates of land price for this period, changes in urban structure, the effects of local decision makings such as Greenbelt adjustment, housing site development, and gentrification, and the effects of business fluctuations or policies at global or national scales could be caught. In addition, the trends for suburbanization and multi-centric urban form could be examined from the results of a negative exponential model explaining the effect of distance from an urban center on spatial variation of land price. These results demonstrate that urban analysis using land price mirroring spatial decision making at various scales could deepen understanding for internal structure and change of a city and provide useful information for establishing regional and urban development policies and evaluating their effects.