• Journal of Digital Convergence
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• v.18 no.3
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• pp.227-234
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• 2020

This study was carried out to provide basic data for the development of an educational program by assessing the its effects on the MDROs infection management performances of nurses at general hospitals. Data was obtained through a structured questionnaire survey conducted on 202 nurses. The average of knowledge score was 17.68 and their perceived susceptibility, perceived severity, perceived benefits, and performances had correlation. There was difference in their performances in accordance with their general characteristics including marriage, clinical experiences, positions, and affiliated department. Factors that affected MDROs infection management performance included perceived benefits and affiliated department with an explanation power of 35%. Therefore, it is necessary to emphasize the benefits by including advantages and effects of performing the MDROs infection control at the time of the development. In addition, nurses are required to have MDROs infection control education.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.463-470
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• 2020

This study was conducted to aid in the development of an infection control educational program for nurses, by assessing the knowledge and educational demand of nurses for MDRO infection control. Totally, 115 nurses participated in the study. Data were collected from November 15-30, 2019, using structured questionnaires. Descriptive statistics, t-test, and ANOVA were applied for analyzing the data. Experience of caring for MDRO patients was reported by 86.1% nurses, whereas 67.8% nurses had received training on MDROs. The average score for knowledge on MDROs was 25.51 out of 27 points, with minimal correct answers given for the query on level of disinfection for medical equipment used by patients, criteria for the preemptive precaution, patient management in the cohort, and timing for removing personal protective equipment. The educational demand was highest for assignment to the precaution, criteria for screening examination, and management of outbreak. Also, educational needs differed with respect to the general educational characteristics and position of the individual. We propose the need to differentiate the educational status according to the career when developing the MDROs program, and the necessity to execute education of MDROs for new nurses and career nurses.

• Journal of Industrial Convergence
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• v.20 no.11
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• pp.205-211
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• 2022

This study is a descriptive research study to identify the knowledge and compliance of multidrug-resistant organisms of nursing students with clinical practice. Data were collected from 212 nursing students in two nursing schools in D city from 1 November 2020 to 10 March 2021. The collected data were statistically analyzed using the SPSS/WIN 25.0 program. Correlations were found between knowledge and compliance of multidrug-resistant organisms (r=.40, p<.001). Therefore, to enhance the compliance of multidrug-resistant organisms of nursing students, it is necessary to prepare detailed theoretical and practical guidelines for multidrug-resistant organisms in the curriculum and clinical practice and to increase knowledge through multidrug-resistant organisms infection control education.

• Journal of Digital Convergence
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• v.19 no.4
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• pp.159-166
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• 2021

This study was an attempt to develop a multidrug resistant organisms infection control simulation program for nurses at small and medium sized hospitals and to evaluate the effectiveness of said simulation program. This is a single-group, pre-post experimental design study conducted on 33 nurses working at small and medium sized hospitals. Data obtained were analyzed using the IBM SPSS 21.0 program, along with the use of descriptive statistics and paired t-test. Regarding the results of the study, multdrug resistant organisms infecion control knowledge(t=-10.764, p<.001)and performance levels(t=-4.215, p<.001) of the nurses displayed statistically significant increases following application of the simulation program. There is a need for the development of more diversified simulation programs in the future since the improvement in the infection control knowledge and performance levels of nurses is important to block the spread of multidrug resistant organisms and prevent infection outbreak thereof with medical institutions.

• 보건세계
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• v.53 no.5 s.597
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• pp.35-39
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• 2006

다제내성 결핵은 치료 성공률이 낮은데 그 원인으로 사용할 수 있는 효과적인 항결핵 약제의 숫자가 제한되어 있고, 약제 부작용이 많고, 장기간의 치료기간으로 인해 환자의 순응도(compliance)가 낮기 때문이다. 치료에 실패한 다제내성 결핵환자는 본인의 고통뿐만 아니라 지속적으로 결핵균을 배출하는 만성배균자가 되어 수 많은 사람들에게 다제내성 결핵균을 퍼뜨리는 전염원이 된다.

• Journal of Digital Convergence
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• v.12 no.2
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• pp.343-351
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• 2014

The present study performed semantic network analysis of the keywords in the headlines of newspapers to investigate the media coverage of the multidrug-resistant microorganisms(MDROs) which is resistant to antibiotics. For this purpose, 229 news stories on MDROs in 28 newspapers from June 1, 2010 to December 31, 2011 were analyzed. The news stories were gathered from the Korea Press Foundation's news database, KINDS (www.kinds.or.kr) and websites of Korean newspapers. The analysis of the keywords revealed 'superbacteria' appeared most frequently (n=155) followed by 'infection' (n=63) which arouses fear among readers. While network was structured with the keywords such as 'domestic', 'multidrug-resistant microorganisms', 'first', 'antibiotics', 'outbreak' and 'infection', the keywords such as 'MDROs related stocks', 'medical staff', and 'safety' were on the periphery of the network.

• Journal of Convergence for Information Technology
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• v.10 no.11
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• pp.87-97
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• 2020

The purpose of this study was to investigate effect of simulation based education using standardized patient for contact precaution infection control for nursing student. This study was conducted by including 67 nursing student A university from October to December 2019. This study was mixed method research design. Knowledge and performance confidence related to multidrug resistant organism(MDRO) infection control were measured using questionnaires pre and post test, analyzed using paired t-test and reflection sheet was analyzed using content analysis method. After intervention, two variables were increased significantly. Results of the content analysis showed there were 39 significant statements, which were classified into 13 categories. These results suggest that education on simulation program using standardized patient for contact precaution infection control is effective strategy to enhance knowledge and performance confidence related to MDRO infection control and practical nursing infection control skill, patient centered care, interprofessional collaboration.

• Journal of Digital Convergence
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• v.19 no.1
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• pp.211-216
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• 2021

This study was carried out to evaluate the effects of disinfection using environmental disinfectant after having assessed the extent of contamination through microbial culture testing and the Adenosine Triphosphate Bioluminescence method among the environmental management evaluation methods used for the environment in the hospital ward of patients infected by multidrug-resistant organisms. This study was conducted with the patient wards isolated due to multidrug-resistant organisms as the environmental surface. Specimens were collected from five locations including infusion pumps, IV poles, bedside cabinets, bed railings, keyboards, and blood pressure measurement cuffs. ATP and microbial culture testing were executed prior to, immediately after, and five minutes post-disinfection. According to the result contamination of the infusion pumps was statistically significantly reduced after disinfection. In addition, the bacteria before and after disinfection reduced in IV pole, bed railing, and keyboard. That is, regular environmental surface disinfection can provide safer environments to patients against infection. Therefore, it is necessary to establish guidelines including disinfection methods and intervals for environmental surfaces by evaluating the persistence of disinfectants at various institutions in the future.

• Tuberculosis and Respiratory Diseases
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• v.55 no.5
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• pp.440-448
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• 2003

Background : Development of rapid drug susceptibility testing provides the opportunity for rapid identification of individuals with drug resistant tubercle bacilli, allowing selection of appropriate therapeutic regimens. Methods : A total of 502 drug resistant isolates were subjected to reverse blot hybridization assay to detect mutations within genes (rpoB, katG, inhA, and ahpC) associated with rifampicin (RMP) and isoniazid (INH) resistance. Results : Among the 264 RMP resistant strains ($RMP^R$) tested, the most prevalent mutation was the Ser531Leu seen in 121 strains (46%). The second common mutation occurred in 84 strains (32%) at codon 526. And 27 strains (10%) showed the mutation at codon 516. Among all 469 INH resistant strains ($INH^R$), the katG mutation was responsible for INH. The inhA mutation was present in 88 strains (19%). In 11 isolates (2%), coexisting of the katG and inhA mutations were identified. Reverse hybridization assay successfully detected over 80% of $INH^R$ and over 92% of $RMP^R$ among Korean isolates. CONCLUSION: Reverse hybridization was useful for rapid detection of $INH^R$ and $RMP^R$.

• Tuberculosis and Respiratory Diseases
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• v.48 no.6
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• pp.853-869
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• 2000

Background : Following several decades of decline, the incidence of tuberculosis has recent1y begun to increase in many countries of this the control of this disease has been impeded by the emergence of multi-drug resistant tuberculosis (MDR-TB). The development of rapid diagnostic methods and effective new drugs are needed to control MDR-TB. One of the new drugs for MDR-TB is rifabutin (RBU) which has been known to be effective in some patients with MDR-TB. A few reports showed that some types of mutations of the rpoB gene, which were known to be present in 96-98% of rifampicin-resistant M. tuberculosis, were associated with the rifampicin-resistant but RBU-susceptible phenotype. This study was performed to investigate the correlation between RBU susceptibility and the patterns of rpoB gene mutations in Korean MDR-TB. Methods : Sixty-five clinical isolates of multi-drug resistant Mycobacterium tuberculosis, gathered from patients who visited the Asan Medical Center from July 1997 to June 1999, were investigated. Clinical responses to rifabutin-containing regimen were evaluated. An RBU susceptibility test and sequencing analysis of rpoB gene were performed, and the results were analyzed to confirm which mutations correlated with RBU-susceptible MDR-TB. Results : Fifty-three of 56 (95%) clinical isolates of MDR-TB had 60 mutations of the rpoB gene. The most frequent mutations were found at codon 531 (43%), and two mutations were combined in seven clinical isolates. Five of 53 (10%) clinical isolates showed the RBU-susceptible phenotype, and in them the characteristic patterns of point mutations were found at codon 509, 516, and 526. Conclusion : The frequency and pattern of mutations of the rpoB gene of Korean MDR-TB isolates were similar to those in western countries, where the prevalence of tuberculosis is low, but some show RBU-susceptible phenotypes. RBU-susceptible MDR-TB isolates showed the characteristic pattern of mutations of the rpoB gene which could be used to rapidly diagnose RBU susceptibility.