• Journal of the KSME
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• v.52 no.12
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• pp.41-48
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• 2012

생명을 위협하는 주요한 소형혈관 치료를 위한 의료기기의 생체재료로서 박막니티놀이 최근 소개되었고, 다양한 실험실 실험(in vitro)과 생체실험(in vivo)을 통하여 혈액적합성과 소형혈관치료 디바이스로서의 가능성에 대한 연구가 이루어졌다. 이 글에서는 박막니티놀의 특성, 제조방법 그리고 이 재료를 이용한 디바이스인 뇌동맥류 유량 조절 스텐트(cerebral aneurysm flow-diverting stent)와 말초동맥질환 스텐트 그라프트(peripheral artery disease stent graft)에 대하여 설명을 하였다.

• The Journal of the Convergence on Culture Technology
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• v.10 no.6
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• pp.309-314
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• 2024

The medical device industry is changing rapidly by applying the latest scientific and technological advancements. In particular, with the development of biotechnology, the proportion of in vitro diagnostic medical devices that diagnose diseases by analyzing body fluids such as blood and implant medical devices that can replace the role of human tissues and organs has recently increased rapidly In order to educate and supply manpower in the newly changing medical device industry, the development of a new practical training course is necessary. In this paper, we develop and report a hands-on training course using nitinol stents and a model stent introducer. The model stent introducer for this practical training can be easily made using raw materials used by the manufacturer, and the stents used in the training were provided by the stent manufacturing company. Through this practicum, students can experience part of the work of an actual medical device company and understand engineering theories applied to medical devices through practicum. In order for the Korean medical device industry to become a global leader, it is necessary to develop practical training courses through close cooperation between universities and industry.

• Journal of The Korean Radiological Technologist Association
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• v.28 no.1
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• pp.338-338
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• 2002

• Polymer(Korea)
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• v.33 no.1
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• pp.84-90
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• 2009

Nitinol alloy (TiNi) has been widely used in vascular stents. To improve the blood compatibility of Nitinol alloy, its surface was chemically modified in this study. Nitinol was first coated with gold, then chemisorbed with L-cysteine (C/N), and followed by grafting of zwitter ionic poly(ethylene glycol) (PEG) (PEG-$N^+-SO_3{^-}$) to produce TiNi-C/N-PEG-N-S. The zwitter ionic PEG grafted on the Nitinol surface was identified by ATR-FTIR, ESCA and SEM. The hydrophilized surface was proven by the decrease of water contact angle. In addition, from the blood compatibility tests such as protein adsorption, platelet adhesion, and blood coagulation time, the surface-modified TiNi alloy exhibited a better blood compatibility as compared to the untreated Nitinol control. These results indicated a feasibility of synergistic effect of hydrophilic PEG and antithrombotic zwitter ion.

• Journal of the Korean Society of Radiology
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• v.81 no.4
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• pp.899-911
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• 2020

Purpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable nitinol stent (NiTi-stent) for peripheral arteries. Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned to the NiTistent group or conventional nitinol stent group. Stents were symmetrically implanted into the iliac arteries of each animal using carotid artery approach and were observed for 1 month (n = 5) and 6 months (n = 9). The angiographic lumen diameter (ALD), late lumen loss, angiographic stenosis, histomorphometric lumen area, neointimal area, and area stenosis were analyzed and compared between the groups. Results Stent migration, stent fracture, or thrombus formation were not observed in either group. At the 1-month follow-up, the neointimal area (p = 0.008) and area stenosis (p = 0.016) were significantly smaller in the NiTi-stent group than in the control group. At the 6-months followup, the NiTi-stent group showed significantly larger ALD (p = 0.014), less late lumen loss (p = 0.019), less angiographic stenosis (p = 0.014), larger lumen area (p = 0.040), and smaller neointimal area and area stenosis (p = 0.004 and p = 0.014, respectively) compared with the control group. Conclusion The NiTi-stent is as safe and effective as the conventional nitinol stent and induces less neointimal hyperplasia in a minipig iliac artery model.

• Journal of Chest Surgery
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• v.33 no.1
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• pp.107-111
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• 2000

Although a tracheal stent can be an option for inoperable tracheal stenoses there still are some troublesome side effects including overgranulation from foreign body irritation restenosis and patient's discomfort associated with the procedure. We report a successful case of a retrievable stent made of self-expandable 'shape memory' metal and polyurethane in a 24 year old female patient with respiratory distress and tight stenosis in the trachea and left main bronchus, The stent was inserted following a balloon dilatation and was successfully removed on the 7th days after the procedure. She regained a normal active life without any repiratory symptoms and a follow-up of 8 months showed satisfactory results.