• Journal of the Korean Society of Radiology
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• v.10 no.3
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• pp.187-193
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• 2016

In this study, we performed the carotid artery ultrasound targeting 140 subjects who have conducted to evaluate the changes in intima-media thickness(IMT) and plaque correlated with the presence or absence of a hematological test of the carotid artery. Considering that the IMT thickness more than 1mm is abnormal based on the carotid artery ultrasound to assess the presence or absence of plaque, and examined the correlation by classifying the blood lipid value and the fasting blood glucose level through the serum test. Consequently, the fasting blood glucose level is being analyzed as independent predictors of causing dental plaque(p=0.033), cut off value was determined as 126 mg/dL(sensitivity 56.25%, specificity 68.38%) in ROC curve analysis. Furthermore, the odds ratio appeared 1.01 times the value in the Logistic regression. Therefore, it seemed that the necessity to prospective studies in a number of subjects are considered, and also taking into account a number of blood test values along with the sonography of the carotid artery as a valuable part for effective primary prevention and follow-up observation of the cardiac and brain vascular disease is highly recommended.

• Journal of the Korean Society of Radiology
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• v.13 no.6
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• pp.873-878
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• 2019

Cerebrovascular disease is one of the three major causes of death in Korea. Since these diseases are associated with atherosclerosis, the diagnosis of atherosclerotic factors should be presented. In this study, we evaluated the relationship between brachial-ankle arterial pulse wave velocity, cerebral artery vascular stenosis, blood pressure, obesity, and abdominal obesity by age group. The significance of cerebral artery stenosis and age group. The risk factors of atherosclerosis, such as blood pressure, obesity, and abdominal obesity, were significant in all age groups. When the pulse wave velocity of the brachial-ankle artery was increased, the cerebral artery stenosis was distributed in 57.3% of the total test subjects. If the arterial stiffness is suspected during the measurement of the pulse wave velocity of the brachial ankle artery, We recommend suspected vascular stenosis and perform a cerebral artery angiography. It is suggested that the data will be used as a baseline data for similar studies after evaluating the significance of blood pressure, obesity, and abdominal obesity as risk factors of atherosclerosis.

• Proceedings of the KSCN Conference
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• 2003.11a
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• pp.1079-1079
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• 2003

최근 노인인구의 증가와 함께 식생활의 변화에 의해 사망원인의 변화가 일어나고 있다 한국인의 주요 사망원인 중 뇌혈관 및 심장질환 등 순환기계 질환에 의한 사망이 증가하고 있는 추세이며, 심장순환계 질환의 위험요인인 고혈압의 이환률도 65세 이상 노인에게서 증가하고 있다. 고혈압은 만성질환으로 산화적 스트레스를 증가시키는 질환이므로 본 연구에서는 건강한 노인과 고혈압 노인의 체내 항산화 영양상태를 비교하기 위해 울산지역 50세 이상 노인을 대상으로 하였다. 대조군은 질환이 없거나 골다공증, 위장질환과 같은 기타 질환을 가진 사람 96명이었으며, 고혈압환자군은 고혈압을 가진 모든 질환자 118명이었고, 항산화 영양소 섭취나 혈장내 항산화 영양상태에 영향을 미치는 성별, 연령, 흡연 및 음주상태를 보정하여 비교하였다. 고혈압환자의 평균 유병기간은 6.1년이었으며, 항산화 비타민 섭취량은 비타민 A, retinol, $\beta$-carotene과 비타민 C 섭취량 모두 고혈압 유무에 따른 유의적인 차이가 나타나지 않았으나 고혈압환자의 섭취량이 높은 경향을 보였다. 한국인영양권장량과 비교한 결과 대조군의 비타민 A 섭취는 권장량의 86.2%, 고혈압환자군은 권장량의 103.0%를 섭취하여 고혈압군에서 유의적으로 높았고, 권장량의 75% 이하 섭취자의 비율은 대조군에서 46.9%, 고혈압군에서 41.5%로 조사되었다. 비타민 C 섭취는 대조군에서 권장량의 176.6%, 고혈압군에서는 189.0%로 나타나 질환의 유무에 관계없이 두 군 모두 권장량의 170%이상을 섭취하고 있었으나 권장량의 75% 이하를 섭취하는 사람의 비율이 대조군에서 13.5%, 고혈압군에서 17.0%로 고혈압군에서 높게 나타났다. 혈장 비타민 C의 농도는 대조군 15.3 mg/L, 고혈압환자 15.9mg/L, 혈장 $\beta$-carotene 농도는 대조군 0.21mg/L, 고혈압환자 0.22 mg/L로 나타나 고혈압 유무에 따른 차이가 없었고, 혈장 비타민 A,E 농도 및 총 항산화능력은 대조군에 비해 고혈압환자에게서 유의적으로 높게 나타났다. 또한 혈장 지질과산화물의 농도도 유의적이지는 않지만 고혈압환자에게서 높은 경향이 나타났다. 따라서 고혈압에 따른 항산화 영양상태를 비교한 결과 전반적인 항산화 비타민의 섭취량, 혈중 비타민 농도 및 총 항산화능력이 예상과 달리 대조군 보다 고혈압환자에게서 유의적으로 높게 나타났다. 이런 결과는 질환자들이 자신이 가진 질병의 진전을 막거나 치료의 목적으로 치료제를 복용하고, 식이요법을 실시하고 있기 때문으로 사료되며, 고혈압과 같이 산화적 스트레스가 증가하는 질환의 경우 체내 항산화 체계 반응이 이러한 변화에 효율적으로 대처하기 위한 방향으로 증가되었을 가능성이 있을 것으로 사료된다. 특히, 본 연구의 대상자들의 유병기간이 6.1년으로 비교적 길기 때문에 질환의 진행정도에 따른 항산화 상태를 측정하거나 비교적 질환으로 판정된 직후의 사람들의 대상으로 한 연구 등 더 많은 연구가 필요하다.

• Journal of Korean Neurosurgical Society
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• v.29 no.4
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• pp.451-460
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• 2000

Objective : This experiment is aimed at clarifying the characteristics of spasmodic basilar arteries in the rabbits of subarachnoid hemorrhage(SAH) with observation of vascular response to nitric oxide(NO) and endothelin-1. Material and Methods : Seventy-nine New Zealand white rabbits were divided into 4 groups : control(n=17), sham operation(n=13), postictal-2-day(n=25), and postictal-7-day group(n=24). Rabbits in the postictal-2-day group and postictal-7-day group underwent transfemoral vertebral angiography 2 days and 7 days after SAH respectively. A vascular ring of spasmodic basilar artery was harvested and suspended in organ chamber($37^{\circ}C$) to observe isometric tension changes in response to NO and endothelin-1 under both high(95% $O_2$/5% $CO_2$) and low(95% $N_2$/5% $CO_2$) $O_2$ tension. To investigate the vascular response to NO, acetylcholine from $10^{-7}M$ to $3{\times}10^{-4}M$ concentration was applied to basilar artery ring precontracted with histamine $10^{-6}-10^{-5}M$ in the organ chamber. The vascular response to endothelin-1 was observed by applying endothelin-1 from $10^{-11}M$ to $3{\times}10^{-8}M$ concentration into organ chamber. Results : Seven of 15 live rabbits which underwent angiography 2 days after SAH, were confirmed to develop vasospasm($64.3{\pm}11.2%$) whereas seven of 13 live rabbits which underwent angiography 7 days after SAH, were confirmed to develop vasospasm($64.9{\pm}10.9%$). In all groups, hypoxia significantly reduced the vascular relaxation of basilar arteries to NO. However, hypoxia made no influence on the vascular contraction of basilar arteries to endothelin-1 in all groups. In vascular relaxation of basilar arteries to NO under high $O_2$ tension between groups, the maximum relaxation of basilar arteries in the postictal-7-day group was significantly reduced compared to the postictal-2-day group. In vascular contraction of basilar arteries to endothelin-1 under high $O_2$ tension between groups, the maximum contraction of basilar arteries in the postictal-7-day group was significantly reduced compared to the postictal-2-day group. Conclusions : This experiment suggests that the characteristics of vascular response to NO and endothelin-1 in the spasmodic basilar arteries of rabbits observed 2 days after SAH is different from those observed 7 days after SAH.

• Health Policy and Management
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• v.29 no.3
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• pp.303-311
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• 2019

Background: Cerebrovascular disease is included in four major diseases and is a disease that has high rates of prevalence and mortality around the world. Moreover, it is a disease that requires a high cost for long-term hospitalization and treatment. This study aims to figure out the correlation between grip strength, which was presented as a simple, cost-effective, and relevant predictor of cerebrovascular disease, and cerebrovascular disease based on the results of a prior study. And furthermore, our study compared model suitability of the model to measuring grip strength and relative grip strength as a predictor of cerebrovascular disease to improve the quality of cerebrovascular disease's predictor. Methods: This study conducted an analysis based on the generalized linear mixed model using the data from the Korea Longitudinal Study of Ageing from 2006 to 2016. The research subjects consisted of 9,132 middle old age people aged 45 years or older at baseline with no missing information of education level, gender, marital status, residential region, type of national health insurance, self-related health, smoking status, alcohol use, and economic activity. The grip strength was calculated the average which measured 4 times (both hands twice), and the relative grip force was divided by the body mass index as a variable considering the anthropometric figure that affects the cerebrovascular disease and the grip strength. Cerebrovascular diseases, a dependent variable, were investigated based on experiences diagnosed by doctors. Results: An analysis of the association between grip strength and found that about 0.972 (odds ratio [OR], 0.972; 95% confidence interval [CI], 0.963-0.981) was the incidence of cerebral vascular disease as grip strength increased by one unit increase and the association between relative grip strength and cerebrovascular disease found that about 0.418 (OR, 0.418; 95% CI, 0.342-0.511) was the incidence of cerebral vascular disease as relative grip strength increased by unit. In addition, the model suitability of the model for each grip strength and relative grip strength was 11,193 and 11,156, which means relative grip strength is the better application to the predictor of cerebrovascular diseases, irrespective of other variables. Conclusion: The results of this study need to be carefully examined and validated in applying relative grip strength to improve the quality of predictors of cerebrovascular diseases affecting high mortality and prevalence.

• Korea journal of population studies
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• v.11 no.1
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• pp.197-203
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• 1988

In order to examine cause-specific mortality in Korea by comparing mortality of Japan, various mortality indicators are calculated using 1995 of ficial statistics of twonations. The mortality measures are cause-specific mortality rate by sex, age, andmarital status, cause-specific age-standardized death rate and potential years of lifelost, and their ratios by sex and nation. Items of major causes of death include allcauses (total deaths),tuberculosis, malignant neoplasm, diabetes mellitushypertensive diseases, heart diseases, cerebrovascular diseases, liver diseasestransport accidents, and suicide. Major characteristics of mortality in Korea are asfollows . (1) Death rates from most causes except suicide are higher in Korea thanJapan and especially death rates from tuberculosis, hypertensive diseases, liverdiseases, and transport accidents are higher for economically active Koreans : (2)Death rates from tuberculosis, liver diseases, transport accidents, and malignantneoplasm are salient for Korean children (3) Sex-differentials in mortality fromliver diseases, tuberculosis , and transport accidents are large for economically activeKoreans, because male mortality is higher than female mortality : (4) Suicide ratesare lower for economically active males, and higher for females aged 10s and 20s inKorea than Japan : (5) Death rates are highest f3r divorced or widowed under 45years of age depending on causes, but death rates from all causes are highest fornever-married of the age 45 and over in Korea : and (6) Sex-differentials inmortality are greatest for widowed in Korea and for divorced in Japan.

• Journal of the Korean Society of Radiology
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• v.15 no.7
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• pp.999-1005
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• 2021

The object of this research is CS, which increases resolution while shortening inspection time, is applied to MRA to compare the quality of images for SENSE and CS techniques and to evaluate SNR and CNR to find out the optimal techniques and to provide them as clinical basic data based on this information. Data were analyzed on 32 patients who performed TOF MRA tests at a university hospital in Chung cheong-do (15 males, 17 females), ICA stenosis:10, M1 Aneurysm:10, and average age 53 ± 4.15). In the inspection, the inspection equipment was Ingenia CX 3.0T, Archieva 3.0T, and 32 channel head coil and 3D gradient echo as a method for equipment data. SNR and CNR of each image were measured by quantitative analysis, and the quality of the image was evaluated by dividing the observer's observation into 5 grades for qualitative evaluation. Imaging evaluation is described as being significant when the p-value is 0.05 or less when the paired T-test and Wilcoxon test are performed. Quantitative analysis of SNR and CNR in TOF MRA images Compared to the SENSE method, the CS method is a method measurement method (p <0.05). As an observer's evaluation, the sharpness of blood vessels: CS (4.45 ± 0.41), overall image quality: CS (4.77 ± 0.18), background suppression of images: CS (4.57 ± 0.18) all resulted in high CS technique (p = 0.000). In conclusion, the Compressed SENSE TOF MRA technique shows superior results when comparing and evaluating the SENSE and Compressed SENSE techniques in increased flow rate magnetic resonance angiography. The results are thought to be the clinical basis material in the 3D TOF MRA examination for brain disease.

• The Journal of the Korea Contents Association
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• v.19 no.7
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• pp.186-191
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• 2019

Introduction: In aged people, stroke incidence is increased. But standardized experimental animal protocol study for the research of stroke therapy is rare. There is little report on the success rate of cerebral artery occlusion model using standardized Nylon thread length of precise thread end-size controlled. Method: In this study, the operator intended the occlusion of middle cerebral artery (MCA) using $0.18{\pm}0.02mm$ end 5-0 Nylon thread. Middle cerebral artery occlusion was induced for 60min under isoflurane anesthesia. After 60min, the operator removed the Nylon thread and reperfusion was induced for 23hrs. The mice was killed 23hrs after reperfusion and infarction area of brain was confirmed by 1.5% TTC (2,3,5-tryphenyl tetrazolium chloride) staining. Results: According to end size and insert length of Nylon thread, Middle cerebral artery occlusion (n=50), internal carotid artery occlusion (n= 14), distal middle cerebral artery occlusion (n= 36), anterior cerebral artery (n= 1) were induced. And no infarction (n= 50) was observed. Conclusion: According to weight of mice, the operator induced reversible cerebral artery occlusion model by different insert length (30.0~36.9g : 9.0mm, 37.0~40.0g : 9.5mm) of Nylon thread. Success of cerebral artery occlusion model was confirmed by checking infarction area using TTC staining. The success rate (66.9%, 101/151) of reversible cerebral artery occlusion model in the mouse and the operational conditions are shown.

• Korean Public Health Research
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• v.44 no.4
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• pp.51-65
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• 2018

Objective : Smoking can increase the risk of secondary conditions for people with disabilities, which can in turn counteract primary disorders and exacerbate existing disorders. More active interventions for smoking cessation are necessary for people with disabilities because the physical condition of people with disabilities is more vulnerable, and risk factors such as smoking, drinking, obesity, and stress can have a decisive influence on people with disabilities compared to non-disabled people. Methods : In this study, the subjects who participated in National Health and Nutrition Survey of 2013 were those aged over 19 and smoker. The final 299 people with disability and 4,260 people without disability were analyzed. Results : Current smoking rate was 21.5% of non-disabled people and 21.4% of disabled people respectively. Factors influencing the current smoking rate of the disabled people were analyzed by type of household, economic status, home ownership, drinking, binge drinking, activity limit. Conclusions : In order to reduce socioeconomic inequalities of smoking and to actively intervene with the disabled, there need a new approach strategy focusing on people with disabilities.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.713-720
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• 2019

The purpose of this study was to propose a new measurement method for accurate measurement of vessel diameter in computed tomography angiography(CTA). CTA test was performed after non-ionic iodine contrast agent was flowed at a constant rate to self-maded perfusion phantom. After obtaining raw data, images were reconstructed with multi-planar reconstruction(MPR) and maximal intensity projection(MIP). Diameters of vascular models were measured for each technique. Relative and conventional measurements were then compared. The mean diameter of the vascular model was closer to the actual measurement when relative measurement was used compared to that when conventional measurement was used both in MPR and MIP. Relative measurements of MPR and MIP were closer to actual measurement than those of conventional measurement (34% VS, 24%, p<0.05). The relative measurement method proposed in this study was closer to the actual measurement than the conventional measurement method. However, both test methods were still larger than actual results. Therefore, further study of relative measurement method is needed using this study as basic data.