• 감성과학
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• 제25권2호
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• pp.79-86
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• 2022

대기오염 등의 영향으로 실내 활동 시간이 증가하는 상황에서 뇌기능과 신체활동 측면에서 보다 건강한 실내 생활을 위한 다양한 방안에 대한 고려가 절실한 실정이다. 본 연구는 실내 산소의 농도와 호흡의 방법에 따라 인지능력과 생체신호에 어떤 영향을 미치는지에 대해 연구하여 보다 건강한 실내 일상생활을 제안하고자 한다. 건강한 성인 20명을 대상으로 공기 전달 시스템을 통해 공급된 공기를 산소마스크를 통해 흡입하도록 하였다. 호흡 방법과 산소농도에 따른 변화를 확인하기 위해 모든 피험자는 3가지 호흡(비강, 구강, 및 고농도 산소공급과 함께 구강 호흡)을 인지부하자극(눈 감은 휴식기, 눈 뜬 휴식기, 1-back 및 2-back 작업기억 과제) 별로 각각 수행하였다. 자극에 대한 반응시간, 정확도 및 생체신호를 측정하여 호흡에 따른 인지부하별 변화를 분석하였다. 그 결과, 3가지 호흡에서 모두 인지부하의 증가에 따라 심박동수는 유의하게 증가하면서 인지부하와 높은 상관성이 있는 생체신호임을 확인하였다. 또한 구강호흡에서는 분당 호흡 횟수가 인지부하증가에 따라 유의하게 증가하는 변화가 나타났으며, 인지활동 시 구강호흡에서 부족한 산소공급을 보완하기 위한 생체신호의 변화를 확인하게 되었다. 반면 고농도 산소공급과 함께 수행한 구강호흡에서는 비강호흡과 같이 분당 호흡 횟수의 유의한 변화는 없는 것으로 나타났다. 이는 고농도 산소공급이 구강호흡과 같이 비효율적인 산소 흡입이나 산소 농도가 부족한 환경에서 이를 보완해 주는 역할을 할 가능성이 있음을 시사한다. 본 연구 결과를 기반으로 후속 연구에서는 자율신경계 변화까지 분석하여 인지 뿐만 아니라 심리에 미치는 영향까지 종합적으로 규명하고자 한다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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• pp.894-897
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• 2008

스트레스는 현대 인간 문명사회에서의 피할 수 없는 결과이며 복잡한 현상이다. 또한 이의 통제 유무에 따라 인간의 활동능력은 심각한 변화를 받을 수 있다. 스트레스는 자극 호르몬인 아드레날린이나 다른 스트레스 호르몬이 혈중 내로 분비되어 우리 몸을 보호하려고 하는 반응으로 위험으로부터 싸우거나 멀리 피해버리는 힘과 에너지를 제공한다. 이러한 변화는 근유, 뇌, 심장에 더 많은 피를 보낼 수 있도록 맥박과 혈압을 증가시키고 더 많은 산소를 얻기 위해 호흡이 빨라지는 현상이 나타난다. 이에 본 논문에서는 스트레스를 통해 증가된 맥박과 혈압, 호흡수를 측정한 후 스트레스를 완화시키기 위한 방편으로 음악을 이용한 감성 기반 매칭 시스템을 설계한다. 음악에 따른 HRV와 APG의 변화율을 살펴보고 Zigbee를 이용하여 맥박, 혈압, 호흡수를 측정한 후 감성 음악을 기반으로 하여 스트레스를 완화시킬 수 있는 시스템을 제안한다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2009년도 추계학술대회
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• pp.183-185
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• 2009

As imaging technology develops, magnetic resonance imaging (MRI) techniques have contributed to the understanding of brain function by providing anatomical structure of the brain and functional imaging related to information processing. Manganese-enhanced MRI (MEMRI) techniques can provide useful information about functions of the nervous system. However, systematic studies regarding information processing of pain have not been conducted. The purpose of this study was to detect brain activation during painful electrical stimulation using MEMRI with high spatial resolution. Male Sprague-Dawley rats (250-300 g) were divided into 3 groups: normal control, sham stimulation, and electric stimulation. Rats were anesthetized with 2.5% isoflurane for surgery. Polyethylene catheter (PE-10) was placed in the external carotid artery to administrate mannitol and MnCl2. The blood brain barrier (BBB) was broken by 20% D-mannitol under anesthesia mixed with urethane and a-chloralose. The hind limb was electrically stimulated with a 2Hz (10V) frequency while MnCl2 was infused. Brain activation induced by electrical stimulation was detected using a 4.7 T MRI. Remarkable signal enhancement was observed in the primary sensory that corresponds to sensory tactile stimulation at the hind limb region. These results suggest that signal enhancement is related to functional activation following electrical stimulation of the peripheral receptive field.

• 한국산학기술학회논문지
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• 제15권4호
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• pp.2170-2178
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• 2014

본 연구에서는 작업수행시의 집중상태 변화를 검출하기 위하여 2011년 1~2월 동안 집중을 유발하는 시각유발자극에 대하여 생체신호를 측정한 피험자들 중 한명의 뇌파신호를 분석하였다. 두피에서 측정한 뇌파신호로부터 집중관련 뇌 안에서의 발원 신호와 안구운동잡음 신호를 분리하기 위하여 독립성분 분석기법을 측정뇌파 신호에 적용하였다. 안구운동잡음신호가 제거된 집중관련 신호원을 단시간 푸리에 변환하여 주파수 성분 신호를 연속적으로 축적함으로서 시변 특징 형태를 나타내는 에포크 그래프와 스펙트럴 칼라 맵에서의 도식 표현상 규칙성을 향상 시킬 수 있었다. 추출한 감각운동리듬 (SMR: 12-15Hz)과 세타파 리듬 (4-7Hz)관련 집중 지표는 집중시험시간이 경과함에 따라 증가 하였다. 실험을 통하여 단시간 푸리에 변환과 결합한 독립성분 분석기법은 참여자의 집중상태 변화를 분석하는데 사용 할 수 있을 것이다.

• Journal of Acupuncture Research
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• 제20권5호
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• pp.133-150
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• 2003

Objective: Recently. many studies have showed the evidences of the effect of the Electro-acupuncture treatment through scientific. Methods : One of these methods is functional MRI. We performed electro-acupuncture on Zusanli(St36) and observed the change of brain activation using fMRI. Zusanli(St36) is located on the lateral side of the lower leg. 3 cun(寸) inferior to the Patella of the lower border. Theoretically and clinically. this point has been considered very important for gynecological disorders. spleen and stomach disorders. and psychological disorders. To see the effects of electro-acupuncture stimulation on Zusanli(St36). the experiment was carried out on twelve healthy volunteers. using the gradient echo sequence with the 3.0T whole-body fMRI system(ISOL). After the needle insertion on right Zusanli(St36). 2 Hz of electric stimulation was given for 30 seconds. repeated five times. with 30 seconds' intervals. The Image analysis including motion correction. talairach transformation, and smoothing was done with SPM99. Results ad conclusion : The electro-acupuncture stimulation on Zusanli(St36) activates Brodmann Area 6, 13, 2, 19, 21, 22, 39, 40, 38, 3which indicates the pathways of the electro-acupuncture stimulation on Zusanli(St36) and the possibility of the relationship of the electro-acupuncture stimulation on Zusanli(St36) with autonomic nervous system, internal organic system.

• Journal of Acupuncture Research
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• 제20권5호
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• pp.187-207
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• 2003

Objective: Recently, many studies have showed the evidences of the effect of the acupuncture treatment through scientific methods. One of these methods is functional MRI. We performed electro-acupuncture on Liv3 and observed the change of brain activation using fMRI. Methods: To see the effect of electro-acupuncture stimulation on Liv3. the experiment was carried out on 12 healthy volunteers. using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Liv3. 2 Hz of electric stimulation was given for 30 seconds. repeated five times. with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation. and smoothing was done with SPM99. Results : 1. Group averaged brain activation induced by bilateral electro-acupuncture stimulation on Liv3 activates Brodman Area 6, 13, 18, 19, 22, 31, 39, 44, 2. Group averaged brain deactivation induced by bilateral Electro-acupuncture stimulation on Liv3 activates Brodman Area 4, 6, 9, 19, 36, 37, 39. 3. Group averaged brain activation induced by unilateral(right side) electro-acupuncture stimulation on Liv3 activates Brodman Area 2, 3, 6, 9, 10, 22, 40, 42, 43. 4. Group averaged brain deactivation induced by unilateral(right side) electro-acupuncture stimulation on Liv3 activates Brodman Area 6, 18, 19, 28, 30, 31, 35, 37. 5. Brain region activated by motor stimulation activates Brodman Area 4, 6, 13, 19, 42.

• 전기학회논문지
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• 제57권3호
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• pp.514-517
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• 2008

Ubiquitous healthcare (U-healthcare) system is one of potential applications of embedded system. Conventional U-healthcare systems are used in health monitoring or chronic disease care based on measuring and transmission of various vital signs. However, future U-healthcare system can be of benefit to more people such as stroke patients which have limited activity by providing them proper medical care as well as continuous monitoring. Recently, an electric brain stimulation treatments have been found to be a better way compared to conventional ones and many are interested in using the method toward the treatment of stroke. In this study, we proposed a remote medical treatment system using ZigBee-based wireless electric brain stimulator that can help them to get a treatment without visiting their doctors. The developed remote medical treatment system connects the doctors to the brain stimulator implanted in the patients via the internet and ZigBee communication built in the brain stimulator. Also, the system receive personal information of the connected patients and cumulate the total records of electric stimulation therapy in a database. Doctors can easily access the information for better treatment planning with the help of graphical visualization tools and management software. The developed remote medical treatment system can extend their coverage to outdoors being networked with hand-held devices through ZigBee.

• 대한감각통합치료학회지
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• 제2권1호
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• pp.21-32
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• 2004

Objective : Effect of treadmill exercise on hippocampal neural cell proliferation under normal conditions and alcohol intoxication conditions has been recently studied; however, this effect under sensory stimulation application has not clarified yet. In the present study, the effect of compression stimulation application on hippocampal neural cell proliferation in the dentate gyrus in normal and alcohol intoxicated rats was investigated. Methods : Experimental design: comparative investigation on number of 5-Bromo-2'-deoxyuridine(BrdU)B-positive cells in dentate gyrus 5 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 3weeks old in age weighing $80{\pm}10gm$. Intervention: animals were randomly assigned into 4 groups; control-rest group(n=8), control-compression group(n=8), alcohol intoxication-rest group(n=8) and alcohol intoxication-compression group(n=8). Animals of the alcohol intoxicated groups were injected intraperitoneally with alcohol(2g/kg) twice per day for 3 days. All animals were injected BrdU(50mg/kg) intraperitoneally, and rats compression stimulation application groups were compressed using sphygmomanometer cuff times per day, for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results : Compression stimulation application significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation, and compression stimulation application alleviated alcohol-induced inhibition of new cell formation. Conclusion : These results suggest the possibility that compression stimulation application may help in improvement following alcohol-induced brain damaged.

• 한국정밀공학회지
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• 제30권5호
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• pp.559-563
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• 2013

This study aims to quantify the effects of medication (Med) and deep brain stimulation (DBS) on resting rigidity in patients with Parkinson's disease. We tested 10 limbs of five patients under each of four treatment conditions: 1) baseline, 2) DBS, 3) Med, 4) DBS + Med. Rigidity at the wrist joint was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS). The examiner randomly imposed flexion and extension movement on patient's wrist joint. Resistance to passive movement was quantified by viscoelastic properties. Not only rigidity score but also damping constant showed improvements in rigidity by DBS and Med treatments (p<0.05). This indicates that the viscosity can represent the change in rigidity due to DBS as well as Med, which was manifested by UPDRS score.

• 동의신경정신과학회지
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• 제14권1호
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• pp.85-106
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• 2003

Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and it is suggested that both of these effects are mediated by the same or closely overlapping dopamine systems. Specifically, the mesolimbic dopamine system has been implicated in the reinforcing and sensitizing properties of morphine. In oriental medicine, Shenmen (HT7) point on the heart channel has been used to treat mental and psychosomatic disorders. This study was designed to investigate the effect of acupuncture on acute and repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and morphine-induced behavioral changes. In the morphine sensitization experiment, male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5mg/kg, s.c.). Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after the morphine challenge. In the acute experiment, rats also received acupuncture for 1 min after an injection of morphine hydrochloride (5 mg/kg, s.c.). Results showed that acupuncture at the specific acupoint HT7, but not at control points (tail) significantly decreased both dopamine release and behavior induced by a systemic morphine challenge or a single sc morphine injection in the acute animals. These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts.