• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.147-150
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• 1995

최근의 마취과학에 관한 연구에 있어서의 주된 경향은 마취심도 및 의식수준의 결정을 신경생리학적인 관점에서 분석하고자 하는 것이다. 즉, 마취와 의식에 관한 인간의 뇌가 가지고 있는 기능이나 약리학적인 반응을 대표할 수 있는 생체신호를 검출, 분석하여 정량화하고 이들을 이용하면 마취심도 및 의식수준과의 큰 상관관계를 얻을 수 있을 것이라 가정하는 것이다. 본 연구에서는 청각유발전위 (LAEP, Long latency Auditory Evoked Potential)를 검출하여 추출된 변수들과 마취제 투여량간의 변화에 따른 상관성을 분석하고자 하였다. 수술환자(17명)를 대상으로 실험을 실시하였으며 마취제로서는 Midazolam과 Diazepam을 인체로 투여하고 1 KHz와 2 KHz의 청각자극을 제시하였을 때 피검자로부터 발생되는 LAEP를 검출하였다. 검출된 LAEP로부터 추출된 N100과 P300의 진폭은 마취량의 증가에 따라서 간소함을 알 수 있었으며, 이러한 유의한 상관성을 보이는 진폭의 변화는 마취제의 투여에 따른 의식수준의 변화를 나타내는 지수(index)의 설정 및 알고리듬의 수립에 이용될 수 있을 것이다.

• The Journal of Korean Physical Therapy
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• v.21 no.4
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• pp.73-79
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• 2009

Purpose: Recently, neurostimulation studies involving manipulation of cortical excitability of the human brain have been increasingly attempted. We investigated whether transcranial direct current stimulation (tDCS) applied to the underlying cerebral cortex, directly induces cortical activation during fMRI scanning. Methods: We recently recruited five healthy subjects without a neurological or psychiatric history and who were right-handed, as verified by the modified Edinburg Handedness Inventory. fMRI was done while constant anodal tDCS was delivered to the underlying SM1 area?? immediately after the pre-stimulation for eighteen minutes. Results: Group analysis yielded an averaged map that showed that the SM1 area and the superior parietal cortex in the ipsilateral hemisphere were activated. The voxel size and peak intensity were, respectively, 82 and 5.22 in the SM1, and 85 and 5.77 in the superior parietal cortex. Conclusion: Cortical activation can be induced by constant anodal tDCS of the underlying motor cortex. This suggests that tDCS may be an effective therapeutic device for enhancing? physical motor function by modulating neural excitability of the motor cortex.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.153-156
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• 2009

본 연구는 3 단계 각성 모드에 따른 자율신경계 반응 모델 구현에 대한 연구이다. 정신생리학(Psycho-Physiology)에서의 각성 시스템 모델은 Boucein(1992, 2006)에 의해 제안되었다. 각성 시스템 1 은 편도체(amygdala)활동과 관계한, 무의식수준에서 주의를 집중시키는 역할을 한다. 각성 시스템 2 는 해마(hippocampus)활동과 관계한, 인지적 각성 단계로서 상황-반응(situation-reaction) 대한 연결을 담당하는 역할을 한다. 각성 시스템 3 은 기저핵(basal ganglia)활동과 관계한, 몸운동(somatomotor)활동과 관계된 뇌 영역의 준비를 활성화시킨다. 각성 시스템은 상황의 변화나 특정 자극이 일어나면, 그에 해당하는 각성 모드에 의해 자율신경계(automatic nervous system)반응이 발생한다. 따라서, 자율신경계반응의 분석을 통하여 각성 시스템의 단계를 평가할 수 있다. 본 연구는 자율신경계반응 중 GSR(galvanic skin Response)과 SKT(skin temperature)분석을 통하여 3단계 각성 모드인 직관적, 인지적, 행동적 모드를 평가하는 연구이다.

• PNF and Movement
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• v.5 no.1
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• pp.9-17
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• 2007

Purpose : The purpose of this study was to test the effect of balance training for proprioceptive and vestibular sensory stimulation and therapeutic environment on expression of BDNF after traumatic brain injury in the rat. Subject : Twelve Sprague-Dawley rats were randomly assigned into group I and group II. After traumatic brain injury, group I was housed in standard cage for 7 days. Group II was housed in therapeutic cage after balance training for 7 days. Method : Traumatic brain injury was induced by weight drop model and after operation they were housed in individual standard cages for 24 hours. After 7th day, the rats were sacrificed and cryostat coronal sections were processed individually in goat polyclonal anti-BDNF antibody. The morphologic characteristics and the BDNF expression were investigated in injured hemisphere section from immunohistochemistry using light microscope. Result : Immunohistochemical response of BDNF in lateral nucleus, purkinje cell layer, superior vestibular nucleus and pontine nucleus appeared very higher in group II than in group I Conclusion : The present result revealed that simultaneously application of balance training for proprioceptive and vestibular sensory stimulation input and therapeutic environment in traumatic brain injured rats is enhance expression of BDNF and it is facilitates neural plasticity.

• Annals of Clinical Neurophysiology
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• v.14 no.2
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• pp.59-63
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• 2012

Epilepsy has continued to provide challenges to epileptologists, as a significant proportion of patients continue to suffer from seizures despite medical and surgical treatments. Deep brain stimulation (DBS) has emerged as a new therapeutic modality that has the potential to improve quality of life and occasionally be curative for patients with medically refractory epilepsy who are not surgical candidates. Several groups have used DBS in drug-resistant epilepsy cases for which resective surgery cannot be applied. The promising subcortical brain structures are anterior and centromedian nucleus of the thalamus, subthalamic nucleus, and other nuclei to treat epilepsy in light of previous clinical and experimental data. Recently two randomized trials of neurostimulation for controlling refractory epilepsy employed the strategies to stimulate electrodes placed on both anterior thalamic nuclei or near seizure foci in response to electroencephalographically detected epileptiform activity. However, the more large-scale, long-term clinical trials which elucidates optimal stimulation parameters, ideal selection criteria for epilepsy DBS should be performed before long. In order to continue to advance the frontier of this field, it is imperative to have a good grasp of the current body of knowledge.

• Journal of IKEEE
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• v.22 no.4
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• pp.1109-1114
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• 2018

Electroencephalogram (EEG) is a tool used to study brain activity caused by external stimuli. In this process, artifacts are mixed and it is easy to distort the signal, so post-processing is necessary to remove it. Independent Component Analysis (ICA) is a widely used method for removing artifact. This method has a disadvantage in that it has excellent performance but some loss of brain wave information. In this paper, we propose a method to reduce EEG information loss by restricting the filter coverage using eye blink information obtained from Eyetracker. We then compared the results of the proposed method with the conventional method using quantization methods such as Signal to Noise Ratio (SNR) and Spectral Coherence (SC).

• Korean Journal of Applied Biomechanics
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• v.32 no.4
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• pp.121-127
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• 2022

Objective: The purpose of this study was to investigate potential effects of transcranial direct current stimulation (tDCS) on bimanual force control capabilities in healthy young adults. Method: Eighteen right-handed healthy young adults (10 females and 8 males; age: 23.55 ± 3.56 yrs) participated in this crossover design study. All participants were randomly allocated to both active-tDCS and sham-tDCS conditions, respectively. While receiving 20 min of active- or sham-tDCS interventions, all participants performed bimanual isometric force control tasks at four submaximal targeted force levels (i.e., 5%, 10%, 15, and 20% of maximal voluntary contraction: MVC). To compare bimanual force control capabilities including force accuracy, variability, and regularity between active-tDCS and sham-tDCS conditions, we conducted two-way repeated measures ANOVAs (2 × 4; tDCS condition × Force levels). Results: We found no significant difference in baseline MVC between active-tDCS and sham-tDCS conditions. Moreover, our findings revealed that providing bilateral tDCS including anodal tDCS on left primary motor cortex (M1) and cathodal on right M1 while conducting bimanual force control trials significantly decreased force variability and regularity at 5%MVC. Conclusion: These findings suggest that providing bilateral tDCS on M1 areas may improve bimanual force control capabilities at a relatively low targeted force level.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.729-732
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• 2008

유비쿼터스 시대의 도래에 따른 서비스의 고급화는 다양한 형태의 사용자 단말기의 개발을 유도 하였으며, 이러한 사용자 단말기의 변화는 다양한 형태의 인간친화형 사용자 인터페이스의 개발로 이어지게 되었다. 이러한 다양한 형태의 인간친화형 사용자 인터페이스 중, 인간의 뇌를 활용한 사용자 인터페이스, 즉 BCI에 관한 연구가 산발적으로 다양하게 진행되고 있다. 현재 진행되어지고 있는 다양한 형태의 BCI관련 연구들은, 연구 초기 수준을 극복하지 못하는 실정이며, 이러한 연구 개발의 지체 이유로는 DB구축부터 시작한 체계적인 연구가 이루어지고 있지 않는 점을 들 수 있다. 또한, 뇌파 신호의 수집 시 효율적인 피험자 지침 관련 연구가 없는 실정이며 기 구현되어진 대부분의 시스템이 로컬시스템 형태로 구성되어져 DB 구축 시 한정적인 피험자 수, 대용량의 뇌파 DB수집 시 한계, 뇌파 DB의 신뢰성이 저하되는 문제점을 야기한다. 본 논문에서는 이러한 문제점을 극복하기 위하여 VoiceXML을 활용한 온라인 기반의 DB구축 시스템 구현을 제안 하며 신뢰성 및 객관성을 확보 하고자 한다.

• Journal of Science and Technology Studies
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• v.10 no.2
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• pp.107-141
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• 2010

Visualization techniques are transformed into reliable representations through socio-technological processes which include the agreement on the instrument and the embodiment of practices in relevant scientific communities. Visual representations thus produced are justified by realistic and epistemic virtues in science. This paper analyzes different visual images presented in the scientific papers of two research groups who argue different theories about the mechanism of face perception. These two scientific groups use the same fMRI technology; yet, different experimental paradigms and visual stimuli change their hypotheses into distinct testable theories, which in turn lead to different evidences to support their own theories. Visual evidences are intermediate representations which lie between fMRI brain images and scientific theories, and theoretical models obtain the scientific value based on the consistency in the chain of visual representations. This study shows that representations in science tend to be good representations within the context of scientific communities. It will provide a chance to think of the value and limit of the scientific knowledge

• Science of Emotion and Sensibility
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• v.16 no.3
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• pp.387-396
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• 2013

In this study, the influence of classroom smells (foot odor, hair smell, sour smell, and sweat smell) of male high school and sweat smell and the offensive odor substance (ammonia and butyric acid) on the electroencephalography (EEG) activities of 20 female volunteers, ranging in age from 30 to 50 were studied. The representative response of brainwave index by these smells stimuli was most pronounced on temporal lobes among the brain lobes. By comparison with background EEG activities on temporal lobes, the smells reduced the relative alpha band power (0.04~0.13) and increased the relative beta band power (0.02~0.06) and the relative gamma band power (0.03~0.09). The alpha wave was deactivated, high beta (18~30Hz) and gamma (30~50Hz) waves were remarkably activated. The order of EEG fluctuation caused by the smell stimulus is as follows; hair smell > butyric acid > foot odor, sour smell > ammonia > sweat smell. It means that the classroom smells cause an excessive brain arousal and straining and may be reducing one's attention and learning ability.