• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 한국감성과학회 2002년도 춘계학술대회 논문집
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• pp.135-138
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• 2002

판매직에 종사하는 여성을 대상으로 100%의 Basil oil, Lavender oil, Lemon oil, Jasmin oil, Ylangylang oil (KIMEX co. Ltd), Skatole의 총 6가지 종류의 천연향을 사용하여 자극하였을 때의 상호 정보량을 분석, 비교하였다. 그 결과, 선호도가 낮은 Basil과 Skatole을 자극할 때 무향에 비해 상호 정보량이 많고, 향 간의 비교에서도 선호도가 낮은 향에 대한 상호 정보량이 선호도가 높은 향에 비해 더 많음을 보여주었다. 이는 뇌에서 상호 정보량이 향에 대한 선호도와 관련이 있고, 특히 선호도가 낮은 향의 경우, 정보량의 증가 경향이 확인되었다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 한국감성과학회 1998년도 춘계학술발표 논문집
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• pp.155-158
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• 1998

본 연구의 목적은 후각 자극에 의한 감성의 변화를 주관적 검사와 동시에 시행한 심전도에서 추출한 HRV parameter와의 상관관계를 보고자 함이다. 후각 자극은 0.6% orange와 2.5% valeric acid를 일정 flow와 일정 농오고 코 점막에 건조를 방지하기 위해 수증기로 포화시킨 향자극기로 주었다. 향의 주관적 검사에서는 오렌지향은 친숙하고 쾌하다고 하였으며 valeric acid경우 불쾌하고 성가시고 친숙하지 않는 감성을 표시하였ㅅ다. 이러한 쾌하고 불쾌한 향자극에 대한 HRV분석결과는 valeric acid에 비해 오렌지향을 제시하였을 때가 HF/LF값이 높은 변화를 보임으로써 부교감신경의 활동이 우세하였음을 확인하였다. 결론적으로 HRV스펙트럼 분석이 감성의 변화를 객관적인 지표로 나타내는데 유용한 정보로서의 가능성을 제시하고자 하였다.

• Sleep Medicine and Psychophysiology
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• 제28권1호
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• pp.2-5
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• 2021

Hyperarousal or increased brain excitability is thought to play a key role in the pathophysiology of insomnia. Neuromodulation techniques are emergent complementary therapies for insomnia and can improve sleep by modulating cortical excitability. A growing body of literature support the idea that neuromodulation can be effective in improving sleep or treating insomnia. Recent evidence has revealed that neuromodulation methods can improve objective and subjective sleep measures in individuals with insomnia, although effects vary according to protocol. Different mechanisms of action might explain the relative efficacy of neuromodulation techniques on sleep outcomes. Further research testing different stimulation parameters, replicating existing protocols, and adding standardized sleep-related outcomes could provide further evidence on the clinical utility of neuromodulation techniques.

• Journal of Korean Academy of Nursing
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• 제34권7호
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• pp.1255-1264
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• 2004

Purpose: The purpose of this study was to determine the effect of a 3-week somatosensory stimulation program on the integrity of the somatosensory pathway of patients with brain damage. Method: The sample consisted of two groups of patients with brain damage matched by Glasgow Coma Scale (GCS) scores and age:8 patients with a mean age of 56.75 years who were treated with somatosensory stimulation, and 8 patients with a mean age of 58.88 years, who were not treated with sensory intervention program. A repeated measures matched-control group design was used to assess functional recovery of the brain. The instrument used in this study was SSEP (somatosensory evoked potentials), a neurophysiological parameter, for the integrity of the somatosensory pathway. Results: The hypothesis that patients with brain damage who were treated with the somatosensory stimulation program will show higher SSEP wave form scores than the non-treatment group was supported (3rd week.: U=13.000, p=.014). Additional repeated measures analysis showed that there were no significant differences in recovery trends between the groups (F=1.945, p=.159). Conclusion: This study demonstrates that a somatosensory stimulation program is effective in promoting recovery of the integrity of the somatosensory pathway of patients with brain damage.

• Physical Therapy Korea
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• 제8권4호
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• pp.91-99
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• 2001

뇌 손상 후 급성기에 기능의 자발적인 회복이 일어나지만 환자들은 환측의 상지를 잘 사용하지 못하게 된다. 그 결과 원하는 움직임을 억제하는 상황을 발생시키는데 이것을 학습 무사용 증후군(learned nonu se syndrome)이라 한다. 이러한 학습 무사용 증후군을 치료하기 위해 억제-유도 치료(constraint-induced therapy)가 고안되었다. 억제-유도 치료는 연속되는 몇 주간에 걸쳐 매일 많은 시간 동안 건측의 상지를 묶어두고 환측 상지를 사용하게 하여 기능을 반복 학습하게 함으로써 기능을 증진시키는 방법이다. 이미 여러 연구자들이 경두개 자기자극(transcranial magnetic stimulation), 움직임 관련 피질전위(movement-related cortical potential), 기능적 자기공명 영상기법(functional magnetic resonance imaging) 등을 통하여 억제-유도 치료 후 운동피질영역에서의 재조직화를 보고함으로써 기능 증진과 관련된 회복 기전을 뒷받침하고 있다. 억제-유도 치료의 영역은 확대되어 뇌졸중, 척수손상, 고관절 치환술 후로 하지에서의 기능증진을 위하여 연구가 진행되고 있으며 특히 뇌졸중 후 실어증 환자에서 새로운 방법으로 제시되고 있다. 따라서, 억제-유도 치료는 신경학적인 손상 후 움직임의 재활에 있어서 치료-유도를 통한 중추신경계의 회복에 효과적으로 작용할 수 있다.

• Proceedings of the KIEE Conference
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1983-1984
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• 2008

뇌 활동의 전기적 신호인 뇌파(EEG)와 외부 자극에 대한 유발 전위(EP)를 측정하여 실시간으로 뇌지형도를 생성하는 real-time brain mapping system을 개발하였다. 측정 전극은 32채널을 사용하였고, EEG를 실시간 및 누적 주파수 분석을 통한 뇌파의 활성도 진단, EP를 측정하여 시각적/청각적 자극에 의한 유발 전위 분석을 할 수 있다. 본 시스템은 측정 대상군의 통계적 분석을 위한 Database를 구축하였고, 신뢰성 높은 뇌파 및 유발 전위 신호를 위하여 실시간 측정과정 및 측정 후 Data 검토과정에서 다양한 Artifact 제거 알고리즘이 도입되었다. 또한, 32 채널 Brain map을 구성하여 뇌파를 공간적으로 분석 가능하며, 시간 및 주파수의 증가에 따라 Brain map을 동영상화하여 시간적/주파수적 변화에 따른 분석이 가능하다.

• Journal of the Korean Society for Precision Engineering
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• 제29권9호
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• pp.1035-1040
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• 2012

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been found to be effective treatment of Parkinson's disease (PD). This study aims to evaluate the effect of DBS for rigidity during DBS surgery. Six Parkinsonian patients who received STN-DBS surgery participated in this study. The examiner imposed flexion and extension of a patient's wrist randomly. Resistance to passive movement was quantified by viscoelastic properties (two damping constants for each of flexion and extension phase and one spring constant throughout both phases). All Viscoelastic constants decreased by DBS (p<0.01). Specifically, reduction in damping constant during flexion ($B_f$) was greater than those of damping constant during extension ($B_e$) and of spring constant (p<0.05). $B_f$ would be appropriate for evaluation of effect of DBS for rigidity during DBS surgery.

• The Korean Journal of Nuclear Medicine
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• 제34권1호
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• pp.10-21
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• 2000

Purpose: Episodic memory is described as an 'autobiographical' memory responsible for storing a record of the events in our lives. We performed functional brain activation study using ${H_2}^{15}O$ PET to reveal the neural basis of the encoding and the retrieval of episodic memory in human normal volunteers. Materials and Methods: Four repeated ${H_2}^{15}O$ PET scans with two reference and two activation tasks were performed on 6 normal volunteers to activate brain areas engaged in encoding and retrieval with verbal materials. Images from the same subject were spatially registered and normalized using linear and nonlinear transformation. Using the means and variances for every condition which were adjusted with analysis of covariance, t-statistic analysis were performed voxel-wise. Results: Encoding of episodic memory activated the opercular and triangular parts of left inferior frontal gyrus, right prefrontal cortex, medial frontal area, cingulate gyrus, posterior middle and inferior temporal gyri, and cerebellum, and both primary visual and visual association areas. Retrieval of episodic memory activated the triangular part of left inferior frontal gyrus and inferior temporal gyrus, right prefrontal cortex and medial temporal area, and both cerebellum and primary visual and visual association areas. The activations in the opercular part of left inferior frontal gyrus and the right prefrontal cortex meant the essential role of these areas in the encoding and retrieval of episodic memory. Conclusion: We could localize the neural basis of the encoding and retrieval of episodic memory using ${H_2}^{15}O$ PET, which was partly consistent with the hypothesis of hemispheric encoding/retrieval asymmetry.

• Journal of Animal Science and Technology
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• 제48권5호
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• pp.651-662
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• 2006

Phthalate esters that are used as plasticizers and also found at low levels in foods such as dairy products are often mentioned as suspected endocrine disrupters. The purpose of the present study is to elucidate whether perinatal exposure to di-n-butyl phthalate(DBP), diisononyl phthalate (DINP) and di-2-ethylhexyl adipate (DEHA) affects several aspects of reproductive function in rats especially sexual differentiation of the brain. To this end, the dams were provided with pulverized soy-free diet containing 20, 200, 2,000 and 10,000 ppm of DBP, 40, 400, 4,000 and 20,000 ppm of DINP, or 480, 2,400 and 12,000 ppm of DEHA from gestational day (GD) 15 to postnatal day (PDN) 21, the day of weaning, and serum sex steroid hormone, gonadotropin levels and sexual behaviors after maturation were assessed. At Postnatal week (PNW) 20-21, serum levels of sex steroids and gonadotropins in both male and female rats, as well as estrous cyclicity in females, were not changed by perinatal exposure to DBP, DINP and DEHA, indicating that these chemicals did not affect sexual differentiation of the brain controlling the endocrine system of hypothalamo-pituitary-gonadal (HPG) axis. On the other hand, inhibitory influences on sexual behaviors, especially on ejaculation in males and lordosis in females, were observed by perinatal exposure to these chemicals. These results suggest that these chemicals may act directly on discrete regions of the hypothalamus regulating sexual behaviors, but not regulating gonadotropin secretion, thereby affect sexual differentiation of the brain with a resultant decrease in sex-specific behaviors in adulthood.

• The Korean Journal of Nuclear Medicine
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• 제34권6호
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• pp.456-464
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• 2000

Purpose: To evaluate the effect of acupuncture on regional cerebral blood flow (rCBF) at acupoints suggested by oriental medicine to be related to the treatment of cerebrovascular diseases. Materials and Methods: Rest/acupuncture-stimulation Tc-99m ECD brain SPECT using a same-dose subtraction method was performed on 54 normal volunteers (34 males, 20 females, age range from 18 to 62 years) using six paradigms: acupuncture at acupoints GV. 20, GV. 26, LI. 4, ST. 36 and SP. 6. In the control study, needle location was chosen on a non-meridian focus 1 cm posterior to the right fibular head. All images were spatially normalized, and the differences between rest and acupuncture stimulation were statistically analyzed using SPM$^{(R)}$ for Windows$^{(R)}$. Results: Acupuncture applied at acupoint GV. 20 increased rCBF in both the anterior frontal lobes, the right frontotemporal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at GV 26 increased rCBF in the left prefrontal cortex. Acupuncture at LI. 4 increased rCBF in the left prefrontal and both the inferior frontal lobes, and the left anterior temporal lobe and the left cerebellar hemisphere. Acupuncture at ST. 36 increased rCBF in the left anterior temporal lobe, the right inferior frontal lobes, and the left cerebellum. Acupuncture at SP. 6 increased rCBF in the left inferior frontal and anterior temporal lobes. In the control stimulation, no significant rCBF increase was observed. Conclusion: The results demonstrated a correlation between stimulation at each acupoint with increase in rCBF to the corresponding brain areas.