• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.13-24
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• 1986

마취과 의사는 신경외과수술시 뇌압이 상승되어 있는 환자의 마취를 자주 접하게 된다. 따라서 이러한 환자에서 뇌압의 상승을 억제시키고 뇌압상승 요인들을 제거하며 적당한 뇌혈류량을 유지시킴으로서 이미 손상된 뇌조직을 보호하고 더 이상의 뇌손상을 가하지 않도록 노력해야 한다. 이를 위하여 마취과적 입장에서 고려해 보아야 할 여러 문제점들, 특히 두개강내 역학 즉 뇌용적, 뇌압, 뇌혈류, 뇌산소대사율의 유기적 관계와 마취과에서 쓰여지는 여러약제 및 기타 뇌압과 관계되는 약제 및 요인들에 관하여 기술해 보았다.

• Journal of Yeungnam Medical Science
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• v.11 no.1
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• pp.167-180
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• 1994

In order to inquire the most effective management of increased intracranial pressure(ICP), mannitol, steroid and hyperventilation were used in rabbits after ligation or non-ligation of the carotid artery. Mannitol was more effective than steroid and hyperventilation in the degree of the reduction of ICP. The intracranial pressure was decreased 43~45% for 25~30 minutes after injection of mannitol. Steroid was less effective than mannitol in the degree of the reduction of ICP. But the time of reduction of ICP was longer, that is, the degree of reduction was 24~60 minutes after injection of steroid. Hyperventilation is effective in the initial time only, for 10 minutes after hyperventilation. The degree of ICP reduction was 13.5~16.7% for 10 minutes after hyperventilation. The combined group, that is three kinds of mangenent were used, is the most effective treatment to reduce ICP of ICP. The degree of the reduction of ICP was 42.1~49.3% for 20 minutes, 47.7~52.5% for 30minnutes. There was no significant difference between ligation and non-ligation group.

• Journal of Yeungnam Medical Science
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• v.2 no.1
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• pp.45-51
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• 1985

It is well known that intracranial pressure (ICP) and mean arterial pressure (MAP) are increased by laryngoscopy and endotracheal intubation during induction of general anesthesia, and It may be very dangerous in neurosurgical patients who had increased ICP. Therefore, this study was performed to know the range of ICP increase during induction of the conventional general anesthesia with intubation following thiopental and succinylcholine injections. Intracranial pressure and MAP were measured in 13patients who underwent cramotomy. All the patients were monitored cerebral epidural ICP and intra-arterial pressure pre-operatively. The results were as follow: 1. Intracranial pressure was increased of $7.1{\pm}7.23mmHg$. 2. Arterial pressure was increased of $43.5{\pm}25.46mmHg$. 3. Cerebral perfusion pressure was increased of $33.3{\pm}27.53mmHg$. It is stressed that certain procedures are necessary to prevent from further increase of ICP due to induction of general anesthesia in patients with increased ICP.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.213-220
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• 1994

Damages on central nervous system induced by the exposure of microwave. However, the effects of microwave on ICP are not studied yet. The ICP affected by the condition of the brain has an significant effect on vital sign. So we investigated the changes of ICP of the rabbits after exposure. Twenty four rabbits were devided into 3 groups depending on the amount of exposure to microwave. One group was composed with 8 rabbits were exposed to microwave for 10 miniutes. Other were composed to microwave for 20 miniutes, 30 miniures, respectively. Intracranial pressure on each group were measured by subdural type ICP monitoring catheter immediately, first day, 3rd day, 5th day and 7th day after exposure of microwave. Results indicates that intracranial pressure of rabbits are not affected with statistical significance by exposure of microwave.

• Journal of Yeungnam Medical Science
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• v.8 no.2
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• pp.35-44
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• 1991

Recently many authors have reported about the relationship of the volumes of hemorrhage in the brain parenchyme, hemorrhagic sites, optimal operation time, and the effects of mannitol and steroid on control of ICP to clinical manifestations. Many attempts to measue ICP in hydrocephalus, brain tumor, and head injury have been reported. But the measurements of intracranial pressure in spontaneous intracerebral hemorrhage are rare. Intracranial pressure was monitored prospectively in 30 patients who had stereotaxic surgery for spontaneous intracerebral hemorrhage. The results are as follows. 1. Intracranial pressure was increased in high $PaCO_2$. 2. There were no correlation in ICP, rebleeding and ADL at discharge(P > 0.05). 3. ICP was the most high level in 72 hours after operation. 4. There was 63.2% decrease in ICP after litigation with 6000 IU urokinase in the site of hemorrhage. 5. There was no correlation between the numbers of natural drainage and ADL at discharge(P > 0.05). 6. The higher the initial GCS, the higher the Postoperative GCS.

• Proceedings of the KIEE Conference
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• 2002.11a
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• pp.54-56
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• 2002

본 논문에서는 뇌압을 측정하기 위해 LC 공진을 이용한 압력센서를 제작하고 그 성능을 시험하였다. 원격 측정용 압력센서는 움직이는 전극역할을 하는 p+ 박막이 있는 실리콘 기판과 고정된 평면 코일이 있는 유리 기판으로 구성되어 있다. 압력에 따라 두 전극 간의 간격이 달라지고 이에 따른 캐피시턴스가 변화하여 공진주파수가 변화하게 된다. 원격 측정용 외부 안테나를 이용하여 측정회로의 공진 주파수에서 위상의 변화를 측정하여 압력을 측정한다. 상부기판은 실리콘 기판을 도핑하여 p+ 막을 형성하고 금속막을 증착하여 전극을 형성한 후 실리콘을 식각하여 완성하고. 하부기판은 유리 기판 위에 금속막을 증착한 후. 전기도금으로 평면 코일을 형성하고 다시 금속막을 증착하여 전극을 형성하여 제작한다. 압력을 변화시킬 때 전극간의 간격의 변화에 따른 공진주파수에서의 위상의 변화를 외부 안테나에 연결된 측정회로를 통해 측정한다. 측정결과 공진주파수인 160 Mhz에서 -0.08 $deg/mmH_2O$의 감도를 얻을 수 있었다.

• Proceedings of the KTCVS Conference
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• 1995.10a
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• pp.21-21
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• 1995

• Journal of Korean Neurosurgical Society
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• v.30 no.sup2
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• pp.309-315
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• 2001

The term slit ventricle syndrome(SVS) refers to an episodic occurrence of headache, vomiting, and possibly some degree of impaired consciousness in shunted hydrocephalic children in whom slit-like ventricles are seen on CT scan or MRI. Authors present 6 cases with SVS who were treated at our institute for last 10 years. From 1986 to 1996, 821 patients underwent shunt surgery for hydrocephalus. The etiology of hydrocephalus included brain tumor(140 patients), post-hemorrhagic(62 patients), idiopathic normotensive hydrocephalus(64 patients), post-meningitic( 58 patients), post-traumatic(54 patients), congenital(48 patients), neurocysticercosis(31 patients), and unknown etiology(364 patients). During the mean follow-up duration of 68 months, 232 shunt revisions were performed by a revision rate of 1.28 per patient. The incidence of SVS was 0.7%(6 patients). Most of them have been operated on in infancy. Time interval from the first operation to the development of slit-ventricle syndrome ranged from 4 to 8 years, the mean was 6 years. Shuntogram showed patent shunt in all patients. Two patients with less severe clinical symptoms improved with conservative treatment. These patients were not measured ICP because of good hospital course. One patient showed high ICP and needed only revision with same pressure valve as previous shunt. Low ICP was noted in 3 patients. Pressure augmentation using an anti-siphon device(ASD) or upgrading valve system were necessary in these patients. The authors stress that determining type of SVS is the first step in treatment planning and that the best treatment is a strategy aimed at resolving the specific type of SVS responsible for the symptoms.

• Journal of Biomedical Engineering Research
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• v.23 no.5
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• pp.391-395
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• 2002

Shunt valves used to treat patient with hydrocephalus were numerically simulated to investigate influence of pressure pulsation on their flow control characteristics. We modeled flow orifice through the shunt valve and imposed pulsating pressure and valve diaphragm movement to compute flow through the valve. The results of our study indicated that flow rates increased more than 40% by introducing pressure pulsation and diaphragm movement on the shunt valve. Our results demonstrate the pressure-flow control characteristics of shunt valves implanted above human brain may be quite different from those obtained by syringe pump test just after manufacture that induces uniform pressure.

• Clinical and Experimental Pediatrics
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• v.49 no.5
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• pp.533-538
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• 2006

Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We intend to investigate the role of substance P(SP) and calcitonin gene-related peptide(CGRP) in aseptic meningitis or meningismus. Methods : We measured leukocyte count, the concentration of protein and glucose in CSF and ICP of patients with meningeal irritation sign. We also measured SP and CGRP levels by using immunoassay. We analyzed the relationship between the presence of headache and the value of SP and CGRP. Results : The concentrations of CGRP($18.8{\pm}10.5ng/mL$) in CSF and ICP($14.8{\pm}4.5cmH_2O$) in aseptic meningitis group were significantly higher than in those($14.1{\pm}7.4ng/mL$ and $12.0{\pm}5.1cmH_2O$, respectively) of the meningismus group(P<0.05). There was no significant difference in the SP levels between the two groups. In the aseptic meningitis group, the concentrations of SP and CGRP were significantly higher in the normal ICP group than in the elevated ICP group(P<0.05). Conclusion : Headaches in children with aseptic meningitis or meningismus is considered to be related to the elevation of the CSF levels of SP and CGRP.