• Journal of Life Science
• /
• v.28 no.11
• /
• pp.1386-1395
• /
• 2018

Over recent years, it has become evident that the central nervous system bidirectionally interacts with the gastrointestinal tract along the gut-brain axis. A series of preclinical studies indicate that the gut microbiota can modulate central nervous system function through a multitude of physiological functions. Polyphenols are ubiquitous plant chemicals included in foods such as fruits, vegetables, tea, coffee and wine, and their consumption is directly responsible for beneficial health effects due to antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, anticancer, vasodilating, and prebiotic-like effects. There is increasing evidence that dietary polyphenol can contribute to beneficial effects in neuronal protection acting against oxidative stress and inflammatory injury as well as in cognitive functions. In this paper, we overview the neuroprotective role of dietary polyphenols especially focusing on the neuroinflammation and neurovascular function by interaction with the gut microbiome. Polyphenol metabolites could directly act as neurotransmitters crossing the blood-brain barrier and modulating the cerebrovascular system or indirectly modulating gut microbiota. In addition, evidence suggests that dietary polyphenols are effective in preventing and managing neurological disorders, such as age-related cognitive decline and neurodegeneration, through a multitude of physiological functions. Dietary polyphenols are increasingly envisaged as a potential nutraceuticals in the prevention and treatment of neurological disorders, because they possess the ability to reduce neuroinflammation, to improve memory and cognitive function and to modulate the gut microbiota.

• Journal of Life Science
• /
• v.32 no.7
• /
• pp.550-566
• /
• 2022

Stroke is among the leading causes of death and long-term physical and cognitive disabilities worldwide, affecting an estimated 15 million people annually. The pathophysiological process of stroke is complicated by multiple and coordinated events. The breakdown of the blood-brain barrier (BBB) in people with stroke can significantly contribute to the development of ischemic brain injury. Therefore, BBB disruption is recognized as a hallmark of stroke; thus, it is important to develop novel therapeutic strategies that can protect against BBB dysfunction in ischemic stroke. Traditional medicines are composed of natural products, which represent a promising source of new ingredients for the development of conventional medicines. Indeed, several studies have shown the effectiveness of Korean medicine on stroke, highlighting the value of Korean medicinal treatment for ischemic stroke. This review summarizes the current information and underlying mechanisms regarding the ameliorating effects of the formula, decoction, herbs, and active components of traditional Korean medicine on cerebral ischemia-induced BBB disruption. These traditional medicines were shown to have protective effects on the BBB in many cellular and animal ischemia models of stroke, and experiments in various animal species, such as mice and rats. In addition, they showed brain-protective effects by protecting the BBB through the regulation of tight junction proteins and matrix metalloproteinase-9, reducing edema, neuroinflammation, and neuronal cell death. We hope that this review will help promote further investigation into the neuroprotective effects of traditional Korean medicines and stimulate the performance of clinical trials on Korean herbal medicine-derived drugs in patients with stroke.

• 한국약용작물학회:학술대회논문집
• /
• 2007.05a
• /
• pp.290-291
• /
• 2007

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.18 no.3
• /
• pp.44-51
• /
• 2004

오늘날 대부분의 에너지를 전기에 의존함에 따라 전력사용이 급증하고 부하가 대용량화되어 및 정적 전력공급이 중요한 문제로 대두되었다. 이러한 추세에 따라 송ㆍ배전 설비도 점차 대용량화 및 고전압화 되고 신뢰성을 요구하게 되며, 각종 배전 설비의 제조기술이 더욱 복합 다양하게 발전하고 있다. 그 중 전력계통에서 뇌 혹은 개폐서지 등의 과전압을 흡수ㆍ억제하여, 전력설비와 계통보호를 위해 설치하는 것이 피뢰기이다. 따라서 어떻게 과전압을 낮게 억제할 수 있을까 하는 것이 피뢰기의 가장 중요한 성능이라고 말할 수 있다. (중략)

• Korean Journal of Food Science and Technology
• /
• v.52 no.3
• /
• pp.263-273
• /
• 2020

In this study, in order to confirm the ameliorative effects of onion (Allium cepa L.) flesh and peel on amyloidbeta (Aβ)-induced cognitive dysfunction, we evaluated their in vitro neuroprotection and in vivo cognitive functions. As the result of in vitro neuroprotection, the protective effect of the ethyl acetate fraction of onion flesh (EOF) on Aβ-induced cytotoxicity was similar to that of the ethyl acetate fraction of onion peel (EOP). In the behavioral tests, the EOF and EOP effectively improved the Aβ-induced learning and memory impairments. For this reason, it could be concluded that the EOF and EOP improved the antioxidant activities (superoxide dismutase, oxidized glutathione/total glutathione, and malondialdehyde) in brain tissue. In addition, the EOF and EOP effectively activated mitochondrial functions by protecting the mitochondrial membrane potential, ATP, mitochondria-mediated protein (BAX and cytochrome c), and caspase 3/7 activities. The EOF and EOP also improved the cholinergic system (acetylcholinesterase and acetylcholine). Therefore, we suggest that onion could be used for management of Aβ-induced cognitive dysfunction.

• Journal of Life Science
• /
• v.20 no.6
• /
• pp.948-954
• /
• 2010

Exercise can favorably influence brain plasticity by facilitating neurogeneration, neuroadaptivity, and neuroprotection. Aerobic exercise has been reported to change brain nerve growth factors (growth hormone, insulin like factor-1, estrogen and serotonin). The purpose of this study was to demonstrate the effects of aerobic exercise for 12 weeks on brain nerve growth factors in girls. Fourteen female participants in elementary school grades 1 through 3 were randomly allocated to the exercise group (EG, n=6) and control group (CG, n=8). The EG participated in 60 minutes of modified ballet exercise as aerobic training three days a week for 12 weeks. Based on comparison between groups by two-way ANOVA with repeated measures, aerobic exercise program participants experienced decreased weight (p<0.01), BMI (p<0.01), fat mass (p<0.001), fat percent (p<0.001) and increased LBM (lean body mass) percent (p<0.001). In addition, we detected that aerobic exercise decreased the level of serotonin (p<0.05) and increased the level of GH (p<0.05) and IGF-1 (p<0.05). These findings suggest that aerobic exercise programs can be an efficient intervention to change body composition, alleviate central fatigue, improve brain function, and induce brain cell proliferation in girls.

• Proceedings of the KIEE Conference
• /
• 2007.07a
• /
• pp.398-399
• /
• 2007

정보통신설비의 발달로 통신속도가 빨라지고 정보처리 용량도 증가하면서 통신설비가 과거에 비해 소형 분산 설치되어 뇌서지에 상대적으로 취약하게 되었으며 이로 인한 피해는 해마다 증가되는 경향이다. 통신설비의 장애는 정보전달의 기능을 상실함과 동시에 업무의 정지 및 통신네트워크의 정지로 이어져 사회적으로 커다란 문제를 야기하고 있다. 통신설비에 서지가 침입하는 경로는 여러 가지가 있으며 전원측으로 침입하는 이상전압의 종류로는 크게 낙뢰과전압, 스위칭과전압, 일시적 과전압으로 구분할 수 있으며 이로부터 통신설비를 보호하기 위하여 전원측에 서지프로텍터를 설치하고 있다. 본 논문에서는 저압선로에 서지프로텍터 설치시 적용방법에 대하여 설명한다.

• Clinical and Experimental Pediatrics
• /
• v.52 no.5
• /
• pp.594-602
• /
• 2009

Purpose : Transforming growth factor (TGF)-${\beta}1$ reportedly increases neuronal survival by inhibiting the induction of inducible nitric oxide synthase (NOS) in astrocytes and protecting neurons after excitotoxic injury. However, the neuroprotective mechanism of $TGF-{\beta}1$ on hypoxic-ischemic (HI) brain injury in neonatal rats is not clear. The aim of this study was to determine whether $TGF-{\beta}1$ has neuroprotective effects via a NO-mediated mechanism and N-methyl-D-aspartate (NMDA) receptor modulation on perinatal HI brain injury. Methods : Cortical cells were cultured using 19-day-pregnant Sprague-Dawley (SD) rats treated with $TGF-{\beta}1$ (1, 5, or 10 ng/mL) and incubated in a 1% O2 incubator for hypoxia. Seven-day-old SD rat pups were subjected to left carotid occlusion followed by 2 h of hypoxic exposure (7.5% $O_2$). $TGF-{\beta}1$ (0.5 ng/kg) was administered intracerebrally to the rats 30 min before HI brain injury. The expressions of NOS and NMDA receptors were measured. Results : In the in vitro model, the expressions of endothelial NOS (eNOS) and neuronal NOS (nNOS) increased in the hypoxic group and decreased in the 1 ng/mL $TGF-{\beta}1-treated$ group. In the in vivo model, the expression of inducible NOS (iNOS) decreased in the hypoxia group and increased in the $TGF-{\beta}1$-treated group. The expressions of eNOS and nNOS were reversed compared with the expression of iNOS. The expressions of all NMDA receptor subunits decreased in hypoxia group and increased in the $TGF-{\beta}1$-treated group except NR2C. Conclusion : The administration of $TGF-{\beta}1$ could significantly protect against perinatal HI brain injury via some parts of the NO-mediated or excitotoxic mechanism.

• Neonatal Medicine
• /
• v.15 no.1
• /
• pp.32-37
• /
• 2008

Purpose : Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to prevent or reduce the harmful effects of hypoxia and ischemia in humans. In the clinical setting, maternal hyperthermia induces adverse effects on the neonatal brain, but recent studies have shown that hyperthermic pretreatment (PT) plays some role in hypoxic-ischemic (HI) injuries of the developing brain. The present study investigated the effect of hyperthermic PT on HI brain injuries in newborn rats. Methods : HI was produced in 7-day-old neonatal rats by unilateral common carotid artery ligation, followed by hypoxia with 8% oxygen at $38^{\circ}C$ for 2 hours. Twenty-four hours before HI, one-half of the pups were exposed to a $40^{\circ}C$ environment for 2 hours. The severity of the brain injury was assessed 7 days after the HI. Results : Hyperthermic PT reduced the gross and histopathologic findings of brain injury from 64.7 to 31.2% (P<0.05). There were no differences in location and severity of injury between the pretreated and control brains. Conclusion : These findings indicate that hyperthermic PT provides neuroprotective benefits on HI in the developing brain. Also, these findings suggest maternal hyperthermia may have protective effect on perinatal HI brain injuries.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.21 no.2
• /
• pp.46-53
• /
• 2007

Extension of the mobile communication and the rapidly developing services connected with wireless multimedia(W-CDMA, DMB, Wibro, and so on) need great many base station transceiver systems, antennas, and many signal transmission line to embody these services. The min communication appliances system is exposed always in danger of transient overvoltage by direct stroke or induced lightning surge flowing in through antenna because the antenna of base station transceiver system or relay equipment is combined with expensive communication network equipments through signal transmission line. Now, gas discharge tube(GDT) or narrow band stub arrestor which is used by the surge protector for communication use is exposing limitations as for lightning surge protective means of the communication facility with high speed and wide frequency band. Therefore, for improving performance of surge arrestor, we applied ceramic filter which can reduce lightning surge invading from antenna effectively, and proved that ceramic filter is effective in residual voltage reduction through the experimental research.