• 약학회지
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• 제33권3호
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• pp.149-155
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• 1989

To predict the influence of carbon monoxide poisonining on cerebral energy metabolism, rats were exposed to 5000 ppm environment for 30 minutes. Carboxyhemoglobin (HBCO) saturation rate in this condition was 72% equally in male and female rats. Cerebral cortex in the rats showed lower level of ATP, glucose, creatine phosphate and higher level of lactate, pyruvate by anaerobic glycolysis. As for the levels of ATP, creatine phsphate and glucose, the cerebral cortex contents of them were larger in female rats of estrus than in male rats, whereas there was no difference between sexes in the levels of pyruvate and lactate. According to time passage from CO intoxication, the mode of changes in cerebral energy metabolite contents was similar in both sexes.

• 동의생리병리학회지
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• 제19권6호
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• pp.1496-1503
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• 2005

This study aims to define the relationship between brain and heart through several literatures about oriental medicine and the conclusions are as follows. Heart in oriental medicine is called as Sinmyeongjishim(神明之心) which has a close connection with Mind, Consciousness, Emotion, and Physiological instinct of Drain in modern medicine. According to Oriental medicine, Brain stores Wonsin(元神) as Heart stores mind(神). Heart is where mind rests whereas Brain is where mind reveals. The external evidences that prove the relationship of Heart and Mind are as follows: First, with ears, eyes, mouth, and nose the subject of cognition is recognized as Sinmyeongjishim(神明之心). Second, Bulin(不仁), which means decreased movement power and sensibility of limbs, proves that Sinmyeongjishim(神明之心) is involved with movement power and sensibility of limbs. The physiological evidences that prove the relationship of Heart and Mind are as follows; First, Heart as the operation of Sinmyeongjishim(神明之心) manages language. Second, Heart is related with Tongue. Third, Heart is linked to Ears through the ear hole. Fourth, Heart is a store of Mind. Fifth, the five viscera control emotional and psychological activities. The pathological evidence of the relationship of Heart and Mind is that the symptoms of heart disease which are related to Sinmyeongjishim(神明之心) are also related to the functions of Brain. Though Brain has a close connection with Heart in oriental medicine, it is recognized that there are distinctive symptoms of disease of Brain and Hyeolyookjishim(血肉之心) respectively. The relationship of Heart and Brain has been researched in this study, even though there are not enough written materials about oriental medicine. But the fact that the majority of Heart operation is deeply connected with Brain activities cannot be denied. Therefore the research of Heart should be done as well as Brain in the clinical study of Brain.

• 대한약리학회지
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• 제27권1호
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• pp.81-88
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• 1991

웅성-마우스의 고환을 diethyl ether마취하에서 제거하고, 수종의 steroid 홀몬을 각각 매일 1회씩 4일간 피하주사한 다음 날의 오전 11-12 시에 뇌, 신장, 간장 및 소장의 polyamine을 검량하여 다음의 성적을 얻었다. 1. 고환절제-마우스(CM)에서, 소장 putrescine(PT)는 비고환절제-마우스(UCM)에 비하여 유의한 저하를 보였으나, 간 및 소장의 spermine(SM)은 오히려 유의하게 증가되었다. 2. Hydrocortisone 50 mg/kg는 UCM의 소장 PT는 현저히 증가시켰으나, CM의 뇌 PT 함량은 오히려 감소시켰다. 3. Estradiol 5 mg/kg는 UCM의 간 PT 함량을 현저히 증가시켰으며, CM에서는 간 PT 뿐만 아니라 신장의 전 polyamin 함량-증가와 아울러, 다소의 뇌 및 소장 PT-증가를 유도하였다. 4. Dehydroepiandrosterone 250 mg/kg(DHEA)와 testosterone 5 mg/kg(TS)는 UCM의 경우 신장 PT 함량만 유의하게 증가시켰으나, CM에서는 신장의 PT, spermidine(SD), 및 SM 모두를 더욱 현저히 증가시켰고, 아울러 DHEA는 간 SM의 감소를, TS는 뇌 SM의 유의한 증가를 유도하였다. 이상의 결과로 미루어 볼때, 간 및 소장의 polyamine대사-특히 PT함량의 변동은 각각 E2 및 HC에 의하여 보다 특이적으로 조절되고, 신장의 polyamine 대사는 성steroid들에 의하여 다소 비특이적인 조절을 받는 것으로 생각되며, 고환절제-마우스에서 나타나는 HC에 의한 뇌의 전potyamine감소 및 성steroid들에 의한 신장의 전polyamine증가의 발현기전에 대한 연구가 있어야 할 것으로 사료된다.

• 대한미생물학회지
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• 제11권1호
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• pp.13-18
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• 1976

가토(家兎)를 DA rat 뇌(腦)로 면역(免疫)하며 anti-rat brain assoriated ${\theta}(RBA{\theta})$ 혈청(血淸)을 만들어 rat 임파조직(淋巴組織)에 대(對)하여 세포독성(細胞毒性), 간접형광항체염색(間接螢光抗體染色) 및 GVH 반응억제능력(反應脚制能力) 등(等)을 검사(檢査)하였다. 이 $RBA{\theta}$ 혈청(血淸)은 강력(强力)한 항(抗)${\theta}$양혈청(樣血淸)이었으며 $RBA{\theta}$ 항원(抗原)은 mouse의 흉선세포(胸線細胞)와 뇌항원(腦抗原)과 교차반응(交叉反應)을 나타내었다. 이 $RBA{\theta}$ 혈청(血淸)을 사용(使用)하여 rat 임파조직(淋巴組織)의 ${\theta}$ 항원(抗原) 양성임파구(陽性淋巴球)를 검사(檢査)하였든 바 흉선임파구(胸線淋巴球)의 약(約) 98%, 임파절임파구(淋巴節淋巴球)의 $70{\sim}76%$, 말초혈액임파구(末梢血液淋巴球)의 72%, 비장임파구(脾臟淋巴球)의 $36{\sim}44%$ 및 골수(骨髓)의 4%가 ${\theta}$ 항원(抗原)을 가지고 있었다.

• Radiation Oncology Journal
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• 제1권1호
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• pp.37-40
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• 1983

Whole brain irradiation is one mode in the treatment of brain cancer and brain metastasis, but it might cause brain injury such as brain necrosis. It has been studied whether the dose distribution could be a cause of brain injury. The dose distribution in whole brain irradiated by Co-60 beam has been measured by means of calibrated TLD chips inserted in the brain of Humanoid phantom. The following results were obtained. 1. Dose distribution on each transverse section of the brain was uniform. 2. On the midsagital plane of the brain, the dose was highest in upper portion and lowest in lower portion, varying 8 from 104% to 90%. 3. When the radiation field includes free space of 2cm or more width out of the head, the dose distribution in the whole brain is almost independent of the field width. 4. It is important to determine adequate shielding area and to set shielding block exactly in repetition of treatment.

• 대한약리학회지
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• 제6권1호
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• pp.15-22
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• 1970

The present study is concerned with the demonstration of the relationship between the behavior and the brain concentration of noradrenaline resulted from pretreatment of amphetamine in isolated or aggregated rats. The experimental subjects were rats weighing from 120g to 200g housed 1, 2, and 6 in a cage. Analeptic activity of amphetamine was measured by determining the sleeping time induced by pentobarbital sod. The noradrenaline content in brain was determined with Aminco-Bowmann's spectro-photofluorometer by Lee's modification of Shore and Olin method. Results: 1) The analeptic activity of amphetamine on the sleeping time induced by pentobarbital sod. was more increased in the grouped rats than in isolated animal. 2) In being isolated and grouped rats, the sleeping time induced pentobarital sod, was markedly prolonged by pretreatment of amphetamine. 3) Means of housing rats, e.g., isolation or aggregation did not seem to affect the brain noradrenaline depleting action. 4) Repeated daily parenteral administration of amphetamine sulfate for a period 1 to 3 weeks resulted in decrement of brain noradrenaline concentration in being isolated and grouped rats. 5) The prolongation of sleeping time of the isolated or aggregated rats, when pretreated with amphetamine, compared with that of stock rats, seems to be attributable rather to the means of housing than the variation of the noradrenaline caused by amphetamine.

• 약학회지
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• 제28권6호
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• pp.305-311
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• 1984

Relationship between hypertension and monoamine oxidase (MAO) activity in rat brain and the change of this relationship by presynaptic ${\alpha}-receptor$ agonist were studied. Animals were divided into three groups. Group I was composed of normotensive Sprague-Dawley rats (NR), group II of spontaneously hypertensive rats (SHR) and group III of acquired hypertensive rats induced by deoxycorticosterone acetate (DOCA) and NaCl treatment. Clonidine, a presynaptic ${\alpha}-receptor$ agonist, was administered to groups II and III. Blood pressures and MAO activities were measured in each group. MAO activities in the brain of SHR were lower than those of NR. Animals in group II received clonidine which lowered blood pressures but did not change MAO activities in the brain. DOCA and NaCl induced hypertension 21 days after these treatments in group III and did not cause any changes in brain MAO activity. Clonidine lowered blood pressures of group III but did not change MAO activities. The data from the present study suggest that abnormaly low MAO activities in SHR brain may be one of the underlying factors for the susceptibility to hypertension and that the decrease in noradrenergic neuronal activities through presynaptic ${\alpha}-receptor$ activation by clonidine may not be related to the changes of brain MAO activities.

• 동의신경정신과학회지
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• 제9권2호
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• pp.87-95
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• 1998

This study was aimed to evaluate the anti-stress effect of Soeuminsohabhyangwon on the mice in Cold and Swimming stress.In order to investigate the anti-stress effect of Soeuminsohabhyangwon in Cold and Swimming stressed mice, the serotonin contents were measured by HPLC method in various part of mouse brain The following results were observed. 1. In Cerebral Cortex of Frontal Lobe, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased in the SHW group as compared with Control group. 2. In hypothalamus, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with Control group. 3. In corpus striatum, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with Control group. 4. In hippocampus, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with control group.Base on the above results, it may be concluded that Soeuminsohabhyangwon are effective to reduce stress.

• Journal of Nutrition and Health
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• 제6권1호
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• pp.31-38
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• 1973

The effect of dietary condition on the acethylcholine and chotinesterase activity in the brain was observed. Rats weighting $120{\sim}130\;gm$ was fed on diets deprived of protein, carbohydrate and lipid, respectively. Experimental terms was devided into 3, 7 and 15 days. The results are summarized as follows: 1. The lipid free diet makes greater contribution to the gain of body weight than the carbohydrate free and protein free diet. 2. The acethylcholine in the protein free diet group is reduced after 7 days and that in the carbohydrate free diet, after 3 days. 3. The cholinesterase activity shows continuing decrease after 3 days by protein free diet, and the other diet groups appear temporal decrease at 7 days and increase, at 15 days. 4. The relation of acethylcholine, and cholinesterase is similar to each other except that of the carbohydrate diet. From the above results, the conclusions are obtained that the protein free diet makes the acethylcholine and cholinesterase activity lower, and the carbohydrate free diet, acethylcholine lower.

• 대한한의학원전학회지
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• 제20권4호
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• pp.297-310
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• 2007

통과대장석순재심적생리방면적천발적연구(通過對張錫純在心的生理方面的闡發的硏究), 득출여하결론(得出如下結論). 혈내생어심화(血內生於心火), 병의뢰대기이운행. 대기이원기위본(大氣以元氣爲本), 원기생어명문혈(元氣生於命門穴), 수수곡지기적배양(受水穀之氣的培養), 류어흉중(留於胸中), 차흉중대기칭위종기(此胸中大氣稱爲宗氣). 군화내시발어심중지양중지화(君火乃是發於心中之陽中之火), 가소화비위지음식물(可消化脾胃之飮食物), 군화하행즉상화왕성(君火下行則相火旺成), 하원변득온난(下元變得溫暖). 상화원어명문혈(相火源於命門穴), 순삼초적유막(망유)여심포결상연(循三焦的油膜(網油)與心包結相連), 개속어화(皆屬於火), 진견어우수척부맥(診見於右手尺部脈). 선천지군화내단전지원양(先天之君火乃丹田之元陽), 상화내명문지화(相火乃命門之火); 후천지군화내심화(後天之君火乃心火), 상화역위명문지화(相火亦爲命門之火), 이속어담중기생지화(而屬於膽中寄生之火). 원양지화여명문상화(元陽之火與命門相火), 가소화대소장적음식(可消化大小腸的飮食), 상초지심화여중초지담화(上焦之心火與中焦之膽火), 가소화위중적음식(可消化胃中的飮食). 장석순종합료서방인제출적신명재뇌적학설(張錫純綜合了西方人提出的神明在腦的學說), 단경적원신설(丹經的元神說), 이급"두자정명지부"화"심자군주지궁(以及"頭者精明之府"和"心者君主之宮), 신명출언"지설(神明出焉"之說), 인위뇌내신명지체(認爲腦乃神明之體), 위원신소거(爲元神所居), 심내신명지용(心乃神明之用), 위식신작용지소(爲識神作用之所).