Effect of Carbon Monoxide Intoxication on the Change in Contents of Cerebral Energy Metabolites of Rats

흰쥐에서의 일산화탄소(一酸化炭素) 중독(中毒)이 뇌(腦)에너지 대사(代謝) 관련물질(關聯物質) 함량변화(含量變化)에 미치는 영향

To predict the influence of carbon monoxide poisonining on cerebral energy metabolism, rats were exposed to 5000 ppm environment for 30 minutes. Carboxyhemoglobin (HBCO) saturation rate in this condition was 72% equally in male and female rats. Cerebral cortex in the rats showed lower level of ATP, glucose, creatine phosphate and higher level of lactate, pyruvate by anaerobic glycolysis. As for the levels of ATP, creatine phsphate and glucose, the cerebral cortex contents of them were larger in female rats of estrus than in male rats, whereas there was no difference between sexes in the levels of pyruvate and lactate. According to time passage from CO intoxication, the mode of changes in cerebral energy metabolite contents was similar in both sexes.