• Environmental Mutagens and Carcinogens
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• v.11 no.2
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• pp.148-160
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• 1991

Localization of isoenzyme of glutathione transferase Pi class was compared in different human tissues by immunohistochemical analysis. Strong enrich-ment of GST-Pi in the epithelial tissues was observed in the granular layer of skin, nipple and esophagus which are vulnerable to exogenous chemicals and in the duct epithelium such as pancreatic, biliary, salibvary, renal tubules as well as in the steroid biosynthesis organs such as theca and granulosa of ovary, leydig cell of testis and zona reticularis of adrenal glands.

• Korean Journal of Agricultural Science
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• v.36 no.2
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• pp.159-165
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• 2009

This study was conducted to identify the PERV (Porcine Endogenous Retrovirus) integration sites and their characterizations using the porcine genomic sequence information. Total 114 Mb (4.2%) sequence of the 2.7 Gb pig genome was investigated for the PERV sequences. As the results, 8 PERV sequences were identified and their genomic structures were deduced from the BLAST searches against previously known PERV genes. Seven PERVs have internal deletions in the protein coding region and they will not be functional. The other one also has internal deletions in the gag and env genes, indicating this PERV is also defective. Even though we could not identify the functional PERVs in this study, the results presented here can be used for the fundamental research materials for controlling PERV infections in relation to xenotransplantation using porcine organs and tissues.

• Clinical and Experimental Reproductive Medicine
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• v.16 no.1
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• pp.93-101
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• 1989

71 cycles of 67 women were treated for superovulation induction in our IVF & ET program from May to September in 1988. Endogenous LH surges were occurred in 21 cycles out of 71 cycles. And then, we selected 50 cycles without endogenous LH surge treated in the same period as control group. We compared egg recovery rate, egg maturity, fertilization rate, cleavage rate and pregnancy rate of study group with those of control group. We were able to detect more than 90% of endogenous LH surge by commencing daily LH monitoring on MCD 9. The egg recovery rate, egg maturity, fertilization rate, and pregnancy rate of the study group were not statistically different from those of the control group. Significantly lower cleavage rate was seen in the study group compared with that of control group. Above results suggested that the cycles with endogenous LH surge do not have to be abandoned and can be treated continuously to achieve successful pregnancy.

• Clinical and Experimental Reproductive Medicine
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• v.18 no.2
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• pp.197-199
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• 1991

The role of estrogen in calcium metabolism has not been well documented. To further investigate the effects of endogenous estrogen on the calcium regulating hormones in women, we correlated the changes of estrogen level with those of calcium regulating hormones during ovulation induction in 12 hypogonadal and 8 normally menstruating women. During ovulation induction, the serum leveles of estradiol rose from 40.0 to 831.0pg/ml. There were no significant changes in the serum leveles of total calcium, inorganic phosphorus, parathyroid hormone, calcitonin. However, 1, $25-(OH)_2D_3$ rose significantly from 31.0 to 47.2pg.ml as the endogenous $E_2$ increaed (p<0.005).

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.2
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• pp.336-340
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• 1995

Urinary excretion of total amino acids was measrued in normal and diabetic rats, streptozotocin-induced diabetic rats excreted increased amount of urinary total amino acids and nitrogen. This suggested increased degradation of body protein. Although excretion of total amino acids increased in the diabetic rats, the amino acid pattern of amino acids for both groups were very similar. The efficiency of dietary protein utilization was significantly lower in diabetic rats then that of normal rats. Streptozotocin injeciton affected the urinary excretion of 3-methylhistidine whereas diet did not. These findings suggest that the rate of urinary excretion of total amino acids can be empolyed as an index of protein metabolism, particulary as a simple index in the assesing the status of protein nutrition.

• The Korean Journal of Nuclear Medicine
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• v.21 no.1
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• pp.55-60
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• 1987

$Digoxin^{(R)}$을 복용하고 있지 않는 각27명의 만성 신부전 환자 및 신생아의 혈청에서 Gammacoat $Digoxin^{(R)}$ kit와 Amerlex Digoxin $RIA^{(R)}$ kit를 이용하여 digoxin과 교차 면역반응을 보이는 내인성 물질(이하 DLI: Digoxin-like Immunoreactivity)을 측정하여 다음의 결과를 얻었다. 1) Gammacoat $Digoxin^{(R)}$ kit로 측정시 27명의 만성 신부전 환자중 12명에서 신생아의 경우는 27명 전원에서 측정 하한치 이상의 DLI가 검출된 반면, Amerlex Digoxin $RIA^{(R)}$ kit로는 1명을 제외한 양 군의 전원에서 DLI가 관찰되지 않았다. 만성 신부전 환자에서 Gammacoat $Digoxin^{(R)}$ kit로 측정된 DLI와 혈청 BUN/Creatinine 값 사이에는 유의한 상관 관계가 없었다. 2) 만성 신부전 환자 및 신생아의 pooled sera에 가한 digoxin의 수거율은 각각 49%, 40%였다. 3) 만선 신부전 환자 및 신생아의 pooled sera에서 측정되는 DLI의 희석 curve는 정상 희석 curve와 다르다고 할 수 없었다. 4) 만성 신부전 환자의 pooled sera에서 측정되는 DLI의 16%, 그리고 신생아의 pooled sera 에서 측정되는 DLI의 20%가 trypsin에 sensitive하였다. 5) 만성 신부전 환자의 pooled sera에서 측정되는 DLI의 56%가, 그리고 신생아의 pooled sera에서 측정되는 DLI의 경우는 전체의 20%미만이 methylene chloride로 추출되었다. 이상에서 만성 신부전 환자 및 신생아의 혈청에서는 방사면역 kit의 증류에 따라 DLI가 검출되며 그 실체를 알기 위해서는 더욱 연구가 필요하다고 할 수 있었다.

• Korean Journal of Psychosomatic Medicine
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• v.16 no.2
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• pp.81-86
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• 2008

Delirium is not developed naturally and is not an endogenous disease. However, delirium has occurred in some specific populations, such as the elderly or medically compromised patients. These become limitations on the systematic study of the epidemiology of delirium. Many epidemiologic studies of delirium have been focused on the elderly due to the fact there are relatively few in the general population. In addition, assessment tools with various sensitivity and specificity have been used. Advanced age, male, poorer cognitive and functional status, and alcohol abuse are well known risk factors of delirium. the epidemiological data will be reviewed in the elderly, patients with dementia, hip fractures, patients hospitalized in intensive care units, terminal cancer and patients with stroke.

• Journal of Oriental Physiology
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• v.14 no.2 s.20
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• pp.1-9
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• 1999

Ethanol induces compoundhemorrhagic gastric lesions and causes a dose-dependent decrease in the concentration of endogenous nonprotein sulfhydryls in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol - induced gastric lesions. Based on this findings, we investigated the involvement of sulfhydryl compounds in the antioxidant effects of Puerariae radix, a traditional herbal medicine, against ethanol - induced gastric lesions in the absence and presence of iodoacetamide(IDA. sulfhydryl blocking agent) in rats. respectively. Because of the known role of sulfhydryls in gastric cytoprotection, its role in gastric antioxidation was of intrest. In vitro, Puerariae radix extract(PRE) reduced linoleic acid autooxidation and exert DPPH radical scavenging effect. In vivo. PRE increased antioxidants(SOD, catalase. GSH) and reduced lipid peroxide level in ethanol-induced gastric mucosal lesions. But treatment with PRE plus IDA significantly inhibit the antioxidant effects such as SOD and GSH but did not affect catalase levels. These results suggest that Puerariae radix may play roles in the gastric cytoprotection through antioxidant effects and increase of SOD activity and GSH level are dependent of endogenous sulfhydryls.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.335-341
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• 2000

In order to search for blood anticoagulant substance from herbal extracts, we extracted with cold water (Fr. I), methanol (Fr. II) and hot water (Fr. III) from 93 commercially available herbs. The anticoagulant activity of herbal extracts was examined through the intrinsic pathway by activated partial thromboplastin time (APTT), the extriansic pathway by prothrombin time (PT) and the common pathway by thrombin time (TT). Onion, garlic, clove, fenugreek, mugwort, thyme and sage had on anticoagulant activity with intrinsic pathway and mint, italian seasoning, rosemary, turmeric, tarragon and wasabie had on anticoagulant activity with common pathway. Nobody had on anticogulant activity with extrinsic pathway. Among commerical herbs tested, clove cultivated in holland was selected because it showed the most potent anticoagulant activity among the samples investigated.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.3
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• pp.225-230
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• 2023

In this study, the porous structure inside the hair were observed using an optical microscope without damaging the hair, and the porosity inside the hair was quantitatively expressed using the results. Experiments were conducted on the effect of the decrease in density inside the hair on the bending and tensile properties of the hair, and experiments on endogenous and extrinsic factors were conducted to find out the causes of the decrease in density inside the hair. As for the endogenous factor, the porosity of gray hair, one of the representative symptoms of aging, was compared with normal hair. As for extrinsic factors, it was observed that the internal density of hair decreased by surfactant and heat, which are factors that can cause hair damage in daily life. In addition, we confirmed whether it is possible to increase the internal density and luster of the hair by using an amino acids and material that can prevent hair lipid predisposition.