• Applied Biological Chemistry
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• v.43 no.2
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• pp.95-99
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• 2000

A series of hetero ring (X) substitued chalcone derivatives with farnesyl protein transferase (FPTase) inhibition activities $(pI_{50})$ values determined in vitro is analyzed by modified Free-Wilson (F-W) and Hansch method for quantitative structure activity relationship (QSARs). On the basis of F-W analysis on the FPTase inhibitory activity of a training set of the compounds, none of the (X)-substituents were not contribute the activity. But the net charge of ${\alpha}$ carbon atom is contribute the activity than that of ${\beta}$ carbon atom. And the relative orders of the (Y)-substituents on the activity are ortho>meta>para-substituents. According to Hansch approach, the activities would depend largely on the optimal, $(R_{opt.}=-0.35)$ resonance effect with ortho substituted $(I_o>0)$ electron donating group (R<0) and STERIMOL parameter, $B_1$ constant. The inhibition activity between hetro ring substituents have been a proportioned with each others and none substituent(H), 45 showed the highest FPTase inhibition $(pI_{50}=4.30)$ activity.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.177-182
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• 2018

This study examined the effects of zerumbone on monocyte migration. Monocytes are recognized as important mediators of various inflammatory diseases, and the possibility of controlling inflammatory diseases by regulating the monocyte functions, such as activity and mobility, has been reported. MCP-1, which is a chemokine with levels that increase upon inflammation, causes the migration of the monocyte cell line, THP-1. Migration occurred at a concentration of 10 ng/mL MCP-1, and the highest migration occurred at 100 ng/mL and 200 ng/mL. MCP-1-induced THP-1 migration decreased by more than 40% in the presence of zerumbone. The concentration of cAMP, an important secondary messenger of the CCR2 signaling pathway, the MCP-1 receptor, was increased in the culture medium after a zerumbone treatment. The concentrations of cAMP decreased significantly under the MCP-1 treatment condition only. On the other hand, an increase in cAMP was observed when zerumbone and MCP-1 were treated simultaneously. Erk phosphorylation induced by an MCP-1 treatment was also found to decrease with the zerumbone treatment. This study introduces the possibility of controlling inflammatory diseases through the function of zerumbone, which regulates the migration of monocytes.

• Journal of Life Science
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• v.14 no.2
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• pp.331-338
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• 2004

Growth and sexual differentiation of the seaweed Porphyra pseudolinearis Ueda have been investigated monthly in the intertidal zone of the East Sea, Korea. Young blades of P. pseudolinearis appeared at the beginning of October. Carp os pores were released at the end of November immediately after carposporangia formation. Then the thalli of P. pseudolinearis were extinguished at the end of March. Young thalli were budded through the stages of conchocelis and conchospore. Thalli showed lanceolate type in shape, cordate type in holdfast, absence of microscopic spinulate process and sexual generation. Ratios of length to width in female thalli ranged from 5.6 to 7.4 at the maturation in December and slightly decreased 3.3 to 4.8 in January and 4.9 to 7.3 in December while the ratios of male thalli ranged from 4.2 to 4.8 in January. On October 12, average five individuals were obsered in a quadrate (30 cm ${\times}$ 30 cm), 238$\pm$18 individuals for the maturation stage in December and then it was reduced to 150 individuals in February and 15 individuals in March. Average sex ratios for female, male and vegetative thalli were 31.3% 46.9% and 21.9% respectively in early December, the beginning time of sex maturation. The sex ratio of female and male thalli in December 17, changed to 69.4%, 30.6% respectively.

• Journal of Korean Society of Environmental Engineers
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• v.37 no.1
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• pp.52-59
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• 2015

Recently the dairy cow industry have faced environmental issues such as eutrophication, global warming, etc. An LCA was used to quantify the environmental impact of a dairy cow system and to identify key issues contributing to the impact. The system boundary crop cultivation for feeding dairy cow, feed production, rearing and manure management (cradle-to-gate). The functional unit was 1 kg of milk (fat protein corrected milk, FPCM) produced. Rearing and cultivation of feed crops stages in system boundary to the environmental impact of the domestic dairy cow system were dominant issues. Techniques such as suppression of enteric fermentation, improvement of the energy efficiency of farm equipment and apparatuses, management of leachate generated during the crop cultivation, and development of controling the loss of fertilizer during crop production would be necessary for the improvement of the environmental key issues of the dairy cow system.

• Journal of Intelligence and Information Systems
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• v.22 no.4
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• pp.217-245
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• 2016

The purpose of this study is to verify how 7 sentiment domains extracted through sentiment analysis from social media have an influence on business performance. It consists of three phases. In phase I, we constructed the sentiment lexicon after crawling 45,447 pieces of VOC (Voice of the Customer) on 26 auto companies from the car community and extracting the POS information and built a seven-sensitive domains. In phase II, in order to retain the reliability of experimental data, we examined auto-correlation analysis and PCA. In phase III, we investigated how 7 domains impact on the market share of three major (GM, FCA, and VOLKSWAGEN) auto companies by using linear regression analysis. The findings from the auto-correlation analysis proved auto-correlation and the sequence of the sentiments, and the results from PCA reported the 7 sentiments connected with positivity, negativity and neutrality. As a result of linear regression analysis on model 1, we indentified that the sentimental factors have a significant influence on the actual market share. In particular, not only posotive and negative sentiment domains, but neutral sentiment had significantly impacted on auto market share. As we apply the availability of data to the market, and take advantage of auto-correlation of the market-related information and the sentiment, the findings will be a huge contribution to other researches on sentiment analysis as well as actual business performances in various ways.

• Elastomers and Composites
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• v.46 no.1
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• pp.45-53
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• 2011

The effect of the silane coupling agent, bis(triethoxysilypropyl)tetrasulfide (TESPT), on mechanical properties of a silica-filled NBR compound for oilseal was investigated. Curing behavior and crosslinking density of the compounds were measured using ODR (oscillating disk rheometer) and swelling ratio in toluene. UTM (universal testing machine) and shore A hardness tester were used in order to study the characteristics of mechanical properties of original vulcanizates and aged ones with heated air and ASTM No. 3. oil. Recovery of elasticity which influences the performance and service life of oilseal was investigated by giving bending deformation to vulcanizates in aging condition. After bending aging test, recovery distance was measured and calculated angle of recovery from it. TR (temperature retraction) test was performed on these vulcanizates to determine the low temperature recovery behavior. Wear resistance was measured by Taber type abrasion tester. In addition, SEM was used to characterize the morphology of the worn surface of vulcanizates. The result showed that addition of TESPT into silica-filled compound improves not only compound flow-ability, interaction between NBR and silica and crosslinking density, but also hardness, 100% modulus, recovery of elasticity, wear resistance, heat resistance and ASTM No.3 oil resistance of vulcanizates.

• CRM연구
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• v.2 no.2
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• pp.21-40
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• 2009

This study conducted to examine how consumer's perception of COO(Country of (Brand) Origin) image affects brand association knowledge, how coo image and brand association knowledge affect buying intention, how these relationship differs in hedonic and utilitarian products and the moderating effect of consumer's ethnocentrism in the influence of brand association to buying intension. The results indicated the followings: First, it was significant COO Image affect brand association knowledge, more strong significant in Hedonic products than in utilitarian products. But it was not supported COO Image affect buying intension significantly. Second, Brand association knowledge affected buying intention significantly. And the last, consumer's ethnocentrism mediated between brand association knowledge and buying intention strong significantly.

• KEPCO Journal on Electric Power and Energy
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• v.6 no.3
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• pp.285-288
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• 2020

The demand for coating technology on electric power equipment that has arisen from such issues regarding the attaching of illegal advertisements and posters to electric power distribution boxes such as TR, SW, etc. in down town areas seeks to produce functional coating surfaces using polymers and nano-materials that will result in improvements in self-cleaning performance and greater stability even under harsh environmental conditions. KEPCO-coatings consist of copolymerized acrylic resin and methacryl-modified reactive silicone that are able to chemically combine, which results in performance improvement without any leakage of of silicone, thus contributing to its properties of high-stability. Thus, the research team has also started long-term on-site testing on 9 electric power distribution spots around a city center in cooperation with the KEPCO Daeduck-yusung branch. The KEPCO-coating technology could advance the best coating materials and processes to meet appropriate circumstances for a variety of outdoor damage environment. It is also predicted that KEPCO could be possible to expand international electric maintenance markets and to arrange business platforms if KEPCO would achieve its original technology (IPs) by the means of upgrading in self-cleaning coating technology and obtaining long-term on-site test records from nationwide electric facilities.

• Korean Journal of Poultry Science
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• v.25 no.4
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• pp.195-202
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• 1998

The present study was conducted to investigate the effects of dietary supplemental dry powder of Rehmannia radix (RR) root on the growth performance and physiological status of broiler chicks. The treatments consisted of corn-soybean meal control diet, and RR 0.5, 1, and 2％ diets. A total of 160 Arbor Acre male broiler chicks were randomly allotted to 16 pens ; four pens per treatment and 10 birds per pen. The growth performance, feed intake and carcass weight did not show any differences among the treatment groups, but feed conversion was significantly lower (P< 0.05) in RR 1％ group than that of the control group. The muscle color was lighter (P < 0.05) in RR lof group than those of the other treatment groups. The blood concentrations of protein, glutamic-oxaloacetic-transaminase (GOT) and glutamic- pyruvic-transaminase (GPT) were not different (P > 0.05) among the treatment groups, but the blood total cholesterol content was significantly decreased (P < 0.05) in RR 2％ group than those the other treatment groups. The blood concentration of sugar was lower (P <0.05) in RR 2％ group than those of the other treatment groups, and hemoglobin concentration was decreased (P <0.05) by addition RR. Crude fat content of thigh muscle was higher in RR 1％ group than those of the other treatment groups, and bone hardness of broiler chicks fed RR was higher (P < 0.05) than that of the control group. The saturated fatty acid content of the thigh muscle tende to be high in control and RR 0.5％ groups, and unsaturated fatty acid content tende to be high in RR 1 and 2％ groups than those of the other treatment groups

• Korean Journal of Soil Science and Fertilizer
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• v.38 no.5
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• pp.238-246
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• 2005

We conducted this investigation to observe competitive adsorption phenomena among the heavy metals onto the available sorption sites of soil particle surfaces in sandy clay loam and clay soil collected from Nonsan city, Chungnam and Yoosung, Daejeon in Korea, respectively. Polluted and contaminated soils can often contain more than one heavy metal species, resulting in competition for available sorption sites among heavy metals in soils due to complex competitive ion exchange and specific sorption mechanism. And the adsorption characteristics of the heavy metals were reported that the selectivity for the sorption sites was closely related with electropotential and electro negativity carried by the heavy metals. The heavy metals were treated as single, binary and ternary systems as bulk solution phase. Adsorption in multi-element system was different from single-element system as Cr, Pb and Cd. The adsorption isotherms showed the adsorption was increased with increasing equilibrium concentrations. For binary and ternary systems, the amount of adsorption at the same equilibrium concentration was influenced by the concentration of individual ionic species and valence carried by the respective heavy metal. Also we found that the adsorption isotherms of Cd and Pb selected in this experiment were closely related with electronegativity and ionic potential regardless number of heavy metals in solution, while the adsorption of Cr carried higher valance and lower electro negativity than Cd and Pb was higher than those of Cd and Pb, indicating that adsorption of Cr was influenced by ionic potential than by electronegativity. Therefore adsorption in multi-element system could be influenced by electronegativity and ionic potential and valance for the same valance metals and different valance, respectively. But it still needs further investigation with respect to ionic strength and activity in multi-element system to verify sorption characteristics and reaction processes of Cr, especially for ternary system in soils.