• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2005.04a
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• pp.166-169
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• 2005

질적인 속성을 양적인 계열로 전환하여 측정하는 방법으로서 설문의 최소 문항으로서 최대의 효과를 나타내기 위하여 한 항목을 k번 측정하여 평균과 $95\%$ 신뢰구간을 퍼지수로 한 데이터들을 리커트 척도로 활용하여 내분비방법에 의하여 검정을 하였다.

• The Science & Technology
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• v.33 no.6 s.373
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• pp.76-78
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• 2000

많은 호르몬의 작용중 동ㆍ식물의 생식과 관련된 호르몬의 작용을 규명하고 호르몬의 응용방법을 개발 연구하는 '전남대 호르몬연구센터'는 생식내분비, 분자내분비, 응용내분비 등 3개 연구부를 두고 왕성한 연구활동을 펴오고 있다. 현재 4명의 연구교수와 국내 각 대학교수 25명 그리고 박사후 연구원과 대학원생 등 모두 1백여명의 연구진으로 구성된 이 연구센터는 매년 국제생식내분비학 심포지엄과 2회의 국내 심포지엄을 개최하고 있다.

• Journal of Digestive Cancer Reports
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• v.9 no.1
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• pp.19-24
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• 2021

The incidence of small and asymptomatic pancreatic neuroendocrine neoplasms (PNENs) has been increased due to the widespread use of high-resolution imaging techniques and endoscopic procedures in screening programmes. Most of PNENs are indolent neoplasms with slow-growing. However, sometimes, PNENs show local invasion or metastasis with poor prognosis. The management of small, nonfunctioning PNENs remain under debate. The National Comprehensive Cancer Network guidelines recommend observation in selected cases of small PNENs less than 2 cm. Pancreatic surgeons are divided into two factions: "the hawks," who indicate the high risk of malignancy even in small PNENs and, therefore, the need for an aggressive surgical treatment, and the "the doves," who accepts the risk of malignancy in some ≤ 2 cm PNENs, advocate that the risk of overtreating many benign ≤ 2 cm PNENs would be much higher. As the pancreatic surgery remains a high-risk operation with a 28-30% morbidity and 1% mortality, the decision for small PNENs is challenging.

• Korean Journal of Microbiology
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• v.44 no.1
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• pp.10-13
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• 2008

Endocrine disrupting chemicals (EDCs) are hard to be degraded in nature, and are also accumulated in diverse organisms. They finally give negative effects to human through the food web. White rot fungi which have lignin-degrading enzymes have high potentials for degradation of recalcitrant compounds, and a white rot fungus, Phlebia tremellosa, isolated in Korea show good degrading activity against the endocrine disrupting phthalates. We have isolated a laccase cDNA which was involved in the degradation of EDCs, and constructed a laccase expression vector to use in the genetic transformation of P. tremellosa. The expression vector was stably integrated into the chromosomal DNAs and showed increased laccase activity in transformants. One of transformants showed not only increased degradation of several EDCs but also faster estrogenic decreasing activities generated by the EDCs.

• The Korean Journal of Zoology
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• v.34 no.3
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• pp.352-367
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• 1991

척추동물 11목 21종의 췌장에서 insulin(B)세포, glucagon(A)세포, somatostatin( D)세포 및 pancreatic polypeptide(PP)세포 등을 면역세포화학적 방법으로 동정하여 이들의 출현율, 분포양상 및 형띨 등을 계통별로 비교하였다. 포유강에서는 전형적인 췌도를 형성하였고, 조강에서는 대 ·소췌도로 구분되었다. 내분비세포의 크기는 계통간의 차이가 있어서 B세포와 PP세포는 포유강의 것이 조강의 것에 비해 윤으나, A세포와 D세포는 그 반대이었다. 세포의 모양은 B세포의 경우 두 강에서 대체로 원형 및 난원형이었고, A세포와 D세포는 원형, 난원형 및 방추형이었다. PP세포는 방추형 및 난원형이 대다수 이었으며 간혹 원형 또는 다각형 등의 모습도 나타났다. 세포들의 출현율은 두 강에서 모두 B세포가가장 많았고, A, D및 PP세포 순으로 낮아졌다. B세포는포유강이 조강보다높았고, A, D및 PP세포는조강이 포유강보다 많았다. B세포는 조강의 경우 대췌도 주변부와 소췌도 중앙부에 분포하였고, 포유강에서는 중앙부에 균등하게 분포하였다. A와 0세포는 포유강에서 주로 췌도 주면부에 분포하나, 조강에서는 췌도중앙부에 위치하였다. PP세포는 두 강에서 대부분 췌도 주변부에 위치하였다. 일반적으로 두강에서 모두 외분비 선포조직에서도 내분비세포들이 출현하였으며 일부 종에서는 췌관상피에서도 내분비세포들이 드물게 나타났다.

• Journal of Gastric Cancer
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• v.8 no.4
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• pp.204-209
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• 2008

Purpose: The goal of this study was to review the clinicopathologic characteristics of neuroendocrine tumor (NET) of the stomach. Materials and Methods: We retrospectively reviewed the medical records of 13 patients who were diagnosed with neuroendocrine tumor from January 1999 to August 2007 at Kosin Medical Center; 4,159 gastric cancer patients were treated surgically during the same time. The average follow up period was 14.3 months. Results: The majority of 13 patients were men (male-female ratio: 11:2) and the average age of patients with NET was 59.4 years (range: 42~72 years). The presenting symptoms were mostly epigastric pain and soreness. The tumor was limited to the mucosa or submucosa in two cases, and the tumor extended beyond the muscle layer in 11 cases. The mean size of the tumor was 7.0 cm, ranging from 0.7 cm to 15 cm. The type of the NEC (according to the WHO classification) was type 3 for eight patients, type 4 for four patients and type 1 for one patient. Regional lymph node metastasis was noted in 11 patients. Four cases showed recurrence of disease and the site of recurrence included liver in two patients, multiple organs (including the peritoneum and lung) in one patient and multiple organs (including liver, pancreas and duodenum) in one patient. The recurrent cases were type 3 and type 4 and the average survival period of the recurrent patients was 12.8 months. Conclusion: The majority of neuroendocrine tumors of the stomach were at an advanced stage at the time of diagnosis. These tumors frequently recurred in the liver and they have a poor prognosis.

• RED RIBBON
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• s.50
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• pp.8-9
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• 2003

남성호르몬 결핍 치료방법으로 테스테론을 투여하면 환자가 느끼기에 삶의 질이 개선되며 성욕 및 의욕이 증가하고 우울증이 호전되는 등의 긍정적인 효과를 볼 수 있다. -지난 호에 이어 연속

• Korean Journal of Veterinary Research
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• v.35 no.1
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• pp.67-73
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• 1995

The distribution and the frequency of endocrine cells in the GIT of the Amur lizard(Takydromus amurensis) were investigated using silver techniques and immunohistochemical method. Only argyrophil cells stained by the Grimelius technique were found numerous in the pyloric glands and moderate in the duodenum. Two types of immunoreactive endocrine cells were identified by immunohistochemical method. Bovine CG-immunoreactive cells were demonstrated the entire GIT. BPP-immunoreactive cells were restricted in the duodenum and the ileum. The results showed that: the number of argyrophil cells was lower than the number of cells stained with bovine CG antiserum. Therefore, bovine CG-immunostaining and the Grimelius silver technique did not correspond with various endocrine cells in the Amur lizard.

• Korean Journal of Animal Reproduction
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• v.23 no.2
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• pp.159-163
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• 1999

Recent development of the molecular biology techniques has made it possible to characterize and analyze early diagnoses of genetic disorders and economic trait loci. In this study, porcine genomic DNA was extracted from both clotted and dried blood to analyze the porcine estrogen receptor (ER) gene by polymerase chain reaction (PCR). By the methods reported here, genomic DNA extracted from clotted or dried blood was efficient enough to detect ER gene by PCR. Moreover, the PCR-RFLP (restriction fragment length polymorphism) of ER gene was identified by PvuII restriction enzyme. Thus the results obtained from this study show that the clotted and dried blood was useful for identification of the certain genotype in a rapid manner with low cost. Importantly, this study implies that the whole blood can be economically utilized in studies of endocrinology, molecular biology, and genetics by obtaining both serum and DNA simultaneously in an efficient manner.

• The Korean Journal of Nuclear Medicine
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• v.30 no.4
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• pp.516-523
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• 1996

The purpose of this study was to evaluate the clinical usefulness of I-123 MIBG scintigraphy with early planar and SPECT image in the diagnosis of neuroendocrine tumors. We reviewed I-123 MIBG scintigraphies of 21 patients who had been suspected to have neuroendocrine tumors by CT or MRI findings. Early 4 hour planar and SPECT images were obtained in all patients and delayed (13-24 hour) planar images were performed in 17 patients. Final diagnoses were made by surgery, biopsy, or clinical follow up. Twelve patients were confirmed to have neuroendocrine tumors. With 4 hour planar and SPECT images, there were 9 true positives(6 pheochromocytomas, 1 paraganglioma, 1 neuroblastoma, and 1 medullary cancer of the thyroid), 8 true negatives(1 adrenal cortical adenoma, 1 malignant fibrous histiocytoma, 1 adenoma in colon and 5 benign nonfunctioning adrenal tumors), 1 false positive(hepatocellular carcinoma) and 3 false negatives(1 recurred medullary cancer of the thyroid, 1 liver metastasis of carcinoid tumor and 1 ganglioneuroma). The sensitivity and specificity of I-123 MIBG scintigraphy were 75% and 89%, respectively. SPECT images provided good anatomical correlation with CT or MRI. Delayed images showed increased tumor to background ratio in 5 out of 8 true positive patients, but did not change the diagnosis. In conclusion, early 4 hour images with I-123 MIBG is clinically convenient and useful method in the detection of neuroendocrine tumors, and SPECT images can provide good anatomical correlation with CT or MRI.