• Title/Summary/Keyword: 기형발생

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A Rare Case of Acquired Arteriovenous Malformation in Transarterial Chemoembolization for Hepatocellular Carcinoma (간세포암의 경동맥 화학색전술 중 발견된 후천성 동정맥 기형에 관한 드문 증례보고)

  • Moon, Sung-Nam;Seo, Sang-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.3
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    • pp.188-193
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    • 2019
  • Transarterial chemoembolization (TACE) is a commonly used and rapidly evolving non-invasive treatment for hepatocellular carcinoma (HCC). It is important that understanding individual anatomical variants and planning for tumor-feeding artery access to acquire adequate treatment effectiveness. In this study, we will report acquired arteriovenous malformation which interferes with TACE for HCC. A 72-year-old man with persistent abdominal pain for 2 days visited our hospital. The patient was chronic hepatitis B carrier and had a history of HCC treated with conventional TACE 10 years ago. Hypervascular nodular HCC in the liver segment 8 and aberrant right hepatic artery from the superior mesenteric artery were detected on computed tomography (CT). When first TACE was performed, the tumor-feeding artery originating from the left hepatic artery was found and embolized. There was no tumor-feeding artery from the right hepatic artery but arteriovenous malformation was found. After a month, follow up CT showed necrotic lesion and residual HCC and we performed secondary TACE. On secondary TACE, we selected the right hepatic artery and passed through arteriovenous malformation. Superselective-angiogram showed remnant tumoral staining and remnant tumor was embolized using drug-eluting bead and Adriamycin. Final angiogram showed no remnant tumoral staining and the patient was discharged without complication. We found the rare case of arteriovenous malformation adjacent to HCC, and we performed superselective TACE beyond arteriovenous malformation to treat HCC.

Stapedectomy for Stapedes Fixation (등골고정증에 대한 등골절제술)

  • 김종선;이광선;조애영
    • Proceedings of the KOR-BRONCHOESO Conference
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    • 1983.05a
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    • pp.19.3-19
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    • 1983
  • Congenital stapes fixation may develop alone or with other systemic anomalis. Acquired stapes fixation is found in otosclerosis or in chronic otitis media. It is our intent to review 4 cases (5ears) of congenital stapedial fixation and 2 cases (2 ears) of acquired stapedial fixation following chronic otitis media, treated by stapedectomy.

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TREACHER COLLINS SYNDROME : A CASE REPORT (Treacher Collins 증후군 환아의 증례보고)

  • Park, Ji-Hyun;Kim, Seung-Hae;Song, Je-Seon;Kim, Seong-Oh;Lee, Jae-Ho
    • Journal of the korean academy of Pediatric Dentistry
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    • v.37 no.3
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    • pp.374-380
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    • 2010
  • Treacher Collins syndrome(TCS) is a rare, incurable condition occurring in approximately 1 of 25,000 to 50,000 births. It may occur as a spontaneous mutation out of genetically normal parents or it may be manifested as an autosomal dominant pattern. TCS is characterized by facial deformities such as, underdevelopment of the maxilla, mandible and zygoma, malocclusion, bilateral deformities of auricles, antimongoloid slant of the palpebral fissures. The syndrome is often associated with cleft lip and palate, ear malformations and hearing loss, short stature, and anomalies of the heart and skeleton. Respiratory difficulty associated with air way obstruction may also be observed, and there is considerable difficulty in airway management during general anesthesia. It is necessary that dentists provide safe dental treatments and guidelines to TCS patients by providing adequate understanding about the characteristics of the syndrome and proper ways of managements. The purpose of this study is to report the dental and medical characteristics of the patient who visited the Department of Pediatric Dentistry, Yonsei University for multiple dental caries treatment and to review the literatures of TCS.

A Patient with Cleft Lip Combined with Branchial Cleft Cyst : A Rare Case Report (새열낭종을 동반한 구순열 환아의 증례보고)

  • Kwon, Myung-Hee;Leem, Dae-Ho;Ko, Seung-O;Shin, Hyo-Keun
    • Korean Journal of Cleft Lip And Palate
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    • v.13 no.1
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    • pp.29-34
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    • 2010
  • 구순구개열은 두경부에서 가장 흔히 발생하는 선천적 기형 중 하나로 554명 중 1명의 빈도로 나타나며 인종에 따라 다양하다. 구순구개열 환아들은 다른 선천적 기형을 동반하여 나타나는 경우가 흔하며, 그 빈도는 문헌에 따라 다르지만 1.5~63.4%로 나타난다. 새열낭종은 두번째 인두강의 폐쇄부전으로 나타나는 선천적 결손으로, 주로 흉쇄유돌근 전방에 나타난다. 구순구개열 환자에 있어 새열낭종을 동반하는 경우는 매우 드물다. 전북대학교 구강악안면외과학 교실에서는 새열낭종을 동반한 구순열 환아 1례를 경험하였다. 환아는 우측 불완전 편측성 구순열로 내원하여, 구순성형술과 함께 우측 목에 존재하던 새열낭종에 대한 제거 수술을 시행하였다. 환아는 출생 당시부터 심실중격결손 및 동맥관개존증 등의 선천적 심장질환 및 갑상선 기능저하증을 가지고 있던 환아로 다양한 선천적인 결손을 동반한 본 환아의 증례를 문헌고찰과 함께 보고하는 바이다.

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참돔 노지종묘생산과 요각류 번식을 위한 적정 시비제

  • 방인철;박상용;권성민;신현웅
    • Proceedings of the Korean Aquaculture Society Conference
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    • 2003.10a
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    • pp.3-63
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    • 2003
  • 우리나라 서해안의 폐염전 또는 대하양식장을 이용한 해산어 종묘생산이 조피볼락, 감성돔, 숭어 등을 대상으로 이루어지고 있다. 이렇게 생산된 종묘는 기형개체가 전혀 없는 건강 종묘이며, 생산 원가 또한 육상수조식에 비해 최고 5배정도 낮다. 한편 참돔은 육상수조에서 종묘생산시 기형률이 비교적 높게 나타나므로 노지를 이용한 종묘생산이 요구되고 있다. 현재 노지 종묘생산시 요각류 번식을 위한 시비제로는 암모니아, 인산염, 칼륨 등이 함유되어 있는 화학비료(요소, 복합비료)나 계분, 돈분, 우분 등의 유기질 비료가 주로 사용되고 있다. 그러나 화학비료를 사용시 급격한 수질변화로 요각류의 폐사가 발생하고, 매년 지속적인 생산량을 기대하기가 어려운 문제점이 있다. 따라서 적절한 시비제를 구명하기 위하여 유기질 비료(알팔파, 숙성계분)와 화학비료(요소, 복합)를 단독 또는 병행 사용하여 2개월간의 동ㆍ식물플랑크톤의 변동량과 치어의 생존율을 조사한 결과, 유기질 비료는 부화자어가 입식된 이후에도 연속하여 시비하여도 생존율에 영향을 미치지 않았으나, 화학비료의 경우 일정 농도 이상에서는 동ㆍ식물플랑크톤의 번식에 장애를 초래하였고 이에 따라 자어가 전량 폐사하였다. 실험군의 생존율은 육상수조에서 40%, 알팔파와 숙성계분을 시비한 실험군이 15%, 요소, 복합, 알팔파를 시비한 실험군이 10%, 요소, 복합, 숙성 계분을 시비한 실험군이 8%, 요소와 복합을 시비한 실험군은 0%를 나타내었다. 또한 기형률에 있어 노지 실험군은 0.7%로 매우 낮게 나타났으나, 육상수조 실험군은 61%에 해당하는 치어가 기형이었으며, 그 형태도 다양하게 나타났다.fer, Artemia sp., copepods, 부화 25일째부터는 copepods였다. 초기성장은 부화직후 전장 1.95 mm였던 것이 10일째는 2.96 mm, 20일째는 3.89 mm, 30일째는 12.9 mm, 50일째는 35.1 mm를 나타내었다. 그러나 말쥐치 자ㆍ치어가 성장함에 따라 발생하는 지속적인 폐사와 종묘의 수송시 발생하는 폐사를 줄일 수 있는 방법이 추후에 해결되어야 할 것으로 사료된다.8,000~215,000 마리의 자어를 낳아서 개체에 따라 큰 차이를 나타내었다. 1999년에는(어미 : 전장 20.7~25.5cm, 체중 205.5~396.4g) 1 회 출산때마다 7,000~50,000 마리의 자어를 출산하였다. 3. 출산간격. 다회 출산한 쏨뱅이 어미가 첫 번째 출산에서 다음 출산까지 소요되는 기간을 조사한 결과 13일에서 25일이 걸리는 것으로 나타났다. 특히 4회 출산 한 1998년 쏨뱅이 어미는 첫 번째 출산 후 19일만에 두 번째 출산이 이루어 졌고 각각 13 일과 14 일만에 세 번째, 네 번째 출산이 이루어져 총 46일 동안 4회에 거쳐 자어를 출산하였다. 4. 출산자어의 크기. 1997년 3회 출산한 쏨뱅이의 출산시기별 자어 크기를 조사한 결과 첫 번째 출산에서는 평균전장 4.1$\pm$0.07mm의 자어를 낳았으나 두 번째 출산에서 자어의 크기는 평균전장이 3.9$\pm$0.11mm, 세 번째 3.8$\pm$0.12mm로 점차 작은 경향을 나타내었다..27mm(평균 1.76mm, n=20) 그리고 Snout length 0.74~l.67mm(평

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Biological Effects and Mouthpart Deformity on Chironomus plumosus Exposed to Chromium and Copper (크롬(Cr)과 구리(Cu) 노출에 따른 Chironomus plumosus 깔다구의 생물학적 영향과 하순기절 기형발생)

  • Kim, Won-Seok;Park, Kiyun;Kwak, Ihn-Sil
    • Korean Journal of Ecology and Environment
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    • v.52 no.1
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    • pp.13-20
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    • 2019
  • Heavy metals resulted from the increase of human industrial activity are introduced into the environment through rainfall and wastewater, and have harmful effects on inhabitants. In this study, we investigated biological responses such as survival rate, growth rate, emergence rate and sex ratio, and morphological effects of mentum deformity in Chironomus plumosus, an indicator organism to evaluate pollutions on aquatic ecosystem. The survival rate of C. plumosus showed time- and dose-dependent decrease after chromium and copper exposures. Growth rate decreased at $4^{th}$ day after chromium exposure and significantly reduced at exposure to relatively high concentration (copper $1000mg\;L^{-1}$) for all exposure times. In addition, we observed that the emergence rate by exposure to copper $1000mg\;L^{-1}$ was significantly lower than that of the control group. The imbalance of sex ratios showed at relatively low concentrations (chromium 10 and $50mg\;L^{-1}$) with the high proportion of female and at the relative high concentration (copper $1000mg\;L^{-1}$) with the high proportion of male. Furthermore, the morphological mentum deformities of C. plumosus observed in the exposed group according to chromium and copper exposure. These results suggest that the heavy metal exposure in environment may influence biosynthetic and morphological stresses of benthic invertebrate C. plumosus, and aquatic midge C. plumosus are potential indicators for toxicity assessment of heavy metals such as chromium and copper.

Incidence and outcome of congenital anomalies of the kidney and urinary tract detected by prenatal ultrasonography: a single center study (산전 초음파로 발견된 선천성 신 요로 기형의 발생률과 임상 결과: 단일 기관 연구)

  • Lim, Gina;Lee, Joo Hoon;Park, Young Seo;Kim, Kun Seok;Won, Hye-Sung
    • Clinical and Experimental Pediatrics
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    • v.52 no.4
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    • pp.464-470
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    • 2009
  • Purpose : This study assessed the incidence and outcome of congenital anomalies of the kidney and urinary tract (CAKUT) detected by prenatal ultrasonography Methods : There were 906 cases of CAKUT detected by prenatal ultrasonography and postnatally confirmed at the Asan Medical Center from October 1989 to October 2007. We investigated the incidence and outcome of these cases by reviewing medical records retrospectively. Results : The order of incidence was hydronephrosis, multicystic dysplastic kidney (MCDK), duplex kidney, vesico-ureteral reflux (VUR), single kidney, hydroureteronephrosis, ectopic kidney, polycystic kidney, ureterocele, and posterior urethral valve (PUV). There were 520 cases (57.4%) of hydronephrosis, and 20% of these needed an operation due to significant obstruction. MCDK was associated with other CAKUT in 25.4% of all cases. Approximately 57.9% of duplex kidney cases needed surgical treatment due to ureterocele and VUR. VUR had a male: female ratio of 10:1. Two out of seven cases of autosomal recessive polycystic kidney had progressed to chronic renal failure. Patients with PUV were relatively uncommon, and one out of nine cases progressed to end-stage renal disease. Conclusion : CAKUTs detected by prenatal ultrasonography were composed of various anomalies, and almost all of them had a good outcome without any intervention. However, in some cases, recurrent urinary tract infection or renal failure occurred, especially in bilateral cases. For further management, a long-term multicenter study is needed to investigate the precise incidence and outcome of each anomaly in the general population.

Effects of Bosaengtang Administration in Pregnant Rats and Fetuses (보생탕이 랫드의 모체와 태자에 미치는 영향에 대한 연구)

  • Kim, Chang-Seok;Lee, Sun-Dong;Kim, Pan-Gyi;Lee, Jang-Woo;Park, Hae-Mo
    • Journal of Society of Preventive Korean Medicine
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    • v.9 no.2
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    • pp.59-75
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    • 2005
  • The experiments were undertaken to evaluate the effects of Bosaengtang in pregnant rats and fetuses. Female Sprague-Dawley rats were orally administered with Bosaengtang at the dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at the 20th day of gestation, and observed internal and reproductive organs. Fetuses were randomly selected and fixed in 95% ethanol. Fetuses were stained with alcian blue and alizarin red S, and observed skeletal malformations. The results obtained were as follows : Bosaengtang administered group showed higher maternal body weight than the control group, but both groups showed increase in weight. Bosaengtang administered group showed lower than the control group, and higher liver and kidney weight than the control group, but the differences were minimal. There were no significant changes between the control and treated group in blood chemistry values and hematological values but all the groups were within in normal ranges. There were no significant changes in the number of corpus luteum, implantation, live fetus and implantation rate, delivery rate, late resorption rate, sex ratio, but Bosaengtang administered group showed higher early resorption rate than control group. comparing the control and Bosaengtang group, neonatal body weight and the number of fetuses were increased in Bosaengtang group. The fetuses of dams treated with Oriental medicine didn't showed external malformation. Vertebral and sternal variations were observed in Bosaengtang group, but the differences were not apparent compared to the control group. The number of ribs, cervical, thoracic and lumbar vertebrae were normal. The number of sacral was similar and the number of caudal was increased. Fetuses showed significant difference in the number of caudal vertebrae. (P<0.01) From these results, we can carefully conclude that Bosaengtang showed beneficial effects on maternal body weight, early resorption rate, number of live fetus. There were no significant changes in organ weight, hematoscopy, reproduction organs. External malformation wasn't visible. Skeletal variations were showed in vertebrae and sternum but compared to the control group, these variations weren't much different.

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A case of Rothmund-Thomson syndrome (Rothmund-Thomson 증후군 1례)

  • Kim, Seung Hyo;Shin, Choong Ho;Yang, Sei Won
    • Clinical and Experimental Pediatrics
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    • v.49 no.5
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    • pp.565-569
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    • 2006
  • Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by : skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities include : dysplasia, absent or malformed bones, such as absent radii, osteopenia, and delayed bone formation. RTS is thought to result from chromosomal instability, and children with RTS are at risk of cancer. Reported cancers in children with RTS include : basal cell carcinoma, squamous cell carcinoma of the skin and osteosarcoma of bone. We report an 11 year-old boy, who presented to our institution with poikilodermatous skin change with telangiectasia and hyperpigmentation, absence of radius and thumb, and the development of osteosarcoma of the left tibia. The patient is now receiving supportive care and is receiving maintenance chemotherapy after surgery for osteosarcoma.

Electromagnetic Retarder's Modeling and Voltage Control (전자기형 리타더의 모델링 및 전압제어)

  • Jung, sung-chul;Lee, ik-sun;Ko, jong-sun
    • Proceedings of the KIPE Conference
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    • 2016.11a
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    • pp.171-173
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    • 2016
  • 일반적으로 대형 버스 및 트럭 등 같은 경우, 부하가 아주 크다. 또한 내리막길이나 장거리 운행 시에 잦은 제동으로 인하여 마찰을 이용한 기존 방식의 브레이크들은 브레이크 파열 및 페이드 현상 때문에 제동 안전성에 문제가 있다. 이러한 제동 부담을 분담하기 위해 현재 보조브레이크(리타더)가 필수적이며, 엔진 계통의 보조브레이크가 아닌 비접촉식 브레이크 같은 친환경 보조브레이크가 요구되고 있다. 그리고 차량 제동시 발생하는 기계에너지를 전기에너지로 회생하여 에너지효율을 향상시키려는 연구가 현재 활발히 진행되고 있다. 본 논문에서는 와전류를 이용한 전자기형 리타더에서 발생되는 전기에너지를 회수하기 위한 전압 제어 방법을 다룰 것이다. 리타더의 제동에너지를 전기에너지로 회생하기 위해 L-C 공진회로로 구성하였다. 리타더를 자여자 유도발전기(Self-Excited Induction Generator)로 모델링 하였고 이를 토대로 시뮬레이션 및 실험을 진행하였다. 자여자 유도발전기의 구동 조건에 대해서 언급하고 이를 파라미터에 따라 3-D map으로 만들었다. 또 회로 중의 FET 게이트에 전압을 인가하는 제어장치의 구동펄스에 따라 바뀌는 공진회로의 전압을 분석하였으며, 이 전압을 제어하기 위하여 PI 제어기를 이용한 알고리즘을 제안하였다. 이 전압을 3상 AC/DC컨버터를 통과한 후 DC/DC컨버터를 통하여 차량 내부의 배터리에 충전되는데 제어를 위해 3상 AC/DC에서의 전압 리플을 MA(Moving Average) 방식의 필터를 사용하여 DC/DC컨버터의 입력에 맞도록 제어하였다. 이와 같이 전자기형 리타더에서 유도되는 전압을 제어기의 제어 펄스에 따라 제어할 수 있으며 Matlab Simulink를 이용하여 리타더의 모델과 그 제어기의 타당성을 보였다. 또 실제 M-G Set 실험을 통하여 그 연관성을 확인하였다.

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