• Title/Summary/Keyword: 기초의학

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MD로써 기대하는 PhD의 역할과 현실

  • 정태섭
    • Proceedings of the KSMRM Conference
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    • 1999.11a
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    • pp.69-71
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    • 1999
  • 최근 한국 의학의 발전은 전체 한국의 선진화를 선도하다고 보기에는 힘드리만 최소한 국제무대에의 진출은 괄목할만한 발전을 보이고 있다. 최근에 들어 국내 방사선영상과련 학회의 발전은 날로 비약적인 추세를 보이고 있다. 일례로 대한방사선의학회는 본 저자가 전공의 하던 1980년도 초기만 해도 호텔의 큰 홀 한 개만 빌려서 하루만 해도 넉넉하게 진행되었다. 그러나 최근의 학회사정은 대형호텔 1개층 통째로 빌리고 3일간 진행해도 여유가 없을 정도이며 더욱이 추계학회는 지방에서 유치할만한 공간이 부족하여 이제는 없어져야할 지경에 이러렀다. 그뿐 아니라 대한 자기공명의과학회를 포함한 각종 학회가 이제 그 규모를 더해가고 있어. 대한민국에 있어서 진단 방사선영역의 의학은 급속히 발전하여 RSNA, ISMRM등에서도 세계 발표순위가 4-5위권을 다투게 되었다. 이러한 발전은 양적인 발전이 우세하여 주로 임상연구에 기반을 두고 있는데 이 자체로는 장기적인 발전에 한계점이 있으므로 앞으로는 기초과학연구에 기초한 질적 발전을 같이 추구하여야만 균형있는 성장을 기대할 수 있겠다. 이러한 기존의 구성에 최근 급격한 변화를 주도하는 학문이 MRI부분이 되며 이 분야를 연구하는 PhD 들의 역할이 크게 대두되고 있다. 현재 국내에도 초기 단계이지만 MRI를 생산하고 있으며 PhD들의 활동이 성장단계에 접어들었다고 할수 있다. 과거 우리의 NRI역사에서는 금성사 MR기계처럼 육성되기 전에 시들며 노력하던 기술진이 흩어져야 했던 어두운 기억이 있다. 이러한 시점에서 우리의 힘들었던 과거를 돌이켜보며 또 하나의 기초부분이 육성되 수 있도록 서로가 격려하며 협조하여야 될 것으로 생각되어 다음과 같이 요약을 하였다. 소기관으로는 세포 막, 미토콘드리아 (mitochondria), endoplasmic reticulum, Golgi 체, lysosome, peroxisome 그리고 세포질등이 있으며, 이들중에서 lysosomes, peroxisomes, 그리고 미토콘드리아가 특정한 유전성 백질질환에 중요한 역할을 하는 것이 밝혀졌다. 이러한 질환들은 최소한 각 소기관에 의한 질환군으로 분류될 수 있다.SXR이 ER의 transactivation 효과를 약간 촉진한 반면 MDA-MB-231세포는 SXR을 제외한 CAR와 PPAR${\gamma}$에 의해 ER의 transactivation 효과가 약간 증가되는 경향을 보였다. 이러한 결과는 유방암세포에서는 CAR, SXR, PPAR${\gamma}$과 같은 xenobiotic nuclear receptor에 의한 ER transactivation 효과가 간암세포와는 다르게 나타나며, 유방암의 종류에 따라서 endogenous CAR, SXR, PPAR${\gamma}$수용체가 다르게 발현됨으로써 이들에 대한 반응이 서로 상이한 특징을 나타낼 수 있을 것으로 사료된다. 따라서 estrogen receptor에 의해 매개되는 estrogn의 전사활성조절기전이 표적세포에 따라 다른 경로를 포함 할 수 있음을 시사한다.서 흡착 능력이 우수하게 나타났으며, 황화수소는 펄라이트, 왕겨, 소나무수피에서 상대적으로 우수한 것으로 나타났으며, 혼합충전재는 암모니아의 경우 코코넛과 펄라이트의 비율이 7:3인 혼합 재료 3번과 소나무수피와 펄라이트의 비율이 7:3인 혼합 재료 6번에서 다른 혼합 재료에 비하여 우수한 것으

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Factors Affecting the Depression of the Elderly Women in Poverty (빈곤층 여성 노인의 우울에 미치는 영향요인)

  • Park, Eun-A;Lee, In-Sook
    • Journal of agricultural medicine and community health
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    • v.34 no.2
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    • pp.256-266
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    • 2009
  • Objectives: This study was to investigate the factors affecting the depression of the elderly women in poverty in community. Methods: The subjects were 1,208 elderly women over 65 years who were enrolled in the Public Health Care Center from Apr. 2008 to Jun. 2008. Data were collected using questionnaires including general characteristics, health related behaviors and health status by nurses at the time of enrollment. The collected data were analyzed by descriptive statistics, $x^2$-test, Pearson correlation coefficients and multivariate logistic regression. Results: The major findings of this study are as follows : The elderly women in poverty show a tendency to have lower level in income, education, self-rated health, cognitive function compared with ordinary women in old age. The predictors of depression of the elderly women in poverty were spouse's existence or nonexistence, type of insurance, cognitive function, and self-rated health. Conclusion: These findings suggest the need to develop nursing strategies for decreasing depression in the elderly women in poverty. To decrease the depression of the elderly women, the above-mentioned major influencing factors should be considered.

Dysphagia and Oral Function in Chronic Stoke Patient: 3 Months Follow up Study (만성 뇌졸중 환자의 시간에 따른 삼킴 기능 변화)

  • Im, Ikjae;Ko, Myoung-Hwan
    • 재활복지
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    • v.22 no.1
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    • pp.141-156
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    • 2018
  • The purpose of this study was to examine changes in the swallowing function with chronic stroke patient. Ten chronic stroke patients with dysphagia followed up for 3 months. Eight normal age match subjects were also participated. A total of 18 participated in this study and they were classified into two groups (stroke patient group and normal control group). Participants underwent videofluoroscopic swallowing examination. The swallowing function was evaluated over time. Oral transit duration, pharyngeal transit duration, laryngeal response duration, Modified Barium Swallowing Impairment Profile ($MBSImP^{TM(c)}$), and Functional Oral Intake Scale (FOIS) were applied. Chronic stroke patient group were showed significantly longer oral transit duration, pharyngeal transit duration and laryngeal response duration than normal control group at baseline. After 3 months in stroke patient group, the mean oral components score of MBSImP (1~5) significantly decreased and the mean score on FOIS increased compared to baseline. In conclusion, oral swallowing function and oral intake function improved by the 3 month evaluation. These results describe changes in swallowing function with chronic stroke patients over time and provide basic informations to understand dysphagia.

Fundamental Study of Relative Measurement for Accurate Measurement of Stent Size in Computed Tomography Angiography (컴퓨터단층 혈관조영술에서 스텐트 사이즈의 정확한 측정을 위한 상대적 측정법의 기초연구)

  • Lee, Seung-Young;Hong, Joo-Wan;Kang, Su-Mi;Kim, Su-Bin;Joon, Sang-Hoon;Heo, Yeong-Cheol
    • Journal of the Korean Society of Radiology
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    • v.13 no.5
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    • pp.713-720
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    • 2019
  • The purpose of this study was to propose a new measurement method for accurate measurement of vessel diameter in computed tomography angiography(CTA). CTA test was performed after non-ionic iodine contrast agent was flowed at a constant rate to self-maded perfusion phantom. After obtaining raw data, images were reconstructed with multi-planar reconstruction(MPR) and maximal intensity projection(MIP). Diameters of vascular models were measured for each technique. Relative and conventional measurements were then compared. The mean diameter of the vascular model was closer to the actual measurement when relative measurement was used compared to that when conventional measurement was used both in MPR and MIP. Relative measurements of MPR and MIP were closer to actual measurement than those of conventional measurement (34% VS, 24%, p<0.05). The relative measurement method proposed in this study was closer to the actual measurement than the conventional measurement method. However, both test methods were still larger than actual results. Therefore, further study of relative measurement method is needed using this study as basic data.

Recommandation for Study of Mortality Depending on Disease in Korean Insurance Market (국내 생명보험 질병별 사망율 연구를 위한 제언)

  • Bang, Eun-Joo;Kim, Yong-Eun
    • The Journal of the Korean life insurance medical association
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    • v.22
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    • pp.55-98
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    • 2003
  • 본 연구는 질병별사망율연구(疾病別死亡率硏究)의 이론적 기초를 제시하고 일본 선진보험사의 질병별사망율연구(疾病別死亡率硏究)의 경험을 고찰하고 국내 보험사들의 질병사망율연관데이터의 현황분석을 통해 향후 질병별사망율연구(疾病別死亡率硏究)의 결과를 얻기 위해 현재 보험사들이 전사적으로 준비하여야 할 것에 대해 제언을 하고자 한다. 사망률연구(mortality study)란 인구통계학적 개념을 기본으로 하여 역학적 연구방법의 하나인 코호트방법과 생존분석방법을 결합하여 인구집단(또는 피보험자 집단)을 대상으로 대량의 자료를 장기적으로 관찰하여 그 사망의 빈도와 분포를 기술하고 사망연관지수들을 알아내어 생명보험사업에 있어서 위험선택기술을 향상시키는 것이다. 초과사망을 및 사망비 산출의 실제를 생명표 방법론과 급성심근 경색증 환자의 생존 분석을 통해 알아본다. 생명표 방법론을 이용한 생존 분석방법이란 의학저널에서 발표된 논문을 사망률표로 변경하기 위한 필수적인 단계에 대한 것이다 관찰된 생존 곡선을 생명표 작성법의 한 방법인 비교 경험 사망률로 바꾸는데 초점을 두었다. 일본생명(日本生命)의 경우, 일본 협영생명(協塋生命)의 경우, 일본사망율조사(MA)위원회 생명보험사망을 연구고서등을 통해 질병별사망율연구(疾病別死亡率硏究)를 살펴 보았다. 일본은 질병별사망율(疾病別死亡率)을 구하기 위해서 1950년대 이후부터 체계적으로 자료를 모으고 축적, 분석하여 지속성을 유지하였다. 또한 일본MA위원회의 경우처럼 보험의학의사, 계리, 통계, 전산부서로 구성된 전담위원회의 통일된 협조가 질병별사망율연구(疾病別死亡率硏究)를 가능하게 하였다. 그리고 의학적인 관점에서 볼 때 일본보험의학계는 일본만의 독특한 질병분류로 분석하여 온 것이 특이하다. 질병별사망율연구(疾病別死亡率硏究)에 대해서는 모두가 필요성을 인정하면서도 구체적인 대비책은 없는 것이 우리나라 보험업계의 실정이다. 이러한 현실의 직접적인 이유는 질병별사망율연구(疾病別死亡率硏究)라는 것이 그 특성상 중장기적인 계획이며 많은 전문인력의 통합되고 집중된 노력이 요구되기 때문이다. 우리도 "생명보험사사망율연구위원회(Life Insurance Mortality Committee" (가칭)를 설치하고 장기적인 계획안을 먼저 만드는 것이 선행되어야 할 것이다. 지금부터 질병별사망율(疾病別死亡率) 데이터를 축적하고 매 5년 또는 매 10년마다 데이터를 분석한다면 질병별사망율(疾病別死亡率)에 대해 고유의 기술을 습득하는 것이 그리 먼 미래의 일만은 아닐 것이다.

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Career Guidance Program Design for the Graduate Medical School Students (의학전문대학원생을 위한 진로지도 프로그램 개발)

  • Yoo, Hyo-Hyun;Park, Kwi-Hwa
    • The Journal of the Korea Contents Association
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    • v.14 no.12
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    • pp.873-880
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    • 2014
  • The purpose of this study was to design career guidance program based on the research of career demand in order to help students choose and prepare careers suitable to students' interests and aptitude. The study surveyed 211 students in the $3^{rd}$ and $4^{th}$ years of C medical school. The survey was about start time of career guidance by medical schools, information collecting method for major selection, conformity degree among interest-aptitude-major after graduation, demanded information for career guidance, considerations in selecting majors, the reasons for not being able to select majors, etc. The result showed that students thought that start time of career guidance should be good for juniors, seniors, or all grades in order. The students got the information about career selection mostly from the direct contact with seniors. Students who had already decided the career, showed the high conformity degree among interest-aptitude-major after graduation Students who had already decided the majors, highly considered the aptitude and interest, while students who had not decided the majors, did not know their aptitude or did not have enough information about majors. This study gave the basic direction for the career guidance and provided necessary information for designing customized career guidance programs by reconstructing contents of the programs according to school conditions.

A Study on the Information Searching Behavior of MEDLINE Retrieval in Medical Librarian (의학전문사서의 정보이용행위에 관한 연구)

  • Lee Jin-Young;Jeong Sang-Kyung
    • Journal of Korean Library and Information Science Society
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    • v.30 no.2
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    • pp.123-153
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    • 1999
  • This article aims at finding the ways, on the basis of the studies about the behaviors to search the existing CD-ROM databases, so that the searchers who retrieve the on-line MEDLINE used in the medical libraries can use the data more efficiently than now. We gave the questionnaires to the librarians in 60 medical libraries and searched the literatures and realities on the behaviors of the data uses to examine the search behaviors of the MEDLINE in the medical libraries. The result is as follows: 1) The medical data system rate for single users was $53\%$ and the ons for multi users $43\%$. As for the time which users retrieve for a week, under two hours was $75\%$, between 3 and 8 hours $18.3\%$, and eve. 9 hours $6.7\%$. 2) The increasing factors of the search result are (1) an enough discussion and interview between librarians and users, and (2) the use of the correct indexing terms, Thesaurus, and Keyword. In principle users must search directly. However, the librarians searched instead in case that the retrieval result was under two hours a week$(75\%)$. 3) As for the search fee, $91\%$ was free and $9\%$ was charged. Also search effectiveness was enhanced by the means of Inter-Library Loan Service & Information Network. 4) The medical librarians answered the questionnaire that they need the application education of professional knowledge, medical terms(thesaurus) and electronic medium, and also they need the computer education, interview technique and reeducation to give a satisfactory service. 5) As for the satisfactory degree of MEDLINE application, they answered $44.6\%$ for economy, $38.2\%$ for the conveniency of the time required, and $58.9\%$ for the users' search satisfaction answered respectively. 6) The application of MEDLINE system enhanced the medical libraries' image and had an effect on the users' satisfaction of using the data and search, the data activities and the research achievement. 7) In the past MeSH was used but as the time passes CD-ROM MEDLINE search behavior was preferred to On-line one.

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Panperitonitis with Advanced Gastric Cancer - Based on Seminar of Korean Family Medicine Palliative Medicine Research Group - (진행된 위암 환자에게 발생한 범복막염 치료의 완화의학적 접근 - 대한가정의학회 완화의학연구회 세미나를 기초로 하여 -)

  • Jung, Yun-Joo;Kim, Dae-Kyun;Choi, Youn-Seon;Korean Palliative Medicine Research Group, Korean Palliative Medicine Research Group;Shim, Jae-Yong
    • Journal of Hospice and Palliative Care
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    • v.9 no.1
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    • pp.35-39
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    • 2006
  • A 77-year-old female presented panperitonitis due to advanced gastric ranter during palliative care. In the case of panperitonitis following obstruction or perforation, surgical treatment is vital to avoid fatal sepsis and dehydration. However, the risk of surgery and the residual life of a patient must be carefully considered because of high mortality and complication rate in those patients with advanced disease due to the poor condition. The therapeutic value of aggressive hydration, nasogastric tube insertion, and the use of antibiotics is also questionable. Palliative surgery was not performed on this case, and she passed away peacefully in the presence of family after 4 days of palliative medical care. Here is the appropriate management for this kind of patients we would like to recommend through review of relevant references and long discussions. Firstly, we need to predict survival time using clinical variables. Secondly, considering patient status and risk of surgery, non surgical palliative care such as pain control, transient nasogastric tube insertion, and parenteral hydration is recommended. Minimal use of fluid is desirable to minimize complications such as edema and dyspnea if massive hydration in the beginning of treatment is not proved to be effective. Even though started earlier in the course of disease, discontinuation of antibiotics could be discussed with patients and their caregiver if patient status is not improved.

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Comparison of Insect Fauna in Transgenic and Common Rice Paddy Fields (형질전환 벼와 일반 벼간 곤충상 비교)

  • Park, Taechul;Choe, Hojeong;Jeong, Hyoujin;Jang, Hojung;Kim, Jukon;Park, Jung-Joon
    • Korean Journal of Environmental Biology
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    • v.36 no.4
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    • pp.488-497
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    • 2018
  • Quantitative classification of insect fauna in transgenic rice in 2 LMO(Living genetically Modified Organism) isolated paddy fields (Gyeongsang National University, Gyeongbuk National University) and rice in 4 paddy fields(Duryang 1, Duryang 2, Hwagye 1, Hwagye 2), were evaluated for consecutive 5 years (2013 to 2017) in Sacheon, Gyeongnam province, and for 2 consecutive years (2015 to 2016) in Gunwi Gyeongbuk province. Sampling insect fauna were evaluated by black light trapping, sticky trapping, visual surveying, and sweeping methods in each target paddy field, respectively. A total of 37,941 individuals, of 464 species from 15 orders, were collected in Sacheon for 5 years. A total of 10,030 individuals, of 366 species from 13 orders, were collected in Gunwi for 2 years. Based on results of comparison between transgenic and non-transgenic paddy fields for 5 consecutive years, the similarity index between LMO paddy field and common paddy field is not different. Thus, this difference is not due to the environment, not the LMO.

Impact of attitude towards digital usage on life satisfaction of middle age and older adults: Sequential Mediation analysis in online networking activity and digital information production·sharing activities (중고령자의 디지털 이용태도가 생활 만족도에 미치는 영향: 온라인 네트워크 활동과 디지털 정보생산·공유활동의 직렬다중매개효과 분석)

  • Kim, Su Kyoung;Yoon, Hee Jeong;Lee, Dae Gyeom;Shin, Hye Ri;Kim, Young Sun
    • 한국노년학
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    • v.40 no.1
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    • pp.131-146
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    • 2020
  • The objective of this study is to examine the relationship between attitude in digital usage and life satisfaction level of the middle-aged people and older adults, and to analyze Sequential Mediation Effects of online networking activity and information producing and sharing in the online context. To achieve the main objectives, we conducted Hayeys'(2013) Process for SPSS Macro. The followings are the results of the study: First, there is a strong relationship between the attitude towards digital usage and the life satisfaction. Second, the results showed that impact of attitude in digital usage on life satisfaction among the older people is 0.291 unit higher, when they are engaged both in online networking activity and digital information production/sharing activities compared to involved in online networking activity alone. The results of the study is meaningful in that they can be used as a baseline data for reconsideration of digital usage and life satisfaction of the older adults, by providing comprehensive examination of relationship among attitude in digital usage, life satisfaction, online network activities, and digital information production·sharing activities of the older adults.