• Journal of Ginseng Research
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• v.32 no.4
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• pp.341-346
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• 2008

In the present study, we assessed the effects of white ginseng and red ginseng extract on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of ginseng extracts was investigated using the Morris water maze and Y-maze test. Drug-induced amnesia was induced by treating animals with scopolamine (2 mg/kg, i.p.), an antagonist of muscarinic acetylcholine (ACh) receptor. Tacrine was used a positive control. Ginseng extract (200 mg/kg, p.o.), tacrine (10 mg/kg, p.o.) administration significantly reduced the escape latency during training in the Morris water maze (p<0.05). At the probe trial session, scopolamine significantly increased the escape latency on day 5 in comparison with control (p<0.01). The effect of ginseng extracts on spontaneous alternation in Y-maze was similar to that of scopolamine treated group. In addition, numbers of arm entries were similar in all experimental groups. Moreover, red ginseng extract significantly inhibited acetylcholinesterase activity in the cortex and serum (p<0.05). Brain ACh contents of ginseng extract treated groups increased more than that of scopolamine group, which did not show statistically significant. These results suggest that ginseng extract may be useful for the treatment of cognitive impairment.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.4
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• pp.1-11
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• 2008

Objectives : Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. Scrophulariae radix is the roots of Scrophularia buergeria. In the present study, we investigated the effects of the aqueous extract of Scrophulariae radix on apoptotic cell death in the hippocampal dentate gyrus following transient global ischemia in gerbils. Methods : For this study, step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, and immunohistochemistry for caspase-3 were performed. Results : The present results showed that apoptotic cell death in the hippocampal dentate gyrus was significantly increased following transient global ischemia in gerbils. Treatment with the aqueous extract of Scrophulariae radix suppressed the ischemia-induced apoptosis in the dentate gyrus and thus facilitated the recovery of short-term memory impairment induced by ischemic cerebral injury. Conclusions : Here in this study, we have shown that Scrophulariae radix has a positive effect on-and possesses protective qualities against ischemia-induced apoptotic neuronal cell death, and it can be used for the treatment of ischemic brain diseases.

• 건강소식
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• v.35 no.10
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• pp.18-20
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• 2011

치매(dementia)는 라틴에게서 유래된 말로서 '정신이 없어진 것' 이라는 의미를 갖고 있다. 태어날 때부터 지적 능력이 모자라는 경우를 정신지체(mental retardation)라고 부르는 반면, 치매는 후천적인 뇌질환이다. 즉, 정상적으로 생활해 오던 사함이 후천적인 뇌 손상으로 인하여 기억력, 언어능력, 방향감각, 판단력 등의 인지기능을 잃어가는 것이다. 또한 이런 인지 기능 장애가 심각하여 일상생활에 상당한 지장이 나타날 때 치매라고 한다.

• Electric Engineers Magazine
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• v.219 no.11
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• pp.28-36
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• 2000

오늘날 전력에너지를 사용하고 있는 가정, 사무실 및 산업체 등 전력수요 전반에 걸쳐 전력품질에 민감하게 반응하는 다양한 전기설비들이 많이 사용되고 있다. 즉, 컴퓨터를 비롯한 정보관리시스템, 산업체 공정제어설비, 에너지관리시스템, 전자현금취급기 및 안전시스템 등은 전력품질 상태에 따라서 데이터 또는 기억내용 상실, 자료 송수신 오류 및 설비 손상이 발생하기도 한다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.4
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• pp.353-362
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• 2020

Korea was recognized as a relatively safe area for earthquake. However, due to considerable damage to facilities caused by the earthquake in Gyeongju and Pohang, interest in the maintenance and repair of structures is increasing. So interest in vibration damping technology applicable to existing structures is also increasing. However, vibration damping technology has a problem in that its usability is reduced due to damage of the damping device when a strong earthquake occurs. Recently, in order to solve such a problem, study is being conducted to apply a superelastic shape memory alloys (SSMA) capable of recentering bracing. Therefore, in this study, nonlinear dynamic analysis is performed to evaluate the seismic performance of the buckling-restrained braced frame (BRBF) applied SSMA to bracing.

• The Korean Journal of Food And Nutrition
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• v.27 no.4
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• pp.673-677
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• 2014

HX106N은 용안육, 맥문동, 단삼 및 천마 등의 4가지 식물로 구성된 추출물로서, 선행 연구에서 amyloid ${\beta}$ peptide에 의한 생쥐의 기억력 저하 및 산화 손상을 억제하는 것으로 밝혀졌다. 이 연구에서는 HX106N이 비선택적 무스카린 수용체 길항제로 잘 알려진 스코폴라민(scopolamine)으로 유도한 콜린성 건망증(cholinergic amnesia)에 어떤 영향을 미치는지를 평가하였다. ICR 생쥐에게 스코폴라민(1 mg/kg body weight, i.p.)을 주입하기 1시간 전에 HX106N(100 mg/kg body weight, p.o.)을 투여하였다. 30분 후 수행한 Y-미로 시험(Y-maze test) 및 수동 회피 시험(passive avoidance test)에서 HX106N는 스코폴라민에 의해 감소되는 자발적 변경 행동(spontaneous alternation) 및 지체시간(step-through latency)을 유의미하게 억제하여 건망증을 개선시키는 것으로 나타났다. 또한 HX106N을 투약 1시간 후 생쥐의 해마와 대뇌피질 부위의 아세틸콜린에스테라제(acetylcholinesterase; AChE)의 활성을 측정한 결과 통계적으로 유의미한 정도의 활성 감소가 관찰되었다. 이러한 결과들을 종합할 때 HX106N은 AD에서 관찰되는 콜린성신경전달 장애로 인한 기억력 저하 억제에 사용될 수 있는 가능성을 가진 것으로 판단된다.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.19 no.3
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• pp.10-15
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• 2011

The separation actuator for the small satellite should fix satellite appendages with high clamping force. After operation, it has to be separated from the satellite body without any damage on satellite system and release the appendages such as a solar panel and an antenna successfully. Therefore, we invent a non-explosive separation actuator for the small satellite which generates low shock and is resettable. In order to confirm performance of the proposed separation actuator, we carried out experiments for separation time, maximum preload for activation, and shock level.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.1
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• pp.77-86
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• 2004

This paper introduces a shape memory alloy-restrainer-damper(SMA-RD) to protect multiple span continuous steel bridges from seismic loads. The type of bridges has only one fixed bearing condition on a pier and expansion bearings are located on the other piers and abutments. Due to this state and a big mass of the deck, these bridges are usually very vulnerable to column's damage on which fixed bearings are located and large deformation of abutments in passive action. Two types of SMA-RDs are developed, and their effect is inspected for protecting the bridges through seismic analyses. Conventional steel restrainer cables are also used to reduce the seismic vulnerability of the bridge and the results are compared to those of the SMA-RDs.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2003.12a
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• pp.406-411
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• 2003

최근, 디지털 기술과 네트워크의 발달로 다양한 무선통신 단말기, 반도체, 디지털 방송, 전자상거래 등 다양한 분야가 융합되어 사람과 디바이스간에 실시간으로 정보를 주고받는 환경 즉, 유비쿼터스 컴퓨팅 환경에 많은 관심이 주목되고 있다. 이러한 유비쿼터스 컴퓨팅 환경에서의 통신은 통신개체간에 실시간 개체인증은 물론 전송되는 정보의무결성, 기밀성 등 보안 서비스가 요구된다. 현재의 개체 인증은 사용자가 기억하는 패스워드 또는, 스마트 카드와 같은 보안 모듈을 사용하여 사용자와 개체간에 인증이 이루어지고 있는 실정이다. 이러한 방식은 사용자가 기억해야 할 패스워드가 증가한다거나, 보안 모듈의 손상 및 분실로 인해 자신의 프라이버시(privacy)가 노출될 수 있는 단점이 있다. 이에 본 논문에서는 사용자 고유의 생체 정보와 기억할 수 있는 패스워드를 비밀정보로 사용하여 양방향 개체 인증 키 분배 프로토콜을 제안한다.

• Journal of Ginseng Research
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• v.20 no.1
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• pp.7-14
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• 1996

This study was performed to examine the effect of red ginseng total saponin and extract on memory in mice using one trial step-down type passive avoidance method. Red ginseng total saponins (No. 1: PD/PT ratio=1.24, No. 2: PD/PT ratio=1.47) were prepared with the different mixing ratio by using the parts of red ginseng. In single administration of total saponin No. 1 (100 mg/ kg, bw) or No. 2 (50 mg/kg, bw) increased the latency time as compared with control group but was not statistically significant. Treatment of total saponin No. 1 (50 mg/kg, bw) for 10 days produced an increase of latency time but was not statistically significant. In scopolamine-induced memory deficient mice total saponin No. 1 (50 mg/kg, bw) and No. 2 (100 mg/kg, bw) significantly improved the latency time. These results show that red ginseng total saponin may improve the memory of sco-polamine-induced memory deficient mice and have nootropic activity.