• Journal of Life Science
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• v.33 no.6
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• pp.523-529
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• 2023

Ubiquitination is a post-translational modification that is involved in the quality control of proteins and responsible for modulating a variety of cellular physiological processes. Protein ubiquitination and deubiquitination are reversible processes that regulate the stability of target substrates. The ubiquitin proteasome system (UPS) helps regulate tumor-promoting processes, such as DNA repair, cell cycle, apoptosis, metastasis, and angiogenesis. The UPS comprises a combination of ubiquitin, ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin-ligase enzymes (E3), which complete the degradation of target proteins. Ubiquitin-conjugating enzymes (UBE2s) play an inter-mediate role in the UPS process by moving activated ubiquitin to target proteins through E3 ligases. UBE2s consist of 40 members and are classified according to conserved catalytic ubiquitin-conjugating (UBC) domain-flanking extensions in humans. Since UBE2s have specificity to substrates like E3 ligase, the significance of UBE2 has been accentuated in tumorigenesis. The dysregulation of multiple E2 enzymes and their critical roles in modulating oncogenic signaling pathways have been reported in several types of cancer. The elevation of UBE2 expression is correlated with a worse prognosis in cancer patients. In this review, we summarize the basic functions and regulatory mechanisms of UBE2s and suggest the possibility of their use as therapeutic targets for cancer.

• Journal of Practical Agriculture & Fisheries Research
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• v.25 no.2
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• pp.5-11
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• 2023

Rehmannia glutinosa is a perennial herb belonging to the family Scrophulariaceae and is used in traditional oriental medicine. This study was carried out current status of breeding of R. glutinosa, its problems, and the matters to be improved were made. Based on the research data published so far, this study summarized the characteristics of breeds cultivated in Korea and compared and analyzed the status of cultivation area, production, import, and price changes for 15 years from 2008 to 2021. The cultivated area of R. glutinosa is gradually decreasing, and the amount of import is increasing and decreasing repeatedly. Amount of import has declined significantly. There was a lot of disinfection and disposal in the middle of import, and dried Jihwang and Sukjihwang were imported without distinction. R. glutinosa must be cultivated and supplied as a variety desired by the industry, cultivation techniques need to be taught to producers. In order to clearly identify the amount of import, import code of dried Jihwang and Sukjihwang must be classify. In addition, it is necessary to develop and supply harvesting agricultural machines for mechanization. For the stable income of producers, supply control through contract cultivation will ensure stable farm income.

• Korean Journal of Culture and Social Issue
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• v.24 no.3
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• pp.491-518
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• 2018

The purpose of this study was to compare with qualitative research articles on the grandparents' parenting experiences of grandchildren between those with primary responsibility and those with partial responsibility in Korean Journals since 2000. For the purpose of the study, this study analyzed research of 43 qualitative research articles(19 grandfamilies, 24 custodial grandparents), with respect to their objectives, basic annual trends, methodology, subject, category of content. The major findings are as follows. Firstly, the annual number of articles of grandfamilies are on an decreasing trend, while those of custodial grandparents are on an increasing trend. Secondly, the phenomenology and interview are frequently used in research of the two types of family. Thirdly, 6~10 participants were the most frequent number of participation in all of the family. However, demographics, caring circumstances, physical circumstances were significantly different in two types of family. Fourthly, caring categories of contents(the meaning, positive factor, conflict factor and resolution of conflicts) were also similar, while these were significant diffent in specific psychological experiences in all of the family. Based on the findings of this comparative study, suggestions for pratical services and implication for future study were proposed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.1
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• pp.47-65
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• 2023

As stakeholder demands and sustainable finance grow, ESG management and ESG evaluation are becoming important. SMEs should also prepare for the trends of ESG rating practices that affects supply chain management and financial transactions. However, SMEs have no choice but to focus on survival first, so there are restrictions on putting into ESG management. In addition, there is a lack of research on the legitimacy of ESG management by SMEs, and volatility in ESG evaluation systems and rating grades is also increasing. Accordingly, it is necessary to review ESG evaluation trends and practical guidelines along with the review of previous studies. As a result of the exploratory study, SMEs need to implement ESG management and make efforts to specialize in ESG related new businesses under conditions in which their survival base is guaranteed in terms of implementation strategies. In addition, it is necessary to focus on the strategic use of various evaluation results along with accumulating information favorable for ESG evaluation through organizational learning and software management. The implications of this study are that various studies such as the classification criteria for SMEs and the relationship between ESG evaluation grades and long-term survival rates are needed in ESG evaluation of SMEs. At the government policy level, it is time to consider the ESG evaluation system exclusively for SMEs so that ESG management can be implemented and ESG evaluation at different levels by industry and size.

• Journal of Space Technology and Applications
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• v.4 no.1
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• pp.27-47
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• 2024

In the New space era, satellites are being developed to perform on-orbit service (OOS) missions. Various missions for orbital service include failure repair, refueling, towing, component replacement, and space construction, and in order to do so, a robot arm payload must be mounted. Unlike conventional satellite payloads, the robot arm payload is not move in a fixed state, but is a payload that must move continuously to perform the mission. It is also characterized by the need to perform the mission while being directly exposed to outer space, rather than existing inside the structure of the satellite. Due to the characteristics of these payloads, thermal design and interpretation that can be operated smoothly in an extreme space thermal environment is essential, but there are not many papers on thermal design and interpretation of the robot arm. This paper introduces and summarizes cases of thermal design and interpretation of robot arm payloads developed so far, and finally, it intends to suggest directions for thermal design and interpretation of robot arm payloads to be developed in the future.

• Journal of Food Hygiene and Safety
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• v.39 no.5
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• pp.357-377
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• 2024

The integration of biosensors and biopolymer-based nanocomposites in food packaging is progressively being recognized by industry professionals, fueled by growing concerns over food quality and safety. Embedded biosensors in food packaging offer the potential to revolutionize the industry by providing real-time monitoring of microbial spoilage in packaged products, a critical aspect of ensuring food safety. Simultaneously, the exploration and application of biopolymer-based nanocomposites or bionanocomposites have expanded substantially, owing to their exceptional mechanical, thermal, optical, and antimicrobial properties. These attributes facilitate the suitability of these materials for innovative packaging applications. However, exploring the potential hurdles and prospects of employing biosensors and bionanocomposites in designing intelligent food packaging systems has not yet been exhaustive. Proposing the amalgamation of bionanocomposites with biosensors represents a groundbreaking step toward redefining smart packaging industries, emphasizing the necessity for a deeper understanding of these technologies to foster the development of sustainable and economically viable smart packaging options. This review examines existing research and developmental strides in biosensors and bionanocomposites, aiming to highlight the anticipated challenges and opportunities that could spearhead progress in the smart food packaging industry in the foreseeable future.

• The Mathematical Education
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• v.63 no.3
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• pp.573-591
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• 2024

The purpose of this study is to explore research trends on AI-based mathematics teaching and learning. For this purpose, a systematic literature review was conducted on 57 literatures in terms of research subject, research method, research purpose, learning content, type of AI, role of AI, and role of teachers. The results indicate that student accounted for the largest proportion at 51% among the research subjects, and quantitative research was the highest at 49% among the research methods. The purpose of study was distributed as follows: effect analysis 44%, theoretical discussion 35%, case study 21%. 'Numbers and Operations' and 'Variables and Expressions' covered learning contents most, and Intelligent Tutoring System (ITS) was used the most among the types of AI. 'Student teaching' was the largest parts of role of AI at 40.4%, followed by 'teacher support' at 22.8%, 'student support' at 21%, and 'system support' at 15.8%. The role of teachers as 'AI recipients' was highlighted in earlier studies, and the role of teachers as 'constructive partner with AI' was highlighted in more recent studies. Also, role of teachers was explored in pedagogical, AI-technological, content aspects. Through this, follow-up research was suggested and the roles that teachers should have in AI-based mathematics teaching and learning were discussed.

• Convergence Security Journal
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• v.24 no.3
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• pp.209-218
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• 2024

Relations between North Korea and Russia have recently reached an inflection point in the wake of the Russia-Ukraine war, and are expected to have a significant military and geopolitical impact on the Korean Peninsula and the security environment in East Asia in the future. The 'Comprehensive Strategic Partnership Agreement between North Korea and Russia' was signed on the occasion of Kim Jong-un's visit to Russia in September 2023 and Russian President Putin's visit to North Korea in June 2024. The security environment on the Korean Peninsula and in East Asia is anticipated to be significantly impacted by developmental changes in North Korea-Russia relations. As North Korea and Russia formed a paramilitary alliance, stipulating provisions that can be interpreted as automatic military intervention, North Korea's military support for the ongoing war in Ukraine was secured, and the basis for Russia's military intervention in future Korean Peninsula issues was laid. Additionally, the possibility of transferring Russian military technology to North Korea increased as an institutional mechanism was established to implement joint measures to strengthen the defense capabilities between the two countries. If Russia uses its position as a permanent member of the UN Security Council to neutralize international sanctions against North Korea and provide large-scale economic support, North Korea will break away from international isolation and strengthen its strategic autonomy. Therefore, this study examines the historical process of change in North Korea-Russia relations and examines the main contents and implications of the 'Comprehensive Strategic Partnership Agreement' concluded after the North Korea-Russia summit in June 2024.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.554-564
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• 2017

The purpose of this study is to assist farmers in determining the optimal time for the shipment of stored apples by investigating the market trends, storage status and release dates of low-temperature stored apples. We surveyed 300 apple cultivation farms in Daegu, Gyeongbuk Province, which is the main producer of apples, and examined the cultivars, cultivation areas, storage conditions, and shipment status of apples. The main results are as follows: the proportion of apples cultivatedat different ripening times was surveyed. According to the results, the proportions of early, middle and late varieties were 78.3%, 63.7% and 96.0%, respectively. Also, 48.7% of the farm households surveyed had cold storage facilities. The average storage cost per apple box(15kg) was 978.3 won for self-storage and 1,771.8 won for consignment storage. For the six(6) months between November and April, the proportion of shipped apples was 91.6% of the total stored apples. The (average total?)annual apple shipment, including apples stored in general storage warehouses, was 744.4 boxes. The (average total?) annual shipment of cold storage apples was 616 boxes. The stored apples were mainly shipped to 'wholesale markets', which have the highest sales share, followed by 'production site collectors' and then 'supermarkets'. The most common shipping method of the apples was by general trucks, followed by low-temperature trucks, and finally by delivery services. The analysis of the factors influencing the decision to release apples by period showed that it was affected by the storage cost, loss rate, and customary shipping in the off-season(from May to August). On the other hand, in the general release season(from November to April), the statistically significant decision factors for the release of apples were the future expected price, storage cost and decision of the leading farmer groups. For farmers with a high share of general shipment, the deciding factors for the release of apples were the future expected price, storage cost, high income expectation, and decision by leading farmers.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.18 no.2
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• pp.89-103
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• 2013

National demands for the ocean forecasting system have been increased to support economic activity and national safety including search and rescue, maritime defense, fisheries, port management, leisure activities and marine transportation. Further, the ocean forecasting has been regarded as one of the key components to improve the weather and climate forecasting. Due to the national demands as well as improvement of the technology, the ocean forecasting systems have been established among advanced countries since late 1990. Global Ocean Data Assimilation Experiment (GODAE) significantly contributed to the achievement and world-wide spreading of ocean forecasting systems. Four stages of GODAE were summarized. Goal, vision, development history and research on ocean forecasting system of the advanced countries such as USA, France, UK, Italy, Norway, Australia, Japan, China, who operationally use the systems, were examined and compared. Strategies of the successfully established ocean forecasting systems can be summarized as follows: First, concentration of the national ability is required to establish successful operational ocean forecasting system. Second, newly developed technologies were shared with other countries and they achieved mutual and cooperative development through the international program. Third, each participating organization has devoted to its own task according to its role. In Korean society, demands on the ocean forecasting system have been also extended. Present status on development of the ocean forecasting system and long-term plan of KMA (Korea Meteorological Administration), KHOA (Korea Hydrographic and Oceanographic Administration), NFRDI (National Fisheries Research & Development Institute), ADD (Agency for Defense Development) were surveyed. From the history of the pre-established systems in other countries, the cooperation among the relevant Korean organizations is essential to establish the accurate and successful ocean forecasting system, and they can form a consortium. Through the cooperation, we can (1) set up high-quality ocean forecasting models and systems, (2) efficiently invest and distribute financial resources without duplicate investment, (3) overcome lack of manpower for the development. At present stage, it is strongly requested to concentrate national resources on developing a large-scale operational Korea Ocean Forecasting System which can produce open boundary and initial conditions for local ocean and climate forecasting models. Once the system is established, each organization can modify the system for its own specialized purpose. In addition, we can contribute to the international ocean prediction community.