• Korean Journal of Schizophrenia Research
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• v.24 no.2
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• pp.52-59
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• 2021

Objectives: Recent studies have reported that delayed initiation of clozapine can affect clinical response in patients with treatment-resistant schizophrenia (TRS). This study aimed to explore the relationship between delayed initiation of clozapine and acute treatment response. Methods: Sixty-five inpatients with TRS who started clozapine for the first time were included through a retrospective chart review. Acute treatment response was defined as a 30% reduction in the Positive and Negative Syndrome Scale score or a Clinical Global Impression of Improvement score of 1 (very much improved) or 2 (much improved) at 4 weeks after initiating clozapine. Results: After meeting the TRS criteria, the mean delay for initiating clozapine was approximately 13.8 months. The delay was shorter in patients who showed a better response to clozapine in logistic regression analysis (p=0.037). Conclusion: Our findings suggest that reducing the delay in initiating clozapine increases the effectiveness of clozapine in patients with TRS.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.4
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• pp.163-171
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• 2022

Objectives : The aim of this study was to report that effect of Korean medicine treatment for patient with peripheral facial nerve palsy accompanied by hemifacial spasm through hospitalization. Methods : We treated a patient with facial nerve palsy by acupuncture, electroacupuncture, herbal medicine, pharmacopuncture and cupping. The effect of treatment was evaluated using the House-Brackmann scale, the Yanagihara grading system, and the visual analogue scale(VAS). Results : During the 18 days hospitalization period, the symptoms of hemifacial spasm disappeared and the facial palsy improved. The House-Brackmann scale changed from 4 grade to 2 grade, the Yanagihara grading system changed from 19 to 47, and the VAS changed from 3 to 0. Conclusions : This case report suggests that Korean medicine could be effective for facial palsy accompanied by hemifacial spasms.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.1-7
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• 2009

Objectives : This Study was prepared for investigating the safety of oriental medicine and continuous intravenous urokinase combined therapy in acute cerebral infarction. Methods : We prospectively estimate safety of hemorrhagic transformation occurred in oriental medical therapy and continuous intravenous urokinase combined therapy. We estimate National Institute of Health Stroke Scale Score and Modified Barthel Index. Results : Hemorrhagic transformation was not noted. and Others are not fatal complication. Conclusions : oriental medical therapy and continuous intravenous urokinase combined therapy are safety method in treatment of acute cerebral infarction. We think this can be a good model of Oriental and western cooperative therapy.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.4
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• pp.187-195
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• 2023

Objectives : The aim of this study is to report the effect of Korean-western combination treatment in two patients with Herpes Zoster. Methods : During hospitalization, two patients were treated with Galgeunkilkyung-tang, acupucture, pharmacopuncture, antiviral agents, painkiller. To evaluate the effect of this treatment, we used Numeric Ration Scale(NRS) and Quality of Sleep(QSP). Results : After treatment, NRS and QSP of 2 patients were improved remarkably. Conclusions : According to the result, these finding suggest that Korean-western combination treatment can be effective for the treatment of herpes zoster.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.37 no.1
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• pp.113-125
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• 2024

Objectives : The purpose of this study is to report the effect of Korean-Western medicine combination treatment administered to two patients with acute herpes zoster. Methods : During hospitalization, the two patients were treated with Hyeonggaeyeongyotang-gagam, Hwangryunhaedok-tang wet dressing, pharmacopuncture, acupuncture, and other western medications including antiviral and analgesic agents. Photographs of skin lesions, numeric rating scale(NRS), and visual analog scale(VAS) were used to assess the improvement of symptoms. Results : At the time of discharge, both patients showed remarkable improvement in skin lesions, NRS for pain, and VAS for pruritus and insomnia. Conclusions : The results demonstrated that Korean-Western medicine combination treatment may be effective for treating herpes zoster.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.39-45
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• 2001

본 논문은 척담(滌痰) 축어(逐瘀) 고본(固本)의 방법으로 천식을 완화시킨 치험에 관한 내용이다. 천식의 병인병기는 폐(肺) 비(脾) 신(腎) 삼장(三臟)의 본허(本虛)로 인한 알레르기성 체질이 내적인 근본요인으로 간주된다. 담어복폐(談瘀伏肺)는 천식의 병리적인 결과로서 증상유발의 요인이기도 하다. 즉 담어(痰瘀)는 천식의 병리적인 부산물이며, 동시에 천식을 일으키는 치병요인이 된다. 담어(痰瘀)가 내복(內伏)하여 철저히 제거되지 않으면 천식은 결코 완치될 수 없다. 이와 같은 한의학적인 관점은 현대의학에서 천식을 기도의 만성 염증에 의하여 유발된 증상으로 파악하고 있는 기전과 일맥상통하다. 또한 담(痰) 어(瘀) 허(虛)는 천식의 병리변화 과정에서 전반적으로 영향을 미치고 있다는 인식이 지배적이며, 이는 천식치료를 위한 처방구성에 이론적 근거를 제시하고 있다. 치료: 천식은 발작기와 완화기로 분류하여 치료하며, 발작기는 냉효(冷哮)와 열효(熱哮)로 구분된다. 냉효(冷哮)의 경우 치료원칙은 온폐산한(溫肺散寒), 척담평천(滌痰平喘), 화어행체(化瘀行滯)를 기본으로 한다. 처방은 구마황(灸麻黃) 행인(杏仁) 황금(黃芩) 세신(細辛) 계지(桂枝) 오미자(五味子) 당귀(當歸) 울김(鬱金) 목단피(牧丹皮) 지룡(地龍) 정력자(?歷子) 담남성(膽南星) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 열효(熱哮)의 경우 치료원칙은 청열사폐(淸熱瀉肺) 척담평천(滌痰平喘), 화어행체(化瘀行滯)를 근본으로 삼고, 처방으로는 구마황(灸麻黃) 행인(杏仁) 황금(黃芩) 목단피(牧丹皮) 적작약(赤芍藥) 당귀(當歸) 정력자(?歷子) 담남성(膽南星) 지룡(地龍) 어성초(魚腥草) 포공영(蒲公英) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 완화단계도 역시 두가지 유형으로 나누어지는데, 폐신음허형(肺腎陰虛型)은 익기양음(益氣養陰) 척담행어(滌痰行瘀)를 치료원칙으로 하고, 처방에는 남북사삼(南北沙蔘) 구자울(灸紫?) 및 관동화(款冬花) 당귀(當歸) 목단피(牧丹皮) 울김(鬱金) 정력자(?歷子) 세신(細辛) 오미자(五味子) 구기자(枸杞子) 산수황육(山茱黃肉) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 비신양허형(脾腎陽虛型)은 온보비신(溫補脾腎) 화어척담(化瘀滌痰)을 원칙으로 하며, 처방에는 구마황( 灸麻黃) 세신(細辛) 오미자(五味子) 당귀(當歸) 단삼(丹蔘) 울김(鬱金) 정력자(?歷子) 반하(半夏) 보골지(補骨脂) 선령비(仙靈脾) 태자삼(太子蔘) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 치험(治驗): (1) 천식의 실증(實證)은 치료를 한 뒤 완화단계에 접어들면서 허증(虛證)으로 전화되는데, 허천(虛喘)도 역시 천식이니 만큼 단순히 보법(補法)만 사용하여서는 안된다. 시종일관 천식치료에는 척담화어(滌痰化瘀)의 원칙을 지켜야 한다. 폐내(肺內)의 담어(痰瘀)가 철저하게 제거되어야 폐(肺)의 순환기능을 개선시켜 기도(氣道)의 염증을 신속히 흡수하고 치유할 수 있다. 이와 같은 치료과정은 약 3-6개월이 필요하다. 완화단계의 기간이 길어질수록 완치될 확률도 높아진다. (2) 급성기 천식은 폐(肺)를 다스려야 한다. 폐(肺)를 다스리는 방법에는 선폐(宣肺), 청폐(淸肺), 온폐(溫肺), 윤폐(潤肺) 및 척담거어(滌痰祛瘀) 등이 있다. (3) 증상이 완화되면 신(腎)을 다스린다. 천식은 신허(腎虛)가 근본적인 원인이므로 완화단계에서 심지어 발작기에도 보신제(補腎劑)를 추가하여 사용하면 배의 효과를 얻을 수 있다. (4) 비(脾)의 기능을 강화하여 근본을 채우는 부비배본(扶脾培本)도 중요하다. 후천의 수곡정미(水穀精微)로 선천을 충족시키고 자양하는 것은 질병에 대한 저항력을 키우고 재발을 경감시키거나 방지하는 효과를 기대할 수 있으므로 역시 천식치료의 중요한 방법 중 하나이다.

• Journal of Pharmacopuncture
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• v.13 no.4
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• pp.139-147
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• 2010

Objectives : The Purpose of this study is to investigate and report the effectiveness of Hominis Placenta using Pharmacopuncture treatment for trigger finger. Methods : 3 Patients are admitted at Dept. of Oriental Rehabilitation, Bu-Chun Jaseng Oriental Medicine Hospital, diagnosed as Trigger finger and treated with Hominis Placenta Pharmacopuncture. Each cases are measured and assessed by Quinnell's classification of triggering and VAS (Visual Analogue Scale) scores. Results : 3 Patients of trigger finger have a different kind of cause and fingers lesion they have, but nodules are not significantly found up, so we could classify all of 3 patients to diffuse type. After treatment of Hominis placenta Pharmacopuncture, spontaneous pain and tenderness, grades of triggering are decreased significantly. We would expect that Hominis placenta Pharmacopuncture has a effect on degenerative diseases of diffuse type's tendon sheath. Conclusions : Trigger finger is generally divided into two stages, inflammatory and degenerative stage, and when degenerative stage, Hominis placenta pharmacopuncture appears to be effective.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.19-19
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• 1982

Pathogenesis of otitis media was studied in an animal model of rats from a histopathological and biochemical point of view. Basic anatomical outline, and distribution and type of normal epithelial cells of the rat bulla were described as a background study. Pseudomonas otitis media was developed in rats by inoculating $10^{9}$ bacteria into the tympanic bulla. Histopathologic change of the mucoperiosteal layer showed acute stage of infection from 3 days to 3 weeks, and it became chronic after 4 weeks animals through 12 weeks. Enzyme profile in the extracts of the inflammatory middle ear tissue was studied. The levels of three enzymes, PZ-peptidase, LDH, and lysozyme were much higher in the middle ear tissue than in the corresponding sera as might be expected. Tissue/serum ratios of the enzyme activities were 13-38 for PZ-peptidase, 63-177 for LDH, and 18-94 for lysozyme. Possible role of the PZ-peptidase and possible origins of the three enzymes detected in the tissue were discussed.

• Journal of Veterinary Clinics
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• v.27 no.3
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• pp.257-261
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• 2010

The development of blood ionic changes could be precipitated in acid-base disorder and subsequent treatment. As technology for detecting circulating ionized $Mg^{2+}$ (the most interesting form with respect to physiological and biological properties) is now available in veterinary clinical medicine. This present study investigated the changes of whole blood ionized $Mg^{2+}$ correlated with acute metabolic and respiratory alkalosis in rodent model. Metabolic alkalosis was induced by intravenous infusion with $NaHCO_3$ and mechanical hyperventilation was applied for respiratory alkalosis. We founded that the blood ionized $Mg^{2+}$ could be reversibly decreased by the $NaHCO_3$-induced acute metabolic alkalosis but irreversibly increased by the mechanical hyperventilation-induced respiratory acidosis and respiratory acidosis. We suggested that the potential change in blood suggested that the potential change in blood ionized $Mg^{2+}$ should be counted in treatment of acid-base disorders.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.61-68
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• 1990

To assess the role of multiple factors in influencing occurrence of ventricular premature complexes after acute myocardial infarction twenty-four hour Holter electrocardiographic tape recording were made in 40 survivors of an acute myocardial infarction 10 to 20 days after attack. Ventricular premature complexes were found in 72.5percent of the patients. The incidence and grade of ventricular premature complexes in the early postinfarction period were not correlated with left ventricular function, age, sex, smoking, dibetes mellitus, previous angina, and previous myocardial infarction. The occurrence of ventricular premature complexes showed a positive correlation with the occurrence of ST-T change. The occurrence of ventricular premature complexes during sleep hours was compared to the awake state. In 22 patients. the incidence of ventricular premature complexes was reduced during sleep. If patients free of ectopic activity during 24-hour monitoring sessions are excluded from analysis, the 22 of patients, or in 76percent, sleep was associated with a lowered occurrence of ventricular extrasystoles.