Browse > Article

Blood Electrolytes and Metabolites in Rat Model of Acute Metabolic and Respiratory Alkalosis  

Kim, Shang-Jin (College of Veterinary Medicine, Chonbuk National University)
Lee, Mun-Young (College of Veterinary Medicine, Chonbuk National University)
Kim, Jin-Shang (Korean Zoonoses Research Institute, Chonbuk National University)
Kang, Hyung-Sub (Korean Zoonoses Research Institute, Chonbuk National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.3, 2010 , pp. 257-261 More about this Journal
Abstract
The development of blood ionic changes could be precipitated in acid-base disorder and subsequent treatment. As technology for detecting circulating ionized $Mg^{2+}$ (the most interesting form with respect to physiological and biological properties) is now available in veterinary clinical medicine. This present study investigated the changes of whole blood ionized $Mg^{2+}$ correlated with acute metabolic and respiratory alkalosis in rodent model. Metabolic alkalosis was induced by intravenous infusion with $NaHCO_3$ and mechanical hyperventilation was applied for respiratory alkalosis. We founded that the blood ionized $Mg^{2+}$ could be reversibly decreased by the $NaHCO_3$-induced acute metabolic alkalosis but irreversibly increased by the mechanical hyperventilation-induced respiratory acidosis and respiratory acidosis. We suggested that the potential change in blood suggested that the potential change in blood ionized $Mg^{2+}$ should be counted in treatment of acid-base disorders.
Keywords
blood ionized $Mg^{2+}$; electrolytes; respiratory alkalosis; metabolic alkalosis;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Unterer S, Gerber B, Glaus TM, Hassig M, Reusch CE. Evaluation of an electrolyte analyser for measurement of concentrations of ionized calcium and magnesium in cats. Vet Res Commun 2005; 29: 647-659.   DOI   ScienceOn
2 Proksch JW, Gentry WB, Owens SM. Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat. J Pharmacol Exp Ther 1998; 287: 616-624.
3 Quamme GA. Renal magnesium handling: new insights in understanding old problems. Kidney Int 1997; 52: 1180-1195.   DOI   ScienceOn
4 Roy DR, Blouch KL, Jamison RL. Effects of acute acid-base disturbances on renal tubule reabsorption of magnesium in the rat. Am J Physiol 1982; 243: 197-203.
5 Hafen G, Laux-End R, Truttmann AC, Schibler A, McGuigan JA, Peheim E, Bianchetti MG. Plasma ionized magnesium during acute hyperventilation in humans. Clin Sci 1996; 91: 347-351.   DOI
6 Berlin D, Aroch I. Concentrations of ionized and total magnesium and calcium in healthy horses: effects of age, pregnancy, lactation, pH and sample type. Vet J 2009; 181: 305-311.   DOI   ScienceOn
7 Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294: 1-26.   DOI
8 Webster MJ, Webster MN, Crawford RE, Gladden LB. Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance. Med Sci Sports Exerc 1993; 25: 960-965.
9 Zaidenberg G, Mimouni FB, Dollberg S. EFFect of bicarbonate on neonatal serum ionized magnesium in vitro. Magnes Res 2004; 17: 90-93.
10 Santella RN, Maddox DA, Gennari FJ, Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis. J Clin Invest 1991; 7: 631- 638.
11 Maguire ME, Cowan JA. Magnesium chemistry and biochemistry. BioMetals 2002; 15: 203-210.   DOI   ScienceOn
12 Morgan TJ. The meaning of acid-base abnormalities in the intensive care unit: part III -- effects of fluid administration. Crit Care 2005; 9: 204-211.   DOI   ScienceOn
13 Chew DJ, Leonard M, Muir WW 3rd. Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats. Am J Vet Res 1991; 52: 12-17.
14 Bleul UT, Schwantag SC, Kähn WK. Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis. Am J Vet Res 2007; 68: 850-857.   DOI   ScienceOn
15 Webster MJ, Webster MN, Crawford RE, Gladden LB. Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance. Med Sci Sports Exerc 1993; 25: 960-965.
16 Weiss D, Burger D, Weishaupt MA, Fakler A, Spichiger UE, Giese L, Liesegang A, Wanner M, Riond JL. Effects of a 61.7 km ride on magnesium and calcium homeostasis in well trained endurance horses. J Equi Vet Sci 2002; 22: 77-83.   DOI   ScienceOn
17 Ozaki J, Tanimoto N, Kuse H, Hori M. Comparison of arterial blood gases and acid-base balance in young and aged beagle dogs, with regard to postprandial alkaline tide. J Toxicol Sci 2000; 25: 205-211.   DOI   ScienceOn
18 Hopper K, Rezende ML, Haskins SC. Assessment of the effect of dilution of blood samples with sodium heparin on blood gas, electrolyte, and lactate measurements in dogs. Am J Vet Res 2005; 66: 656-660.   DOI   ScienceOn
19 Levin M, Winaver J. Effects of systemic alkalosis on urinary magnesium excretion in the rat. Miner Electrolyte Metab 1989; 15: 214-220.
20 Lindinger MI, Heigenhauser GJ, Spriet LL. Effects of alkalosis on muscle ions at rest and with intense exercise. Can J Physiol Pharmacol 1990; 68: 820-829.   DOI   ScienceOn
21 Gunnerson KJ. Clinical review: the meaning of acid-base abnormalities in the intensive care unit part I- epidemiology. Crit Care 2005; 9: 508-516.   DOI   ScienceOn