• Title/Summary/Keyword: 글리세린

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Transdermal Permeation of Xanthan Gum Bases on the Water-soluble and Lipophilic Antihyperlipoproteinemic Drugs (수용성과 지용성 항고지단백혈증제에 대한 Xanthan Gum 기재에서의 경피투과)

  • 이석우;임윤택;공승대;황성규;이우윤
    • KSBB Journal
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    • v.16 no.3
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    • pp.253-258
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    • 2001
  • Recently, there were many studies not only to enhance drug delivery effect but to reduce side effect. Drug delivery system(DDS) is able to improve efficiency with decreasing side effect of drug dosage. Among these application fields, DDS is often used as the method of drug dosage into the epidermic skin. We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying DDS. We investigated the permeation of xanthan gum containing drug in rat skin using borizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug with oxiniacic acid and also for lipophilic drug with clofibrate. The permeation rate of lipophilic drug was found to be faster than that of water-soluble drug in vitro. The rate differences of both water-soluble drug and lipophilic drug according to drug content were negligible. We used glycerin, PEG 600 and oleic acid as enhancers. These results showed that skin permeation rate of each drug across the composite was mainly dependent on the property of base and chemical property of drug etc.. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer base as a transdermal delivery system of antihyperlipoproteinemic agent.

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Superconducting Properties of Mg(B1-xCx)2 Bulk Synthesized Using Magnesium and Glycerin-treated Boron Powder (마그네슘과 글리세린 처리한 붕소 분말로 합성한 Mg(B1-xCx)2의 초전도 특성)

  • Kim, Yi-Jeong;Jun, Byung-Hyuk;Park, Soon-Dong;Tan, Kai Sin;Kim, Bong-Goo;Sohn, Jae-Min;Kim, Chan-Joong
    • Journal of Powder Materials
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    • v.15 no.3
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    • pp.182-187
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    • 2008
  • Carbon was known to be one of effective additives which can improve the flux pinning of $MgB_2$ at high magnetic fields. In this study, glycerin $(C_3H_8O_3)$ was selected as a chemical carbon source for the improvement of critical current density of $MgB_2$. In order to replace some of boron atoms by carbon atoms, the boron powder was heat-treated with liquid glycerin. The glycerin-treated boron powder was mixed with an appropriate amount of magnesium powder to $MgB_2$ composition and the powder pallets were heat treated at $650^{\circ}C\;and\;900^{\circ}C$ for 30 min in a flowing argon gas. It was found that the superconducting transition temperature $(T_c)$ of $Mg(B_{1-x}C_x)_2$ prepared using glycerin-treated boron powder was 36.6 K, which is slightly smaller than $T_c$(37.1 K) of undoped $MgB_2$. The critical current density $(J_c)$ of $Mg(B_{1-x}C_x)_2$ was higher than that of undoped $MgB_2$ and the $T_c$ improvement effect was more remarkable at higher magnetic fields. The $T_c$, decrease and $J_c$ increase associated with the glycerin treatment for boron powder was explained in terms of the carbon substitution to boron site.

Storage Stability of Baikseolgi (백설기의 저장성 연구)

  • Yeo, Kyung-Mok;Chang, Moon-Jeong;Kim, Myung-Hwan
    • Applied Biological Chemistry
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    • v.42 no.3
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    • pp.218-222
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    • 1999
  • The effects of storage temperature, moisture content and the concentration of additives, such as sucrose fatty acid ester(SE), isomaltooligosaccharide(IO) and glycerin(GL), on texture properties, hardness(HA), cohesiveness(CO) and chewiness(CH) of Baikseolgi after 7 days storage were analyzed by response surface methodology(RSM). The contour values of HA of SE added Baikseolgi at 20, 50 and $80^{\circ}C$ of storage temperate were $1500{\sim}3200,\;500{\sim}1300$ and $100{\sim}400\;g_f$, respectively. The HA of IO or GL added Baikseolgi decreased with increased storage temperature, moisture content and additive concentration. The storage temperature was the most significant factor affecting the HA of Baikseolgi. However, the second and third significant factors were moisture content and additive concentration, respectively. These results imply that the control of storage temperature is the most effective method to increase the storage stability of Baikseolgi. The CO of IO or GL added Baikseolgi was increased by the change of strage temperature from $20{\circ}\;to\;50{\circ}$. While, there was no significant difference between $50{\circ}\;and\;80{\circ}$ of storage temperature. The CO of IO or GL added Baikseolgi was maximized around 40% of moisture content and that of GL added Baikseolgi was minimized around 0.5% of GL concentration. The storage temperature, additive concentration and moisture content were the first, second and third affacing factors on the CO of Baikseolgi, respectively. The CH of Baikeolgi was decreased by increasing storage temperature, moisture content and additive concentration. The storage temperature, moisture content and additive concentration were the first, second and third affacting factors on the CH of Baikseolgi, respectively.

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Selection of Brevibacillus brevis B23 and Bacillus stearothermophilus B42 as Biological Control Agents against Sclerotinia Rot of Lettuce (상추 균핵병 생물적방제를 위한 Brevibacillus brevis B23과 Bacillus stearothermophilus B42의 선발)

  • Hwang, Ji-Young;Shim, Chang-Ki;Ryu, Kyung-Yeol;Choi, Du-Hoe;Jee, Hyeong-Jin
    • Research in Plant Disease
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    • v.12 no.3
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    • pp.254-259
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    • 2006
  • Bacillus spp. isolated from mushroom medium wastes were evaluated for their biocontrol potentials on control of Sclerotinia rot of lettuce. The Bacillus isolates were more effectively obtained from waste suspension when directly added into nutrient agar(NA) medium than plating on the agar medium. Totally 42 isolates obtained from the wastes B23 and B42 showed highest antifungal activity against eight fungal pathogens such as Sclerotinia sclerotiorum, Rhizoctonia solani, Pythium ultimum, Phytophthora capsici, Fusarium oxysporum, Colletotrichum gloeosporioides, Cladosporium cucumerinum, and Botrytis cinerea and B23 and B42 were finally selected for further studies. Optimal concentration of the isolates was $10ml(10^7cfu/ml)$ to suppress the Sclerotinia rot of lettuce. Supplements such as starch, glycerol, and egg-yolk successfully maintained the bacterial population for 30 days in vitro and increased bio-control potentials against the disease. The bacterial isolate B23 alone showed 72% control value, furthermore it presented 95% control value when supplemented with 0.2% of starch, glycerol, and egg-yolk. The promising Bacillus isolates B23 and B42 were identified as Brevibacillus brevis and Bacillus stearothermophillus, respectively, based on morphological and physiological characteristics according to API database.

Control Effects of Bemisia tabaci on Eggplant using Sticky Trap (가지에서 끈끈이트랩을 이용한 담배가루이 방제효과)

  • Kim, Ju;Choi, In-Young;Lee, Jang-Ho;Kim, Ju-Hee;Lim, Joo-Rag;Cheong, Seong-Soo;Kim, Jin-Ho
    • Korean Journal of Organic Agriculture
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    • v.25 no.4
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    • pp.759-772
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    • 2017
  • This experiment was conducted to develop control method for Bemisia tabaci (Gennadius) on eggplant using sticky trap method. According to the color of the sticky traps, the attractiveness of the B. tabaci was the highest in the yellow trap, followed by the green and orange. However, white, blue, red, black and green sticky traps have reduced attractiveness of B. tabaci. In order to improve the efficiency and attractiveness of sticky trap to the B. tabaci, the different kinds of sugars such as glucose, fructose, oligosaccharide, starch syrup and pure sugar were added to sticky traps respectively. However, the effect of B. tabaci attractiveness was low in starch syrup, pure sugar, and non-treated sticky traps. The attracting effect of B. tabaci was depending on the location of sticky trap. The highest value was obtained where sticky traps were located in the top of the eggplant, followed by 30 cm above from the top level. In addition, we were installed up to 40 sticky traps to determine the optimal amount of sticky traps to control B. tabaci in eggplant. When increasing the sticky traps, the number of adult and nymphs of B. tabaci were tended to be decreased significantly. This tendency was more effective in the latter stages than in the early stages. As the number of sticky traps increased, not only the growth rate of eggplant, leaf length, and stem diameter were to be better. But also number of fruits and product marketable value were increased at the early stage of growing as well. The study had proven that the sticky traps had an effect on increasing the yield at the early stage of growth, but the efficiency of controlling decreased due to the high density of B. tabaci of the next generation.

The Study on Implementation of a Semi-Solid Flat Phantom with Equivalent Electrical Properties to Whole Human Body at MICS and ISM Band (MICS 대역과 ISM 대역에서 인체 전기적 상수를 갖는 준(準) 고체형 플랫 팬텀 제작)

  • Lee, Soon-Yong;Seo, Won-Bum;Kwon, Kyeol;Choi, Jea-Hoon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.23 no.1
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    • pp.101-107
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    • 2012
  • When wireless devises for MICS(Medical Implant Communication Service) or ISM(Industrial Scientific and Medical) bands are designed, it is necessary to verify the performance by using a human body flat phantom. However, most of studies on the phantom are limited to the biological effects of mobile-phone EMF. In this paper, semi-solid phantoms having the electric properties suggested by FCC at MICS and ISM bands are fabricated. The manufactured phantoms satisfy the electric properties($\varepsilon_r=56.7$ and $\sigma=0.94$ at MICS band, $\varepsilon_r=52.7$ and $\sigma=1.95$ at ISM band) at each band. All the composing materials for phantoms are commercially available in domestic market. Two methods using both polyethylene powder and TX-151 and glycerin at each band are proposed for diverse purpose. The electrical properties of the fabricated phantoms are measured by a dielectric probe kit and network analyzer after the lapse of one day (24 hours).

Fuel Properties of Various Biodiesels Derived Vegetable Oil (다양한 식물성유지에서 유래된 바이오디젤의 연료 특성)

  • Kim, Jae-Kon;Park, Jo Yong;Jeon, Cheol Hwan;Min, Kyong-Il;Yim, Eui-Soon;Jung, Choong-Sub;Lee, Jin-Hui
    • Journal of the Korean Applied Science and Technology
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    • v.30 no.1
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    • pp.35-48
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    • 2013
  • Biodiesel is an alternative diesel fuel which can be obtained from the transesterification of vegetable oils, animal fats and waste cooking oil. The objective of this study is to evaluate the properties of biodiesel obtained from different feedstocks (soybean, waste cooking, rapeseed, cottonseed and palm oils). The biodiesel derived from different feedstocks was analyzed for FAME (fatty acid methyl esther) content, kinematic viscosity, flash point, CFPP (cold filter plugging point) and glycerin content. The quality of biodiesel was tested according to the Korean and European standard (EN14214, requirements and test method for biodiesel fuel). The biodiesels derived from soybean, waste cooking, rapeseed and cottonseed oils contain high amount of unsaturated fatty acid, while palm biodiesel is dominated by saturated fatty acid. The fuel properties of biodiesel, such as low temperature performance, kinematic viscosity and oxidation stability are correlated with the FAME composition components in biodiesel.

Study on the Filter Collection Methods of Ammonia and Ammonium Salts in the Atomosphere (대기중의 암모니아 및 암모늄염의 필터포집법에 관한 연구)

  • Hui Kang Kim;橋本芳一;Yong Keun Lee
    • Journal of the Korean Chemical Society
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    • v.26 no.1
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    • pp.36-42
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    • 1982
  • Filters were evaluated to use in the collection of ammonia and ammonium salts in the atmosphere. Ammonia from standard gas generator was collected on a glass fiber filter impregnated with a mixture of 3% boric acid and 25% glycerin. The collection efficiency by the impregnated filter was 96.4${\pm}$2.15% in pH control method and 97.4${\pm}$1.06% in the atmosphere for five measurements, respectively. Adsorption and desorption of gaseous ammonia were compared using three commercially available filters; glass fiber, quartz fiber and polycarbonate filters. Both glass and quartz fiber filters indicated some loss of ammonium salts and adsorption of ammonia, respectively. However, polycarbonate filter was found to be satisfactory for the collection of ammonium salts in the atmosphere. The minimum measurable concentration of ammonia was 0.83ppb (ca. 0.63${\mu}g$/$m^3$) by spectrophotometry of the indophenol method for the sample collected by 47mm${\phi}$ filter(20l/min, 60min). The sensitivity of the present method is about 20 folds higher than that of conventional method of bubbler collection followed by spectrophotometry, so that this method makes it possible to measure thevariation of ammoniacal concentrations in the atmosphere for a short time period of about 60 min.

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Hand Cream purchase consumer awareness of Domestic and Foreign Brands and effect of Sebum and Moisture in the Skin (국내 및 수입브랜드의 핸드크림이 소비자 구매인식과 피부 유, 수분에 미치는 영향)

  • Seo, Hyun-Woo;You, Seon-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.4
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    • pp.373-381
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    • 2016
  • To investigate the influence of hand cream of domestic and foreign brands on the purchase tendency, a survey was conducted on hand cream application, purchase tendency, and perception of 105 women in a metropolitan area. Market research was then conducted to compare the hand cream cost, quantity, and total substance, and the hand creams were sorted according to high-price and low-price, and foreign brand and domestic brand, and a clinical demonstration was conducted by back-hand application on 17 recipients to analyze the moisture and skin oil differences and the moisture endurance. As a result, the percentage of subjects who perceived that the price and brand of hand cream affects the quality was higher than those who did not, and the hand cream prize per 1mg (g) varied as much as fourfold among the high-price and low-price, and among foreign and domestic brands. The result of the total substance comparison, glycerin the moisturizer and cetearyl alcohol the skin conditioner were included in all hand creams. As a result of the clinical demonstration, the difference in moisture and skin oil difference and moisture endurance between the high-price and low-price and foreign brand did not show a statistically significant difference. These results show that there are no relationships between skin moisture and sebeum of the brand. Therefore, considering that hand cream is a highly consumptive product that is used multiple times on a daily basis, these results might provide fundamental data that could contribute to the increase in hand cream product quality by determining the consumers' needs.

New Implementation Method of the Pulsed Nuclear Magnetic Resonance Apparatus (펄스방식의 핵자기 공명장치에 관한 새로운 구현방법)

  • 김청월
    • Journal of the Korean Institute of Telematics and Electronics C
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    • v.35C no.10
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    • pp.1-11
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    • 1998
  • This paper presents a new implementation method of the pulsed NMR(nuclear magnetic resonance) apparatus, which contains a single coil in a magnet console, to detect a NMR signal. Applying an RF magnetic field of 5MHz to the magnet console which is designed to have Larmor frequency of 5MHz for hydrogen atom, the hydrogen NMR signal was obtained from the glycerin which was put in the magnet console as a sample. The DC magnetic field in the magnet console was implemented with a permanent magnet of 1168 gauss and the RF magnetic field was generated appling an RF signal with the frequency of 5MHz and the current magnitude of 8A to a coil of 5.73${\mu}$H. The magnitude of the NMR signal was maximum when the RF magnetic field was generated for 2.8 ${\mu}$sec, and the period of generating the RF magnetic field was designed to 100msec for detecting the NMR signal repeatedly. The NMR signal, radiated from the sample in the magnetic console, was appeared as an amplitude-modulated signal with a frequency equal to the Larmor frequency. The signal, induced in the coil, was amplified in the tx/rx separation circuit, preamplifier and intermediate amplifier by a factor of 20.7dB, 36dB and 40dB, respectively, and the signal was detected by a synchronous detection circuits, then the NMR signal was obtained.

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