• Journal of the korean veterinary medical association
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• v.50 no.9
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• pp.523-525
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• 2014

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.24-40
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• 2007

Purpose: This study was carried out to investigate the effects of Guibi Tang(GT) and Placenta Hominis blended Guibi Tang(GTPH) on the postmenopausal osteoporosis. Methods: In order to observe the potential effects of GT and GTPH on the osteoporosis induced by ovariectomy, antioxidative effects of GT and GTPH were measured. Antioxidative activity for the samples was investigated by Rancimat method. Animals were observed for 8 weeks, and vehicle and extracts of prescriptions were administered ad libitum. And we measured the variance of body weight, femoral bone weight, serum level of osteocalcin, calcium, alkaline phosphatase(ALP), estradiol, cholesterol, triglyceride, alanine aminotransferase(ALT) and creatinine. Results: As a result, GTPH showed antioxidative effect, but did not in GT. Body weight increased significantly in 6 weeks after ovariectomy, and the weight of GTPH administered group decreased significantly. GT and GTPH decreased the serum level of cholesterol and triglyceride. Administration of GTPH increased the serum level of ALP when compared with control group. Ovariectomy and GT, GTPH administration had no influence on serum level of ALT and creatinine. Conclusion: According to above results. We suggest that GT and GTPH may be used prevention and curing the postmenopausal osteoporosis.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.698-708
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• 2017

Objectives: The aim of this study was to report the clinical effects of a combination of Gamiguibi-tang and sweet bee venom on a patient with Raynaud's disease. Methods: The patient with Raynaud's disease was treated with Gamiguibi-tang three times a day for 43 days and with sweet bee venom daily. The effects on Raynaud's disease were measured on both hands using a cold stress test and an infrared thermometer and by digital infrared thermographic imaging and a NRS (Numeric Rating Scale). We conducted the cold stress test at 6-8 day intervals from 2016.04.27 to 2016.06.08. Results: After treatment, the symptoms of pain were decreased in both hands and digital infrared thermographic imaging (DITI) confirmed a rise in the temperature of the fingers. The fingertip temperature increased from 29.6 to 30.4 degrees and the cooling/rewarming ratio (CRR) increased steadily. No adverse events were found at discharge. Conclusions: Gamiguibi-tang combined sweet bee venom may improve symptoms in patients with Raynaud's disease.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.2
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• pp.198-205
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• 2008

Objective : We report a case of BPPV responded to the Guibitang, Spleen Tonifying Sa-Am Acupuncture and Canalith Reposition Therapy. Methods : 1. Diagnosis and Evaulation: Bithermal Caloric test, Video Nystagmography, Dix-Hallpike test, VAS 2. Treatment: Guibitang, Acupuncture, Canalith Reposition Therapy. Results : We can observe remarkable improvement evaulated by VAS. Conclusion : It is considered that Guibitang and Acupuncture can be applied to the treatment of BPPV.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.105-110
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• 2011

Purpose: This paper is aimed to report the effects of Gamiguibitang on the Climacteric Syndrome. Methods: A patient who had been suffering from Climacteric symptoms was enrolled in this study. She received oriental treatment such as herbal medicine for 3 months. We gave her Gamiguibitang five times. During the treatments, we requested her to visit hospital twice a week. If she could not come to hospital, we called her to take follow-up. Results : After oriental medical treatments, several symptoms of Climacteric Syndrome were improved. Conclusion: This clinical case indicate that Gamiguibitang is effective in treatment of the Climacteric Syndrome. More clinical data and studies are requested for the treatment of Climacteric Syndrome Patient.

• Journal of Haehwa Medicine
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• v.14 no.1
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• pp.129-140
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• 2005

1. In Dong-Eui-Bo-Gam, Ondamtng & its Gagambang are applied for the sudden palpitation, epilepsy, the insomnia of exhaustion and an acute convulsion which are caused by the asthenia of heart and gall bladder(心膽虛怯). 2. In Dong-Eui-Bo-Gam, Guibitang & its Gagambang are applied for amnesia, amenorrhea, upper abdominal pain, the itching sign the pubic region, the hernia of the vulva which are caused by the asthenia of heart and spleen(心脾兩虛). 3. In Dong-Eui-Bo-Gam, Soyosan & its Gagambang are applied for epilepsy, the hemorrhage in time of coughing, the intermittent fever, metrorrhagia, various woman's diseases which are caused by the depression of vital energy of liver(肝氣鬱結).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.2
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• pp.48-58
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• 2004

Objective: This study was performed to investigate the depigmentation effects of the extracts of Kamikwibi-Tang. Methods Inhibition of tyrosinase activity, melanin production & cell viability in cultured B16 melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide were measured. Results: The extracts of Kamikwibi-Tang did not have any inhibitory effects on tyrosinase activity and did not show any inhibitory effects on melanin production in melanoma cells and also did not have any inhibitory effects on UV screen. But the extracts showed high cytoprotective effects on PC12 cells injured by hydrogen peroxide. Conclusion : These results suggest that Kamikwibi-Tang indrectly inhibits melanin biosynthesis which is involved in hyperpigmentation and could be used as a whitening agent for the skin.

• Korean Journal of Pharmacognosy
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• v.19 no.1
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• pp.39-46
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• 1988

Experimental studies were conducted to investigate the hemostatic effect of the water extracts of Kwibitang. For this purpose, the effects of the extracts on the bleeding time in mouse tail and prothrombin time in vitro were estimated. Furthermore, its activity on the isolated uterine muscle in rats were investigated. The results obtained were as following; The bleeding time was not shortened, but the plasma prothrombin time in vitro test was significantly shortened. The uterotonic action produced by the extract was not inhibited by pretreatment of diltiazem at the doses of $10^{-5}g/ml$.

• Journal of Oriental Neuropsychiatry
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• v.20 no.1
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• pp.1-19
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• 2009

Objectives : This Study was performed to assess the antioxidative and neuroprotective effect of Guibi-tang(Guipi-tang) and Guibi-tang gamibang(Guipitang jiaweifang) on PC12 cells. Methods : The antioxidative effect was investigated through the DPPH radical and ABTS cation scavenging methods and total polyphenol amount of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang). The neuroprotective effect of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) was assessed using MTT assay in PC12 cells. The scavenging effect of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) on NO and ROS production induced by 6-OHDA in PC12 cells was evaluated, as well as the attenuating effect of Guibi-tang gamibang(Guipitang jiaweifang) on GSH reduction. Results : 1. Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) had concentration-dependent scavenging activities of DPPH radical 2. Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) had concentration-dependent scavenging activities of ABTS cation. 3. Total polyphenol amount of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) was calculated 79.10${\pm}$2.20 pg/IO mg and 121.03${\pm}$1.11 pg/IO mg, respectively. 4. Cell viability of Guibi-tang(Guipitang) was increased in a dose dependent manner. Guibi-tang gamibang(Guipitang jiaweifang) was increased at low concentrations, but decreased at high concentrations. 5. In Guibi-tang(Guipitang), cell viability of PC12 cell treated with 6-OHDA was decreased by pre-treatment, and increased by post- and co- treatment. Cell viability of Guibi-tang gamibang(Guipitang jiaweifang) showed variable effects by pre-treatment, but increased by post- and co- treatment. 6. NO production rate of Guibi-tang(Guipitang) didn't show a significant effect, but that of Guibi-tang gamibang(Guipitang jiaweifang) was decreased in a dose dependent manner. 7. ROS production rate of Guibi-tang(Guipitang) was decreased at some concentrations. In Guibi-tang gamibang(Guipitang jiaweifang), ROS production rate was decreased at high concentrations. 8. Guibi-tang gamibang(Guipitang jiaweifang) protected the 6-OHDA-induced GSH reduction. Conclusions : These results demonstrate that both Guibi-tang(Guipitang) and GBTGMB have antioxidative and neuroprotective effect, but Guibi-tang gamibang(Guipitang jiaweifang) has more antioxidative and neuroprotective effect than Guibi-tang.

• Journal of Veterinary Clinics
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• v.26 no.2
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• pp.181-184
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• 2009

Immune-mediated hemolytic anemia(IMHA) is one of the most common causes of anemia in small animals and immune-mediate thrombocytopenia(IMT) is also an immune mediated disease that affects small animals. The initial treatment for IMHA and IMT is medical suppression of the immune system with glucocorticoids and other immunosuppressive drugs. However, even with appropriate treatments, some animals are not responsive to the treatment and may need further immunosuppressive therapies or some alternative medicines. An eight-year-old spayed female Siamese cat with IMHA and an eight-year-old castrated male King Charles Spaniel dog with IMT were referred to the traditional medical service of the veterinary medical center. Both animals were unresponsive to steroids or other immunosuppressive treatments. Gui-Pi-Tang, one of the traditional herbal medicines, was administered to the animals. After 1-month of Gui-Pi-Tang administration, the packed cell volume(PCV) of the cat and platelets count of the dog had showed remarkable improvement. After four months of follow up in the cat, and 18 months of follow up in the dog, the improved PCV and platelet counts of the animals were maintained normally. Therefore, Gui-Pi-Tang might be considered as an alternative treatment in small animals with immune-mediated blood disorders.