• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.843-848
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• 2023

The purpose of this study is to understand in detail the development of infants in the 18-24-month period when language develops the most, and to prepare new standards for developmental evaluation that can promote appropriate intervention design at an early time. We divided sub-items such as screening tests and standardized test tools to know the language development ability indicators of infants aged 18-24 months were divided into syntax/phonology, meaning, and speech, and each question was classified and a checklist was made on a five-point scale to conduct a survey on parents with infants aged 18-24 months. Low sensitivity to screening of infants with language delays in nationally implemented infant health checkups, and domestic test tools are standardized for at least six to as many as 10 years, which is always possible in questionnaires related to acceptance and expression, with many reports from parents or teachers.The proportion of "wow" and "started to do" was more than 50-60%. Based on the results of this study, it is hoped that new standards for developmental evaluation will be developed to promote the design of appropriate interventions in detail at a short time.

• International Journal of Highway Engineering
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• v.14 no.3
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• pp.97-110
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• 2012

In case of the axial line bikeway, the residents in the riverside use it frequently but those in the city center hardly do as the axis is formed along the riverside of the Han river. This situation happens due to the inefficient connectivity between the bikeway that leads to the riverside and that in the city center, which means the administrative policies have been focused on the facilities rather than on raising connectivity of the bikeway networks in the south of the Han River. Also, this is the point of time when a reasonable improvement plan is needed to raise the accessibilities of the bikeways in Seoul, not just a utilization of those in the south of the Han River. This study intends to analyse the connectivity between Gangseo (west of the Han River) and Gangdong (East of the Han River) districts by comparing the current spatial structure in the southern areas of the Han River and that after the installation of the axial line, and that after installation of the ordinary bikeway respectively with use of the Space Syntax Model, and to predict resultant changes there of. The Space Syntax Model was used as the major method of analysis in this study to find out characteristics of the bikeways in the south of the Han River. Consequently, as the analysis shows that when the bikeways in the Gangseo and Gangdong-gu districts are connected, the accessibility of the bikeways in the south of the Han River will improve while the spatial structure intelligibility will be lowered, it can be said the prediction rate in the all areas is low compared with the current status. It is analyzed that the intelligibility of the current bikeways in the south of the Han River appeared highest when compared with those of plans for installation of the axial line and ordinary bikeway because they don't interconnect with other areas.

• Journal of Life Science
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• v.18 no.1
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• pp.16-22
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• 2008

In this study to evaluate the involvement of EGFR, HER-2/neu and ALCAM (CD166) oncogene products in canine mammary neoplastic lesions, sections of archived paraffin-embedded samples of 49 mammary tumors were analyzed immunohistochemically using antibodies against human EGFR and HER-2/neu and ALCAM. These 49 tumors were divided into 2 groups: 22 benign (19 adenoma, 3 benign mixed tumors) and 27 malignant tumors (2 simple adenocarcinomas, 5 complex adenocarcinomas, 3 solid carcinoma, 5 sclerosing carcinoma, 8 malignant mixed tumors and 4 malignant myoepithelioma). As a result of immunostaining, 31.8% (7/22) of the benign tumors and 29.6% (8/27) of the malignant tumors expressed the HER-2/neu oncogene product, EGFR expression was detected in 27.3% (6/22) of benign tumors and in 22.2% (6/27) of the malignant tumors. ALCAM expression was detected in 40.9% (9/22) of benign tumors and in 7.4% (2/27) of the malignant tumors. These results suggest that some of the biological and morphological characteristics of the tumor are associated with canine mammary gland tumors, as also reported for human breast cancer, the possibility of using anti-HER-2/neu antibodies in the treatment of canine mammary tumors.

• Journal of Life Science
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• v.17 no.12
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• pp.1766-1770
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• 2007

We describe here a case of malignant mixed osteogenic tumor of the mammary gland with alveolar carcinomatous appreance. A firm, 2 to 2.5cm (in diameter) mass under the 5th nipple, showing the structure of extraosseous osteogenic sarcoma, was removed from the left 5th mammary gland of 12-year-old female dog. When investigated under the microscope, the osteoid material undergoing mineralization was surrounded by numerous scattered osteoblasts and a few osteoclastic cells throughout the osteoid tumorous stroma. The osteoid lesions were continuous with hypercellular myoepithelial cells of a very immature character with several mitotic figures. In addition, there were also carcinomatous tubules and alveoli, with invading cells into peripheral stroma, surrounded by myoepithelial cells in the mammary gland. In these lesions, emanating cords of tumor cells appear to be continuous with the myoepithelial cell layer of a duct. The presence of all these cell types suggests the existence of a common malignant origin, the stem cell being differentiated into epithelial carcinomatous and mesenchymal sarcomatous chondral and osteogenic tissues.