• Korean Journal of Cleft Lip And Palate
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• v.10 no.1
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• pp.1-16
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• 2007

이차구개는 발생과정에서 구개선반의 형성과 성장, 거상과 융합의 과정을 통해 형성된다. 이와 같은 이차구개의 형성과정은 미세한 분자유전학적 신호전달기전에 의해 조절되는 것으로 알려져 있어서, 신호전달과정에 관여하는 유전인자의 발현이상이 되면 정상적인 이차구개가 형성되지 못하고 구개파열이라는 선천성 기형이 발생된다. 구개파열의 유발인자들에 대한 많은 연구에도 불구하고 현재까지 정상적인 이차구개의 형성을 조절하는 분자유전학적 기전에 대해서는 명확히 알려져 있지 않다. 따라서 본 연구에서는 이차구개의 형태분화를 조절하는 분자유전학적 기전을 알아보고자, 이차구개 형성의 내적 조절인자 중 핵심유전자로 알려져 있는 Osr2가 결손된 생쥐의 이차구개 형성과정에서 정상생쥐에 비해 발현의 변동이 나타나는 유전자를 확인하였다. 유전자 발현의 변동은 발생 14.5일(E14.5)의 구개선반으로부터 추출한 total RNA를 이용하여 ACP-based GeneFishing PCR을 시행하여 확인하였고, 각각의 변동된 유전자를 동정하여 정상생쥐의 이차구개 형성과정에서의 발현양상을 in situ hybridization을 시행하여 확인하였다. 총 120쌍의 primer를 이용한 검색을 통해서 정상생쥐의 구개선반에 비해 mutant에서 발현이 변동된 유전자는 7개가 검출되었고, 이들은 모두 정상생쥐에 비해 mutant에서 발현이 증가되는 것으로 확인되었다. 검출된 유전자는 vimentin(Vim), ${\beta}$-tropomyosin 2(Tpm2), thioredoxin-like 5(Txnl5), procollagen type II alpha 1(Col2a1), Insulin-like growth factor binding protein 7(IGFbp7), Sui 1 homologs(Sui 1), Defender against cell death1(Dad1)이었다. 검출된 유전자를 동정하여 정상생쥐의 구개 형성과정에서의 발현양상을 알아본 결과, Col2a1 을 제외한 유전자들은 모두 E13.5의 구개선반에서 특이적으로 발현되고 있었으나 구개선반이 융합된 E15.5에서는 Vim, Txnl5 그리고 Dad1 만이 봉합선을 따라 발현이 지속되고 있었다. 이상의 결과로 보아 검출된 유전자들은 구개선반의 형태분화과정에서 발현되어 이차구개의 형성과정에 관여할 것으로 여겨진다. 또한 이들은 이차구개 형성의 내적조절인자인 Osr2의 downstream target 으로 구개선반의 성장과 융합과정에 직접적으로 관여하는 유전물질일 것으로 추정된다.

• The korean journal of orthodontics
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• v.30 no.4 s.81
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• pp.433-440
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• 2000

The purpose of this study was to investigate osteonectin expression patterns in cleft palate compare to normal palate rats. We used 4 pregnant rats, and beta-aminoproprionitrile was oral dose to rat according to 1g/kg body weight at gestation days 13 to induce cleft palate. Total 6 fetus was got with cleft formed, then 3 fetus was used for immunohistostain and 3 fetus was used for western blot analysis. Expression patterns of osteonectin in mesenchymal cells of cleft palate was more dilute to mesenchymal cells of normal palate with immnunohistostain, and width and length of band of maxilla in cleft palate was more thin than maxilla of normal palate with western blot study.

• Journal of the korean academy of Pediatric Dentistry
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• v.47 no.2
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• pp.167-175
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• 2020

The purpose of this study was to determine whether the palatal rugae could be used as an appropriate reference area for serial model superimposition following Rapid maxillary expansion(RME) and facemask treatment. A total of 52 pediatric patients who had undergone RME and facemask treatment were selected. Palate and palatal rugae in the pre- and post- treatment casts from the patients were measured. In spite of dentoalveolar changes occurred by RME and facemask, anteroposterior changes in palate and palatal rugae were not significant. Anatomical changes of palate and palatal rugae were mostly shown in the transverse dimension. The soft tissue of the palatal rugae stretches in adaptation to hard tissue movement. Among the evaluated landmarks, the medial point of the third palatal rugae seemed to be the most stable. The observed alterations in the palatal rugae demonstrated the potential of medial points of third palatal rugae as a reference point in model superimpositions to evaluate dental movement within the maxillary arch following RME and facemask treatment.

• The Journal of Korean Academy of Prosthodontics
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• v.51 no.4
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• pp.353-360
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• 2013

Cleft lip and palate is congenital deformity in oral and maxillofacial area. Normal soft palate has velopharyngeal closure action by connecting oral cavity and nasal cavity at rest and moving upward at swallowing and specific pronunciation. Cleft palate patients with velopharyngeal insufficiency have difficulty in mastication, swallowing and pronunciation because velopharyngeal closure is incomplete. At this time, a prosthetic device used to cover palate defects is called a palatal obturator. A palatal obturator separates oral cavity and nasal cavity and recovers pronunciation, mastication, swallowing and esthetic function. The purpose of this case study is to report the results because it reaches a satisfactory result in functional and esthetic aspects through functional impression procedures using modeling compound and tissue conditioner for restoration of a cleft palate patient with velopharyngeal insufficiency.

• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.4
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• pp.421-426
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• 2011

Most of the intraoral infections origin in odontogenic infection. Odontogenic infection spreads out along the least resistant path. In maxilla, the thickness between periapical area and cortical bone is narrower on the buccal side than the palatal side. So infection usually spreads out along the buccal side rather than the palatal side. The failure of root canal treatment more frequently occurs on the buccal root compared to the palatal root. So the palatal abscess is rarer than the buccal abscess. It is difficult to differential diagnosis palatal abscess from salivary gland tumors, benign neural tumors and cysts on the palate. Therefore, when the palatal swelling is observed in children, you need to prevent the systemic spread of infection by early diagnosis of the odontogenic palatal abscess. In these cases, the patient who complained of the pain in deciduous teeth and the palatal swelling was diagnosed with odontogenic palatal abscess. The patient was treated with extraction and antibiotic medication. The palatal abscess was resolved, and we report after treatments.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.4
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• pp.696-706
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• 2003

The purpose of this study was to clarify the palatal forms through palatal curvatures of right to left, anterior to posterior direction, and difference of right and left palatal volumes in the primary and permanent dentition. Samples were consisted of normal occlusion of both dentition(50 males and 50 females each). Their upper plaster casts were used, measuring points were decided, through 3-dimensional laser scanning(3-D Laser Scanner, DS4060, LDI, U.S.A.), and fitting standard horizontal plane were made for measuring the height and sectioned volumes of palate. The results were as follows: 1. Palatal volume and height were greater at the right side of the palate in the primary and permanent dentition of male and female, but there was no significance. 2. Palatal height was greater in male compared to female, especially, there was significant difference at intercuspid, inter-second premolar area in the permanent dentition(P<0.05). 3. To the height of A-P direction of mid-palatal area, the highest point was 20mm in the primary dentition, 30mm in the permanent dentition from interdental papilla of central incisors. 4. Palatal height of inter-cuspid and inter-second premolar became shallow and broad, high and broad each, compared to inter-deciduous canine and inter-second deciduous molar.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.3
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• pp.338-345
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• 1991

Velopharyngeal incompetence (VPI) is a condition of inadequate functional valving between the oral and nasal cavities that results in hypernasal speech and nasal air escape. VPI is caused by the following factors ; cleft palate, soft palate defect, pharyngomegaly, velopharyngeal sphincter muscle anomaly and maxillary advancement surgery, etc. Velopharyngeal function is assessed by a variety of measures that include speech evaluation, cephalogram, airflow study, videofluoroscopy and nasoendoscopy. The management of VPI is classified into four main groups ; prosthesis, insertion of implant, palatoplasty and pharyngoplasty. Pharyngeal flap is the most common surgical procedure for correcting VPI since Schoenborn's report in 1875. We report seven cases of VPI which were treated by modified modified superiorly based pharyngeal flap with good results.

• The Journal of Korean Academy of Prosthodontics
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• v.60 no.2
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• pp.152-159
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• 2022

The role of the posterior palatal seal is important in retention of the maxillary complete denture. After taking the final impression, additional retention can be given to the maxillary denture through a mechanical method of forming a groove on master cast, but this is often overlooked in the clinical process. As a result, the posterior palatal seal is formed in a uniform way by the technician without considering the individual characteristics of the patient. Until now, various types of posterior palatal seal have been introduced by many people. This case report describes the process of manufacturing the maxillary complete denture by determining the position and form of an appropriate posterior palatal seal after considering the patient's anatomical palatal form and tissue displacement during function.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.22-22
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• 1991

구개열 및 구개근의 기능부전 등에 의한 인두문(velopharyngeal valve)의 폐쇄부전으로 인하여 발생하는 구개범인두부전증(velopharyngeal insufficiency)은 흔히 과비성으로 알려진 구음장애를 나타내는 병적현상으로 Von Langenbeck(1861)이 구개 외측 점막성 골막편을, Smith(1895) 와 Ganzer(1920)는 각각 구개 4-판 및 3-판 점막성 골막편을 이용한 수술적 치료법을 통하여 구음장애를 해결하여 주려하였고, 그외 인두후벽의 증대 및 언어보조기 등을 이용한 방법으로 구음장애를 해결하여 주려는 연구가 최근까지 활발하게 이루어지고 있으나 만족할 만한 성적을 거두지 못하고 있는 실정에 있다. 이에 저자들은 구개범인두부전증에 대한 수술적 치료후 증상의 호전정도를 관찰하고, 술후에도 증상의 호전을 보이지 않는 환자의 음성재활에 대한 향후 방향제시에 도움을 주고자 1987년 1월부터 1991년 1월까지 과비성을 주소로 본원 이비인후과에 내원하여 구개성형술을 시행받고 3개월 이상 추적 관찰이 가능하였던 14례의 환자를 분석한 결과 구개범인두부전에 대하여 1차 수술을 시행받은 14례중 5례(36%)에서 정상적인 구음이 가능하였으며 실패한 9례중 5례에 대하여는 재 수술을 시행하였으나 만족할 만한 음성회복을 거두지 못하여 그 원인과 저자들의 술식을 분석 검토함으로써 구개범인두부전증의 치료에 대한 보다 효율적인 방법을 모색하고자 문헌고찰과 함께 보고하는 바이다.

• The Journal of the Korean dental association
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• v.20 no.9 s.160
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• pp.743-747
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• 1982

구강은 다양한 기능을 가지고 있다. 즉, 소화, 호흡 및 발음의 기능을 주로 하며, 심미적으로 매우 중요하다. 그러므로 토진 및 구개열과 같은 기형은 위에 열거한 작용을 훼손시켜, 환자 본인은 물론, 주위 사람들에게 커다란 불행이라 할 수 있다. 그리하여 토진 및 구개파열을 수정하려는 노력은 고대로부터 출발된다. Boo-Chai는 A.D390년경에 중국에서 토진수술이 있었다고 1966년에 보고한 바 있다. 이후에는 수많은 사람들이 토진 및 구개파열에 대한 수술방법을 제시하여 왔으며 현재에도 여러 가지 다양한 수술방법이 이용되고 있다. 그러므로 토진 및 구개파열을 전반적으로 다루는 것은 매우 방대한 것이기 때문에, 먼저 발생빈도, 원인 및 분류에 대하여 간단히 이야기하고 수술시기와 장 많이 쓰이고 있는 수술방법을 다루기로 한다.