• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.3
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• pp.1663-1670
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• 2014

Stress is closely associated with oral diseases, being considered to be one of important variables to affect the improvement of oral health and the quality of life. In this study, a survey was conducted on 550 adults from July 1, 2012, to February 28, 2013. A path analysis was carried out to determine the influence of physical stress symptoms and psycho-emotional stress symptoms on dry mouth, oral mucosal disease and halitosis symptoms. The findings of the study were as follows: Oral mucosa affected halitosis in a direct effect and dry mouth exerted a direct influence on that as well. When stress symptoms affected halitosis, dry mouth and oral mucosa had an indirect impact on that as parameters. Dry mouth exercised a direct influence on oral mucosa. The above-mentioned findings suggested that the physical stress symptoms and psycho-emotional stress symptoms of the adults affected their dry mouth, oral mucosal disease and halitosis both in direct and indirect effects. As the stress of adults is closely bound up with their oral diseases, how to properly cope with stress should carefully be considered in order for them to lead a better life.

• Journal of Oral Medicine and Pain
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• v.38 no.2
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• pp.109-114
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• 2013

Chemical burn on the oral mucosa is caused by contact with various chemical products and manifests with localized mucositis, keratotic white lesions, bleeding, and painful tissue surface due to the coagulation of the tissue. Policresulen ($Albothyl^{(R)}$) is a topical antiseptic, commonly used over-the-counter drug for vaginitis, thrush and stomatitis. This drug is highly acidic with pH 0.6, and can act as a strong corrosive agent to oral mucosa. When inadvertently used in oral cavity, it may cause chemical burns of oral mucosa, resulting necrosis and bleeding surface resembling to erythema multifome. A 56 years old female patient presented with the chief complaints of painful ulcerations on the tongue, the upper and lower lips. On intraoral examination, an erythromatous, erosive or ulcerative surface covered with inflammatory exudates or bleeding crust is observed on the anterior half of the tongue and the upper and lower lips. She has occasionally applied the policresulen solution topically on the tongue to relieve pain from recurrent focal glossitis for about 10 years. In this time she applied it broadly and repeatedly to the tongue, the upper and lower lips for the purpose of pain relief by herself without instruction by physician or dentist. After cessation of policresulen application, the oral mucosa was rapidly recovered with use of topical steroids. In 2 weeks the lesions subsided completely. In summary, inadvertent use of $Albothyl^{(R)}$ on oral mucosa may result in chemical burn, causing mucosal erosion, ulceration and inflammation. It can be recovered by topical use of corticosteroid for 2 weeks after cessation of using $Albothyl^{(R)}$.

• Journal of Oral Medicine and Pain
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• v.38 no.1
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• pp.7-17
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• 2013

The purpose of this study is to investigate the relationship between personality type and symptoms of oral mucosa disease. 393 college students completed the MBTI(Myers-Briggs Type Indicator) and a questionnaire and collected data were analyzed by SAS 9.2 program. The obtained results were as follows : 1. Dysgeusia(p<0.05) and xerostomia(p<0.01) occurred significantly more frequently in I type than E type. 2. Herpetic stomatitis, recurrent aphthous ulcer, glossitis, dysgeusia, burning mouth syndrome and xerostomia seemed to occur more frequently in S type than in N type. 3. Most symptoms of oral mucosa disease seemed to occur the most frequently in the type including NF among 16 types of personality of MBTI. 4. Most subjects had negative attitude in curing their symptoms of oral mucosa disease(p<.0001). Significantly more subjects with I type than E type had negative attitude in curing herpetic stomatitis(p<0.01) and dysgeusia(p<0.05). 5. Most symptoms of oral mucosa disease appeared to occur the most frequently in nervous or sensitive subjects. Therefore a guideline for the individual cure of oral mucosa diseases meeting personality type is necessary.

• Journal of Oral Medicine and Pain
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• v.20 no.1
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• pp.19-28
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• 1995

타액은 구강 환경을 조절하는 여러 가지 유기질과 무기질의 혼합물로 구성되어 있다. 구강 점막은 여러 타액 점액 단백질과 타액 항세균 단백질에 의해서 윤활이 되며 보호된다.타액의 다른 작용은 구강 점막을 축축하게 하고 음식을 부드럽게 한다. 구강건조증은 세균의 침착을 야기시키거나 점막면을 거칠게 하여 출혈이 되기 쉽게 하며 이로 인해 감염이 야기될 수 있다. 이러한 타액의 보호 작용은 mucin, fibronectins, proline-rich glycoproteins, histidine-rich proteins, $\alpha$-amylase, s-IgA 같은 특별한 타액 당단백질에 기인한다고 하는 것이 지난 30년 동안에 알려져 있다. 이러한 분자들의 구조, 구조와 기능사이의 관계, 타액 내 이러한 물질들의 농도에 관한 것들이 알려지고 있는 중이다. 이러한 타액 당단백질 특히 mucin, fibronectin, fucose-rich protein과 s-IgA의 구조와 기능에 대한 현재의 견해들을 이 논문에서 요약하고자 한다.

• Journal of Food Hygiene and Safety
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• v.16 no.2
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• pp.111-116
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• 2001

This study was carried out to evaluate the irritant potential of P-toothpaste in hamster cheek pouch. The test materials were applied once at the beginning of this study into right pouches of hamsters and maintained for 14 days. Animals were administered with P-toothpaste, Bamboo salt toothpaste, D.W. and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, morality, body weights and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between D.W. and P-toothpaste treated group in gross and histopathological findings. Therefore, these results suggest that there was little irritant potential of P-toothpaste in hamster cheek pouch.

• Journal of Oral Medicine and Pain
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• v.19 no.2
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• pp.7-23
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• 1994

구강내 작열감 증후군은 객관적 징후없이 구강점막에 작열감을 나타내는 만성동통장애이다. 다양한 원인요소들이 제시되어 있지만, 이러한 요소들의 관련성에 대해서는 아직 분명하지 않은 실정이다. 그러므로, 이러한 구강내 기능이상의 근본적이고 효과적인 치료를 위해서는 다양한 임상적 관찰과 원인요소의 분석등이 계속 연구 조사되어져야 할 것이다. 저자는 구강내 작열감 증후군의 증상을 호소하는 112명의 환자의 임상적 특징에 대해 조사하고자, 환자군과 대조군에 대해 구강내 작열감 증후군에 관한 설문조사 및 구강검사와 혈액학적 검사를 시행하였으며, 점도계를 사용하여 구강내 작열감 증후군 환자의 자극이 전타액의 점도를 측정하였다. 또한, 환자의 심리적 요인을 파악하고자 간이정신진단검사를 실시한 결과 다음과 같은 결론을 얻었다. 1. 구강내 작열감 증후군은 주로 페경기 전후의 여성에서 많이 나타났으며, 호발부위는 혀, 치주 및 치조점막, 구개, 협점막의 순이었다. 2. 구강내 작열감 증후군 환자에게서 대조군 비해 구강건조감, 미각 및 수면장애, 빈혈, 소화기 장애, 두통과 기타 다른 신체불편감의 호소 등이 더 많이 나타났다. 3. 혈액학적 검사결과, 구강내 작열감 증후군 환자중의 26%와 12%에서 각각 혈중 엽산농도와 철분농도의 저하를 나타냇다. 4. 자극시 분비된 전타액의 점도는 40대와 50대이상의 연령군에서 구강내 작열감 증후군 환자가 정상인에 비해 높았다.(p<0.01). 5. 구강내 작열감 증후군 환자군의 간이정신진단검사의 각 증상차원 및 전체지표의 T점수의 평균치는 정상범위내에 있었으며, 신체화(SOD)와 우울 (DEP)차원의 평균치가 가장 높았다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.38 no.4
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• pp.305-310
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• 2012

Through our entire life, oral care products such as toothpaste are used. Thus the safety of oral care products used every day to our mouth is very important. As the previous study in animal tests or clinical trials, surfactant in toothpaste may cause the oral irritation. However, EU cosmetics legislation prohibits animal testing of cosmetics and its ingredient for animal welfare. Therefore the development of alternative in vitro test has been actively performed to replace or reduce using the animal in many areas. However, the way to evaluate oral mucosal toxicity has been done using animal models or clinical trials from now on. Even more, the experiment with human oral 3D tissue or human oral cell line is used recently. The aim of this study is the development of oral mucosal irritation method without using animal for the safety of the oral care product. We developed in vitro test method for oral irritation by using human oral cell line (YD-38 cell) acceptable to toothpaste which contains insoluble material. By the results of this assay, we could discriminate toothpaste with or without irritating substance as same manner in animal studies reported previously. In addition, we confirmed that toothpaste for babies and children toothpaste irritated oral musoca lower than the general adult toothpaste. The present study suggest that this new in vitro method by using human oral cell line (YD-38 cell) could be used for evaluation of oral irritation without using animal.

• Journal of Dental Rehabilitation and Applied Science
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• v.31 no.2
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• pp.134-142
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• 2015

Lichen planus is an immune-mediated mucocutaneous disease, affects more frequently middle-aged Caucasian women and makes signs and symptoms in the oral mucosa. Cutaneous lichen planus lesions cause itching but they are self-limiting, oral lichen planus lesions are usually chronic, recalcitrant to treatment and potentially premalignant in some cases. Although, oral lichen planus is non-plaque related disease, they possess particular problems because plaque control is complicated by pain and bleeding and might cause plaque-related disease. The resulting condition comprises accumulations of plaque, which again can influence the progress of oral lichen planus with burning sensation, spontaneous gingival bleeding. Thus, it should be noted that both medication and supportive periodontal treatment are essential for the remission of the lesions. This case report introduces topical corticosteroid therapy and supportive periodontal treatment including intensive oral hygiene procedures to obtain an improvement of subjective symptoms and objective changes and to prevent relapse the lesions.

• Journal of Oral Medicine and Pain
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• v.33 no.4
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• pp.317-322
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• 2008

The moderners of industrial society suffer from various stresses, which bring about increase in prevalence of temporomandibular disorders, oral mucosal disease and chronic neuropathic pain, therefore, the number of patients seeking help of those symptoms tend to increase. The purpose of this study was to discuss the importance of oral medicine related disease by investigating questions that appeared in cyber consultation of Kangnung National University Dental Hospital web site. Among the nearly 2000 questions, the rate of questions related to oral medicine was 20.92%, and the rate of questions related to other departments were oral and maxillofacial surgery 16.87%, conservative dentistry 16.67%, orthodontics 14.02%, prosthodontics 12.25%, periodontics 8.36%, pediatric dentistry 4.93%, preventive dentistry 2.08% and otherwise questions 3.90%. Among the 403 questions related to oral medicine, the frequent questions were oral mucosal diseases 44.17%, temporomandibular disorders 41.19%, halitosis 4.47%, xerostomia 3.23%, other orofacial pain 2.23%, forensic dentistry 1.49% and otherwise questions 2.98%. From the higher rate of questions related to oral medicine compared with other fields of dentistry, we would consider that the people are considerably concerned about the oral medicine related disease, such as oral mucosal diseases and temporomandibular disorders.

• The Journal of the Korean dental association
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• v.25 no.4 s.215
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• pp.315-322
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• 1987