• Journal of Chest Surgery
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• v.27 no.5
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• pp.386-389
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• 1994

신생아에서 심실중격결손을 동반하지 않은 대혈관전위증 (Transposition of th egreat arteries with intact ventricular septum)의 해부학적교정은 저체중등의 외과적 위험인자에도 불구하고 심방내 교정보다 생리적이다는 점에서 선호되고 있고 조기수술성적이 향상되었다고는 하나 아직도 국내사망율은 높은 편이다. 저자들은 최근 3.5Kg(생후 19일), 3.6 Kg(생후 16일)된 신생아에서 Jatene operation 2례를 치험하였기에 보고하는 바이다.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.13 no.4
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• pp.295-300
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• 2015

The precise determination of the activity for each radionuclide in environmental samples requires the self-absorption correction factor. In this research, we derived the self-absorption correction factor for three p-type high purity germanium detectors using the Monte Carlo code MCNPX. These detectors have different characteristics such as crystal diameter, height and size of the core. We compared the calculated full-energy peak efficiency with the experimental value using a standard sample with $1g/m^3$ density and verified the modeling. We simulated the dependency of the full-energy peak efficiency on the 0.3, 0.6, 0.9, 1.0, 1.2 and $1.5g/m^3$ samples and obtained the corresponding self-absorption correction factor. The self-absorption correction factors calculated for the three detectors differ by less than 1% over most of the energy range and sample densities considered. This indicates that the self-absorption correction factors are independent of the crystal characteristics of HPGe detector.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.11
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• pp.1427-1434
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• 2008

This study was aimed to compare nutrition knowledge, dietary attitude and habit of elementary school children with and without education. Eighty-four subjects with unbalanced eating behavior were selected and assigned to either control or education group. The subjects in education group participated in a nutrition education program once a week for 8 weeks. The contents of nutrition education were on food tower, balanced nutrition, nutrient function, food group, importance of breakfast, and nutrition label, etc and the program was performed by a school dietitian. The effects of education was assessed by self-administered questionnaire prior to and after nutritional education. Nutrition knowledge except on snack, dietary self-efficacy except on low fat/ low calorie, attitude except on functional food and favorite, and general dietary habits of children in education group were significantly improved while those in control group showed no changes. Also, factors for unbalanced eating was improved by nutrition education indicating the need for correction on unbalanced eating was diminished. However, children's adherence to snack, instant and fast food remained to be corrected. The dietary habit of balanced eating was improved by education reducing the percentage of unbalanced eating on grain and meat.fish.milk groups. The nutrition education appears to be effective to provide nutrition knowledge thereby to improve dietary attitude, dietary self-efficacy, and partly to reduce children's unbalanced eating factor.

• Progress in Medical Physics
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• v.21 no.1
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• pp.120-125
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• 2010

For the measurements of an absorbed dose using the standard dosimetry based on an absorbed dose to water the variety of factors, whether big, small, or tiny, may influence the accuracy of dosimetry. The beam quality correction factor ${\kappa}_{Q,Q_0}$ of an ionization chamber might also be one of them. The cylindrical type of ionization chamber, the PTW30013 chamber, was chosen for this work and 9 chambers of the same type were collected from several institutes where the chamber types are used for the reference dosimetry. They were calibrated from the domestic Secondary Standard Dosimetry Laboratory with the same electrometer and cable. These calibrated chambers were used to measure absorbed doses to water in the reference condition for the photon beam of 6 MV and 10 MV and the electron beam of 12 MeV from Siemens ONCOR. The biggest difference among chambers amounts to 2.4% for the 6 MV photon beam, 0.8% for the 10 MV photon beam, and 2.4% for the 12 MeV electron beam. The big deviation in the photon of 6 MV demonstrates that if there had been no problems with the process of measurements application of the same ${\kappa}_{Q,Q_0}$ to the chambers used in this study might have influenced the deviation in the photon 6 MV and that how important an external audit is.

• Journal of Chest Surgery
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• v.36 no.12
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• pp.911-920
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• 2003

In this study, we analyzed the long-term surgical outcome of partial atrioventricular septal defects during the past 17 years at Seoul National University Hospital. Material and Method: A retrospective analysis on mortality, survival, and reoperation and their risk factors was done in 93 patients who underwent surgical correction of partial atrioventricular septal defects between April 1986 and December 2002. 32 patients were male and 61 were female with a median age of 68 months (3∼818 months) and a mean follow-up period of 108 months (1∼200 months). Result: There were 4 operative deaths (4.3%) and one mortality during the follow-up period. 3, 5, 10, and 15 year actuarial survival rates were 95.7%, 94.3%, 94,3%, and 94.3%, respectively. After the surgical correction, left atrioventricular valve Incompetence was improved in 61patients (67.7%), remained same as the preoperative status in 14 patients (15.1%), and was aggravated in 12 patients (12.9%). Reoperation was performed in 8 patients (9.0%) after a mean interval of 38.6 months (3∼136 months). Freedom from reoperation rates at 3, 5, 10, and 15 years after surgical correction were 94.0%, 91.4%, 91.4%, and 88,2%, respectively Reasons for reoperation were 7 left atrioventricular valve incompetence, 2 left ventricular outflow tract obstruction, a residual atrial septal defect, a left atrioventricular valve stenosis, and a right ventricular failure. Left ventricular outflow tract obstruction was the only statistically significant factor. In ten patients, significant arrhythmia was developed and three of them were supraventricular arrhythmia. Complete atrioventricular block occurred in 7 patients and permanent pacemakers were implanted in six of them. Conclusion: Surgical corrections of partial atrioventricular septal defects were performed with low operative mortality. Since left atrioventricular valve incompetence was the most common cause of reoperation and left ventricular outflow tract obstruction was the only risk factor for reoperation, a precise estimation of the left atrioventricular valve morphology and the structure of left ventricular outflow tract are needed. Although left ventricular outflow tract obstruction rarely developed, reoperation was frequently required and resection of subaortic tissue could be peformed but the possibility of recurrence was high, so modified Konno operation could be performed with satisfactory results. Complete atrioventricular block developed frequently in early periods, but was overcome with a precise anatomical understanding of conduction system and experience.

• Journal of Plant Biotechnology
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• v.48 no.1
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• pp.34-43
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• 2021

Targeted genome editing using the CRISPR/Cas9 system is a ground-breaking technology that is being widely used to produce plants with useful traits. However, for woody plants, only a few successful attempts have been reported. These successes have used Agrobacterium-mediated transformation, which has been reported to be very efficient at producing genetically modified trees. Nonetheless, there are unresolved problems with plasmid sequences that remain in the plant genome. In this study, we demonstrated a DNA-free genome editing technique in which purified CRISPR/Cas9 ribonucleoproteins (RNPs) are delivered directly to the protoplasts of a hybrid poplar (Populus alba × Populus glandulosa). We designed three single-guide RNAs (sgRNAs) to target the stress-associated protein 1 gene (PagSAP1) in the hybrid poplar. Deep sequencing results showed that pre-assembled RNPs had a more efficient target mutagenesis insertion and deletion (indel) frequency than did non-assembled RNPs. Moreover, the RNP of sgRNA3 had a significantly higher editing efficacy than those of sgRNA1 and sgRNA2. Our results suggest that the CRISPR/Cas9 ribonucleoprotein-mediated transfection approach is useful for the production of transgene-free genome-edited tree plants.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.45-51
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• 2013

Purpose: This study was performed to provide indicator of expected aniseikonia by correcting refractive error and to investigate influential factors on aniseikonia. Methods: 20 college students (14 males, 6 females, a mean age of $22.50{\pm}2.72$ years) were selected as subjects whose refractive error with spherical equivalent were within ${\pm}0.50$ D, corrected visual acuity were more than 1.0, and aniseikonia values by AWAYA were less than 1%. After correcting refractive error with spectacles in anisometropia induced by wearing contact lens on their dominant eye or non-dominant eye, practical measured values of aniseikonia were compared with theoretical expected values of it by the formula of spectacle magnification. Results: Practical measured values were higher than theoretical expected values in induced aniseikonia over the whole range of diopter of wearing contact lens. And there was higher measured value of aniseikonia in case of higher diopter of wearing contact lens to induce anisometropia and correcting refractive error with spectacles of (+) diopter after wearing contact lens of (-) diopter to induced anisometropia in dominant eye of women. Conclusions: It is considered that dominant eye plays more important role for visual function in induced aniseikonia and factors such as the induced eye of aniseikonia, the diopter of wearing contact lens, and gender have influenced on aniseikonia.

• Progress in Medical Physics
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• v.15 no.4
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• pp.215-219
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• 2004

Due to their excellence for the high-energy therapy range of photon beams, researchers show increasing interest in applying MOSFET dosimeters to low- and medium-energy applications. In this energy range, however, MOSFET dosimeter is complicated by the fact that the interaction probability of photons shows significant dependence on the atomic number, Z, due to photoelectric effect. The objective of this study is to develop a very detailed 3-dimensional Monte Carlo simulation model of a MOSFET dosimeter for radiological characterizations and calibrations. The sensitive volume of the High-Sensitivity MOSFET dosimeter is very thin (1 ${\mu}{\textrm}{m}$) and the standard MCNP tallies do not accurately determine absorbed dose to the sensitive volume. Therefore, we need to score the energy deposition directly from electrons. The developed model was then used to study various radiological characteristics of the MOSFET dosimeter. the energy dependence was quantified for the energy range 15 keV to 6 MeV; finding maximum dependence of 6.6 at about 40 keV. A commercial computer code, Sabrina, was used to read the particle track information from an MCNP simulation and count the tracks of simulated electrons. The MOSFET dosimeter estimated the calibration factor by 1.16 when the dosimeter was at 15 cm depth in tissue phantom for 662 keV incident photons. Our results showed that the MOSFET dosimeter estimated by 1.11 for 1.25 MeV photons for the same condition.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.383-385
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• 2008

본 논문은 헤드스페이스 추출에 의한 절연유중 가스분석 결과의 정확도 향상을 위해 여러 가지 인자들을 고려하였으며, 진단결과의 신뢰도 향상을 위해 표준절연유를 직접 제조하여 이에 의한 교정을 통해 분석법의 진단 신뢰도 향상을 제고하였다. 기존의 추출율이 높은 토플러 추출방법에 대한 결과와 Headspace 분석법에 의한 결과를 각각 비교하고, Headspace 추출법에 의한 결과의 정확도 향상을 위해 여러가지 인자들을 고려하였다. 향후 최적 조건을 수립하여 수은에 의한 인체 유해성이 없는 Headspace 분석법으로의 전환을 모색하고자 한다.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2004.11a
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• pp.117-118
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• 2004

에어로졸의 측정은 다양한 변수에 영향을 받는다. 입자가 공기 중에 떠 있으므로 입자 주위의 유체온도와 압력에 영향을 받을 뿐 아니라 측정 대상인 입자의 크기, 농도, 하전 상태에 따라서 제약을 받는다. 특히, 에어로졸의 발생이나 측정은 복잡한 메커니즘으로 이루어지기 때문에 장비의 성능을 평가하거나 교정하는 과정은 쉽지 않고, 적당한 지침이나 문헌 또한 부족한 실정이다. 고농도, 고하전인 극한 조건에서 나노 에어로졸 입자를 측정하는 경우에는 측정 장비가 신뢰성 있는 결과를 제공할 수 있도록, 측정 대상인 나노 입자의 하전량, 형상, 크기 분포를 미리 예측하여 SMPS의 운전조건을 적절하게 결정할 수 있도록 미리 확인해야 한다