• Journal of Acupuncture Research
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• v.22 no.3
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• pp.227-241
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• 2005

Objective & Methods : The purpose of this study is to observe the effects of Asari Herba Cum Radice herbal-acupuncture solution(AHCR-HAS) on arthritis of mice induced by Collagen II at Joksamni(ST36). The author performed several experimental items. First, it is the cell survival rate of mice lung fibroblasts and expression of TNF-${\alpha}$ in synovial cells. Second, it is the incidence rate of arthritis and the weight of spleen. Third, it is the levels of IL-6, TNF-${\alpha}$, INF-${\gamma}$, IgG, IgM and anti-collagen II in serum Fourth, it is histological analysis of the mice joint. Fifth, it is expression ratio of CD3e+ to CDl9+ cell, CD4+ to CD8+ cell, CD69+/CD3e+ cells, CD11+/CD19+ cells and CD11b+/Gr-1+ cells. Result : 1. The highest survival rate of mice lung fibroblasts were measured in the 1% AHCR-HAS, and the expression of TNF-${\alpha}$ in synovial cells were significantly decreased in the 1% AHCR-HAS. 2. In the AHCR-HA I & AHCR-HAII groups, the incidence of arthritis and the weight of spleen were significantly decreased. 3. In AHCR-HAI & AHCR-HAII groups, the levels of IL-6, INF-${\gamma}$, TNF-${\alpha}$, IgG, IgM and anti-collagen II in serum of CIA mice were significantly decreased. 4. In histology, the cartilage destruction and synovial cell proliferation were decreased in the AHCR-HA I & AHCR-HAII groups, and the collagen fiber expressions in the AHCR-HA I & AHCR-HAII groups were similar with that of the Normal group. 5. In the AHCR-HA I & AHCR-HA II groups, the expression ratio of CD3e+ to CD19+ cell and CD4+ to CD8+ cell were similarly maintained as Normal group in lymph nodes, and CD69+/CD3e+ cells and CD11a+/CD19+ cells were decreased in Iymph nodes, and CD11b+/Gr-1+ cells were decreased in synovium. Conclusion : Taking all these observations into account, AHCR-HA is considered to be effective in prophylaxis and treatment of rheumatoid arthritis, and then more effective in prophylaxis than treatment, so put to practical use in future rheumatoid arthritis clinic.

• Korean Journal of Plant Resources
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• v.19 no.4
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• pp.491-496
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• 2006

Antimicrobial activity of 18 different traditional medicinal herbs extracts against Staphylococcus aureus was determined by a paper disc method. The Prunella vulgaris, Caesalpinia sappan and Rhus javanica extracts in 5 mg/ml, Poncirus trifoliata, Lonicera japonica and Seutellaria baicalensis extracts in 10 mg/ml and Schizandra chinensis, Alpinia katsumadai, Siegesbeckia orientalis extracts in 30 mg/ml showed a significant antimicrobial activity against Staphylococcus aureus. Minimum inhibitory concentrations of medicinal herbs extracts were in the range of $1{\sim}34\;mg/ml$ and $1{\sim}46\;mg/ml$, in the case of MeOH extracts and EtOH extracts, respectively. In addition, the antimicrobial activity of each solvent fraction was most significant with EtOAc layer. Optical density at 620nm after 24 hours incubation of Staphylococcus aureus in the presence of 100, 300 or 500 ppm of Caesalpinia sappan extract ranged from 0.02 to 0.03 compared to 0.4 in the absence of Caesalpinia sappan extract, indicating that growth of Staphylococcus aureus was significantly inhibited within 24 hours by the addition of at least 100 ppm of Caesalpinia sappan extract. Optical density at 620 nm after 24 hours incubation of Staphylococcus aureus in the presence of 300 ppm of Rhus javanica extract ranged from 0.02 to 0.03 compared to 0.4 in the absence of Rhus javanica extract, indicating that growth of Staphylococcus aureus was also significantly inhibited within 24 hours by the addition of at least 300 ppm of Rhus javanica extract. Optical density at 620 nm after 24 hours incubation of Staphylococcus aureus in the presence of 300 ppm of Seutellaria baicalensis extract ranged from 0.02 to 0.07 compared to 0.4 in the absence of Seutellaria baicalensis extract, indicating that growth of Staphylococcus aureus was also significantly inhibited within 24 hours by the addition of at least 300 ppm of Seutellaria baicalensis extract. In conclusion, these findings suggest that extracts from medicinal herbs may play important roles for antimicrobial activities against Staphylococcus aureus.

• Journal of agricultural medicine and community health
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• v.30 no.3
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• pp.279-292
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• 2005

Objectives: The purpose of this study is to analyze agricultural accident and disease using statistical data and materials about National Survey for Health & Nutrition in 2001 and to provide fundamental materials for studies about farmers' health and safety, decision of priority about research and policy. Results: Diagnosed chronic disease prevalence is 72.4% in farmer/fisher group, 49.8% in non farmer/fisher group. The chronic disease prevalence of musculoskeletal disease, circulatory disease, and gastroenteric disease is 46.5%, 18.2%, and 17.9% in farmer/fisher group respectively. The prevalence of musculoskeletal disease in farmer/fisher is 2.4 times higher than non farmer/fisher. This result shows that it need to evaluation for risk factors of musculoskeletal disease preferentially. Lifetime accident/poisoning rate is 18.2% In farmer/fisher group and 13.3% in non farmer/fisher group. The types of accidents were fracture>sprain>contusion and the reasons of accidents were traffic accident>falling/sliding. Conclusions: "Bad or very bad" response of farmer/fisher is almost 2 times higher than non farmer/fisher group. The rate of smoking and no exercising in farmer/fisher group is higher than non farmer/fisher group.

• Journal of agricultural medicine and community health
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• v.33 no.1
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• pp.1-10
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• 2008

일개 농촌 마을에서 농한기를 활용하여 시행된 근골격계 질환 예방사업을 소개하고 주요 사업결과를 분석하여 농업인의 건강증진을 위한 기초자료로 활용하고자 본 연구를 수행하였다. 2006년 12월 5일부터 2007년 1월 26일까지 사곳리 마을회관을 12회 방문하여 4번의 기초교육과 5번의 심화교육 등 9번의 근력 및 유연성 강화교육을 실시하였다. 교육 전(사전평가), 기초교육과 심화교육 사이(중간평가), 교육 후(최종평가) 등 3회에 걸쳐 의사 2인에 의한 근골격계 질환 평가, 시각통증척도에 의한 근골격계 통증 평가, 생활체육 전문가 3인에 의한 좌우의 악력, 배근력, 하지근력, 몸통, 어깨, 하지, 무릎유연성 측정을 통한 근골격계 근력 및 유연성 평가, 설문지를 사용한 어깨, 허리, 무릎의 기능 평가를 실시하였다. 총 12회의 일정 중 1회 이상 참석한 농업인은 총 57명이었으며 남자가 20명(35.1%), 여자가 37명(64.9%)이었으며 평균 연령은 60.7(±8.1)세였다. 근골격계 질환 검진에서 한 번 이상의 검진을 받았던 43명중 32명(74%)이 한 가지 이상의 근골격계 질환을 가지고 있었으며, 퇴행성관절염이 26명(60.5%), 근막통 증후군이 19명(44.2%), 허리디스크가 10명(23.3%)이었다.목어깨, 허리, 무릎다리의 통증정도는 1차, 2차 평가 간, 2차, 3차 평가 간, 1차, 3차 평가 간의 비교에서 모두 감소하는 경향을 보였으며 3차 평가에서 1차 평가에 비해 목어깨, 허리, 무릎다리 모두 유의한 통증의 감소를 보였다(p<0.05). 근골격계의 기능을 1차, 2차 평가 간, 2차, 3차 평가 간, 1차, 3차 평가 간 비교한 결과 모두 기능점수가 우수하게 변화했으나 통계적으로 유의하지 않았다. 근력 및 유연성 정도는 좌우의 악력, 배근력, 하지근력, 몸통, 어깨, 하지, 무릎유연성을 측정하였으며 1차 평가에 비해 3차 평가에서 모든 항목에서 근력 및 유연성 정도가 통계적으로 유의하게 증가하였다(p<0.05).연구대상자의 수가 적었고, 농한기에 의한 근골격계 질환의 개선 효과를 배제할 수는 없었지만 이번연구를 통하여 일부 농업인에서 근골격계 질환 관리 프로그램 실시 후 근골격계 질환의 단기적인 개선효과를 볼 수 있었다. 근골격계 질환의 중장기적인 개선효과를 기대할 수 있는 추가적인 연구와 농번기를 통한 관리 프로그램에 대한 추가적인 연구가 필요하다.

• Journal of Dental Rehabilitation and Applied Science
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• v.31 no.2
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• pp.150-157
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• 2015

The purpose of this report is to suggest clinical managements of implant periapical lesions by presenting three clinical cases managed by either the infected form or the inactive form with the follow-up period of five to twelve years. One patient with no clinical symptom was regarded as inactive form. Two patients having pain were regarded as infected form and have been under the systemic antibiotic therapy. In one patient, the symptom subsided and the size of radiolucent lesion decreased. However, the other patient showed increased size of lesion causing the implant unstable, which leaded to remove the implant and to replace it. There was neither additional increase of the lesion nor functional problem for all three. It is important to detect implant periapical lesion in early stage before jeopardizing the stable implant and manage properly using systemic antibiotic therapy and surgical approach if needed, depending on infected form and inactive form.

• Journal of Preventive Medicine and Public Health
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• v.34 no.4
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• pp.331-336
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• 2001

Objectives : To assess the prevalence of knee osteoarthritis through proper diagnosis in a rural community and to elucidate the relevant factors of this health problem in order to develop educational methods for the prevention of female knee osteoarthritis as well to provide basic data for prospective research. Methods : Over a period of three months starting from August, 2000, 432 women over the age of 40 and living in a rural area were selected by a multistage cluster sampling method in order to investigate the prevalence of knee osteoarthritis and the related factors. The study utilized interviews and radiological examination. The criteria of knee osteoarthritis used was the American College of Rheumatology classification criteria for osteoarthritis of the knee(1995). Results : The adjusted prevalence of knee osteoarthritis among the subjects was 55.0%, and multiple logistic regression analysis showed that the odds ratio(OR) of knee osteoarthritis among subjects 50-59 years of age and subjects older than 60 years of age as compared to subjects 40-49 years of age were 2.43(95% CI: 1.30-4.70) and 4.40(95% CI: 2.47-7.83), respectively. The OR of knee osteoarthritis among factory workers or farmers as compared to others was 1.79(95% CI: 1.03-3.12). The OR of knee osteoarthritis among subjects who had a family history and subjects who had knee injury or surgical history against those subjects had neither were 2.56(95% CI: 1.42-4.03) and 4.70(95% CI:1.45-15.19), respectively. The OR of knee osteoarthritis among smokers against non smokers was 0.47(95% CI: 0.22-0.97). Conclusions : Related factors of knee osteoarthritis included age, occupation, family history, smoking, knee injury and history of surgery In order to prevent knee osteoarthritis in high risked rural woman, education concerning self-care methods and safety guideline must be provided at the work place by the public and private health sectors. Additionally, these women should be continually encouraged to exercise, including jogging and swimming regularly.

• Clinical and Experimental Pediatrics
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• v.48 no.1
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• pp.75-80
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• 2005

Purpose : Internal tibial torsion is prevalent in East Asian countries such as Korea and Japan, where sitting on the floor is common behavior. Internal tibial torsion or excessive lateral tibial torsion may cause esthetical, functional, or psychological problems and also may induce degenerative arthritis in older age. The purpose of this study is to measure the tibial torsion in children of the Jeju area. Methods : Tibial torsion was measured in 1,042 lower extremities of 521 children from one to 12 years of age. The values of transmalleolar angles were analyzed for each age group divided by 6 months. Quadratic and linear regression models were used to fit patterns of changes in mean values of transmalleolar angles. The age at seven, which provides the highest coefficient of determination for quadratic regression analysis, was used as a cut-off point to fit different statistical models. Results : The mean transmalleolar angle was $0.10{\pm}5.79^{\circ}$ in all children,$ 0.90{\pm}5.49^{\circ}$ in males, and $-0.80{\pm}5.97^{\circ}$ in females. The value was $4.25{\pm}4.04$ in 1 year of age, gradually decreased to the lowest level of $-1.98^{\circ}$ in four years and seven months of age, increased again with age until it reached $0.67{\pm}1.10^{\circ}$ at seven years of age, and stayed at that level thereafter. Conclusion : Internal tibial torsion in infancy is known to correct spontaneously in the normal developing process. But in this study, the mean transmalleolar angle in children of Jeju area annually decreased after one year of age; to the lowest angle at four years and seven months of age; increased again gradually to the age of seven; and persisted in that level, about $10^{\circ}$ less than western children, not correcting further thereafter. These findings suggest tibial torsion might be caused by lifestyle, especially sitting on feet. To prevent abnormalities of joints and gaits, early diagnosis of tibial torsion in childhood and posture correction or early treatment when needed, seems to be necessary.

• Journal of Life Science
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• v.30 no.11
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• pp.983-989
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• 2020

The balance between bone-resorbing osteoclasts and bone-forming osteoblasts is key to bone health. An imbalance between osteoclasts and osteoblasts leads to various bone-related disorders, such as osteoporosis, osteomalacia, and osteopetrosis. However, the bone-resorption inhibitor drugs that are currently used may cause side effects. Natural substances have recently received much attention as therapeutic drugs for the treatment of bone health. This study was designed to determine the effect of Tenebrio molitor larvae ethanol extract (TME) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. To measure the effect of TME on osteoclast differentiation, RAW264.7 cells were treated with RANKL with or without TME for 5 days. The tartrate-resistant acid phosphatase (TRAP) activity was significantly inhibited by treatment of TME without cytotoxicity up to 2 mg/ml. In addition, TME effectively suppressed expression of osteoclast differentiation-related marker genes and proteins such as TRAP, NFATc1, and c-Src. TME also significantly inhibited the p38 mitogen-activated protein kinase (MAPK) signaling pathway without affecting ERK and JNK signaling in RANKL-induced RAW264.7 cells. Consequently, we conclude that TME suppresses osteoclast differentiation by inhibiting RANKL-induced osteoclastogenic genes expression through the p38 MAPK signaling pathways. These results suggest that TME and its bioactive components are potential therapeutics for bone-related diseases such as osteoporosis.

• Journal of agricultural medicine and community health
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• v.36 no.4
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• pp.207-217
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• 2011

Objectives: The purpose of this study is to garner useful information through a comparative analysis of health behaviors and health states between the young-old and old-old elderly in a rural Korean area. Methods: We define the young-old elderly as those 65 to 74 years of age, and the old-old as those over 70. The survey was administered in October and November of 2009 at senior citizen centers in Sangju City, Kyongsangbuk-do, South Korea. The number of subjects surveyed approximated the demographics of the aged population of the administrative district of centers of 24 eup, myeon, and dong. Results: Compared with the young-old elderly, the old-old were vulnerable to population sociological characteristics. While there were many cases of contraction of diseases, only a small percentage of old-old elderly were engaged in regular exercise. In addition, the old-old elderly lagged behind the young-old in terms of physical activity, mental and oral health, hearing, and vision. Conclusions: The vulnerability of the old-old elderly in terms of physical and mental health needs to be acknowledged as various characteristics of the elderly that appears according an age group. A variety of disease prevention and health promotion programs that focus on the health behavior and status of the young-old and old-old elderly need to be developed and put into practice.

• Journal of Preventive Medicine and Public Health
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• v.9 no.1
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• pp.1-10
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• 1976

This study was conducted in order to observe some descriptive epidemiological findings and causes of life-long labour force loss in the rural population of Korea, and to consider, on the basis of these observations, some principles of the necessary control measures. The total number of subjects in the study was 27,172, all family members of 4,174 households. The study population was located in the 81 counties, out of a total of 138 counties, where the college students conducted service activities during the summer of 1974. In each village area where these service activities were conducted, one household per student interviewer was randomly selected. Student interviewers were instructed on the contents of the questionnaire prior to the survey. The main contents of the questionnaire form included address, name, sex and age of each family members, and present life-long labour force loss, if any, of each family member. In cases of current labour force loss, the age of onset and causes were recorded. Of the total households surveyed, 8.9% had family members (1-4 in number) with life-long labour force loss. Of the total persons surveyed, the crude prevalence rate for life-long labour force loss was 15.1 per 1,000; and the age-standardized prevalence rates for male and female were 16.3 per 1,000 and 13.4 per 1,000, respectively. The rates, in both sexes, were gradually increased as the ages were increased. The prevalence rates per 1,000, in order, for life-long labour force loss by the causes were 10.2 for senility, 2.4 for impairment of extremities, 1.2 for chronic diseases of internal organs, 0.5 for other conditions of muosculoskeletal system, 0.4 for blindness in both eyes, 0.2 for impairment of spine, 0.2 for psychoses, and 0.1 for epilepsy. Among them the causes of impairment of extremities were stroke, poliomyelitis, accidents, arthritis and injury due to war operation, in that order of higher relative frequency. The frequency ratios by age of onset were also observed by the causes and sex.