• Journal of Life Science
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• v.21 no.11
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• pp.1652-1657
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• 2011

The production of blood cells is regulated by more than 20 different growth factors, called hematopoitic growth factors. These factors have been produced in prokaryotic and mammalian systems for their clinical use. Glranulocyte-Colony Stimulating Factor (G-CSF) is an important therapeutic factor for cancer patients as well as patients with congenital conditions. These patients do not have enough neutrophils and have a high risk of infection. Two groups of recombinant G-CSF have been used to specially treat cancer patients after chemotherapy because chemotherapy induces neutropenia, a major side effect of chemotherapy drugs. Here, structural and biological characteristics of G-CSF are presented. In addition, the relationship between chemotherapy and neutropenia, which is a severe reduction of neutrophils in the blood, and clinical application of G-CSF is discussed. Recombinant G-CSFs are grouped in two forms. Non-glycosylated G-CSF, filgrastim, is produced in Escherichia coli and glycosylated G-CSF, lenograstim, is produced in Chinese hamster ovary cells. Differences in structure and biological activity are compared and challenges for biosimilar production are also highlighted.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.257-257
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• 2017

본 연구는 기상이변의 영향으로 지속적으로 발생되고 있는 댐 저수지 붕괴에 대한 원인 분석과 기존의 관련 연구 및 지침 등을 비교 분석하여 현재 실무에서 적용되고 있는 댐 저수지 비상대처계획(EAP) 수립 대상 기준에서 제외되는 시설물의 붕괴 가능성 평가를 통해 EAP 수립 대상의 적정 범위를 제시하고자 하였다. 이를 위해 본 연구에서는 시설물의 붕괴 가능성에 대한 정량적 판단 기준을 각 요인별로 제시하고, EAP 수립 대상에서 제외되는 댐 저수지를 대상으로 붕괴 가능요인을 적용하여 3개 이하의 붕괴요인에 해당될 경우 저위험군, 4개 및 5개의 붕괴요인에 해당될 경우 중위험군과 고위험군으로 각각 분류하여 시설물 붕괴 위험성 정도에 따른 적절한 대응이 이루어질 수 있도록 제안하였다. 댐 저수지 붕괴 사례 분석을 통해 도출된 붕괴 가능성의 주요 요인으로는 저수용량, 제체 높이, 준공 경과연수, 우심피해 및 지진피해 잠재지역이 포함되며, 각 요인별 객관적인 판단기준은 댐 저수용량의 경우 EAP 법적 수립기준 및 과거 붕괴사례 등의 분석을 토대로 붕괴사례 61개소 중에서 약 88%를 차지하는 저수용량 10만톤을 선정하였으며, 댐 높이의 경우 댐의 파괴양상(이종태, 1987)에서 제시한 댐 붕괴부 특성과 미국주댐안전협회(ASDSO: American Society of Dam Safety Official) 학술지인 Dam Safety(2006) 등에서 제안한 기준을 기존의 댐?저수지 붕괴사례에 적용하여 댐 붕괴폭과 댐 높이의 상관관계 분석 결과를 바탕으로 댐 높이 8m 이상을 적정 범위로 고려하였다. 준공 경과연수의 경우에는 국민안전처 "재해위험저수지 댐 관리 지침" 타당성 평가기준인 '시설노후도' 기준과 한국시설안전공단 사회간접자본 노후화 기준에 해당하는 경과연수 기준을 토대로 30년 이상을 기준으로 선정하였으며, 우심피해 및 지진피해 잠재지역은 국민안전처 재해연보(2014)를 기준으로 과거 10년 동안의 우심피해 발생 지역과 기상청 국내 지진 규모 10위권 내에 포함되는 지역을 고려 대상으로 하였다. 본 연구에서 도출한 시설물 붕괴 가능성에 대한 판단기준을 국민안전처에서 고시한 EAP 수립 대상에서 제외되는 지자체 재해위험저수지 354개소에 적용해 본 결과, 저위험군 16개소, 중위험군 5개소, 고위험군 2개소로 각각 조사되었다. 저위험군은 전문 시설물 관리자에 의한 주기적인 시설물 점검 및 관찰이 필요할 것으로 사료되며, 중 고위험군에 속하는 시설물의 경우 본 연구의 결과를 바탕으로 시설물 하류지역의 실질적인 인명 및 경제적 피해 가능성에 대한 보다 면밀한 조사를 통해 EAP 수립 대상 포함여부를 결정하여야 할 것으로 판단된다.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.6 no.3
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• pp.191-202
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• 2016

Social distance can indicate cognitive and behavioral attitudes toward a social group, and is useful for investigating people situated in a socially vulnerable position. When the children from multicultural family aware negative attitudes from peer Korean children, self-confidence and social competence can be disturbed. This study intended to examine influential factors on children's social distance towards children from multicultural families including multicultural contact experience, stereotype, ethnically homogeneous nationalism, thereby providing empirical evidence on social distance regarding multicultural families and their children. The results of this study are as follows. First, when the Korean children felt closeness with a multicultural child, when the ethnicity of the foreigner resided in the neighbor is White or Black, when they contact multicultural children through the media and a multicultural education, the level of social distance was higher, while the neighbor's ethnicity is Abrab, social distance was lower. Second, there was a significant association between the higher level of Korean children's positive cognition and emotion and the lower level of social distance. Third, hierarchial regression analyses demonstrated that positive emotion and cognition decreased the level of social distance, while both closeness with a multicultural child and taking the multicultural education increased the level of social distance. Finally, based on these results, this study suggested implications for social work practice and research to better understand and reduce children's social distance towards children from multicultural families.

• Journal of dental hygiene science
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• v.14 no.4
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• pp.571-579
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• 2014

This study was conducted to provide basic data for improvement of the oral health management ability and the factors affecting oral health recognition and practice of 6th graders. The research subjects total 259 numbers of 6th grade students in two schools located in Changwon, it was investigated and analyzed with structured questionnaires. The collected data is analyzed by using IBM SPSS Statistics 19.0. The average oral health recognition score investigated were $3.19{\pm}0.41$, and $2.95{\pm}0.43$ for oral health practices. The oral health recognition was statistically significant differences by father's education (p<0.01), perceived oral health status (p<0.01), perceived grade (p<0.01), intention to attend oral health education (p<0.001). The oral health practices was statistically significant differences by father's education (p<0.01), perceived oral health status (p<0.001), perceived grade (p<0.05), parent's interest in child's toothbrushing (p<0.01), experience of oral health education (p<0.001), intention to attend oral health education (p<0.05). The factors that may improve the oral health recognition are in order of oral health practices, intention to attend oral health education, and parent's attention to child's tooth brushing. The factors that may improve the oral health practice was found to be in order of oral health recognition, parent's attention to child's tooth brushing, and perceived oral health status. As a result, in order to improve oral health management ability of 6th grade students, the surrounding environment, the attitude on oral care, the interest of oral, and the current disease status of oral health are required to be identified, then the oral health education program should be provided.

• Journal of Life Science
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• v.33 no.3
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• pp.277-286
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• 2023

Sarcopenia is the age-related loss of muscle mass and function. It is a natural part of aging and can lead to decreased mobility and increased frailty. The ubiquitin-proteasome pathway, which is involved in muscle protein degradation, is closely linked to sarcopenia. Germinated Rhynchosia nulubilis hydrolysate (GRH) has been reported to have anti-inflammatory and antioxidant properties, but there have been no reports on its inhibitory effect on muscle reduction. However, no study has yet explored the relationship between GRH and muscle loss inhibition. In this study, we evaluated the effects of GRH on muscle atrophy inhibitory activity in dexamethasone (Dexa)-induced muscle atrophy C2C12 myotubes and mouse models. Moreover, we identified a molecular pathway underlying the effects of GRH on skeletal muscle. May Grunwald-Giemsa staining showed that the length and area of myotubes increased in the groups treated with GRH. In addition, the GRH-treated group significantly reduced the expression of muscle ring finger protein 1 and muscular atrophy F-box (MAFbx) in the Dexa-induced muscular atrophy C2C12 model. GRH also improved muscle strength in C57BL/6 mice with Dexa-induced muscle atrophy, resulting in prolonged running exhaustive time and increased grip strength. We found that muscle strengthening by GRH was correlated with a decreased expression of the MAFbx gene in mouse muscle tissue. In conclusion, GRH can attenuate Dexa-induced muscle atrophy by inhibiting the ubiquitin-proteasome pathway via downregulation of the MAFbx gene expression.

• Cartoon and Animation Studies
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• s.46
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• pp.63-84
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• 2017

Overwhelming images of vividly colored aircraft flying across the blue sky and steam gushing from massive machines are reminiscent of Japanese animation films, especially of works by master director Hayao Miyazaki. By presenting together steam engines, which are mechanical devices of the Industrial Age in the past, and aircraft of the future age, the director constructs ambiguous space and time. These special time and space constitute nostalgia for past time, with devices called steam engines as a medium, and a longing for science and the future as represented by aircraft. In addition, the anticipation and disappointment, ideals and regrets of humans who see these two from the perspective of the present are projected on the works. This shares the characteristic of the steam punk genre, which seeks to return to the past rather than to face current problems. A subgenre of science fiction (henceforth "sci-fi"), steam punk reflects fundamental skepticism of science and technology and mechanized civilization, which have developed beyond human control. In addition, as works that clearly display such characteristics, director Miyazaki's and < $Nausica{\ddot{a}}$ of the Valley of Wind> can be examined. With spectacles of steam engines and aircraft, these two works enticingly visualize narratives about nature and humans and about the environment and destruction. Such attractiveness on the part of the master director's works has led to support from fans worldwide. However, often in the backgrounds of director Miyazaki's works, which have depicted ideal worlds of nature, environment, and community as highly concentrated fantasies, lie presuppositions of war and the end of the world. As works that are especially prominent in such characteristics, there are and . These two works betray the expectations of the audience by establishing the actual wartime as the temporal background and proceeding toward narratives of reality. Trapped in the ontological identity of the director himself, the war depicted by him projects a subjective and romantic attitude. Such a problem stems also from the ambiguity of the hybrid space and time, which is basic to the steam punk genre. This is because the basic characteristic of steam punk is to transplant past time, which humans were able to control, in the future from a perspective of optimism and longing via steam engines rather than to face current problems. In this respect, steam punk animation films in themselves can be seen as having significance and limitations at the same time.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.2
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• pp.46-65
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• 2013

Purpose: Generally menstrual disorder caused by functional deficiency of ovary is not treated clinically because it manifests as normal process of growth. In this study we collected experimental group having several or severe menstrual disorder and we tried to find out whether there is any relationship between menstrual disorders and the function of Thoroughfare and Conception vessels or not. Methods: First, this study was researched to learn the meaning and the symptoms of 'the emaciation of Thoroughfare and Conception vessels', and to learn the relationship between menstrual disorders and 'the emaciation of Thoroughfare and Conception vessels' through literature review. And we set up a experimental group who have two or more menstrual disorders or severe degree of menstrual disorders(N=97) and control group who don't have menstrual disorders(N=97) as a result of the menstruation survey. Afterwards we conducted the DSOM in both experimental group and control group. Results and Conclusions: The meaning of 'the emaciation of Thoroughfare and Conception vessels' is deficiency of qi and blood from the Thoroughfare and Conception vessels. As a result, the female reproductive system is difficult to be worked properly with deficiency of skin, muscles, bone, and vessels. Symptoms of the emaciation of Thoroughfare and Conception vessels are classified into drying, skinny body, feeling of cold, menstrual disorders, pain and personality traits. In this study, severity of drying, skinny body, feeling of cold, menstrual disorders, pain and personality traits is significantly higher in experimental group than in control group. Like this, symptoms of 'the emaciation of Thoroughfare and Conception vessels' appear with menstrual disorders because disorder of circulation is occurred by qi and blood deficiency of Thoroughfare and Conception vessels. It is appropriate to identify this case as 'the emaciation of Thoroughfare and Conception vessels' pattern and necessary to treat actively through regulating qi and blood in advance.

• Journal of Life Science
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• v.18 no.8
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• pp.1140-1146
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• 2008

In order to improve the functional properties of kochujang, garic porridge was added to traditional kochujang during manufacturing. Changes in physiochemical properties of kochujang by garic porridge addition were then investigated. No big differences in general chemical compositions was observed between three kinds of kochujangs tested in this study, general kochujang purchased from a market (GK), kochujang added with raw garlic (RGK) and kochujang added with garlic porridge (GPK). However, GPK showed higher level of antioxidant and anticancer activities than those of others. The methanolic extract of GPK showed 66.38% of DPPH radical scavenging activity, while the extracts of GK and RGK exhibited 38.44% and 50.97%, respectively. Also, the effects of three different extracts of kochujangs on cell proliferation of stomach cancer cell (MKN 45), colon cancer cell (HCT116), and lung cancer cell (NCI-H460) were investigated using MTT assay. All of three extracts exhibited the highest anti-proliferative activity against stomach cancer cell, even though the proliferation of colon cancer cell and lung cancer cell were also inhibited. Among them, the extract of GPK showed the highest anti-proliferative activity (62.35%) against stomach cancer cell. From the results obtained in the present study, we concluded that the antioxidant and anticancer activity of GPK mainly originated from garlic because GPK was consisted of 23% garlic (w/w) compared to 10% (w/w) of RGK.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.4
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• pp.636-644
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• 2003

This study compared the perceptions of children and their mothers of the effects of school lunch programs on the children's dietary behaviors in elementary schools. Questionnaires were answered by 425 elementary school students and their 412 mothers in the Busan area. The results indicated: The school lunch program had positive effects on children's dietary behaviors such as understanding healthy meals, correcting unbalanced diets, snack intake, attitude toward the meal, table manners, and table hygiene. However, there were still some negative habits in the home related to snack time, reading books or watching television during mealtime, eating foods before seniors have started. The gender of the children and whether the mothers worked or not produced no significant differences (in most cases). Still mothers more positively perceived the effect of school lunch programs on their children's dietary behaviors than did the children themselves. Thus, the school lunch program had positive effects for a balanced diet and making good eating habits. And, therefore, teachers-as well as the dieticians- should actively regard the school lunch program as an educational activity which can produce positive effects for a balanced diet, and make every endeavor to strengthen their relationship with the home.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.11
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• pp.1843-1847
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• 2013

This study is carried out to sanitize rape (Brassica napus) pollen by gamma irradiation. Rape pollens were treated with 0, 5, 10 and 15 kGy gamma irradiations, and then analyzed for the following: general composition, microbial population, reducing sugar, Hunter color values, TBARS (2-thiobarbituric acid reactive substances) values, and VBN (volatile basic nitrogen). Mold and coliform bacteria were not detected in the samples irradiated at 5 kGy or more. Yeasts and total aerobic bacteria were not detected in the samples irradiated at 10 kGy or more (<$10^2$ CFU/g). Moisture, ash, crude protein, crude fat, carbohydrate, reducing sugar and the contents of volatile basic nitrogen in the irradiated pollen did not show any significant changes by irradiation. Hunter color values, $L^*$, $a^*$ and $b^*$ values were decreased with increment of irradiation dose. TBARS values were increased with an increment of irradiation dose. In conclusion, gamma irradiation at 5 kGy was considered to be an effective treatment to control for mycotoxin producing fungi in rape pollen to minimize changes of general composition and physicochemical properties. Further studies should be investigated to reduce the detrimental effects induced by irradiation.