• Tuberculosis and Respiratory Diseases
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• 제64권5호
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• pp.369-373
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• 2008

결절성경화증은 유전성 신경피부 증후군으로 피부, 뇌, 신장 등의 여러 장기에 과오종을 형성하는 질환이다. 결절성경화증의 폐 침범은 드물지만 다발성 미세결절의 소견을 보이는 경우, 정확한 진단을 위해서는 고해상 흉부 전산화 단층 촬영 및 조직 검사가 필요하겠으며, 다발성 미세결절폐세포증식증을 감별 진단으로 고려해야 할 것이다. 이 질환의 임상적 의의 등 아직 알려진 것이 많지 않으나 현재까지의 보고로는 특별한 치료는 없으며 예후는 좋은 것으로 알려져 있다.

• 대한핵의학회지
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• 제32권4호
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• pp.332-343
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• 1998

목적 : 폐 FDG PET 동적영상을 분석하는 다양한 분석 방법을 개발하고 표준섭취계수, 패트랙 도표 분석법, 3구획 추적자 역학 모형(5매개변수 모형, 6매개변수 2관심영역 모형)으로 얻은 매개변수 값을 서로 비교, 분석하여 각 분석 방법들의 종양 진단 정확성과 유용성에 대해 고찰하였다. 대상 및 방법 : 22명의 폐종양 환자(9명: 양성 종양 환자(과오종: 1, 활동성 염증: 8), 13명: 악성 종양 환자(기관지 세포암: 5 포함))에게 약 370 MBq (10 mCi)의 FDG를 정맥 주사한 후, GE Advance 양전자방출단층촬영장치를 이용하여 56분 동안 PET 동적영상을 얻은 후, 감쇠보정하여 횡단면 영상을 얻었다. 환자의 몸무게와 혈장 포도당 농도로 규격화된 SUVglu를 계산하였으며, 패트랙 도표 분석법과 3구획 5매개변수 모형과 3구획 6매개변수 2관심영역 모형을 이용하여 FDG 섭취상수($K_{pat},\;K_{5p},\;K_{6p}$)와 당대사율($MR_{pat},\;MR_{5p},\;MR_{6p}$)을 구하였다. 다양한 분석 방법들로 얻은 매개변수들을 수신자판단특성곡선으로 분석하였으며 곡선 아래 면적을 구하였다. 결과: 다양한 분석방법으로 측정한 악성과 양성 병변의 섭취상수와 당대사율은 통계적으로 유의한 차이가 없었다. 각 방법으로 구한 수신자판단특성곡선 아래 면적은 다음과 같다: $SUVglu:\;0.73,\;K_{pat}:\;0.66,\;MR_{pat}:\;0.77,\;K_{5p}:\;0.71,\;MR_{5p},\;0.73,\;K_{6p}:\;0.70,\;MR_{6p}:\;0.78.\;K_{pat} $와 $MR_{pat}$의 곡선 아래 면적은 통계적으로 유의한 차이를 보였다(p<0.05). 결론: FDG PET 동적영상을 이용한 다양한 추적자 역학 분석 방법을 사용자가 편리하게 사용할 수 있도록 개발하였다. 표준섭취계수, 패트랙 도표 분석법, 3 구획 모형 분석법 둥에 의한 정략적 매개변수의 정확성은 유사헌 것으로 관찰되었다. 추적자 역학 분석 방법으로 얻어진 정량적 매개변수는 객관적 수치정보를 제공하므로써 FDG PET의 유용성을 증가시킬것으로 기대되며, 정량적 매개변수의 임상적 유용성을 밝히기 위해서는 활동성 염증, 과오종이나 기관지 세포암 확률이 낮은 환자군을 대상으로 한 추가 연구가 필요한 것으로 판단된다.

• Journal of Chest Surgery
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• 제18권3호
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• pp.470-473
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• 1985

We performed clinical analysis about 20 cases of pulmonary parenchymal and intrabronchial hamartoma in Korea by literatures of the Korean Journal of Thoracic and Cardiovascular Surgical Society during 8 years from September 1976 to September 1984 and in addition to our hospital experienced 4 cases of pulmonary parenchymal hamartoma during same periods. 1] There were no cases below second decades. 2] Patients of pulmonary parenchymal hamartoma were asymptomatic, but patients of intrabronchial hamartoma were symptomatic [dyspnea & frequent upper respiratory tract infections]. 3] Pulmonary parenchymal hamartoma were confirmed by removal of mass, but intrabronchial hamartoma were confirmed by bronchoscopic biopsy. 4] There were no malignant changes in both type of pulmonary hamartoma.

• Journal of Chest Surgery
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• 제12권2호
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• pp.101-104
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• 1979

Lymphoid hamartomas are a rare benign disease which can be easily treated by complete surgical excision. They developed most often in the thorax, and can be discovered usually on routine chest X-ray.p But some of them can also be found because of pressure symptoms or the presence of a palpable mass if outside the thorax. We experienced a case of the hyaline-vascular type of lymphoid hamartoma in the left hilum of a 29 year-old Korean male in March, 1979. He was well except intermittent cough and left chest discomfort of a year duration and was treated by resection of the left upper lobe including nodular tumor masses. The histological characteristics were an aggregation of lymphoid follicles composed of concentrically arranged mature lymphocytes with centrally placed thick walled arterioles showing endothelial proliferation and some of them were hyalinized. Between the follicles, there was extensive capillary proliferation and infiltration of numerous lymphocytes, scanty plasma cells and eosinophils.

• Journal of Chest Surgery
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• 제27권3호
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• pp.215-220
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• 1994

From Jan. 1981 to Dec. 1993, 24 cases of pulmonary hamartoma were experienced sugically at the Department of Thoracic Surgery, College of Medicine, Seoul National University. They consisted of 11 females and 13 males. The age distribution was 24 years to 71 years with a mean age of 49 years. They included 3 cases of endobronchial hamartoma, and 21 cases of pulmonary parenchymal hamartoma. Fifty eight percent of patients [14/24] were asymptomatic. One patient had a multiple pulmonary parenchymal hamartoma, and 1 patient also had combined lung cancer. The operative procedures were 9[37.5%] wedge resections, 5[20.8%] lobectomies, 3[12.5%] enucleations, 3[12.5%] segmental resections, 2[8.3%] bilobectomies, 1[4.2%] lobectomy and segmentectomy, and 1[4.2%] lobectomy, wedge resection, and enucleation. All of the operative results were excellent and without complication.

• 대한기관식도과학회지
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• 제14권2호
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• pp.48-52
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• 2008

Ectopic Hamartomatous thymoma(EHT) is a rare benign tumor that occurs mainly in the supraclavicular or suprasternal area. Since this entity was first reported by Smith et al. in 1982, less than 50 cases have been reported in the literature. Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or malignant peripheral nerve sheath tumor because EHT follows a benign clinical course. We experienced a case of ectopic hamartomatous thymoma in the suprasternal area in a 53-year-old man. Here, we present the case with a review of the related literatures.

• Journal of Chest Surgery
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• 제22권3호
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• pp.473-477
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• 1989

Pulmonary hamartoma has been considered as rare disease, which consists of lung tumor less than 1 %. Originally described by Albrecht in 1904, hamartoma is tumor like malformation-abnormal mixing of the normal components of organ-and is applied also to tumor found in many organs other than the lung. Lately, the major conclusions are that pulmonary hamartoma is neoplastic rather than developmental error in origin. Because pulmonary hamartoma frequently mimics lung cancer, especially in cancer-risk age groups, its clinical significance is great. Recently, we experienced 1 cases of endobronchial hamartoma which located at the right main stem bronchus. The patient was a 54 year old male who was admitted due to symptoms of fever 4 chilliness and dyspnea. Radiologic studies such as chest x-ray, chest tomogram and chest C-T scan revealed that the nearly total haziness of the right lung was caused by endobronchial tumor. The mass was considered as a benign by bronchoscopic exam, so we removed it surgically by tracheobronchotomy without pulmonary resection. Postoperative chest x-ray revealed satisfactory reexpansion of previous collapsed right lung. The patient discharged uneventfully.

• 대한세포병리학회지
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• 제11권1호
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• pp.19-24
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• 2000

Pulmonary hamartomas are uncommon benign tumors, usually discovered radiologically as a solitary coin lesion in asymptomatic individual. The approach to the patient with a peripheral lung nodule has changed with the increasing acceptance of fine needle aspiration cytology(FNAC) as a rapid, safe, inexpensive, and highly accurate diagnostic tool. However, a few reports describing the FNAC findings of pulmonary hamarioma have appeared in the cytologic literature and the experience of FNAC is limited. We reviewed all 9 cases of pulmonary hamartoma with histologic confirmation after FNAC seen at Asan Medical Center since 1995 to evaluate cytologic findings and to determine the value of FNAC in identifying that lesion. Originally, seven of nine patients were diagnosed as pulmonary hamartoma, while two patients were diagnosed as inflammatory lesion and adenocarcinoma of each. On review, eight of nine patients were considered as diagnostic of pulmonary hamartoma. The diagnostic findings in FNAC of pulmonary hamartoma were the presence of fibrillary myxoid tissue with spindle cells as well as hyaline cartilage.

• Journal of Chest Surgery
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• 제15권2호
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• pp.155-161
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• 1982

The term hamartoma was first used by Albrecht to describe what he considered to be localized errors of development involving one or more tissue native to the organ of origin. The definition was meant to encompass not only abnormal local growth rate, but also the spatial arrangement, relative proportions and degree of the component tissue. But lately the major conclusions are that this group of lesion is neoplastic than developmental in origin. The Importance of pulmonary hamartoma is that they are relatively common among the benign tumor of the lung, but they usually present as asymptomatic coin lesion on chest x-ray film and were find out In routine check up and frequently mimic clinically the more common lung tumor such as cancer. Recently, we have experienced three cases of pulmonary hamartoma which were all discovered during routine chest film check up for certificate of health and evaluation of other disease. All of these were surgically resected with good result. Among the operations, one of these was mass enucleation and the others were lobectomy of lung involved by the mass.

• Journal of Chest Surgery
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• 제9권2호
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• pp.169-174
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• 1976

Since. its first description by Albrecht in 1904 that hamartoma (Greek. meaning "error" and "tumor")is tumor-like malformation characterized by abnormal mixture of normal constituent in any organ it arises, hamartoma involving the lung has assumed the following clinical features.: 1) all the pulmonary lesions presenting as "coin lesions", it occupies about 8% according to various reports. It also constitutes the most prevalent lesion of all the benign lung tumors, appearing in 0.25% of the general population. 2) Peak incidence of the lesion occurs in the 5th and 6th decade as the carcinoma patient do, and the occasional growing tendency and periperal location as in this presentation renders the differential diagnosis from the malignant disease difficult and surgical intervention inevitable for definite histological diagnosis and treatment. 3) Nearly all the clinical investigations such as history, physical exam, bronchoscopy, culture, and cytological exam of sputum sre likely to futile:the only tool for detecting the presence of the lesion is X-ray, butthat's short of telling the true nature of it. 4) Because of its age of presentation and growing tendency in middle-aged adult, it still controversial whether it is developmental anomaly as Albrecht described, or true neoplasm denovo of fibrous connective tissue origin. This is a case report of surgical experience of pulmonary hamartoma which had nearly all the typical clinical features above mentioned and was reviewed with related literatures.