• Journal of Chest Surgery
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• v.23 no.1
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• pp.9-15
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• 1990

This study was designed to investigate the protective effect of chlorpromazine against the reperfusion injury of myocardium after high potassium cardioplegic arrest. Langendorff`s preparations of rat heart were infused with high potassium cardioplegic solution[St. Thomas Hospital Solution] at 25oC. Chlorpromazine [10-7Ｍ] increased the recovery of myocardial contractility[dp/dt], left ventricular pressure[LVP], and coronary flow rate of the reperfused heart. Both in control and experimental groups, the restoration of myocardial activity could not reach to the level of preplegic control. These results suggest that the etiologic factors of the reperfusion injury include the influence of high potassium cardioplegic solution and/or reperfusion itself, and that chlorpromazine protects myocardium from the reperfusion injury.

• Annual Conference on Human and Language Technology
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• 1996.10a
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• pp.222-228
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• 1996

기존의 미등록어 추정 방법은 대부분 단일 어절 접근 방법으로 단일 어절에서 추출할 수 있는 추정 정보가 부족하여 과분석과 오분석의 가능성이 높았다. 그래서 동일 미등록어를 가진 어절들을 동시에 분석하는 유사 어절 접근 방법이 제시되었다. 그러나 이 방법도 유사 어절의 범위를 조사나 어미만 다른 어절로 정의함으로써 수집될 수 있는 유사 어절의 수가 제한되어 대략의 텍스트에서만 적용이 가능하였다. 이에 본 논문은 유사어절을 동일 음절열을 공유하는 어절들로 확장 정의하여 작은 크기 N의 텍스트 윈도우에서 유사 어절의 발견 가능성을 높임으로써 실시간으로 미등록어를 추정할 수 있게 하는 방법을 제시한다. N을 100으로 한 실험결과는 미등록어 추정 정확도가 99.3%였고 재현율은 약 32%였다.

• Annual Conference on Human and Language Technology
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• 1996.10a
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• pp.255-261
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• 1996

한국어 형태소 분석 방법중 최장일치법은 영어의 분석처럼 one-pass로 한국어를 분석할 수 있도록 하는 기법에 가장 적절하다. 그러나 최장일치법은 매우 많은 분석 후보를 생성하여 탐색 회수가 많아 시스템의 성능을 떨어뜨린다. 또한 대부분의 한국어 형태소 분석 시스템들은 형태소 자체에만 중점을 두어 한국어 분석 시스템 전체의 성능은 고려하지 않아 형태소 분석 시스템의 결과가 파서의 입력에 적절치 못한 결과를 생성한다. 본 논문에서는 형태소 분석의 원형복원 규칙과 사전 탐색을 통합하여 과분석 후보에 대한 탐색 회수를 줄이고 전체 시스템의 성능을 향상시키기 위해 파서에 적합한 입력을 제공하는 확장된 최장일치법을 제안한다.

• The Monthly Diabetes
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• s.214
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• pp.35-37
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• 2007

당뇨병환자에서 발생하는 가장 중요한 급성 합병증인 당뇨병성 케톤산증이나 고삼투성 비케톤성 혼수는 인슐린의 투여를 중단하였거나 감염, 외상 등의 신체적 손상이나 정신적 스트레스에 의하여 인슐린에 대한 길항 호르몬들이 과분비돼 발생한다. 일반적으로 당뇨병성 케톤산증은 인슐린 의존형 당뇨병환자 중 주로 젊은 층에서 자주 나타나며 병의 경과가 빠르게 진행되기 때문에 고삼투압 상태보다는 케톤산혈증이 주요 문제가 된다. 반면에 고삼투압성 비케톤성 혼수는 인슐린 비의존형 당뇨병환자 중 주로 노인층에서 호발하며 병의 경과가 서서히 진행하기 때문에 심한 고혈당 상태로 인한 고삼투압 상태가 주요 문제가 된다. 이와같은 당뇨병의 급성 대사성 합병증들은 치료가 지연되거나 적절한 치료가 행해지지 못했을 때는 예후가 극히 불량하며 사망률 또한 높은 것으로 보고되고 있다. 이에 급성 대사성 합병증 중 당뇨병성 케톤산증의 병인, 진단 및 치료 등을 알아보기로 한다.

• Applied Biological Chemistry
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• v.42 no.1
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• pp.45-48
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• 1999

Rice was ground on a blade-type food mixer and sieved on meshes. The throughs on 60 and 80 mesh sieves were significantly different among maturity groups. The hardness of rice grain was negatively correlated with throughs on 60 and 80 mesh sieves and positively correlated with overs on 20 mesh sieve. The amylograph peak viscosity was increased as the particles became finer, but peak viscosities of the throughs on 60 and 80 mesh sieves were not significantly different.

• Journal of KIISE:Software and Applications
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• v.28 no.3
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• pp.305-315
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• 2001

본 논문에서는 우리말 문서에 있는 오류를 어절 단위로 검증하는 철자 오류와 여러 어절을 분석해야 처리할 수 있는 문법 오류로 분류하였다. 문법 오류를 처리할 때 전체 문장 분석은 시간이 많이 소요되고 구현하기 어려우므로 대부분 부분 문장 분석 방법을 이용한다. 기존 연구에서 사용한 부분 문장 분석은 분석 어절에 어휘 중의성이 있을 때 문장 분석 종결 또는 과분석 등의 오류가 발생한다. 본 논문에서는 문법 검사기에서 어휘 중의성 때문에 발생하는 문제점을 해결하는 방법으로 어휘 중의성 제거 규칙을 사용한다. 본 논문에서 구현한 어휘 중의성 제거 모듈은 코퍼스 데이타에서 얻은 경험적 규칙을 기반으로 한다. 이 경험적 규칙은 언어적 지식을 기반으로 한다.

• Korean Journal of Environment and Ecology
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• v.30 no.1
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• pp.130-134
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• 2016

How does $CO_2$ affect on the stomatal mechanism? The mechanism of stomatal opening by $CO_2$ is not clear as it is difficult to see $CO_2$ effect on light-induced stomatal opening. Furthermore, stomata may react differently according to the concentration of $CO_2$. The significance of the possible endogenous rhythms must consider to understand on $CO_2$-related response. It is clear that $CO_2$ has an effect on the accumulation of osmotic materials which determines the degree of stomatal apertures because it is known that stomata open in the condition of the reduced $CO_2$ concentration. However, it is not fully understood how $CO_2$ leads to the stomatal opening. It has been thought that $CO_2$ can not affect on the ion fluxes which determines the increase of osmotic potential in guard cells. However, in this study, the changes of guard cell membrane permeability by $CO_2$ have been focused on. There are many reports that $CO_2$ related reactions are dominant when the leaf is exposed to certain a mount of $CO_2$. The hypothesis of the stomatal opening by light is based on the increase of osmotic materials in guard cells including $K^+$, $Cl^-$, sucrose and $malate^{2-}$. It was reported that $CO_2$ induced a big hyperpolarization indicating that $H^+$ was extruded to the cell outside. It was also found that $CO_2$ caused guard cell membrane hyperpolarization in the intact leaf up to 3 or 4 times higher than that of light induced membrane hyperpolarization. These results represent that $CO_2$ can affect on the change of physical characteristics which affects on the change of the membrane permeability.

• Tuberculosis and Respiratory Diseases
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• v.55 no.1
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• pp.21-30
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• 2003

Background : Mucin synthesis in airways has been reported to be regulated by the epidermal growth factor receptor (EGFR) system. Epidermal growth factor receptor transactivation was identified as a critical element in G-protein-coupled receptors (GPCRs)-induced mitogenic signaling. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. This study was hypothesized that lipopolysaccharide (LPS)-induced mucin production associates with epidermal growth factor receptor transactivation, and MUC5AC production associates with epidermal growth factor receptor transactivation by G-protein-coupled receptors that regulates by metalloproteinase. Method : MUC5AC mucin production was examined in NCI-H292 cells and MUC5AC protein synthesis was assessed using ELISA. For the evaluation of mechanism of LPS-induced MUC5AC production, $TNF{\alpha}$ was measured using ELISA with or without pretreatment of heterotrimeric G-protein inhibitor, mastoparan. MUC5AC protein was measure with pretreatment of polyclonal $TNF{\alpha}$ antibody or mastoparan on LPS-induced MUC5AC production. For the evaluation of relation of G-protein and MUC5AC production, G-protein stimulant, mastopara-7, or matrix metalloproteinase, ADAM10, was added to NCI-H292 cells. MUC5AC protein was measure with pretreatment of polyclonal EGF antibody on mastoparan-7-induced MUC5AC production. Results : LPS alone did not increase significantly MUC5AC production. LPS with $TNF{\alpha}$ induced dose-dependently MUC5AC production in NCI-H292 cells. LPS increased dose-dependently $TNF{\alpha}$ secretion, which was inhibited by mastoparan. LPS with $TNF{\alpha}$-induced MUC5AC production was inhibited by neutralizing polyclonal $TNF{\alpha}$ antibody, mastoparan or AG 1472. Mastoparan-7 or ADAM10 increased dose-dependently MUC5AC production, which was inhibited by polyclonal neutralizing EGF antibody. Conclusion : In LPS-induced MUC5AC synthesis, LPS causes $TNF{\alpha}$ secretion, which induces EGFR expression. EGFR tyrosine kinase phosphorylation result in MUC5AC production. EGF-R transactivation by G-protein-coupled receptors requires matrix metalloproteinase cleavage of proHB-EGF.

• Journal of Embryo Transfer
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• v.21 no.1
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• pp.35-43
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• 2006

Ions play important roles in various cellular processes including fertilization and differentiation. However, it is little known whether how ions are regulated during early embryonic development in mammalian animals. In this study, we examined changes in $Ca^{2+}\;and\;K^+$ concentrations in embryos and oviduct during mouse early embryonic development using patch clamp technique and confocal laser scanning microscopy. The intracellular calcium concentration in each stage embryos did not markedly change. At 56h afier hCG injection when 8-cell embryos could be Isolated from oviduct, $K^+$ concentration in oviduct increased by 26% compared with that at 14h after injection of hCG During early embryonic development, membrane potential was depolarized (from -38 mV to -16 mV), and $Ca^{2+}$ currents decreased, indicating that some $K^+$ channel might control membrane potential in oocytes. To record the changes in membrane potential induced by influx of $Ca^{2+}$ in mouse oocytes, we applied 5 mM $Ca^{2+}$ to the bath solution. The membrane potential transiently hyperpolarized and then recovered. In order to classify $K^+$ channels that cause hyperpolarization, we first applied TEA and apamin, general $K^+$ channel blockers, to the bath solution. Interestingly, the hyperpolarization of membrane potential still appeared in oocytes pretreated with TEA and apamin. This result suggest that the $K^+$ channel that induces hyperpolarization could belong to another $K^+$ channel such as two-pore domain $K^+(K_{2P})$channel that a.e insensitive to TEA and apamin. From these results, we suggest that the changes in $Ca^{2+}\;and\;K^+$ concentrations play a critical role in cell proliferation, differentiation and reproduction as well as early embryonic development, and $K_{2P}$ channels could be involved in regulation of membrane potential in ovulated oocytes.

• Clean Technology
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• v.29 no.1
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• pp.10-21
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• 2023

Hydrogels that are made of natural polymer-based double networks have excellent biocompatibility, low cytotoxicity, and high water content, assuring that the material has the properties required for a variety of biomedical applications. However, hydrogels also have limitations due to their relatively weak mechanical properties. In this study, hydrogels based on an alginate di-aldehyde (ADA) and gelatin (Gel) double network that is reinforced with additional hydrogen bonds formed between the hydroxyl (-OH) groups of the hyperbranched polymer (HPG) and the functional groups present inside of the hydrogels were successfully synthesized. The enhanced mechanical properties of these synthesized hydrogels were evaluated by varying the amount of HPG added during the hydrogel synthesis from 0 to 25%. In addition, magnetite nanoparticles (Fe₃O₄ NPs) were synthesized within the hydrogels and the structures and the magnetic properties of the hydrogels were also characterized. The hydrogels that contained 15% HPG and Fe₃O₄ NPs exhibited superparamagnetic behaviors with a saturation magnetization value of 3.8 emu g^-1. These particular hydrogels also had strengthened mechanical properties with a maximum compressive stress of 1.1 MPa at a strain of 67.4%. Magnetic hydrogels made with natural polymer-based double networks provide improved mechanical properties and have a significant potential for drug delivery and biomaterial application.