• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.96-100
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• 2010

Objective : The purpose of this case series was to investigate the effectiveness of GagamZihwang-tang for enuresis and frequent urination. Method : We prescribed GagamZihwang-tang and provided acupuncture therapy weekly. Results of before and after therapy were evaluated and scored twice a month. Results and conclusion : The study showed decrease of urination frequency from 17th-20th a day to 6th a day.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.1
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• pp.106-115
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• 2012

Purpose: The purpose of this study is to report the clinical effectiveness of oriental medicine on overactive bladder. Methods: The patients suffering from overactive bladder were treated by oriental medical treatment such as herbal medication, acupuncture and moxibustion therapy. Results: After Oriental medical treatments, the symptoms of overactive bladder disappeared and the patients' quality of life improved. Conclusions: This case report shows that the oriental medical therapy is effective against overactive bladder.

• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.1
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• pp.69-81
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• 2013

Purpose: The aim of this study is to determine associated factors affecting the utilization of Medical Care for an overactive bladder. Methods: Total 114 women with overactive bladder participated in this study. Patients were categorized in two groups, the patients with treatment experiences for an overactive bladder(n=40) and without treatment experiences for an overactive bladder(n=74). Patients completed Overactive Bladder Severity Score, Beck Depression Inventory, King's Health Questionnaire, and questionnaires on treatment experience. The results were analysed using SPSS for Windows 12.0k. All statistical tests were two-sided with a p-value < 0.05 being significant. Results: Patients with treatment experience had a greater score on KHQ, OABSS, BDI and had longer symptom duration period than those without treatment experience. And only Impact of Life(P=0.004), Role Limitation(P=0.004), Social Limitation(P=0.007), Emotion(P=0.035), Sleep/Energy(P=0.001), Incontinence Severity Measures(P=0.012) among KHQ domains were statistically significant difference between two groups. Conclusions: The most influencing factor associated with utilization of Medical Service in overactive bladder is the impact of the patient's quality of life.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.1
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• pp.66-75
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• 2010

With the advances in ubiquitous service infrastructure, healthcare services have drawn attention as one of promising application domains. In ubiquitous healthcare services, patients or care-givers as well as medical personnel are asked to play their roles and, in addition, the information system is supposed to have active roles. In medicine, clinical protocols have been developed and put into practice in order to reduce treatment variances and assure the service quality. In the same token, clinical protocols on ubiquitous service practices are need to be developed which takes into account both the clinical details and the ubiquitous service functionality. This paper introduces a clinical protocol modeling methodology which pays attention to participants and their tasks including contextual information. The proposed method has been successfully applied to a real application domain, OAB(overactive bladder) syndrome patient care to see how it builds a clinical protocol.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.3
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• pp.116-126
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• 2011

Objectives: To identify the difference of autonomic nervous system activity in women with overactive bladder between women with pre-menopausal onset and post-menopausal onset. Methods: Total of 46 women with overactive bladder participated in this study. Patients were categorized in two groups, patients with pre-menopausal onset(n=31) and post-menopausal onset(n=15). We measured and compared parameters of Heart Rate Variability of patients. The results were analysed using SPSS for windows 12.0. Results: On frequency domain analysis, the patients with post-menopausal onset had significantly decreased mean value of Total Power, High Frequence, Low Frequence, compared with the patients with post-menopausal onset. Conclusion: Decreased Total Power of patients with post-menopausal onset indicated that they may have had decreased activity of autonomic nervous system. Also, the patients with pre-menopausal onset had relatively increased sympathetic activity than the patients with post-menopausal onset.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.2
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• pp.83-102
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• 2014

Objectives: This study aimed to review Korean medical clinical management of female overactive bladder (OAB). Methods: We reviewed domestic and foreign papers related to Korean Medicine Treatment for OAB and literatures on Korean Medicine added clinical views of authors. Results: OAB is usually diagnosed to Deficiency pattern (Kidney qi deficiency-cold, Spleen-Lung qi deficiency et al.). The primary treatment goals of OAB is improvement of urinary symptom. But a comprehensive treatment approach including improvement of accompanied symptoms such as depression, insomnia, sexual dysfunction and improvement of quality of life is needed. Warming and tonifying herbal medicine, electro-acupuncture and moxibustion using acupoints specially acting bladder function in lower abdomen and lumbar-sacral area and behavioral therapies such as lifestyle modification, bladder training are usually primary treatments. Treatment period is recommended about 3~6 months to recover and stabilize bladder function. Conclusions: OAB is a clinical area that Korean Medicine tend to be more effective. but additional research about Korean Medical Clinical Management of OAB is needed.

• Journal of Sasang Constitutional Medicine
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• v.32 no.3
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• pp.46-54
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• 2020

Introduction This study aims to report a significant improvement of Sjögren's syndrome patient with irritable bladder, diagnosed as 'Soyangin chest-binding symptomatology' based on Sasang medicine. Methods The patient had treatment with 'Dojeokganggi-tang' and western medications. We evaluated the treatment outcome of Sjögren's syndrome symptoms by using a numerical score of 0 to 10, based on the patient's subjective discomfort of dry eye and dry mouth, and irritable bladder symptoms by recording the number of night urination every month. Results Sjögren's syndrome symptoms were significantly improved, and the number of night urination was decreased. After 41 weeks of treatment, the patient didn't have dry mouth any more and had only a little dry eye. The number of night urination was decreased from 3-4 times to once a night. Discussion The patient diagnosed with Sjögren's syndrome, treated with Dojeokganggi-tang and western medications for 41 weeks, showed a significant improvement in dry eye, dry mouth, and night urination compared to the first visit.

• Journal of Sasang Constitutional Medicine
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• v.34 no.4
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• pp.38-48
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• 2022

This study was aimed to report an significant improvement of urinary disturbance in overactive bladder patient using Soeumin's Sibimigwanjung-tang based on Sasang constitutional medicine. Methods A female overactive bladder patient with urinary disturbance including urgency, frequency, nocturia, tenesmus, weak stream was enrolled in this study. The patient was diagnosed as Soeum type greater-yin pattern and medicated with Sibimigwanjung-tang three times a day. Clinical improvement was evaluated with urination diary, International Prostate Symptom Score, Overactive Bladder Symptom Score, Numeric Rating Scale, and percentage of improvement compared to the day of hospitalization. Results Significant improvement was seen in urinary disturbance after 26 days of admission treatment. Also, symptoms of dyspepsia, coldness of hands and feet, and facial edema were improved. Conclusions This clinical case suggests that Sibimigwanjung-tang can be valuable option in treating urinary disturbance in overactive bladder within Soeum type greater-yin pattern.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.3
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• pp.169-184
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• 2009

Purpose: The aim of this study was to estimate the effect of Korean medicine treatment on overactive bladder. Methods: 64 patients of overactive bladder received Korean medicine treatment for at least 30days. We studied retrospectively symptom disappearance rate, the relationship between the improvement rate and age, scale of symptoms, BMI(Body Mass Index), WHR(Waist Hip Ratio). Results: Symptoms of 27 patients were disappeared, and those of 28 patients were improved. But 9 patients didn't show the improvement of their urination problems. The symptom disappearance rate was 43.08%. The improvement rate was 85.15%. The mean${\pm}$standard deviation of daily frequency was reduced from 10.05128 to 7.44872 after treatment(p<0.0001) The symptom disappearance rate was reverse-related with the OABSS score, KHQ and WHR. The improvement rate of married patients was higher than unmarried patients. And especially that was co-related with the frequency of acupuncture and moxibustion treatment. Conclusion: The results of this study suggested that Korean medicine treatments, such as acupuncture, moxibustion and herbal prescriptions have positive efficacy on overactive bladder patients in ordinary clinical practice.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.23 no.1
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• pp.25-30
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• 2023

Leigh syndrome is a rare progressive neurodegenerative mitochondrial disorder with clinical and genetic heterogeneity. Recently, balletic IARS2 variants have been identified in a number of patients presenting broad clinical phenotypes from Leigh and West syndrome to a rare syndrome CAGSSS characterized by cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia syndrome (OMIM#616007). We describe a child with Korean Leigh syndrome with urologic manifestations resulting from a compound heterozygote mutation in IARS2. A 5-year-old girl visited the emergency room with a complaint of abdominal pain accompanied by abdominal distension. Abdominal-pelvic CT showed a markedly distended urinary bladder without definite obstructive lesions. She was diagnosed with neurogenic bladder dysfunction based on a urodynamic study. She had global delayed development due to neurologic regression after 6 months of age and a history of bilateral cataract surgery at the age of 2 years. Her brain magnetic resonance imaging showed symmetrically increased signal intensities in the bilateral putamen and caudate nuclei with diffuse cerebral atrophy. No gene variants were identified through whole-mitochondrial genome analysis. Whole exome sequencing was performed for diagnosis, and compound heterozygous pathogenic variants were identified in IARS2: c.2446C>T (p. Arg816Ter) and c.2450G>A (p. Arg817His). To the best of our knowledge, this is the first case report of bladder dysfunction manifestation in a patient with IARS2-related Leigh syndrome. Thus, it broadens the clinical and genetic spectrum of IARS2-associated diseases.