• The Journal of the Korean life insurance medical association
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• v.25
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• pp.9-24
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• 2006

지속적으로 증가 하고 있는 악성 종양 발병률의 증가, 생존률의 향상, 조기발견의 증가 등이 암 기왕자의 보험 수요 상승을 가져오고 있으며, 보험시장에서 더 이상 암 기왕자를 도외시하기 어렵게 만들고 있다. 그러나, 현재 국내에서는 암 기왕자를 인수할 수 있는 상품과 언더라이팅 인수 기법이 부족한 실정이다. 본 논문은 이러한 상황 하에서 기존에 거절체로 인식되었던 암 기왕자의 적극적인 인수를 위해 악성종양에 대한 보험 의학적인 고찰과 사망률, 위험도에 대해 분석하고, 국내에서 암 기왕자의 보험 인수 시 문제점과 그 해결방안을 모색해 보았다. 종양은 종양세포의 성장과 확산의 정도를 나타내는 병기와 조직학적 등급에 의해 그 예후와 경과가 예측 가능하며, 이 병기를 표준화하려는 국제적 시도로 1977년 American Joint Committee on Cancer(AJCC)는 TNM system 을 제시하였다. 병기를 기초로 치료의 결정도 함께 이루어지는데, 주요 치료법을 수술, 방사선치료, 항암치료, 면역요법이 있다. 이러한 치료법들은 후기 부작용을 일으키거나 이차성 암(Secondary malignant neoplasm)의 원인이 되기도 한다. 병기에 따른 암환자의 사망률을 살펴 보면, 암은 일정시기 동안 사망률이 급격히 증가하다가 이후에 점차 사망률이 감소하고, 그 이후에는 사망률에 영향을 미치지 않는다. 이러한 사망률 변화의 특성은 암 기왕자에게 평준식 정액 할증법(Per mille flat extra)의 적용이 적절함을 보여준다. 그러나, 현재 국내에서는 악성 종양 기왕자를 위한 상품이 전무한 상태이며, 암의 병리적 병기와 치료에 관련된 정보를 얻을 수 있는 도구도 부족하고, 명확한 인수 기법이 없다. 또한, 자체의 경험통계의 부족으로 위험에 대한 부담감이 큰 것이 현실이다. 하지만, 병기에 따른 사망률의 변화에서도 알 수 있듯이 평준식 정액 할증법의 도입이나, 악성종양의 병기(Stage)별 정액 할증률을 삭감법으로 전환하는 기준을 개발한다면, 종신보험은 충분히 인수가 가능하다. 또한, CI 보험도 암에 대한 부담보를 하는 선진사의 인수 기법을 도입하거나, 암 기왕자만을 위한 CI 상품을 개발하는 등 새로운 인수 기법을 모색한다면, 암기왕자 인수의 폭은 넓어질 것이다. 이와 같은 노력과 함께, 언더라이팅의 정보 획득을 위한 암 기왕자만의 고지서를 개발하고, 전문 언더라이터의 양성을 위한 노력을 게을리 하지 않는다면, 암기왕자를 적극적으로 인수할 수 있을 것이다. 앞으로 국내 보험사가 위와 같은 노력을 지속적으로 해 나가고, 비교적 예후와 경과가 양호한 0기와 1기 암 기왕자부터 단계적으로 종신보험의 인수를 시도한다면, 비교적 안전하게 경험치를 축적할 수 있을 것이다. 뿐만 아니라 국내 보험업계는 새로운 시장의 확보와 보험에 대한 대외 이미지 개선이라는 효과도 함께 얻게 될 것이다.

• Journal of Yeungnam Medical Science
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• v.21 no.2
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• pp.198-206
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• 2004

Background: To evaluate the efficacy and safety of paclitaxel and cisplatin against advanced non-small cell lung cancer (NSCLC) as a second-line chemotherapy. Subjects and Methods: Twenty-five patients were enrolled. The patients received 200 $mg/m^2$ paclitaxel as a 3-hour intravenous infusion and 60 $mg/m^2$ cisplatin as 2D-minute intravenous infusion with vigorous hydration on day 1 every 28 days. The response was assessed every 2 cycles. Results: All 25 patients were assessed for their response and toxicity. Partial responses were observed in 5 patients. The overall response rate was 20%(95% confidence interval, 4%-36%) and the median response duration was 4.5(range, 2-11) months. The median time to progression was 3.3(range, 0-14) months. The median overall survival of all patients was 7.4(range, 1.3-39) months. The hematologic toxicities were minor and easily controlled. Conclusion: The combination chemotherapy of paclitaxel and cisplatin as a second-line treatment has a moderate efficacy with an acceptable toxicity in patients with advanced NSCLC.

• Korean Journal of Environment and Ecology
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• v.28 no.2
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• pp.253-262
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• 2014

This study was conducted to find methods of qualitative landscape assessment for vegetational landscapes using ecological analysis. The study site was Seoraksan National Park in Korea. For this study, differing unique landscape resources were categorized and identified according to ecosystems. After identifying the study areas, the relationship between trail visitor preference and the amount of visible overexposure caused by people to the resources was examined. Landscape resources chosen for ecological analysis at Seoraksan National Park were subalpine vegetation community, high mountain rocks, ombrogenous deciduous broadleaf forest in the valley area, edaphic climax community, big tree community, flowering tree dominant community, autumnal tree dominant community and needle-leaf forest in the subalpine area. As a result of the study, it was found that the landscape resources with the highest correlation to visitor trail preference were big tree community area, flowering tree dominant community area, and needle-leaf forest in the subalpine area. As a result of overlapping the analysis of the amount of visible overexposure to the landscape resources and the analysis of preferential use of trails by visitors, guidance for the appropriate season for each trail can be provided. Since a positive correlation exists between certain sections of the natural landscapes and visitor preference, ecological impact on landscape resource ecosystems did not appear to cover wide areas of the trails, but was limited to certain areas preferred by visitors.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.306-312
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• 2013

The purpose of this study was to grasp the recognition of medical consumer over the infection in dental clinic. The study performed the questionnaire by selecting the patients visiting 3 dental clinics of Daegu area as targets and analyzed 213 question papers collected. The result revealed that the infection control, which was most important for the patients, was 'instrument disinfection' (64.3%) and it was significant in age factor(P<0.01). For the responsibility of infection control, 72.3% replied that 'dentist or dental clinic staff' should be responsible for it and it was significant in academic background factor(P<0.001). For the importance of cleaning and sanitation, 70.0% replied that 'it is very important' and it was gender(P<0.05)and the age factor.((P<0.01) The person who experienced the information about the infection control of dental clinic observed hand washing(P<0.001), replacement of suction tip(P<0.001) and replacement of teeth washing cup (P<0.01) more carefully and considered whether dentist wears protective goggle more importantly than the person who did not experience it(P<0.01). If dental clinic recognizes the evaluation of infection control notified by the Ministry of Health & Welfare and performs the infection control suitable for the eye level of general medical consumer on the basis of the study result above, it can improve the reliance of hospital as well as patient's satisfaction.

• Korean Journal of Food Science and Technology
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• v.41 no.2
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• pp.191-195
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• 2009

We assessed the effect of surimi gel, which is prepared from the king oyster mushroom (pleurotus eryngii) and cuttlefish meat paste (KCP) on lipid metabolism and antioxidant activity in high-cholesterol-fed rats. Three groups of 3-week-old male Sprague-Dawley rats were fed on a diet containing 1 g cholesterol/kg for 6 weeks. We administered only a high-cholesterol diet to the control group, one group was fed on surimi gel containing cuttlefish paste and king oyster mushrooms, and another group was fed with general boiled fish meat paste (GFP), which is commonly sold in marketplaces. Plasma and hepatic lipid profiles were measured, and the antioxidant status of the liver was assessed. The plasma triglyceride concentration did not differ significantly among the groups. Supplementation with KCP resulted in lower plasma and hepatic cholesterol concentrations and atherogenic index as compared to the control group and GFP, whereas the plasma high-density lipoprotein-cholesterol concentration was elevated. Moreover, the KCP-supplemented animals evidenced greater bile acid excretion. The KCP groups evidenced significantly lower plasma and hepatic levels of thiobarbituric acidreactive substances as compared to the control group. Besides, hepatic antioxidant enzyme activities, including catalase and superoxide dismutase, were significantly higher in the KCP group. In conclusion, KCP was quite effective in improving the lipid metabolism and reducing oxidative stress by upregulating the hepatic antioxidant enzymes in high-cholesterol-fed rats.

• Journal of the Korean Society of Food Culture
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• v.5 no.1
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• pp.77-99
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• 1990

In this thesis, according to the kinds of tzeam in the main materials of fish, vegetable and etc was to analysis reference frequency to them the materials, the measuring unit of materials, the terms of cooking by 49 books published in Korea from 1670 to 1987. 1. It was 69 kinds of tzeam in the main materials of fish vegetables and etc. 2. Materials were classified into the main-materials, sub-materials, seasioning and decorations. 3. There were 42 kinds of measuring units, of them 16 kinds were for volume, 16 kinds were for quantity, 2 kinds were for length and the rest measuring units were 8 kinds. 4. There were 22 kinds of cooking terms. The terms of them, 15 kinds were for heating methods, 7 terms of them were for the cutting process.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.21-26
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• 1984

The balance between metabolic activation of xenobiotics and detoxification of their active metabolites may playa vital role in controlling mutagenic and carcinogenic processes. To assess the possible role of P. ginseng C.A. Meyer in detoxification of xenobiotics, we studied the effects of ginseng on several parameters of the monooxygenasd system, including benzo(a) pyrene monooxygenase(AHH) and benzo(a) pyrene epoxide hydratase(EH) as well as effects of ginseng on the conjugation system. Test animals receiving ginseng saponin-fraction induced epoxide hydratase activity to over $150\%$ (20mg/kg b.w.) of the control and increased glutathione transferase activity (GSH-T) up to $140\%$ (20mg/kg b.w.) of the control, whereas no significant changes were observed in the benzopyrene monooxygenase activity (AHH). Such a selective induction of the inactivation enzyme epoxide hydratase, combined with a marked elevation of the detoxifying enzyme glutathione transferase, without a concurrent induction of benzopyrene monooxygenase which is responsible for the formation of carcinogenic intermediates, demonstrates that ginseng has the potential to alter the metabolic course of carcinogenic polycyclic aromatic hydrocarbons, and thereby enhance detoxification. Thus, ginseng may play an important role in the prevention of tumors caused by carcinogens.

• Journal of Life Science
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• v.24 no.8
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• pp.895-902
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• 2014

Adiponectin has been known to improve insulin sensitivity and elicit glucose uptake via increased glucose transporter 4 (GLUT4) translocation. In the current study, mRNA expression levels of adiponectin and GLUT4 were measured in subcutaneous adipose tissue from C57BL/6 mice fed normal (ND) or high-fat diet (HFD) until 16, 26, 36, 47, or 77 weeks of age starting from 6 weeks of age. Expression levels were also measured in mice with calorie restriction (CR) and in thiazolidinedione (TZD) treated mice. Using quantitative real-time PCR, we demonstrated that GLUT4 expression in adipose tissue significantly decreased in HFD mice groups and increased in CR (p<0.05) and TZD (p=0.007) groups while there was no difference in adiponectin mRNA expression levels between experimental and control groups. General linear regression models were used to assess the association of gene expression levels between adiponectin and GLUT4 and to determine whether adiponectin affects GLUT4 transcription. mRNA expression levels of adiponectin and GLUT4 are significantly associated each other in mice fed a ND (p<0.0001) or HFD (p<0.0001), in groups separated into each age and diet, and CR group (p=0.002), but not in TZD group (p=0.73). These results demonstrated that gene expression of adiponectin and GLUT4 is strongly associated, suggesting that there is a common regulatory mechanism for adiponectin and GLUT4 gene expression and/or adiponectin has a direct role in GLUT4 gene expression in adipose tissue.

• 한국지구과학회:학술대회논문집
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• 2010.04a
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• pp.106-106
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• 2010

오일샌드는 비투멘(bitumen), 물, 점토, 모래의 혼합체로 이루어진 비재래형 탄화수소 자원으로 세계적인 고유가 시대에 큰 관심을 받고 있는 석유자원 중 하나이다. 오일샌드는 대부분이 캐나다 앨버타주에 분포하고 있으며 주요 저류층으로는 아스바스카(Athabasca), 콜드레이크(Cold Lake) 지역의 멕머레이층(McMurray Formation), 클리어워터층(Clearwater Formation), 그랜드래피드층(Grand Rapid Formation)과 피스리버(Peace River) 지역의 블루스카이층(Bluesky Formation), 게팅층(Gathing Formation)이 있다. 오일샌드 저류층은 고생대 탄산염 기반암 위에 하성-에스츄어리에 이르는 다양한 퇴적환경에서 형성되어 매우 복잡한 지질특성이 나타난다. 오일샌드 저류층의 효율적인 개발을 위해서는 저류층의 복잡한 지질학적 특성의 이해가 반드시 필요하다. 본 연구에서 캐나다 오일샌드 시추코어 분석 DB, 물리검층 자료, 현장 및 현생 시추코어를 통하여 오일샌드 저류층의 지질특성화 정보의 도출을 시도하였다. 우선 캐나다 앨버타 전역에 분포하는 시추공의 기본 정보(표고, 위경도, 층서별 최상부 심도, 생산광구명, 광구개발업체)를 제공하는 AccuMap DB 프로그램을 이용하여 광역적인 오일샌드 저류층의 분포 특성을 이해하고자 주요층서에 대한 고지형도 및 층후도를 생산광구별로 도면화하여 분석하였다. 또한 캐나다 ENCANA사와 국제공동연구의 일환으로 확보된 크리스티나 레이크(Christina Lake)광구의 현장 시추코어를 이용하여 코어의 상세기재, 비파괴 물성측정, 입도/비투멘 함유량 분석과 같은 다양한 실내 시추코어분석 실험을 수행 중이다. 비파괴 물성측정은 현장 시추코어의 물리적/화학적 특성을 파악하고자 MSCL(Multi sensor core logger)과 XRF 코어 스캐너(X-ray fluorescence core scaner)를 통해 이루어지며, 분석결과로 시추코어의 감마밀도(gamma density), P파 속도(P-wave velocity), 전기비저항(resistivity), 대자율(magnetic susceptibility) 및 색지수의 물성과 정량적 화학조성을 측정한다. 현장 시추코어의 일부는 유기용매를 이용하여 퇴적물 내의 비투멘을 완전히 추출하고 퇴적물 입도와 저류층 비투멘 함유량 측정에 이용되었다. 현장 시료 분석 결과들은 물리검층 자료와 대비를 통하여 저류층의 지질특성을 규명하는 연구에 이용될 예정이다. 마지막으로 오일샌드의 현생 유사 퇴적환경으로 알려진 서해 경기만 조간대에서 시추코어 퇴적물을 획득하여 상세 기재하였으며, 이를 통해 오일샌드 저류층의 퇴적 모델을 제시하고자 퇴적층서 연구를 진행 중이다. 향후 오일샌드 관련 시추코어의 분석 결과들이 종합되면 기존 보다 비투멘 회수효율을 향상시킬 수 있는 정밀한 오일샌드 저류층 지질모델을 수립할 수 있을 것으로 기대된다.

• Tuberculosis and Respiratory Diseases
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• v.51 no.6
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• pp.503-516
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• 2001

Background : The present study was carried out in association with neutrophilic respiratory burst in the lung in order to clarify the pathogenesis of acute respiratory distress syndrome(ARDS) following acute severe hemorrhage. Because oxidative stress has been suggested as one of the principal factors causing tissue injury, the role of free radicals from neutrophils was assessed in acute hemorrhage-induced lung injury. Method : In Sprague-Dawley rats, hemorrhagic shock was induced by withdrawing blood(20 ml/kg of B.W) for 5 min and the hypotensive state was sustained for 60 min. To determine the mechanism and role of oxidative stress associated with phospholipase A2(PLA2) by neutrophils, the level of lung leakage, pulmonary myeloperoxidase(MPO), and the pulmonary PLA2 were measured. In addition, the production of free radicals was assessed in isolated neutrophils by cytochemical electron microscopy in the lung. Results : In hypotensive shock-induced acute lung injury, the pulmonary MPO, the level of lung leakage and the production of free radicals were higher. The inhibition of PLA2 with mepacrine decreased the pulmonary MPO, level of lung leakage and the production of free radicals from neutrophils. Conclusion : A. neutrophilic respiratory burst is responsible for the oxidative stress causing acute lung injury followed by acute, severe hemorrhage. PLA2 activation is the principal cause of this oxidative stress.