• Journal of Korean Public Health Nursing
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• v.37 no.1
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• pp.54-65
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• 2023

Purpose: The purpose of this study is to identify the factors influencing COVID-19 infection prevention behavior of nursing students. Methods: Data collection is from December 17 to October 22, 2021. One hundred and ninety-seven nursing students participated in this study. Data were analyzed using an independent t-test, ANOVA, correlation coefficient, scheffé test, and multiple regression analysis. Results: COVID-19 knowledge (r=.49, p<.001), attitude (r=.41, p<.001), and COVID-19 risk perception (r=.40, p<.001) were related to COVID-19 infection prevention behaviors. The factors influencing COVID-19 preventive behaviors were identified as knowledge (𝛽=.28, p<.001), attitude (𝛽=.25, p<.001), risk perception (𝛽=.18, p=003), 2th grade (𝛽=.19, p=.011), 3th grade (𝛽=.21, p=.006), 4th grade (𝛽=.20, p=.008), and gender (𝛽=.12, p=.033). Conclusion: The results of this study can be used for the development of health policies suitable for community infectious disease prevention behaviors and the development of infectious disease educational intervention programs.

• Korean Journal of Microbiology
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• v.54 no.4
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• pp.343-353
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• 2018

Our previous research demonstrated the essential role of the xenB gene in stress response to RDX by using Pseudomonas sp. HK-6 xenB knockout. We have extended this work to examine the cellular responses and altered proteomic profiles of the HK-6 xenA knockout mutant under RDX stress. The xenA mutant degraded RDX about 2-fold more slowly and its growth and survival rates were several-fold lower than the wild-type HK-6 strain. SEM revealed more severe morphological damages on the surface of the xenA mutant cells under RDX stress. The wild-type cells expressed proportionally-increased two stress shock proteins, DnaK and GroEL from the initial incubation time point or the relatively low RDX concentrations, but slightly less expressed at prolonged incubation period or higher RDX. However the xenA mutant did not produced DnaK and GroEL as RDX concentrations were gradually increased. The wild-type cells well maintained transcription levels of dnaA and groEL under increased RDX stress while those in the xenA mutant were decreased and eventually disappeared. The altered proteome profiles of xenA mutant cells under RDX stress also observed so that the 27 down-regulated plus the 3 up-regulated expression proteins were detected in 2-DE PAGE. These all results indicated that the intact xenA gene is necessary for maintaining cell integrity under the xenobiotic stress as well as performing an efficient RDX degradation process.

• Journal of Life Science
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• v.32 no.6
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• pp.421-429
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• 2022

The expression of interleukin-1α (IL-1α) is elevated in monocytic cells, such as monocytes and macro-phages, within atherosclerotic arteries, yet the cellular molecules involved in cytokine upregulation remain unclear. Because peptidoglycan (PG), a major component of gram-positive bacterial cell walls, is detected within the inflammatory cell-rich regions of atheromatous plaques, it was investigated if PG contributes to IL-1α expression in monocytes/macrophages. Exposure of THP-1 monocytic cells to PG resulted in elevated levels of IL-1α gene transcripts and increased secretion of IL-1α protein. The transcription and secretion of IL-1α were abrogated by OxPAPC, an inhibitor of TLR2/4, but not by polymyxin B that inhibits lipopolysaccharide-induced TLR4 activation. To understand the molecular mechanisms of the inflammatory responses due to bacterial pathogen-associated molecular patterns (PAMPs) in diseased arteries, we attempted to determine the cellular factors involved in the PG-induced upregulation of IL-1α expression. Pharmacological inhibition of cell signaling pathways with LY294002 (a PI3K inhibitor), Akti IV (an inhibitor of Akt activation), rapamycin (an mTOR inhibitor), U0126 (a MEK inhibitor), SB202190 (a p38 MAPK inhibitor), SP6001250 (a JNK inhibitor), and DPI (a NOX inhibitor) also significantly attenuated the PG-mediated expression of IL-1α. These results suggest that PG induces the monocytic or macrophagic expression of IL-1α, thereby contributing to vascular inflammation, via multiple signaling molecules, including TLR2, PI3K/Akt/mTOR, and MAPKs.

• Journal of Chest Surgery
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• v.34 no.1
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• pp.64-71
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• 2001

배경: 최근 치료법의 진보에도 불구하고 진행성 식도암의 예후는 5년 생존율이 10% 이하로매우 불량하기 때문에 식도암에 대한 새로운 치료방법의 하나로 암면역 치료가 대두되고 있다. 암면역 치료를 위해서 MAGE 등 종양 특이항원이 연구의 대상이 되고 있으나 국내에서는 아직 이에 대한 연구가 없다. 대상 및 방법: 1995년 1월부터 1998년 12월까지 고신대학교 복음병원 흉부외과에서 수술 치험한 125례의 식도암중 병리조직 보관상태가 양호한 편평세포암 79례를 병기에 따라(1병기 19례, IIa병기 19례, IIb병기 10례, III병기 21례, IV병기 10례) 무작위로 추출하고 대조군으로 평활근종 20례와 정상 식도점막 20례를 대조군으로 하여 DO7 단클론 항체와 항 MAGE-3 단클론 항체 57B를 이용하여 면역조직화학검사를 시행하여 변형 p53 단백과 MAGE-3 유전자 산물의 발현율을 조사하고 식도암 조직에서 질병의 진행도를 반영하는 병기에 따른 발현율 및 변형 p53 단백과 MAGE-3 유전자 산물의 발현율간의 상관관계를 조사하였다. 결과: 식도암조직에서 변형 p53 단백과 MAGE-3 유전자 산물의 발현율은 각각 51.9%, 60.8%의 발현율을 보였으나 식도평활근종과 정상 식도점막에서는 한례도 발현되지 않아 변형 p53 단백과 MAGE-3 유전자 산물은 대조군에 비해 식도암 조직에서 의미있게 발현되었다(p<0.001). 변형 p53 단백과 MAGE-3 유전자 산물의 발현은 I병기에서 68.4%, 52.6%, IIa병기에서 57.9%, 47.6%, IIb병기에서 60%, 70%, III병기에서 33.3%, 71.4%, IV병기에서 40%, 70% 각각 발현되어 병기에 따른 발현율의 차이는 없었다(p=0.193, p=0.452). 식도암 조직내에서 변형 p53 단백과 MAGE-3 유전자 산물의 발현간에는 상관관계가 없는 것으로 나타났다(p=0.679). 결론: 이상의 결과로 변형 p53 단백과 MAGE-3 유전자 산물의 발현은 식도암에서 예후인자로서의 역할은 할수 없으나 식도 편평세포 암조직에서만 특이하게 높은 빈도로 발현됨으로써 식도암도 면역치료의 대상이 될 수 있음을 확인하였다.

• Journal of Christian Education in Korea
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• v.67
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• pp.267-299
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• 2021

This study is purposed to discuss attributes and limitations of neo-liberalism and to offer some roles of Christian education corresponding neoliberalism. Neo-liberalism is an econosuperism that entrusts all things to market order, and it regards this market as utopia. It does not remain as just an economical principle, but influences all aspects in human life. Then it shows its religiosity connecting to capitalism. Every human in it is thought of as flexible workforces appropriate to neo-liberalism market. Such being the case neo-liberalsim strenghtens instrumentation in education. Then it distorts freedom and equality, and it weakens traditional values. Because of this, modern people's identity is getting to be lost and their human characters to be floated. This study discusses these things critically, and offers roles of Christian education such as founding a well balanced understanding on the Scripture against this neo-liberalsim market, restoring the essential purpose of education from instrumentation in education, and investigating and applicating a holistic human character on the basis of a Christian anthropology against this new human character of neo-liberalsim.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.281-285
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• 2018

The purpose of this research is to make a Flipped-MOOC model which can be applied and practiced in the college course after analyzing the characteristics and cases of MOOC and Flipped learning. For this, this study implemented the following tasks. First, this study analyzed the management and class types of MOOC and flipped learning through literature research. Secondly, flipped learning was applied in the course for a semester and the strong point and weak point of the course was analyzed and the alternative was suggested. Thirdly, the core ideas and strategies of Flipped-MOOC model was deducted for enhancing the participation and interaction of the students in the course which uses the MOOC content and applies flipped learning, and the instructional strategies and direction for the effective management in the real educational field was suggested. As a result, Flipped-MOOC model is expected to contribute for the educational revolution, change and quality improvement, and it is expected that Flipped-MOOC model might contribute to the lifelong education and educational competitiveness.

• Journal of the Korean Dietetic Association
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• v.25 no.3
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• pp.199-216
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• 2019

We conducted this study to compare the awareness and attitude of Busan housewives about consuming marine products. The survey was conducted from April 10 to May 31, 2019 by using a questionnaire. The degree of preference of seafood was higher among individuals in their 40s than those in the other age groups. Among the women in their 30s, 40s, 50s and 70s, the reason for liking seafood was 'taste', and for those in their 60s it was 'nutrition'. Overall the most common reason for disliking seafood was the 'fishy smell (37.4%)'. Conception degree of nutritive value of seafood was higher among individuals in their 30s and 40s than that for those individuals in their 50s, 60s and 70s. As for the price of seafood, the wives over 40s thought seafood was more expensive than did those wives in their 30s. The younger the individuals were, the lower was the perceived degree of safety was 49.8% of the subjects reported that the main concern for purchase was 'freshness'. The perceived degree of safety for imported seafood was better for the wives in their 60s and 70s than that for those wives in their 30s, 40s and 50s. The confidence level for local Korean seafood was higher for the wives in their 60s than that for the wives in their 50s. The degree of preference for seafood was moderate overall, except for Jellyfish. Age was positively correlated with conception for safety and dietary attitude (P<0.01), whereas age was negatively correlated with monthly food expenditure, nutrition knowledge and intake requirements (P<0.01). Preference for seafood was positively correlated with conception for safety (P<0.05), nutrition knowledge (P<0.05), dietary attitude (P<0.01), awareness for nutritive value (P<0.01) and intake requirements (P<0.01). Laws and regulations should be reinforced in order to promote eating more seafood and periodic research to determine the actual amount of consumed seafood and people's preferences should be conducted.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.18 no.3
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• pp.58-67
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• 2019

The low-voltage connection box used as a low-voltage transmission line of KEPCO is intended to branch or connect to an underground line. In comparison with the utility considering the aesthetics of the distance, and safety measures are needed. In this paper, temperature and humidity, $CO_2$, water level, acceleration, and vibration sensor are installed inside the underground low voltage handhole, and the sensor data is transmitted to the ground using the Zigbee module. Antenna (Bolted Antenna) for communication with the ground was proposed and the data reception through it was confirmed. In the LF mode and the HEX mode, the transmitted data was confirmed to be a perfect reception success rate. In the case of the bolted antenna, the difference between the ground state and the underwater state was observed as a result of the experiment in the environmental environment. However, It was judged that reception sensitivity was sufficient for communication. The received data could be confirmed through PC based GUI.

• The Journal of the Korea Contents Association
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• v.18 no.12
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• pp.676-681
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• 2018

This paper is designed to address the extent of impacts that religious musicals may have upon on audience in contrast to the mainstream musicals by exploring choice attributes of Christian musicals, which are based on the stories of the Bible. Through empirical analysis, the paper shows that there is positive correlation between choice attributes and viewing satisfaction, while explaining choice attributes' impact on behavioral intention of audience, typically in word-or-mouth intention. It further shows that choice attribute of Christian musicals have direct positive impacts on both of behavioral and word-of-mouth intentions, which revisit intention is positively related to its reputation and the performance place. This study's significance lies in the use of Christian musicals to explore the complex interactions between choice attributes and audiences' behavioral intentions afterwards. However, it will also further benefit if future research include further mediating, control variable, including non-Christians.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.18 no.5
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• pp.171-182
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• 2019

Bicycles are a pollution-free means of transportation. In addition to leisure, the use of bicycles is increasing as alternative eco-friendly transportation. Accordingly, bicycle accidents are also increasing. The purpose of this study is to implement bicycle black box technology to identify situation when a bicycle accident occurs. Currently, bicycle black box products are mainly based on video cameras, and are commercially available by adding various functions mainly on high resolution cameras and are sold at high prices. If a bicycle accident occurs, quantitative data on the accident location at the time of the accident and the state of the bicycle at the time of the accident is required. In this study, IMU sensor used to obtain acceleration and slope, and time and coordinates are obtained. In addition, real-time acceleration and tilt data while is stored in memory card and by using Bluetooth transmit to the smart phone owned by the in real time to prevent accidents and to monitor status.