• Title/Summary/Keyword: 고경

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Hepatoprotective Effects of Lycium chinense Mill Fruit Extracts and Fresh Fruit Juice (구기자 추출물과 생과즙의 간독성 보호효과)

  • Kang, Kyung-Il;Jung, Jin-Young;Koh, Kyung-Hee;Lee, Cherl-Ho
    • Korean Journal of Food Science and Technology
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    • v.38 no.1
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    • pp.99-103
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    • 2006
  • Hepatoprotective effects of Bulro Kugi (Lycium chinense Mill) fruit extracts on $CCl_4-administered$ rats were investigated in vivo. Administration of $CCl_4$ increased plasma glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and lactate dehydrogenase (LDH) activities, induced lipid peroxidation as measured by malondialdehyde (MDA) content of rat liver, and significantly increased liver weight. Feeding of B. Kugi (Lycium chinense Mill) slightly increased body weight gain, although not significantly different from normal group. B. Kugi (Lycium chinense Mill) fruit extracts reduced blood cholesterol level and inhibited $CCl_4-induced$ increases of plasma GPT, GOT, and LDH activities, whereas increased contents of MDA and cytochrome P-450, and GST activity in liver tissue of $CCl_4-administered$ rats. Roasted B. Kugi (Lycium chinense Mill) fruit extract showed highest hepatoprotective effect among samples tested. These results suggest water extracts of B. Kugi (Lycium chinense Mill) fruit possess promising hepatoprotective activity against $CCl_4-induced$ hepatic damage in rats.

Generation Characteristics and Prediction of Acid Rock Drainage(ARD) of Cut Slopes (건설현장 절취사면의 산성암반배수 발생특성과 잠재적 산발생능력 평가)

  • Lee, Gyoo-Ho;Kim, Jae-Gon;Lee, Jin-Soo;Chon, Chul-Min;Park, Sam-Gyu;Kim, Tack-Hyun;Ko, Kyung-Seok;Kim, Tong-Kwon
    • Economic and Environmental Geology
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    • v.38 no.1
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    • pp.91-99
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    • 2005
  • Acid Rock Drainage(ARD) is the product formed by the atmospheric(i.e. by water, oxygen and carbon dioxide) oxidation of the relatively common iron-sulphur mineral pyrite($FeS_2$). ARD causes the acidification and heavy metal contamination of water and soil and the reduction of slope stability. In this paper the generation characteristics and the prediction of ARD of various cut slopes were studied. An attempt to classify the rocks into several groups according to their acid generation potentials was made. Acid Base Accounting(ABA) tests, commonly used as a screening tool in ARD predictions, were performed. Fourteen rock samples were classified into PAF(potentially acid forming) group and four rock samples into NAF(non-acid forming) group. The chemical analysis of water samples strongly suggested that ARD with high content of heavy metals and low pH could pollute the ground water and/or stream water.

Vertical Dimension during Swallowing and Speech Pattern in Patients with Temporomandibular Disorders (측두하악장애환자에서 연하고경과 발음양상에 관한 연구)

  • Lee, Gyu-Mee;Han, Kyung-Soo;Kwag, Dong-Kon
    • Journal of Oral Medicine and Pain
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    • v.25 no.2
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    • pp.191-203
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    • 2000
  • This study was performed to investigate the relationship between vertical dimension during swallowing and speech pattern in patients with temporomandibular disorders. For this study, 33 patients with temporomandibular disorders(TMDs), namely, 17 patients with disc displacement with reduction and 16 patients with disc displacement without reduction, and 30 normal subjects without any signs and symptoms in the masticatory system were selected as the patient group and as the normal group, respectively. Biopak $system^{(R)}$(Bioresearch Inc., Milwaukee, USA) was used for recording of electromyographic(EMG) activity(${\mu}V$) of the anterior temporalis, the superficial masseter, the sternocleidomastoideus and the trapezius insertion muscle during swallowing, and of mandibular positional change with function time(sec.) during swallowing and speech. A sentence of 'Sue is missing her house' was used for observing of speech pattern. Comparison between the two groups and relationship of the mandibular positional change and the function time between during swallowing and during speech were analysed by SPSS windows program. The results of this study were as follows : 1. Mean EMG activity of the trapezius insertion during swallowing was higher in the patient group, and the value was $3.4{\mu}V$ in patients and $2.1{\mu}V$ in normal subjects. 2. Vertica1 dimension(VD) at mandibular rest position before swallowing was slightly higher in the patient group, but VD at swallowing-late stage and at rest position after swallowing were not different between the two groups. 3. Swallowing time were 2.1 sec. in the patient group, and 1.5 sec. in the normal group, and the difference was significant. 4. VD during speech were generally higher in the normal group. In this case, speaking position showing the most difference between the two groups was 'her' position. The distance from habitual intercuspal position to 'her' position was 4.9mm in the patient group, and 6.6mm in the normal group. Speaking time was also longer in the patient group. 5. There were no difference in all observed items between the two categories of the patient group according to reduction of disc displacement. 6. Relationship between the positional changes during swallowing and speech were different between the patient group and the normal group. And in the normal group, VD at rest position before swallowing was negatively correlated with speaking time.

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Analysis of Rock Slope Behavior Utilizing the Maximum Dip Vector of Discontinuity Plane (불연속면의 최대경사벡터를 활용한 사면거동해석)

  • Cho, Taechin
    • Tunnel and Underground Space
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    • v.29 no.5
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    • pp.332-345
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    • 2019
  • Maximum dip vector of individual joint plane, which can be uniquely defined on the hemispherical projection plane, has been established by considering its dip and dip direction. A new stereographic projection method for the rock slope analysis which employs the maximum dip vector can intuitively predict the failure modes of rock slope. Since the maximum dip vector is uniquely projected on the maximum dip point of the great circle, the sliding direction of discontinuity plane can be recognized directly. By utilizing the maximum dip vector of discontinuity both the plane sliding and toppling directions of corresponding blocks can be discerned intuitively. Especially, by allocating the area of high dip maximum dip vector which can form the flanks of sliding block the potentiality for the formation of virtual sliding block has been estimated. Also, the potentiality of forming the triangular-sectioned sliding block has been determined by considering the dip angle of joint plane the dip direction of which is nearly opposite to that of the slope face. Safety factors of the different-shaped blocks of triangular section has been estimated and compared to the safety factor of the most hazardous block of rectangular section. For the wedge analysis the direction of crossline of two intersecting joint planes, which has same attribute of the maximum dip vector, is used so that wedge failures zone can be superimposed on the stereographic projection surface in which plane and toppling failure areas are already lineated. In addition the maximum dip vector zone of wedge top face has been delineated to extract the wedge top face-forming joint planes the orientation of which provides the vital information for the analysis of mechanical behavior of wedge block.

Establishment of Human Embryonic Stem Cells using Mouse Embryonic Fibroblasts and Human Fetal Fibroblasts as Feeder Cells (인간태아 섬유아세포와 생쥐배아 섬유아세포를 기저세포로 활용한 인간 배아줄기세포의 확립)

  • Cho, Hye Won;Ko, Kyoung Rae;Kim, Mi Kyoung;Lee, Jae Ik;Sin, Su Il;Lee, Dong Hyung;Kim, Ki Hyung;Lee, Kyu Sup
    • Clinical and Experimental Reproductive Medicine
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    • v.32 no.2
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    • pp.133-147
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    • 2005
  • Objectives: This study was carried out to establish human embryonic stem cells derived from frozen-thawed embryos using mouse embryonic fibroblasts (mEFs), human fetal skin and muscle fibroblasts as feeder cells, and to identify the characteristic of embryonic stem cells. Methods: When primary mEFs, human fetal skin and muscle fibroblasts were prepared, passaging on 4 days from replating could have effective trypsinization and clear feeder layers. Eight of 23 frozenthawed 4~8 cell stage embryos donated from consenting couples developed to blastocysts. Inner cell mass (ICM) was isolated by immunosurgery. ICM was co-cultured on mEFs, human fetal skin or muscle fibroblasts. The ICM colonies grown on mEFs, human fetal skin or muscle fibroblasts were tested the expression of stage specific embryonic antigen-3, -4 (SSEA-3, -4), octamer binding transcription factor-4 mRNA (Oct-4) and alkaline phosphatase surface marker. Results: We obtained 1 ICM colony from 2 ICM co-cultured on mEFs as feeder cells and did not obtain any ICM colony from 6 ICM clumps co-cultured on human fetal skin or muscle fibroblasts. The colony formed on mEFs could be passaged 30 times every 5 days with sustaining undifferentiated colony appearance. When the colonies cultured on mEFs were grown on human fetal skin or muscle fibroblasts, the colonies could be passaged 15 times every 9 days with sustaining undifferentiated colony appearance. The colonies grown on mEFs and human fetal fibroblasts expressed SSEA-4 and alkaline phosphatase surface markers and positive for the expression of Oct-4 by reverse transcription-polymerase chain reaction (RT-PCR). The produced embryoid body differentiated spontaneously to neural progenitorlike cells, neuron-like cells and beating cardiomyocyte-like cells, and frozen-thawed embryonic stem cells displayed normal 46,XX karyotype. Conclusions: The human embryonic stem cells can be established by using mEFs and human fetal fibroblasts produced in laboratory as feeder cells.

Design Methodology on the Steel-type Breakwater I.Design Procedure and Wave Pressure Estimation (철재형 이안제 설계기법 연구 I. 설계 및 파압추정 단계)

  • Kweon, Hyuck-Min;Han, Yu-Shik;Kwon, Oh-Kyun;Ko, Kyoung-Lae
    • Journal of the Korean Society of Hazard Mitigation
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    • v.11 no.3
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    • pp.209-218
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    • 2011
  • The present study proposes a new estimation relationship for the transmission rate of the steel breakwater which is expected to make up for the weakness points in existing hard solution for shore protection. The steel breakwater consists of the wave dissipator of the dual horizontal plates, the supporting columns and their foundations, and thus its respective designs should also be conducted one by one. Furthermore, the breakwater has to ensure both functions of shore protection and structure stabilization. The study produced experimental data for the stability and safety investigation of the steel breakwater. The forces acting on the steel breakwater were classified into two categories, one is vertical up and down loads for the pile resistance and the other was maximum difference of the vertical load acting on horizontally different position for the torsion. The study applied the stability force produced by the summation of maximum pressure at each point and the safety force acting on each point simultaneously. The regular wave corresponding to the significant wave was utilized for measuring wave pressure and force. The study showed the method for the proper position of submerged upper plate by considering occurrence frequency of tide level. The design process finally determined by trial and error is proposed in the present study.

All-on-6 implant fixed prosthesis restoration with full-digital system on edentulous patient: A case report (무치악 환자에서 완전 디지털 시스템을 활용한 All-on-6 임플란트 고정성 보철물 수복 증례)

  • Lee, SeungJin;Jeong, Seung-Mi;Chung, Chae-Heon;Fang, YiQin;Choi, Byung-Ho
    • The Journal of Korean Academy of Prosthodontics
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    • v.59 no.4
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    • pp.497-507
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    • 2021
  • All-on-six concept can be used as one of the treatment options to maximize the use of available residual alveolar bone for implant-supported fixed prosthesis on edentulous patients. But this process is complex and cumbersome. Digital system can be used at multiple steps, from implantation to prosthetic restoration, to overcome this shortcoming. In this case of a maxillary edentulous patient aged 76, digital system was used for restoration of 1-piece design, screw retained fixed prosthesis from diagnosis, implant surgery to fabrication of provisional and final prosthesis. For preoperative diagnosis and treatment planning stage, intra-oral information of a patient was digitalized by direct intra-oral scan. Surgical guide and immediate provisional prosthesis was designed based on this digitalized data. Patient's inconvenience was minimized by applying immediate provisional prosthesis, which was delicately fabricated according to the location data of six implants on most suitable residual alveolar bone. Then, final prosthesis was designed and fabricated going through new interim prosthesis which was newly designed and fabricated, considering patient's requests, stable vertical dimension and occlusion, and esthetic factors using digital system. We hereby report a case successfully applying digital system to multiple steps including implant surgery to fabricating prosthesis, to simplify existing complicated implant treatment procedure to an edentulous patient.

A Study on the Ovipositional Characteristics of Endangered Species Prosopocoilus astacoides blanchardi (Coleoptera: Lucanidae) for Indoor Mass-rearing (멸종위기종 두점박이사슴벌레의 실내 증식을 위한 산란 특성 연구)

  • Ko, Gyeong Hun;Kim, Dong-Soon
    • Korean journal of applied entomology
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    • v.60 no.4
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    • pp.423-429
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    • 2021
  • The ovipositional characteristics of the endangered species Prosopocoilus astacoides blanchardi was investigated for indoor mass-rearing. This insect required 3 weeks or more for mating after emergence when introduced at the 1:1 ratio of male to female. Among temperatures studied at 16, 20, 24, 28, and 32℃, the pre-ovipositional period of P. astacoides blanchardi was longest at 16℃ with an average of 109 days after emergence, while it was shortest at 32℃ with an average of 59.4 days. The number of eggs laid at 24℃ was highest with an average of 40.6 per female. The average lifespan of adults at 16℃ was 208.8 days for males and 263.9 days for females, while at 32℃ 96.1 days for males and 130.3 days for females. The number of laid eggs was dependent on insect rearing chamber size. The oviposition-trees did not significantly (P > 0.05) affect the number of laid eggs and ovipositional period. The results of this study could be used as rearing data for the restoration and mass propagation of the endangered species P. astacoides blanchardi.

Prosthetic rehabilitation of an oligodontia patient with atrophic maxilla (위축된 상악골을 가진 부분무치증 환자의 보철수복)

  • Chi, Seung-Seok;Kim, Ye-Jin;Kang, Hyeon-Goo;Ko, Kyung-Ho;Huh, Yoon-Hyuk;Park, Chan-Jin;Cho, Lee-Ra
    • The Journal of Korean Academy of Prosthodontics
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    • v.59 no.2
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    • pp.238-247
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    • 2021
  • Congenital tooth agenesis is the most common developmental dental anomaly, of which oligodontia is defined as the absence of six or more permanent teeth, except the third molars. Tooth agenesis causes malocclusion, alveolar atrophy, aesthetic and psychosocial problems. This clinical report describes a multidisciplinary treatment for a patient diagnosed as oligodontia, who exhibited absence of 14 permanent teeth, atrophy of maxillary alveolar bone, and mandibular protrusion. Restoration space was secured and tooth axis was improved by the extraction of deciduous teeth and orthodontic treatment. However, edge-to-edge bite of posterior teeth and arch dimension discrepancy due to atrophic maxilla was remained. To restore the aesthetics and functionality, implant retained prosthesis was planned. Considering minimal bone grafts, location and number of dental implants and prostheses design were determined. Through the gradual adjustment of provisional restoration, the appropriate centric and eccentric occlusion was reflected into a definitive prosthesis. Currently, stable functional results were attained, however, regular follow up and maintenance care over lifetimes should be performed.

Evaluation on the Structural Performance and Economics of Ultra-high Performance Concrete Precast Bridges Considering the Construction Environment in North Korea (북한 건설환경을 고려한 초고성능 콘크리트 프리캐스트 교량의 구조성능 및 경제성 평가)

  • Kim, Kyoung-Chul;Koh, Kyung-Taek;Son, Min-Su;Ryu, Gum-Sung;Kang, Jae-Yoon
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.9 no.2
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    • pp.208-215
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    • 2021
  • In this study, a customiz ed bridge system was developed for North Korea application. For the application of North Korea, the customized bridge system design, fabrication, and construction performance evaluation were performed using ultra-high performance concrete a compressive strength 120MPa or more and a direct tensile strength 7MPa or more. The comparison of the North Korean truck luggage load(30, 40, 55) and the Korean standard KL-510 load showed that cross-section increased as the load increased. Furthermore, a bridge with a span length of 30m was fabricated with ultra-high performance concrete for the construction performance evaluation. The evaluation of the load condition analysis was performed by a flexural test. The results showed that a bridge with a span length of 30m secured about 167% of sectional performance under initial cracking load conditions and about 134% of load bearing capacity under ultimate load conditions. As a result of economic analysis, the customized bridge system using ultra-high-performance concrete was less than about 11% of the upper construction cost compared to the steel composite girder bridge. Therefore, these results suggest that the price competitiveness can be secured when applying the ultra-high-performance concrete long-span bridge developed through this study.