• 한국임상약학회지
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• 제5권2호
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• pp.75-84
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• 1995

Drug delivery by red cells was established to maintain the release of drugs in the blood. The entrapment method by amphotericin B was re-examined and evaluated for obtaining the suitable entrapping conditions without hemolysis. The amphotericin B treatment below $10{\mu}g/ml$ induced the non-hemolysis to entrap daunorubicin into red cells within 10min. Under these conditions intracellular ATP level was decreased as $18\%$. Membrane fluidity and the shape factor of red cells were maintained. To maintain intracellular ATP, ATP and sodium pyruvate were added during the entrapment procedure because hemolysis during the release test would reflect the loss of intracellular ATP that would be postulate the decrease of the viability invivo. Consequently, the addition of ATP in the reaction solution can raise the intracellular level of ATP.

• 정보처리학회논문지A
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• 제9A권2호
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• pp.163-170
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• 2002

연속미디어 파일을 위한 버퍼 캐시 기법들은 연속 미디어의 순차적 접근만을 고려하고 반복참조는 고려하지 않았다. 그러나, 외국어 영상 학습의 경우 사용자가 어떤 장면을 반복 구간으로 설정하면 자동으로 수회 반복 상영하는 기능이 있을 수 있다. 본 논문에서는 순차 참조와 반복 참조가 혼재하는 연속미디어 파일 시스템을 위한 새로운 버퍼 캐시 기법을 제안한다. 제안한 기법은 파일의 참조 유형을 탐지하고 파일 별로 적절한 교체 정책을 적용하여 버퍼 캐시 적중률을 높인다.

• 약학회지
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• 제41권2호
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• pp.220-224
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• 1997

This study was carried out to investigate the dose dependent antifibrotic effects of polysaccharide from mycelium of Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 0.5 mg, 2.0 mg, 5.0 mg or 10.O mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents, and light microscopical histology. The results obtained were as follows: 1) Hydroxyproline contents in liver of 5.0 and 10.0mg polysaccharide-treated BDL/S rats were significantly reduced 2) In serum test, ALT, AST, ALP values in polysaccharide from Ganoderma lucidum-treated group were lower than BDL/S control group 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 mg and 5.0 mg polysaccharide-treated rats. These results suggest that polysaccharide from mycelium of Ganoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis.

• 한국통신학회논문지
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• 제19권7호
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• pp.1304-1320
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• 1994

실시간 시스템에는 정확한 계산 기법과 부정확한 계산 기법이 있다. 부정확한 계산 기법은 실시간 시스템에서 스케쥴링의 유연성을 제공하는 수단이다. 지금까지 큐잉이론을 이용한 부정확한 스케쥴링에 관한 연구들은 태스크들의 평균 결과의 질과 평균 대기시간을 정충한 때의 비용과 장점들을 명확하게 수량화하는 것들이었다. 이논문은 두개의 부정확한 스케쥴링 방법을 사용할 때, 어떤 태스크가 부정확한 계산이 될 부정확한 확률들을 구하였으며 또한, 이런 두 방법의 부정확한 확률들의 여러 단조형 부정확한 시스템 매개변수들에 대한 의존성을 비교 분석하였다.

• 대한의용생체공학회:의공학회지
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• 제36권4호
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• pp.128-134
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• 2015

Recently, the structured data format in RDF/OWL has played an increasingly vital role in the semantic web. We converted pediatric and oncologic nuclear medicine imaging reports in free text into RDF/OWL format and evaluated the usefulness of nuclear medicine imaging reports in RDF/OWL by comparing SPARQL query results with the manually retrieved results by physicians from the reports in free text. SPARQL query showed 95% recall for simple queries and 91% recall for dedicated queries. In total, SPARQL query retrieved 93% (51 lesions of 55) recall and 100% precision for 20 clinical query items. All query results missed by SPARQL query were of some inference. Nuclear medicine imaging reports in the format of RDF/OWL were very useful for retrieving simple and dedicated query results using SPARQL query. Further study using more number of cases and knowledge for inference is warranted.

• 약학회지
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• 제41권5호
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• pp.622-628
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• 1997

Hepatic cirrhosis is a common response to chronic liver injury from many causes and is one of the most common cause of all deaths. This study was carried out to compare experimental hepatic cirrhosis in rats to understand this disease and to apply for the pharmacokinetics in disease state. Following three kinds of experimental models were induced; 1) Bile duct ligation/scission (BDL/S), 2) N, N-dimethylnitrosamine(DMN), 3) Carbon tetrachloride. The hepatic cirrhosis was characterized by examing the liver/body weight ratio, serum biochemical values, hydroxyproline content in liver and histopathological lesions in cirrhotic rat liver. The results are as follows : (1) In BDL/S, the liver was enlarged to 250% of normal liver. In contrast the liver was shrinked to 48% and 78% of the normal liver in DMN and carbon tetrachloride, respectively. (2) In carbon tetrachloride and BDL/S, the serum ALT, AST, ALP and total bilirubin levels were significantly increased to 200~300% of normal level, while ALT and total bilirubin levels were significantly increased in DMN group. (3) Hydroxyproline content in cirrhotic rat liver was significantly 200~500% higher than that of normal liver. (4) Nodular formation with fibrosis was observed in BDL/S, DMN, carbon tetrachloride induced cirrhotic rat liver.

• Journal of Pharmaceutical Investigation
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• 제26권1호
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• pp.23-28
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• 1996

The dissolution characteristics of DDB were markedly enhanced by preparing solid dispersions of drug with polyethylene glycol 6000. Solid dispersions of various weight fraction were formed by a melting method. And various tablets$(A{\sim}E)$ were prepared from these solid dispersions with excipients (lactose, com starch, Avicel and PVP) by wet granulation method. There were no significant differences in dissolution rates between physical mixture and DDB alone. But dissolution rates of solid dispersions were $1.4{\sim}2.0$ times greater than that of DDB alone and $1.2{\sim}1.8$ times greater than those of a commercial tablet.

• 한국정보과학회논문지:시스템및이론
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• 제34권4호
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• pp.138-144
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• 2007

최근 VOD(Video-On-Demand) 서비스가 널리 이용되면서 멀티미디어 스트리밍 서버를 위한 데이타 캐슁 기법의 중요성이 점점 증가하고 있다. 기존 연구를 통해 인터벌 캐슁 기법과 이를 객체의 인기도를 반영하도록 확장한 기법들이 다양한 환경에서 우수한 성능을 나타냄이 입증되었다. 본 논문에서는 이와 같은 기존의 기법을 블록 수준으로 세분화할 경우 멀티미디어 스트리밍 서버의 성능을 더욱 향상 시킬 수 있음을 보인다. 실제 VOD 서버의 트레이스를 이용한 시뮬레이션 실험을 통해 본 논문이 제안한 알고리즘이 캐쉬 적중률과 스트림의 초기 지연 시간을 향상시킴을 보인다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 봄 학술발표논문집 Vol.30 No.1 (C)
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• pp.277-279
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• 2003

본 논문에서는 편재 컴퓨팅(ubiquitous and pervasive computing) 환경에 입력 시스템으로 사용하는 센서 네트워크에서 측정한 데이터의 품질 (sampling rate and quantization depth) 을 보증하며 네트워크 트래픽 또는 소모전력과 같은 비용을 최소화하기 위한 방법으로, 휴리스틱 알고리즘에 의한 비주기적 샘플링과 신뢰성 있는 전송규약을 사용하는 비주기적 전송방식을 제안한다. 그리고 제안한 비주기적 전송방식에 핵심기술인 신뢰성 있는 전송 규약의 비용을 최적화하기 위한 방법으로 ACK방식과 NACK방식을 패킷 에러율과 동일한 라우터를 사용하는 이웃 노드의 수와 같은 네트워크 상황에 따라 상보적으로 사용하는 상보적 방식(alternative method)을 제안하고, 전체 통신규약을 설계하며, 해석을 통해 성능을 분석하고, 네트워크 상태에 따라 두 방식의 성능상의 우열이 전환되는 전환점을 유도한다. 제안하는 상보형 신뢰성 있는 전송규약은 전체 센서 네트워크에서 처리되는 패킷의 비트 수를 최소화해, 각 노드의 총 전력 소모의 20-60%를 차지하는 통신모듈의 소비 전력을 줄일 수 있어 전력소모를 크게 개선 할 수 있다. 나아가서 다양한 센서 네트워크에서 설계한 전송규약을 바탕으로 하는 제안하는 비주기적 전송방식을 활용한다면 최적의 비용으로 측정하는 데이터의 품질을 보증할 수 있다.

• 한국임상약학회지
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• 제9권1호
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• pp.55-61
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• 1999

The object of this work was to study the pharmacokinetic differences and the cause of these differences in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride treatment when aminophylline (8 mg/kg as theophylline, i.v.) was injected. The concentrations of theophylline and its major metabolite (1,3-dimethyluric acid) in plasma were determined by HPLC. In addition, formation of 1,3-dimethyluric acid from theophylline in microsomes was determined. In cirrhotic rats, the systemic clearance of theophylline was reduced to $17\%$ of the control value while AUC (area under the plasma concentration-time curve) and $(t_{1/2})_{\beta}$ were increased to about 6 fold and 10 fold, respectively. The formation of 1,3-dimethyluric acid was decreased to $33-41\%$ of the control value in microsomes of cirrhotic rat liver. From these results, it can be concluded that in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride the total body clearance of theophylline is markedly reduced due to a reduced hepatic metabolism.