• Progress in Medical Physics
• /
• v.17 no.3
• /
• pp.144-152
• /
• 2006

The telemedicine using independent client-server system via networks can provide high quality normalized services to many hospitals, specifically to local/rural area hospitals. This will eventually lead to a decreased medical cost because the centralized institute can handle big computer hardware systems and complicated software systems efficiently and economically, Customized cancer radiation treatment planning for each patient Is very useful for both a patient and a doctor because it makes possible for the most effective treatment with the least possible dose to patient. Radiation planners know that too small a dose to the tumor can result in recurrence of the cancer, while too large a dose to healthy tissue can cause complications or even death. The best solution is to build an accurate planning simulation system to provide better treatment strategies based on each patient's computerized tomography (CT) image. We are developing a web-based and a network-based customized cancer radiation therapy simulation system consisting of four Important computer codes; a CT managing code for preparing the patients target data from their CT image files, a parallel Monte Carlo high-energy beam code (PMCEPT code) for calculating doses against the target generated from the patient CT image, a parallel linear programming code for optimizing the treatment plan, and scientific data visualization code for efficient pre/post evaluation of the results. The whole softwares will run on a high performance Beowulf PC cluster of about 100-200 CPUs. Efficient management of the hardware and software systems is not an easy task for a hospital. Therefore, we integrated our system into the client-sewer system via network or web and provide high quality normalized services to many hospitals. Seamless communication with doctors is maintained via messenger function of the server-client system.

• Korean Journal of Clinical Pharmacy
• /
• v.15 no.1
• /
• pp.41-45
• /
• 2005

심바스타틴은 cholesterol 생합성 과정에서 속도 조절 효소인 HMG-CoA reductase의 강력한 상경적 길항약으로서 고지혈증 치료에 널리 쓰이는 약물이다. 심바스타틴 제제인 MSD 사의 조코 20 mg정을 대조약으로 하여 시험약인 유영 제약의 엘바스타 20mg정의 생물학적 동등성 평가를 하기 위해 22명의 건강한 지원자를 모집하였다. 지원자를 두 군으로 나누어 2정씩 투여하였고 $2{\times}2$ 교차시험을 실시하였다. 심바스타틴의 혈장 중의 농도를 정량하기 위하여 발리데이션된 LC/MS/MS를 사용하였다. 채혈 시간은 투약 전 및 투약 후 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 시간에 걸쳐 총 12시점에 걸쳐 시행하였다. 생물학적 동등성을 판정하기 위한 파라미터로 12시간까지의 혈장 중 농도곡선 하 면적 ($AUC_{12hr}$)과 최고 혈중 농도($C_{max}$)를 사용하였다. 12시간 까지의 혈중 농도 곡선 하 면적의 기하 평균은 $17.30ng{\cdot}ml/hr$(시험약)과 $17.35ng{\cdot}ml/hr$(대조약)으로 나타났다. 최고 혈중 농도의 경우 각 각 5.08 ng/ml(시험약)과 5.20 ng/ml(대조약)으로 관찰 되었다. $AUC_{12hr}$의 경우 로그변환한 평균치 차의 $90{\%}$ 신뢰구간이 log0.8510 - log1.1694이었고, $C_{max}$의 경우 log0.8176 - log1.1649로 계산되어 두 항목 모두 log0.8-log1.25이어야 한다는 식품의약품 안전청과 FDA의 기준을 모두 만족시켰다. 이상의 결과를 종합하면 시험약 엘바스타 정 20mg은 대조약 조코정 20 mg에 대하여 생물학적 동등한 것으로 판정되었다.트리머 전기비저항 탐사를 수행하였다. 이를 통해 하저에 케이블을 설치하는 방식에 비해 매우 신속하고 경제적으로 하저에 분포하는 이상대의 분포범위와 발달방향을 규명할 수 있었다.대에 대해 가장 효과적이다. 모델과 현장 적용 결과들을 통해 GRM SSM 방법을 이용하여 불규칙한 굴절면을 가진 지층들에 대해 좀 더 신뢰할 수 있는 정밀한 탄성파 속도를 산출할 수 있음을 보여주고 있다.별한 주의를 기울여야 한다.EX>$\alpha/\beta$=10인 경우 $62.0\~121.9\;Gy_{10}$ (중앙값: $93.0\;Gy_{10}$)의 분포를, ${\alpha/\beta}=3$인 경우 $93.6\~187.3\;Gy_3$ (중앙값=$137.6\;Gy_3$ )의 분포를 보였다. MD-BED $Gy_3$는 직장합병증 발생과의 관계는 통계적으로 유의하였고, 방광합병증과는 유의하지 않았다. 직장합병증과의 연관성은 MD-BED $Gy_3$보다 개별 환자의 직장전벽 총 선량 BED값인 R-BED $Gy_3$가 훨씬 더 높았다. 요도카테터 풍선의 후방지점이 대변하는 방광의 총 선량 BED값인 V-BED $Gy_3$도 방광합병증과 경향성 테스트에서 통계적 유의성을 보였다. 하지만, 어떠한 방사선선량도 골반제어율과 의미 있는 상관관계를 보이지 않았다. 본 기관에서 주치의의 선호도에 따라 강내근접치료가 외부방사선치료의 중간에 시행되는 형태인 샌드위치기법과 외부방사선치료 후반부에 시행되는 순차적 기법으로 구분하였을 때, 두 방식간 치료성적 및 합병증의 차이는 없었다. 총 치료기간에 대한 분석에서는 치료기간이 길어질수록 재발 위험이 커지는 경향을 보였으나, 나이 및 병기, 종양의 크기, MD-BED $Gy_{10}$

• Explosives and Blasting
• /
• v.28 no.2
• /
• pp.17-27
• /
• 2010

With the development of modern society, there have been great technical advances, and the meaning, shape, and type of preservation objects have also become diverse. However, the legislation of executives established in 1961 has nt yet been revised realistically. Thatses administrative problems related to the usge and storage of explosives. In this study, the cases of civilian's question and thought that had been submitted to the government agency were surveyed. In order to analyze the effects of preservation object, ENPro3.1, which is a simulation program to analyze the sound pressure, was used to estimate the blast pressure when a magazine containing preservation objects exploded. With the damage due to the blast pressure, the problem with the safe distance depending on the preservation object levels was investigated. From the investigation, the blast pressures in the two cases with the artificial structures at the real distance 309 m and without the artificial structures at the legitimate standard space distance 440 m, were found to be 123 dB(L) and 138 dB(L), respectively. That means the influence of blast pressure in shorter distance with artificial structures is 15 dB(L) lower than longer distance without them. Therefore, it is recommended to apply the preservation distance based on the engineering analysis with a consideration of surrounding environment.

• Radiation Oncology Journal
• /
• v.24 no.4
• /
• pp.211-216
• /
• 2006

$\underline{Purpose}$: An analysis of the infrastructure for radiotherapy in Korea was performed to establish a baseline plan in 2006 for future development. $\underline{Materials\;and\;Methods}$: The data were obtained from 61 radiotherapy centers. The survey covered the number of radiotherapy centers, major equipment and personnel. Centers were classified into technical level groups according to the IAEA criteria. $\underline{Results}$: 28,789 new patients were treated with radiation therapy in 2004. There were 104 megavoltage devices in 61 institutions, which included 96 linear accelerators, two Cobalt 60 units, three Tomotherapy units, two Cyberknife units and one proton accelerator in 2006. Thirty-five high dose rate remote after-loading systems and 20 CT-simulators were surveyed. Personnel included 132 radiation oncologists, 50 radiation oncology residents, 64 medical physicists, 130 nurses and 369 radiation therapy technologists. All of the facilities employed treatment-planning computers and simulators, among these thirty-two percent (20 facilities) used a CT-simulator. Sixty-six percent (40 facilities) used a PET/CT scanner, and 35% (22 facilities) had the capacity to implement intensity modulated radiation therapy. Twenty-five facilities (41%) were included in technical level 3 group (having one of intensity modulated radiotherapy, stereotactic radiotherapy or intra-operative radiotherapy system). $\underline{Conclusion}$: Radiation oncology in Korea evolved greatly in both quality and quantity recently and demand for radiotherapy in Korea is increasing steadily. The information in this analysis represents important data to develop the future planning of equipment and human resources.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2006.05a
• /
• pp.130-134
• /
• 2006

본 연구의 목적은 하천 복원과 관리에 필수적인 하천의 특성 분석 및 물순환 분석시스템 구축에 있다. 연구 대상지역으로 최근 하천의 생태 기능 회복을 위해 도심생태하천조성 사업이 추진되고 있는 대전 3대 하천유역을 선정하였다. 대전 3대 하천 유역의 물수지와 도시화에 따른 영향을 파악하기 위하여 SWAT을 이용한 물순환 분석시스템을 구축하였다. 모형적용 결과, 유출량과 지하수 수위 변화 등 대전 3대 하천 유역의 특성을 관측치에 가깝게 모의할 수 있었다. 모델의 검보정 실시결과에서 나타난 모델의 계산 값들의 관측된 유출량뿐 아니라 기저유출량 및 지하수 수위와의 높은 상관관계는 본 연구에서 구축한 모델의 구조나 변수의 유효성에 많은 신뢰도를 제공한다고 판단된다. SWAT을 이용하여 대전 3대 하천 유역의 물수지 분석 및 도시화에 따른 영향을 평가하였다. 물수지 분석결과에 의하면, 전체적으로 총 유출량 중 지하수 유출량이 47%정도, 중간 유출량이 31% 그리고 지표유출량이 22%이다. 각 소유역의별 유출 성분 분석결과는 각 소유역의 토지 이용도, 토양 그리고 지형적 특징에 따른 유출 특성을 확인하였다. 도시화 영향 분석 결과 전체적으로 1975년에서 2000년까지 갑천 유역의 약 5%가량의 도시화는 총 유출량의 변화에 있어서는 현저한 차이를 보이지 않았으나, 각 유출 성분의 경우에는 많은 영향이 있는 것으로 나타났다. 특히 지표유출량은 45% 가량의 증가를 보였고, 전체 유역의 지하수함양 량이 5%정도 감소한 반면, 도시화가 31%정도 진행된 소유역의 경우에는 17%정도의 현저한 감소를 나타냈다. 본 연구에서 수행한 물수지 분석 및 도시화 영향분석 결과는 향후 대천 3대 하천의 생태하천복원을 위한 물순환 정상화 대책마련 및 하천의 유량확보방안 마련에 기초자료를 제공할 수 있을 것이다.득증대를 꾀함으로 농촌문제 해결에 도움이 될 것으로 기대된다. 본 연구를 통해 GIS 와 RS의 기술이 농촌분야에 더 효율적으로 적용될 것으로 기대되며, 농업기술센터를 통한 정보제공을 함으로써 대농민 서비스 및 농업기관의 위상이 제고 될 것으로 기대된다.여 전자파의 공간적인 가시화를 수행할 수 있었다. 본 전자파 시뮬레이션 기법이 실무에 이용될 경우, 일반인이 전자파의 분포에 대한 전문지식을 습득할 필요 없이, 검색하고자 하는 지역과 송전선, 전철 등 각종 전자파의 발생 공간 객체를 선택하여 실생활과 관련된 전자파 정보에 예측할 수 있어, 대민 환경정보 서비스 질의 개선측면에서 획기적인 계기를 마련할 것으로 사료된다.acid$(C_{18:3})$가 대부분을 차지하였다. 야생 돌복숭아 과육 중의 지방산 조성은 포화지방산이 16.74%, 단불포화지방산 17.51% 및 다불포화지방산이 65.73%의 함유 비율을 보였는데, 이 중 다불포화지방산인 n-6계 linoleic acid$(C_{18:2})$와 n-3계 linolenic acid$(C_{18:3})$가 지질 구성 총 지방산의 대부분을 차지하는 함유 비율을 나타내었다.했다. 하강하는 약 4일간의 기상변화가 자발성 기흉 발생에 영향을 미친다고 추론할 수 있었다. 향후 본 연구에서 추론된 기상변화와 기흉 발생과의 인과관계를 확인하고 좀 더 구체화하기 위한 연구가 필요할 것이다.게 이루어질 수 있을 것으로 기대된다.는 초과수익률이 상승하지만, 이후로는 감소하므로, 반전거래전략을 활용하는 경우 주식투자기간은 24개월이하의 중단기가 적합함을 발견하였다. 이상의 행태적 측면과 투자성과측면의 실증결과를 통하여 한국주식시장에 있어서 시장수익률을 평균적으로 초과할 수 있는 거래전략은 존재하므로 이러한 전

• Journal of radiological science and technology
• /
• v.36 no.3
• /
• pp.237-244
• /
• 2013

The purpose of this study is to compare method in the treatment of breast cancer using dose index. And, it is to find the optimized treatment technique to the patient. The phantom filled with tissue-equivalent material were used simulation and treatment as techniques of 3D-CRT, IMRT, VMAT was planned using Eclipse v10. By using HI(homogeneity index), CI(Conformity index), OED(Organ equivalent dose), EAR(Excess Absolute Risk), were assessed for each treatment plans. HI and CI of 3D-CRT, IMRT, VMAT were calculated 16.89, 11.21, 9.55 and 0.59, 0.61, 0.83. The organ average doses of Lt lung, Rt lung, liver, heart, esophagus, cord, Lt breast, trachea and stomach were 0.01 ~ 2.02 Gy, 0.36 ~ 5.01 Gy, 0.25 ~ 2.49 Gy, 0.14 ~ 6.92 Gy, 0.03 ~ 2.02 Gy, 0.01 ~ 1.06 Gy, 0.25 ~ 6.08 Gy, 0.08 ~ 0.59 Gy, 0.01 ~ 1.34 Gy, respectively. The OED, EAR of the IMRT and VMAT show higher than 3D-CRT. As the result of this study, we could confirm being higher dose index(HI, CI) in IMRT and VMAT than 3D-CRT, but doses of around normal organs was higher IMRT, VMAT than 3D-CRT.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.46 no.2
• /
• pp.150-158
• /
• 2018

Numerical simulation and experimental study on the thermal flow field of the micro turbojet engine have been carried out for the purpose of developing infrared reduction technology for aircraft. A circular basic nozzle and five rectangular nozzles with different aspect ratio were considered. The conditions for CFD analysis were derived from the analysis of the engine performance. The temperature distribution of the nozzle plume was measured using a temperature sensing system. The thrust of the rectangular nozzle with the aspect ratio 5 was reduced about 1.8% compared to the circular nozzle, and the thrust decreased with increasing the aspect ratio of the nozzle. In the case of thermal flow field, it was observed that, as the aspect ratio increases, the exhaust plume in the experiment was formed wider than in the CFD analysis.

• Journal of Advanced Marine Engineering and Technology
• /
• v.35 no.4
• /
• pp.436-442
• /
• 2011

To obtain the engine output correctly is basically very important factor for estimating a engine performance. But, it has been reported that the IHP measured from electronic indicator such as MIPS(Mean Indication Pressure System) has a deviation compared to mechanical indicator. It was reported by authors that the uncertainty of crank angle for TDC position could be one of the reasons. In this paper, the uncertainty of crank angle for TDC position and its influence to engine output were investigated respectively about M/E and G/E for marine diesel engines. For the purpose, two sampling methods of pressure in cylinder were considered which were 'angle base sampling' and 'time base sampling'. Angle base sampling is real crank angle acquired from angle encoder which is attached to crank shaft and time base sampling is crank angle calculated by detected revolution with Z-pluse of encoder. Time base sampling is same method of MIPS. This paper concluded that time base sampling method is not suitable for obtaining the output of marine diesel engine on board because of instantaneous speed variation and load fluctuation. Also it is verified that the variation of engine speed by load fluctuation should be one of reasons additionally in case of M/E.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.23 no.1
• /
• pp.1-5
• /
• 1987

The authors carried out an experiment to determine the vertical opening of the midwater trawl, which is the same used in the former experiment in this series of studies. To determine the vertical opening of otter board and front weight, three fish finders were used. A 200 KHz fish finder set on board the research vessel was used to sound the depth of water. A transmitter of 50 KHz fish finder was set through the shoe plate of otter board to determine the height of otter board from the sea bed, and a transmitter of another 50 KHz fish finder was set downwardly on the net pendant right before the front weight to determine the height of weight from the sea bed. The depth of otter board and weight were calculated by subtract the height of those from the depth of water, respectively. To determine the vertical opening of mouth, a transmitter of net recorder was set on the head rope and the vertical opening of that to ground rope was directly read on the recording paper. The results obtained can be summarized as follows: 1. The rate of the depth of otter board to the length of warp was in the range of 0.44 to 0.25, and the depth was linearly shoaled about 5m per 0.1m/sec of the towing speed or per 20rpm of the main engine. The rate of the observed depth to the calculated depth of otter board was in the range of 0.92 to 0.080 with a decreasing tendancy in accordance with the increase of towing speed. 2. The depth of head rope was 2 to 3m deeper than that of otter board, and the vertical opening of net mouth was in the range of 22 to 19m, with a decreasing tendancy in accordance with the increase of towing speed, 3. The difference of depth between front weight and otter board was about 20m and 22m respectively in the length of warp 100m and 150m without distinct change in accordance with the towing speed. The depth of front weight was 2 to 3m shallower than that of ground rope. 4. The changing range of depth of head rope according to the revolution of main engine was about 4m per 20rpm.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.6
• /
• pp.119-128
• /
• 2017

This study estimated the optimal nursing workforce and financial costs of providing comprehensive nursing services at hospitals under the national health insurance system. Data on registered nurses, nursing aids, medical institutions, and number of patients were obtained from the Health Insurance Review and Assessment Service. The optimal size of the nursing workforce was calculated using the workload model. A bottom-up approach was used to estimate the annual total financial cost of comprehensive nursing services. The number of registered nurses and nursing aids would need to be increased by 81.75% and 83.23%, respectively, in order to fully apply comprehensive nursing care on a national scale. The additional financial costs for comprehensive nursing services at all hospitals was estimated to be as much as 110.39% of the current cost. For the comprehensive nursing service, nurses with a career and newcomers need to be retained at their hospitals, and the validity of the nurse-patient ratio should be continuously checked. The financial shock to the national health insurance system could be minimized by gradually extending the system to all hospitals.