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Effects of Zingiberis Rhizoma Pharmacopuncture Injected at GB30 and ST36 on Neuropathic Pain in Rats (환도(GB30) 및 족삼리(ST36) 건강약침이 신경병증성 통증 유발 흰쥐에 미치는 영향)

  • Hwang, Min Sub
    • Korean Journal of Acupuncture
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    • v.36 no.1
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    • pp.52-62
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    • 2019
  • Objectives : The objective of this study was to investigate the effects of Zingiberis Rhizoma Pharmacopuncture(ZP) at GB30 and ST36 in neuropathic pain induced SD rats by the block of Transient Receptor Potential Vanilloid 1(TRPV1). Methods : Neuropathic pain in rats was induced by tibial and common peroneal nerve transection of right leg. The rat subjects were divided into 6 groups : normal(Nor, n=5), control(Con, n=5), neuropathic pain plus 2 mg/kg ZP injection at GB30 and ST36(ZP-A, n=5), 10 mg/kg ZP(ZP-B, n=5), 20 mg/kg ZP(ZP-C, n=5) and 0.45 mg/kg Tramadol(Tra, n=5). Three days after the surgery, injections were administered once a day for 17 days. Withdrawal response of neuropathic rats' legs were measured by stimulating the paw of Right leg with von frey filament, acetone and radient heat on day 3, 7, 11, 15, 19 after surgery. After all treatments were completed, c-Fos in the midbrain central gray and TRPV1 & TRPA1 of DRG(L5) were analyzed. Results : Groups ZP-B and ZP-C showed a meaningful decrease in the withdrawal response of mechanical allodynia, thermal hyperalgesia and cold allodynia compared to the control group(p<0.05, p<0.01, p<0.001). Groups ZP-B and ZP-C showed a meaningful decrease in the expression of c-fos and TRPV1 protein level compared to the control group(p<0.05, p<0.01, p<0.001). Conclusions : These results suggest that Zingiberis Rhizoma Pharmacopuncture at GB30 and ST36 could decrease mechanical & cold allodynia and thermal hyperalgesia by block the TRPV1 on the model of neuropathic pain.

Case Report of Two Cases on Effect of Combined Bee Venom and CS Pharmacopuncture with Koream Medicine Treatment on HIVD of L-spine (요추 추간판탈출증 환자에 대한 봉약침과 CS약침을 병행한 한의학적 복합치료 효과에 대한 증례보고)

  • Hwang, Ji Hye;Kim, Deok-Hyun
    • Korean Journal of Acupuncture
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    • v.35 no.4
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    • pp.239-246
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    • 2018
  • Objective : This case study reports the therapeutic effect of Korean Medicine (KM) treatments including CS(care special pain) and BV(bee venom) pharmacopuncture on herniated intervertebral disc(HIVD) of lumbar spine(L-spine). Methods : Two patients diagnosed with HIVD of L-spine were treated with CS and BV pharmacopuncture on GV3 and EX-B2, acupuncture, cupping, and herbal medicine. The Numeric Rating Scale(NRS), the Oswestry low back pain Disablility Index(ODI) and the Roland Morris Disability Questionnaire(RMDQ) scores were evaluated before and after treatment for comparison. Results : Low back pain(LBP) and radiating pain was improved with a decrease in patients' NRS, ODI and RMDQ scores. Conclusion : These results suggest that KM treatments including combined CS and BV pharmacopuncture could be an effective treatment on patients with HIVD of L-Spine.

A Systematic Review on Thread Embedding Therapy of Knee Osteoarthritis (퇴행성 슬관절염의 매선 치료에 대한 체계적 문헌 고찰)

  • Park, Jang Mi;Lee, Jae Sung;Lee, Eun Yong;Roh, Jeong Du;Jo, Na Young;Lee, Cham Kyul
    • Korean Journal of Acupuncture
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    • v.35 no.4
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    • pp.159-165
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    • 2018
  • Objectives : This study was performed to review the efficacy of national and international randomized controlled trials (RCTs) investigating evidence on thread embedding therapy for knee osteoarthritis. Methods : Online databases (PubMed, EMBASE, Cochrane, NDSL, OASIS, CNKI) were searched for studies where thread embedding therapy was performed for Knee Osteoarthritis from their inception to July 2018. Two researchers independently performed the search. Only RCTs were selected. Eligible studies were selected first by the abstract and the title and then included after full-texts were read. Risk of bias of the included studies were evaluated using the Cochrane risk of bias assessment tool. Data were narratively summarized. Results : There were 334 studies retrieved from the databases, resulting in analysis of 3 RCTs. There was an average of 1.5 treatment visits over a 7 day period and evaluation tool used was efficacy rate, with traditional acupuncture being the most common control used in the trials. Statistically significant improvement by thread embedding therapy was reported. None of the included RCTs reported on adverse reactions. The risk of bias of the included studies was generally unclear. Conclusion : The review suggests that thread embedding therapy can be effective in knee osteoarthritis. But there was a lack of detailed information about the treatment procedures, and the risk of bias was unclear. Therefore, there is insufficient evidence for thread embedding therapy for knee osteoarthritis.

A Survey on the Treatment of Sports Injury Patients: Focusing on Ankle Sprain (스포츠 손상 환자 치료 현황 조사: 발목 염좌를 중심으로)

  • Ha, Dohyung;Won, Jiyoon;Jang, Se In;Lee, Hyangsook;Kim, Song-Yi
    • Korean Journal of Acupuncture
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    • v.35 no.4
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    • pp.174-186
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    • 2018
  • Objectives : The aim of this survey was to investigate the general characteristics of sports injury patients in Korean medical institutions by Korean Medicine Doctors (KMDs) and the treatment patterns of Korean medicine for ankle sprain which is one of the common sports injuries. Methods : An online survey was conducted on KMDs interested in sports injuries to assess their experience and perception of sports injuries including diagnosis, intervention, and treatment plan for ankle sprain. Results : A total of 276 KMDs participated in the survey. They answered that 12% (median, range 0~80%) of patients visiting a Korean medical institution had sports injuries. Sports injuries frequently occur in the ankle, back, shoulder, knee, and elbow and the most common sports injury was sprain/strain. Many participants were aware that sports injuries should be treated differently from other musculoskeletal diseases in general. They reported that confirmation of fracture, swelling, and tenderness was essential to diagnose ankle sprains. Acupuncture was the most commonly used treatment and reported to need 2 to 6 weeks of treatment period, depending on the severity. Conclusions : Based on the findings regarding treatment of sports injury patients by KMDs, this study would be utilized as basic information for pragmatic clinical research design related to sports medicine in the future.

Results of Korean Medicine Treatment in Community Dwelling Elderly with Mild Cognitive Impairment: Focusing on the Change in Cognitive Ability (지역사회 거주 경도인지장애 노인들을 대상으로 시행한 한의치료의 보고: 인지기능을 중심으로)

  • Kim, Yun-Na;Bae, Joon-Sang;Eom, Yoon-Ji;Lee, Kyung-Seok;Yoon, Hyun-Min;Cho, Seung-Hun
    • Journal of Oriental Neuropsychiatry
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    • v.30 no.3
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    • pp.185-198
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    • 2019
  • Objectives: The purpose of this study was to identify the effectiveness of Korean medicine treatment in mild cognitive impairment (MCI) among a group of community dwelling elderly. Methods: Two-hundred and twenty-nine elderly living in a community and diagnosed with MCI were recruited. Participants were evaluated with various instruments such as the Korean version of Mini-Mental State Examination for Dementia Screening (MMSE-DS) and the Korean version of Montreal Cognitive Assessment (MoCA-K). Korean medicine treatment consisted of herbal medicine, acupuncture, and pharmacoacupuncture. The change in cognitive ability was assessed by using the MMSE-DS and the MoCA-K. Data were analyzed by SPSS/WIN 22.0 using the paired t-test, and the ANOVA. Results: The MMSE-DS and the MoCA-K score generally increased after six months of Korean medicine treatment and the differences in both instruments were statistically significant. Additionally, some consecutive participants maintained long-term cognitive improvement. When analyzed specifically by herbal medicine group based on syndrome differentiation and pharmacoacupuncture group, most showed improvement in the MMSE-DS and the MoCA-K but not all data were statistically significant. The satisfaction score was mostly high and most participants were willing to re-participate in the program. Conclusions: Korean medicine treatment may contribute to the improvement and prevention of cognitive decline in the elderly. However, further systematic research based on large scale sample data and standardized protocols is needed to uplift the welfare and mental health of the elderly.

Association between Korean Medicine Hospital Utilization and Cardiovascular Risks in Patients with Hypertension: a National Korean Cohort Study (고혈압 환자에서 한방의료기관 이용과 심혈관 위험 요소와의 관계: 국민건강보험공단 표본코호트 DB)

  • Cho, Hyunjoo;Jung, Hyejin;Lim, Sabina
    • The Journal of Korean Medicine
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    • v.40 no.3
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    • pp.1-20
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    • 2019
  • Objectives: This study aims to investigate the effects of Korean Medicine Hospital Utilization (KMHU) on major adverse cardiovascular events (MACE), myocardial infarction (MI), stroke, and death in hypertensive patients taking antihypertensives. Methods: Using the Korean National Health Insurance Service-National Sample Cohort database, this study identified and diagnosed 68,457 hypertensive patients taking antihypertensives between 2003 and 2006. They were divided into KMHU and non-KMHU groups. The follow-up period ended with the diagnosis of myocardial infarction, stroke, or death. After propensity score matching (PSM), there were 18,242 patients each in the non-KMHU and KMHU groups. We calculated the incidence rate, hazard ratio (HR), and 95% confidence interval (CI) for MACE, myocardial infarction, stroke, and death in patients with hypertension using a stratified Cox proportional hazard model. In addition, secondary outcome analyses for stroke and cardiovascular mortality were performed. Results: After PSM, the HRs for MACE (HR: 0.84, 95% CI: 0.81-0.87), all-cause mortality (HR: 0.75, 95% CI: 0.72-0.79), and myocardial infarction (HR: 0.90, 95% CI: 0.83-0.97) were significantly lower in the KMHU group than in the non-KMHU group. Moreover, the HRs for stroke-related mortality, haemorrhage and ischaemic stroke-related mortality, and ischaemic heart disease-related and circulatory system disease-related mortality were significantly lower in the KMHU group than in the non-KMHU group. Conclusions: On long-term follow-up observation, this study supported the effect of KMHU for managing hypertension and reducing the burden of cardiovascular diseases.

Sympathetic Nervous Activity is Involved in the Anti-Inflammatory Effects by Electroacupuncture Stimulation (전침자극 매개성 항염증 반응에 대한 교감신경의 작용연구)

  • Jo, Byung Gon;Kim, Nam Hoon;Namgung, Uk
    • Korean Journal of Acupuncture
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    • v.36 no.3
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    • pp.162-170
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    • 2019
  • Objectives : Increasing evidence suggests that parasympathetic vagus nerve activity plays a role in modulating acupuncture-induced anti-inflammatory reaction, but the function of sympathetic nerve is not known. Here, we investigated whether splanchnic sympathetic nerve activity was involved in the regulation of splenic expression of $TNF-{\alpha}$ mRNA by electroacupuncture (EA) in LPS-injected animals. Methods : DiI was injected into the stomach or celiac ganglion (CG) for retrograde labeling of the target tissues. EA was given at ST36 and the electrical stimulation on the sciatic nerve in LPS-injected mice. c-Fos signals in the tissues were analyzed by immunofluorescence staining, and $TNF-{\alpha}$ mRNA was analyzed by real-time PCR. Results : Application of EA at ST36 or electrical stimulation on the sciatic nerve induced c-Fos expression in neurons of the spinal cord and celiac ganglion (CG). Then, the vagotomy reduced c-Fos levels in CG neurons but not in the spinal cord in animals given EA. Expression of $TNF-{\alpha}$ mRNA which was induced in the spleen after LPS was significantly inhibited by EA, then the vagotomy elevated $TNF-{\alpha}$ mRNA level similar to that in LPS-injected animals. Splanchnectomy in animals given LPS and EA also increased $TNF-{\alpha}$ mRNA though it was less effective than vagotomy. Conclusions : Our data suggest that EA delivered to the spleen via the splanchnic sympathetic nerve may be involved in attenuating splenic inflammatory responses in LPS-injected animals.

Contemporary Application of Roller Needle and Stamp Needle: A Patent Review (국내 특허 분석을 통한 롤러침 및 도장침의 현대적 활용)

  • Jeong, Seung-Yeon;Park, Ji-Yeun;Kim, Youn-Sub;Kim, Song-Yi
    • Korean Journal of Acupuncture
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    • v.36 no.3
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    • pp.139-149
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    • 2019
  • Objectives : A dermal needle is one of the therapeutic method by stimulating or tapping on the certain points of skin. Recently, roller or stamp-needle have been applied to various diseases in combination with microneedle technology. In this study, we analyzed the trend of roller and stamp-needle in Korean patent. Methods : Electronic search for Korean patent of roller or stamp needle was performed in Korea Intellectual Property Right Information Service database to April, 2019. Results : Sixty seven patents (51, roller-needle; 15, stamp-needle; 1, both types of needle) met the inclusion criteria. According to patent details, 34 of 67 patents were skin stimulation, 14 patents were intended to increase the efficiency of drug delivery through skin stimulation, 16 patents combined skin stimulation with technologies such as electrode or high frequency, and three patents applied both electrode or high frequency stimulation, and drug application as well as physical skin stimulation. Each of these patents aims to increase the efficiency of the needle manufacturing process (n=24), to facilitate the use of tools or to increase the efficiency of the technology (n=61), or to increase the technical skill of the needle itself (n=23). Conclusions : This study confirms that technological advances were being made by combining various types of stimuli to dermal needle and there have been attempts to expand the scope of drug delivery in terms of application of dermal needle. In the future, more research and development is needed in order to apply the dermal needle to modern technology.

A Systematic Review and Meta-Analysis of Fire Needling Treatment for Knee Osteoarthritis: Focused on Comparative Studies with Manual Acupuncture Treatment during Recent Five Years (퇴행성 슬관절염의 화침 치료에 대한 체계적 문헌 고찰 및 메타분석: 최근 5년간의 호침 치료 비교 연구를 중심으로)

  • Ko, Hong-Je;Yoo, Jae-Hee;Shin, Jeong-Cheol
    • Korean Journal of Acupuncture
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    • v.36 no.2
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    • pp.104-114
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    • 2019
  • Objectives : The purpose of this study is to review the effectiveness of fire needling treatment for knee osteoarthritis in comparison with manual acupuncture treatment. Methods : Through four foreign online databases (PubMed, Cochrane library, EMBASE, and CNKI) and five domestic online databases (NDSL, RISS, KISS, OASIS, and KTKP), we searched for clinical studies that performed fire needling treatment for knee osteoarthritis until May 10, 2019. Only randomized controlled trials were selected and we assessed the risk of bias according to the Cochrane RoB criteria. This review examined the selected studies into first author, publication year, sample size, outcome measurements, results, acupoints, treatment time & period and so on. Results : A total of 7 RCTs were selected in this review and all were conducted in China. Treatment period of more than 4 weeks and treatment visits of 10 to 20 times were the most common. EX-LE4 and ST35 (=EX-LE5) acupoints were most frequently selected in treatment. Among the evaluation indexes, a total efficacy rate was used the most. Most of fire needling groups showed more significant results compared with the manual acupuncture groups statistically. Conclusions : All studies showed that fire needling treatments for knee osteoarthritis were more effective than manual acupuncture treatments statistically. Therefore, the results of this study could be utilized as a preliminary data for another clinical research on fire needling treatment for knee osteoarthritis. However, further well-designed randomized controlled trials will be needed to develop sufficient evidence about the effectiveness and safety of fire needling treatment for knee osteoarthritis in the future.

Forsythiae Fructus Extract Inhibits RANKL-Induced Osteoclast Differentiation and Prevent Bone Loss in OVX-Induced Osteoporosis Rat (연교의 파골세포 분화 및 골 흡수 억제 기전 연구)

  • Eom, Ji-Whan;Kim, Jae-Hyun;Kim, Minsun;Kim, Sangwoo;Shin, Hwajeong;Jung, Hyuk-Sang;Sohn, Youngjoo
    • Korean Journal of Acupuncture
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    • v.36 no.2
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    • pp.115-126
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    • 2019
  • Objectives : Osteoporosis is a condition characterized by low bone mass and increased bone fragility. It has become a major problem of senior citizens. The purpose of this study is to experiment the effect of water extract of Forsythiae Fructus (wFF) on osteoclast differentiation; and the other purpose is to examine the effect of wFF on osteoporosis in ovariectomized rat. Methods : To investigate the effect of wFF on osteoclast differentiation and activity, RAW 264.7 cells were used. The number of TRAP positive cell, TRAP activity, pit area, mRNA expression of makers (RANK, TRAP, CA II, CTK, MMP-9, NFATc1, c-Fos), protein expression of makers (NFATc1, c-Fos) were investigated. For in vivo study, 40 female Sprague-Dawley (SD) rats were induced osteoporosis by ovariectomy (OVX) and then tested for anti-osteoporosis effect by administration of wFF. Results : wFF suppressed osteoclatogenesis, TRAP activity and pit area formation. Moreover, wFF decreased the expression of master differentiation factors (NFATc1, c-Fos) and also reduced the osteoclastogenesis-related markers (TRAP, CA II, CTK, MMP-9). These suggest that wFF inhibit osteoclasts differentiation and bone resorption. In the OVX rat model, wFF inhibited decreasing of BMD and trabecular area. Conclusions : Forsythiae Fructus should be effective for osteoporosis prevention and treatment.