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Weed Population Distribution and Change of Dominant Weed Species in Paddy Field of Southern Gyeonggi Region (경기 남부지역 논잡초 발생분포 및 군락변화)

  • Park, Jungsoo;Won, Taejin;Roh, Ahnsung;Jang, Jaeeun;Kim, Heedong
    • Weed & Turfgrass Science
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    • v.3 no.2
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    • pp.86-94
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    • 2014
  • Survey was carried out in paddy fields to investigate the dominance of weed species and weed occurrence on 200 fields of southern Gyeonggi region in Korea during the year 2013. We observed 3 species of grass, 5 species of sedge, and 11 species of broadleaf and other weeds. The most dominant weed species was Eleocharis kuroguwai, followed by Echinochloa crus-galli, Sagittaria trifolia, Monochoria vaginalis, Scirpus juncoides and Bidens tripartita. The dominance value of E. kuroguwai and B. tripartita decreased compared to the survey results performed in 2005 but that of M. vaginalis, S. juncoides, S. trifolia and E. crus-galli increased. Weed occurrence increased from 2.83 g in 2005 to 3.51 g in 2013 based on weed dry weight per $m^2$. Occurrence ratio of annual weeds to perennial weeds changed from 45.2% : 54.8% in 2005 to 45.8% : 54.2% in 2013. If we analyze dominance of weed species based on the rice transplanting timing, E. kuroguwai and E. crus-galli were the most dominant weed species at mid-May transplanting, and M. vaginalis and S. juncoides were the most dominant weed species at late- May transplanting, and M. vaginalis and E. kuroguwai were the most dominant weed species at early-June transplanting. Since paddy weeds resistant to sulfonylurea herbicides are expected to be continuously increased, the regular monitoring of their occurrence and efficient control methods should be considered in future.

Use of Discriminant Analysis to Identify Soil Quality Variation by Land Use (판별분석을 이용한 토지이용별 토양 특성 변화 연구)

  • Ko Kyung-Seok;Kim Jae Gon;Lee Jin-Soo;Kim Tack Hyun;Lee Gyoo Ho;Cho Choon Hee;Oh In Suk;Cheong Young Wook
    • Economic and Environmental Geology
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    • v.38 no.3 s.172
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    • pp.207-219
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    • 2005
  • The physical and chemical characteristics of soils in a small watershed were investigated and the effect of geology and land use on soil quality were examined by using multivariate statistical methods, principal components analysis and discriminant analysis. The soil developed from andesite had finer texture and higher contents of water extractable inorganic components, clay, and mafic minerals than the soil developed from granite. It is considered that the accumulation of salts in the farmland soils indicated by electrical conductivity, contents of cations and anions and pH was caused by fertilizer input during cultivation. The low contents of organic matter in the farmland soils was due to the enhanced oxidation of organic matter by tillage and by the harvest of crops. The contents of inorganic components are increased as following order: upland > orchard > paddy field > forest. The high contents of water soluble $SO_4\;^{2-}$ of paddy soils is due to the oxidation of sulfides mineral formed during the flooding period during the air-dry and extraction. The results of principal components analysis show the difference of soil quality was controlled by geology and land use. PCI indicate the input of fertilizer, mineral weathering and ion exchange reaction by application of nitrogenous fertilizers. The results of two discriminant analyses using water extractable inorganic components and their ratios by land use were also clearly classified by discriminant function 1 and 2. In discriminant analysis by components, discriminant function 1 indicated the effect of fertilizer application and increased as following order: upland > orchard > paddy field > forest soil. The investigated and predicted data for land use from discriminant analysis showed similar results. The discriminant analysis can be used as a useful method certifying the change of land use.

Field Performance of a Miniature Power Tiller (소형(小型) 동력경운기(動力耕耘機)의 포장작업성능(圃場作業性能)에 관한 연구(硏究))

  • Kim, Hong-Yun;Choi, Kyu-Hong
    • Journal of Biosystems Engineering
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    • v.6 no.1
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    • pp.15-27
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    • 1981
  • In order to investigate on the field performance of 3.5PS power tiller and to obtain the optimum using conditions of it, this experiment has been carried on the plowing operation, the rotary harrowing operation and the ridging operation that compared 3.5PS power tiller(KC-450) with the existing 5PS(DT-40) and 8PS(DT-85) power tiller. It has been performed at Suck Jung-Dong, Ansung Country, from March to October in 1980. The results of this field test were obtained as follows; 1. The plowing performance of KC-450 tiller was found to be 125min/10a that was lower than that of DT-85 tiller by 26min/10a in the effective plowing speed 0.9m/sec. 2. The field efficiency of KC-450 tiller was the highest among the power tillers as to be 82 persent that was higher than that of DT-85 tiller by 5 persent in the effective plowing speed 1m/sec. 3. The rotary harrowing performances of DT-40 tiller and DT-85 tiller were higher than that of KC-450 tiller in the rotary harrowing operation of the same speed, and the field efficiency of KC-450 tiller and DT-40 tiller were higher than that of DT-85 tiller in the rotary harrowing operation. 4. The ridging Performance of testing power tillers were nearly equality in the ridging operation of the same speed, and the field efficiency of testing tillers were higher KC-450 tiller than DT-40 tiller, DT-40 tiller than DT-85 tiller. 5. The work performance of power tiller increased with increase in the size of field area. Work performance and field efficiency of KC-450 tiller were higher than other tillers below 8a in field size 6. DT -85 tiller was more useful in deep plowing depth. But below 8a in field size KC-450 tiller was more easily operated and its field efficiency was higher 7. KC-450 tiller should be more useful to operate in the small size field or in the small scale farming and for the cultivation of vegetables, gardening plants, medicinal herb and tobacco plants, or for the cultivation in vinyl house.

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Distribution of Weeds with Different Surface Management Systems of Greenhouse Soil in Gyeongnam Province (경남지역 시설원예작물 재배지 및 표토관리별 잡초발생 양상)

  • Hwang, Jae-Bok;Yun, Eul-Soo;Park, Chang-Young;Park, Sung-Tae;Nam, Min-Hee
    • Korean Journal of Weed Science
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    • v.31 no.3
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    • pp.221-228
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    • 2011
  • Weed control is of fundamental importance when planting horticultural crops, particularly during the establishment phase. Weeds compete for nutrients, water and light, and can severely threaten the survival and early growth of newly planted crops. Failure to control weeds represents one of the single most important factors leading to crop loss. Knowledge on the existence of the diversity of weed species in greenhouses is of our main concern in this study in order to develop a most efficient and effective weed control strategies. Sixty-two greenhouses were surveyed in 3 cities and counties of Gyeongnam area in March to October 2009 to investigate the feature of weed occurrence in polyvinyl chloride (PVC) after harvesting of the main crops. Forty-one weed species were identified and classified to 18 families which were composed of 14 annual weeds, 18 summer annual weeds and 9 perennial weeds. On the other hand, broadleaf, grasses and sedges recorded with 30, 7 and 4 weed species, respectively. Asteraceae was the most dominant weed species (9 species) noted followed by Poaceae (7 species), Cyperaceae (4 species), Caryophyllaceae and Brassicaceae (3 species respectively) and other families have 1~2 species. The dominant weed species occurred in the greenhouse based on the summed dominance ratio. These weeds were Digitaria sanguinalis, Cyperus iria, Portulaca oleracea, Rorippa islandica, Mazus japonicas, Cardamine flexousa, and Eclipta prostrata and others. Weed occurrence in the greenhouse after horticultural crops consisted of summer annuals (4 species), winter annuals (3 species), and perennial annuals (1 specie). The dominant species occurred in tilled soil based on summed dominance ratio of weeds were Cardamine flexousa (88.1%), Eclipta prostrate (57.4%) and Portulaca oleracea (55.2%). Comparison of weed occurrence was thoroughly surveyed also in which field without PVC, weed species were Portulaca oleracea (55.2), Eclipta prostrata (57.9%) and Trigonotis peduncularis (25.1%) and field with PVC, the identified weeds were Portulaca oleracea (98.75), Trigonotis peduncularis (49.1%), and Eclipta prostrata (36.8%).

Study on Dry Matter Yields and Persistence of Forage Plants Using Cattle Feedlot Manure in Fallow Paddy Land Located in the Mid-mountain Area (퇴구비를 시용한 중산간지 휴경답에서 초종별 영속성 및 건물생산성에 관한 연구)

  • Yoon, Sei-Hyung;Ji, Hee-Chung;Lee, Sang-Hoon;Choi, Eun-Min;Jeong, Min-Woong
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.30 no.4
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    • pp.317-324
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    • 2010
  • Recently, fallow paddy land located in the mid-mountain area (FPL) due to a decrease in rice consumption has increased in some regions of our country. So, grasses and forage crops available for years in once sowing should be introduced in FPL. This study was conducted to develop the technique for cultivation of grasses and forage crops using animal manure in FPL The field experiments were carried out from 2007 to 2009 on FPL at Kumsan, Chungbuk province in Korea. Cattle feedlot manure (CFM) was prepared by mixing feces and urine of cattle with rice straw in cattle feedlot for 6 months. The experimental plots were consisted of four treatments; tall fescue-based mixed pasture applied with chemical fertilizer (Control), mono-tall fescue pasture (MTFP), tall fescue-based mixed pasture (TFBMP), mono-Perennial ryegrass (MPR-FCM), mono-Italian ryegrass (MIR-FCM), mono-Red clover (MRC-FCM) and mono-Reed canarygrass (MRCG-FCM) applied with FCM. The field of tall fescue-based pasture had been sown with a grasses mixture containing 'Fawn' tall fescue, 'potomac' orchardgrass, 'Reveille' Perennial ryegrass, and 'kenblue' Kentuky bluegrass, 'Kenland' Red clover. Seeding rates were 16, 6, 4, 2 and $2\;ha^{-1}$, respectively. DM yields of forages and rates of grass coverage was higher in MTFP, TFBMP and MRCG-FCM as compated with control treatment. This result means that FPL has contained with favorable conditions for growing grass, because forage productivity is more than 15 tons per ha per year in fallow paddy land. In addition, the farmer can save the trouble of repeated plowing and sowing every year, due to the introduction of perennial grasses. The farmer must conduct the re-seeding and induce the improvement of management methods for the elevation of the persistence of red clover and perennial ryegrass, because both red clover and perennial ryegrass having high nutritive value and palatability was less persistent. Therefore, we suggest that FPL may be the good land for forage production utilizing FCM and FCM can be applied on FPL without any negative effects on DM production and the property of soil. FPL of Korea can be better utilized by applying FCM to the mono and/or mixed swards.

Study on Dry Matter Yields and Persistence of Forage Plants Using Swine Slurry in Fallow Paddy Land Located in the Mid-mountain Area (돈분액비를 시용한 중산간지 휴경답에서 다년생 목초의 초종별 영속성 및 건물생산성에 관한 연구)

  • Yoon, Sei Hyung;Kim, Sang Woo;Lim, Young Chul;Jung, Min Woong
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.32 no.4
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    • pp.411-418
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    • 2012
  • This study was conducted to develop the technique for cultivation of forage crops using swine slurry in fallow paddy land located in the mid-mountain area (FPL). The field experiments were carried out from 2007 to 2009 on FPL at Kumsan, Chungbuk province in Korea. Swine slurry was prepared which decayed for 6 months. The experimental plots were consisted of seven treatments; tall fescue-based mixed pasture applied with chemical fertilizer (Control), mono-tall fescue pasture (MTF), tall fescue-based mixed pasture (TFBM), mono-Perennial ryegrass (MPR), mono-Italian ryegrass (MIR), mono-Red clover (MRC and mono), Reed canarygrass (MRCG) applied with swine slurry. The field of tall fescue-based pasture had been sown with a grasses mixture containing 'Fawn' tall fescue, 'potomac' orchardgrass, 'Reveille' Perennial ryegrass, and 'kenblue' Kentuky bluegrass, 'Kenland' Red clover. Seeding rates were 16, 6, 4, 2 and 2 (kg) per ha, respectively. DM yields of forages and rates of grass coverage were higher in MTF, TFBM and MRCG as compared with control treatment. This result means that FPL has contained with favorable conditions for growing grass, because forage productivity is more than 14.5 tons per ha per year in fallow paddy land. In addition, the farmer can save the trouble of repeated plowing and sowing every year, with the introduction of perennial grasses. The farmer must conduct the re-seeding and induce the improvement of management methods for the elevation of the persistence of red clover and perennial ryegrass, because both red clover and perennial ryegrass having high nutritive value and palatability was less persistent. Therefore, we suggest that FPL may be the good land for forage production utilizing swine slurry and swine slurry can be applied on FPL without any negative effects on DM production and the property of soil. FPL of Korea can be better utilized by applying swine slurry to the mono and/or mixed swards.

Improvement of Rotary Tine for Barley Seeder Attached to Rotary Tiller (로우터리 맥류파종기 경운날의 개량시험)

  • 김성래;김문규;김기대;허윤근
    • Journal of Biosystems Engineering
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    • v.4 no.1
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    • pp.1-23
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    • 1979
  • The use of barley seeder attached to rotary tiller in the rural area has a significant meaning not only for the solution of labor peak season, but also for the increase of land utilization efficiency. The facts that presently being used barley seeders are all based on the mechanical principles of the reverse rotation, center drive and are all using forward rotating tine, which is used to be easily and heavily worn out when it rotates reversely, raise problem of recommending them to rural area in Korea. Therefore, the main objective of the study was to develop new type of rotary tine attachable to barley seeders. To attain the objective the following approaches were applied. (1) The kinematic analysis of reverse rotating barley seeders. (2) The studies on the soil bin and artificial soil. (3) The comparative experiment on the power requirement of prototype tine. The results obtained from the studies are summarized as follow: 1. The kinematic analysis of barley seeder attached to rotary tiller: The following results were obtained from the kinematic analysis for deriving general formulae of the motion and velocity characterizing the rotary tine of barley seeders presently being used by farmers. a) The position vector (P) of edge point (P) in the rotary tine of reverse rotating, center drive was obtained by the following formula. $$P=(vt+Rcos wt)i+Rsin wt j+ \{ Rcos \theta r sin \alpha cos (wt- \beta +\theta r) +Rsin \theta r sin \alpha sin (wt-\beta + \theta r) \} lk $$ b) The velocity of edge point $(P^')$ of reverse rotating, center drive rotary tine was obtained by the following formula. $$(P^')=(V-wR sin wt)i+(w\cdot Rcoswt)j + \{ -w\cdot Rcos \theta r\cdot sin \alpha \cdot sin (wt-\beta +\theta r) + w\cdot Rsin \theta r\cdot sin \alpha \cdot cos (wt- \beta + \theta r \} k $$ c) In order to reduce the power requirement of rotary tine, the angle between holder and edge point was desired to be reduced. d) In order to reduce the power requirement, the edge point of rotary tine should be moved from the angle at the begining of cutting to center line of machine, and the additional cutting width should be also reduced. 2. The studies on the soil bin and artificial soil: In order to measure the power requirement of various cutting tines under the same physical condition of soil, the indoor experiments Viere conducted by filling soil bin with artificially made soil similar to the common paddy soil and the results were as follows: a) When the rolling frequencies$(x)$ of the artificial soil were increased, the densIty$(Y)$ was also increased as follows: $$y=1.073200 +0.070780x - 0.002263x^2 (g/cm^3)$$ b) The absolute hardness $(Y)$ of soil had following relationship with the rolling frequencies$(x)$ and were increased as the rolling frequencies were increased. $$Y=37.74 - \frac {0.64 + 0.17x-0. 0054x^2} {(3.36-0.17x + 0.0054x^2)^3} (kg/cm^3)$$ c) The density of soil had significant effect on the cohesion and angle of internal friction of soil. For instance, the soil with density of 1.6 to 1.75 had equivalent density of sandy loam soil with 29.5% of natural soil moisture content. d) The coefficient of kinetiic friction of iron plate on artificial soil was 0.31 to 0.41 and was comparable with that of the natural soil. e) When the pulling speed of soil bin was the 2nd forward speed of power tiller, the rpm of driving shaft of rotary was similar to that of power tiller, soil bin apparatus is indicating the good indoor tester. 3. The comparative experiment on the power requirement of prototype tine of reverse rotating rotary: According to the preliminary test of rotary tine developed with various degrees of angle between holder and edge pcint due to the kinematic analysis, comparative test between prototype rotary tine with $30 ^\circ $ and $10 ^\circ$ of it and presently being used rotary tine was carried out 2nd the results were as follows: a) The total cutting torque was low when the angle between holder and edge point was reduced. b) $\theta r$ (angle between holder and edge point) of rotary tine seemed to be one: of the factors maximizing the increase of torque. c) As the angle between holder and edge point ($\theta r$) of rotary tine was $30 ^\circ $ rather than $45 ^\circ $, the angle of rotation during cutting soil was reduced and the total cutting torque was accordingly reduced about 10%, and the reduction efficiency of total cutting torque was low when the angle between holder and edge point ($\theta r$) of rotary tine was $10 ^\circ $, which indicates that the proper angle between holder and edge point of rotary tine should be larger than $10 ^\circ $ and smaller than $30 ^\circ $ . From above results, it could be concluded that the use of the prototype rotary tine which reduced the angle between holder and edge point to $30 ^\circ $, insted of $45 ^\circ $, is disirable not only decreasing the power requirements, but also increasing the durabie hour of it. Also forward researches are needed, WIlich determine the optimum tilted angle of rotary brocket, and rearrangement of the rotary tine on the rotary boss.

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A Study on the Forming and the Transformations of Seokjojeon Garden in Deoksugung (덕수궁 석조전 정원의 조성과 변천)

  • Kim, Hai-Gyoung;Oh, Kyusung
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.33 no.3
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    • pp.16-37
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    • 2015
  • As a result of analyzing the forming and the transformations of Seokjojeon Hall garden by linking it to the changes of Deoksugung Palace influenced by the social atmosphere, the Seokjojeon garden can be classified into four phases. The first phase starts from 1896 to 1914. Gyeongungung was built in the late 19th century(1896-1897) as an official palace and Junghwajeon Hall and Seokjojeon Hall was built for Gojong. J.M.Brown was in charge of the construction of Seokjojeon in the beginning but H.W.Davidson saw the end also set up the garden. In the process of forming the garden the incorporating of Dondeokjeon Hall and the demolishing of the west wing corridors of Junghwajeon Hall occurred. At this phase of the garden a statue of an eagle was put up in the garden but was soon taken down. The shape of the garden was quiet simple with a central axial pathway, a round assorted flower bed placed in front of Seokjojeon Hall. The second phase starts from 1915 to 1932 which lasted for 17 years. At the last years of the Great Han Empire the duties of Gungnaebu(宮內府) was transferred to Leewangjik(李王職) in 1911 and a research on the existing buildings was done by Jujeonkwa(主殿課) in 1915. According to the research drawings, the garden still maintained the axial pathway formed in the previous phase but the garden had an asymmetric form. The flower bed was formed in a round shape and an open-knot technique and boundary plantation was applied to the garden. The third phase starts from 1933 to 1937 and is the period when Seokjojeon Hall was made public. By the year of 1932 many buildings of Deoksugung Palace had been demolished in the preparation of the opening of Seokjojeon Hall as a permanent exhibition hall. The central axial pathway still remained in the new garden and added a pond with a turtle statue in the center. The fourth phase starts from 1938 until the liberation from Japan and is the period when Deoksugung Palace became a park. Yi Royal-Family Museum was built and linked to Seokjojeon Hall with a bridge and the garden transformed into a sunken garden. The garden adopted a fountain and a pagora. Despite the minor changes in the after years the garden still posses most of its form from the fourth phase. As we can see the current garden of Seokjojeon Hall is not the same as the initial garden and therefor the importance of this study lies in the fact that modifications to the statements regarding to Seokjojeon Hall garden should be made.

Diagnostic Value of MRI in Schwannoma (신경초종 진단에 있어 자기공명영상촬영(MRI)의 진단적 가치)

  • Kim, Jeung Il;Kim, Um Ji;Moon, Tae Yong;Lee, In Sook;Song, You Seon;Choi, Kyung Un
    • The Journal of the Korean bone and joint tumor society
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    • v.20 no.2
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    • pp.60-65
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    • 2014
  • Purpose: To diagnose soft tissue tumor, such as lipoma and Schwannoma, magnetic resonance imaging (MRI) is sufficient in most cases. However, various characteristics are found in MRI images of Schwannoma, thus other type of tumors are often misdiagnosed as Schwannoma with MRI images. In this study, we evaluate the diagnostic value of specific MRI findings of Schwannoma. Materials and Methods: From January 2002 to May 2013, 104 patients who are suspected as Schwannoma rith MRI images are included in data, and the final diagnosis is confirmed with biopsy. Patients are divided into group 1 and group 2 who are confirmed as Schwannoma and other disease with biopsy, respectively. Results: 92 patients were diagnosed as Schwannoma (group 1) and 12 patients were diagnosed as other disease (group 2). We investigate the diagnostic value of specific MRI findings of Schwannoma. 41 patients of group 1 (45%) and 0 patients of group 2 (0%) showed target sign, 47 patients of group 1 (51%) and 2 patients of group 2 (17%) showed fascicular sign, 44 patients of group 1 (48%) and 5 patients of group 2 (42%) showed fat split sign, 28 patients of group 1 (30%) and 1 patients of group 2(9%) showed nerve entering and exiting sign, and 8 patients of group 1 (9%) and 6 patients of group 2 (50%) showed none of four specific findings on their MRI images. 52 patients of group 1 (57%) and 5 patients of group 2 (42%) have tumors on the pathway of nerve. Target sign could be considered as the best diagnostic value of the sign we investigate (p<0.05). Conclusion: Although specific MRI findings have powerful diagnostic value, patients are often misdiagnosed as Schwannoma with MRI findings. Therefore, if patients who are suspected as Schwannoma based on MRI findings have no target sign on their MRI images, we should consider the possibility of other disease.

Comparative Evaluation on Sperm Parameter of Transgenic Pigs with General Pigs (형질전환 돼지의 정자와 일반돼지의 정자성상에 대한 비교평가)

  • Park, Sang Hyoun;Lee, Gunsup;Lee, Joo Yung;Kim, Kyung Woon;Byun, Sung-June;Ock, Sun A;Hwang, Seongsoo;Yang, Hyeon;Woo, Jae-Seok;Oh, Keon Bong
    • Journal of Embryo Transfer
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    • v.32 no.3
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    • pp.227-233
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    • 2017
  • Pig has been known to be one of the most feasible animals as a bioreactor to produce pharmaceuticals in milk and as a mediator in xenotransplantation research. Previously, we generated transgenic pigs for both purposes, which were expressing Factor 8, vWF, hTPA, and hEPO in milk, along with expression of MCP at GalT gene locus ($GalT^{-MCP/-MCP}$) as well as expressing MCP at GalT gene loci with CD73 expression ($GalT^{-MCP/+}/CD73$). In this study, we performed comparative analyses of sperm parameters between wild type male (WT) pig and those transgenic males to examine the effects of transgenes integrated into the pigs on motility, morphology, viability, and acrosome integrity of the spermatozoa. Our results showed that the rates of actively motile spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 85.0%, 83.3%, 82.5%, 83.3%, 82.5%, 77.5%, and 78.7%, respectively. Whereas, the rates of morphologically normal spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 90.0%, 80.0%, 80.0%, 83.3%, 85.0%, 91.8%, and 80.8%, respectively. In addition, the viability in spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 93.9%, 82.4%, 89.9%, 83.9%, 87.4%, 92.8%, and 83.6%, respectively. The rates of spermatozoa with normal acrosome integrity in WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 98.1%, 98.6%, 98.6%, 98.7%, 98.1%, 99.5%, and 95.1%, respectively. There were no significant differences in motility, morphology, viability, and acrosome integrity of the spermatozoa among WT, Factor 8, vWF, hTPA, and hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs. These mean that neither random integration nor targeted integration of the transgene into chromosome of pig effect on characteristics of spermatozoa. Ultimately, the transgenic male pigs subjected in this study could apply to propagate their progenies for production of human therapeutic proteins and advancing the xenotransplantation research.