• The Korean Journal of Applied Statistics
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• v.29 no.7
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• pp.1459-1473
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• 2016

Both longitudinal data and survival data are collected simultaneously in longitudinal data which are observed throughout the passage of time. In this case, the effect of the independent variable becomes biased (provided that sole use of longitudinal data analysis does not consider the relation between both data used) if the missing that occurred in the longitudinal data is non-ignorable because it is caused by a correlation with the survival data. A joint model of longitudinal data and survival data was studied as a solution for such problem in order to obtain an unbiased result by considering the survival model for the cause of missing. In this paper, a joint model of the longitudinal zero-inflated count data and survival data is studied by replacing the longitudinal part with zero-inflated count data. A hurdle model and proportional hazards model were used for each longitudinal zero inflated count data and survival data; in addition, both sub-models were linked based on the assumption that the random effect of sub-models follow the multivariate normal distribution. We used the EM algorithm for the maximum likelihood estimator of parameters and estimated standard errors of parameters were calculated using the profile likelihood method. In simulation, we observed a better performance of the joint model in bias and coverage probability compared to the separate model.

• Communications for Statistical Applications and Methods
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• v.5 no.2
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• pp.431-437
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• 1998

본 논문의 목적은 계층적 베이즈 일반화 선형모형을 이용하여 경시적 자료를 분석하는 것이다. 구체적으로 계층적 베이즈 변량효과 모형을 소개하고 무정보적 사전분포 하에서 사후분포가 진(proper)인지에 대한 충분조건을 찾는다 또한, 깁스(Gibbs) 표본자를 사용하여 제안된 계층적 베이즈 절차의 수행에 관해 논의한다. 현실자료를 사용하여 제안된 계층적 베이즈 분석을 예시하고, 이에 대응하는 경험적 베이즈 분석과 비교한다.

• The Korean Journal of Applied Statistics
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• v.35 no.6
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• pp.703-724
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• 2022

Although longitudinal studies mainly produce multivariate longitudinal data, most of existing statistical models analyze univariate longitudinal data and there is a limitation to explain complex correlations properly. Therefore, this paper describes various methods of modeling the covariance matrix to explain the complex correlations. Among them, modified Cholesky decomposition, modified Cholesky block decomposition, and hypersphere decomposition are reviewed. In this paper, we review these methods and analyze Korean children and youth panel (KCYP) data are analyzed using the Bayesian method. The KCYP data are multivariate longitudinal data that have response variables: School adaptation, academic achievement, and dependence on mobile phones. Assuming that the correlation structure and the innovation standard deviation structure are different, several models are compared. For the most suitable model, all explanatory variables are significant for school adaptation, and academic achievement and only household income appears as insignificant variables when cell phone dependence is a response variable.

• The Korean Journal of Applied Statistics
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• v.29 no.1
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• pp.113-122
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• 2016

Longitudinal data often occur in prospective follow-up studies. Joint model for longitudinal data and failure time has been applied on several works. In this paper, we extend it to the case where longitudinal data involve informative observation time process as well as competing risks survival times. We use a likelihood approach and derive an EM algorithm to obtain maximum likelihood estimate of parameters. A suggested joint model allows us to make inferences for three components: longitudinal outcome, observation time process and competing risk failure time. In addition, we can test the association among these components. In this paper, liver cirrhosis patients' data is analyzed. The relationship between prothrombin times measured at irregular visiting times and drop outs is investigated with a joint model.

• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.335-342
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• 2015

Joint hierarchical generalized linear models proposed by Molas et al. (2013) extend the simple longitudinal model into multiple models fitted jointly. It can easily handle the correlation of multivariate longitudinal data. In this paper, we apply this method to analyze KoGES cohort dataset. Fixed unknown parameters, random effects and variance components are estimated based on a standard framework of h-likelihood theory. Furthermore, based on the conditional Akaike information criterion the correlated covariance structure of random-effect model is selected rather than an independent structure.

• The Korean Journal of Applied Statistics
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• v.21 no.1
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• pp.65-80
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• 2008

Small scale time-course microarray experiments are those which have a small number of time points. They comprise about 80 percent of all time-course microarray experiments conducted up to 2005. Several statistical methods for the small scale time-course microarray experiments have been proposed. In this paper we applied three methods, namely, QR method, maSigPro method and STEM, to a real time-course microarray experiment which had six time points. We compared the performance of these three methods based on a simulation study and concluded that STEM outperformed, in general, in terms of power when the FDR was set to be 5%.

• The Korean Journal of Applied Statistics
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• v.33 no.3
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• pp.281-296
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• 2020

Repeated outcomes from the same subjects are referred to as longitudinal data. Analysis of the data requires different methods unlike cross-sectional data analysis. It is important to model the covariance matrix because the correlation between the repeated outcomes must be considered when estimating the effects of covariates on the mean response. However, the modeling of the covariance matrix is tricky because there are many parameters to be estimated, and the estimated covariance matrix should be positive definite. In this paper, we consider analysis of multivariate longitudinal data via two modeling methodologies for the covariance matrix for multivariate longitudinal data. Both methods describe serial correlations of multivariate longitudinal outcomes using a modified Cholesky decomposition. However, the two methods consider different decompositions to explain the correlation between simultaneous responses. The first method uses enhanced linear covariance models so that the covariance matrix satisfies a positive definiteness condition; in addition, and principal component analysis and maximization-minimization algorithm (MM algorithm) were used to estimate model parameters. The second method considers variance-correlation decomposition and hypersphere decomposition to model covariance matrix. Simulations are used to compare the performance of the two methodologies.

• Communications of Mathematical Education
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• v.16
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• pp.345-365
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• 2003

우리 나라 수학경시대회의 운영은 선발에 초점이 맞추어져 있어, 지속적인 교육 및 피드백이 결여되어 있고 단순히 경시대회성 기출문제만을 반복하여 출제하고 있는 실정이다. 그러므로 영재의 특성을 고려하고, 영재성을 키워주기 위해서는 무엇보다도 수학 창의적 문제해결력을 신장시켜줄 수 있는 학습 자료의 개발이 시급하다. 따라서 본 논문에서는 초등수학경시대회 기출문제와 시중에 출판되어 있는 경시대회 준비를 위한 학습자료를 분석하여, 일선 초등학교 현장에서 실시되고 있는 영재교육을 활성화시킬 수 있는 방안을 연구하는 데 목적이 있다.

• The Korean Journal of Applied Statistics
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• v.30 no.2
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• pp.203-213
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• 2017

We study estimation and inference of joint conditional distributions of bivariate longitudinal outcomes using regression models and copulas. We consider a class of time-varying transformation models and combine the two marginal models using Gaussian copulas to estimate the joint models. Our models and estimation method can be applied in many situations where the conditional mean-based models are inadequate. Gaussian copulas combined with time-varying transformation models may allow convenient and easy-to-interpret modeling for the joint conditional distributions for bivariate longitudinal data. We apply our method to an epidemiological study of repeatedly measured bivariate cholesterol data.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1439-1447
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• 2014

Most of literatures on Korean child aggression are based on using the cross-sectional data sets. Although there is a related study with a longitudinal data set, it is assumed that the data sets measured repeatedly in the longitudinal data are mutually independent. A longitudinal data analysis for Korean child aggression is then necessary. This study is to analyze the effect of child development outcomes including academic achievement, self-esteem, depression anxiety, delinquency, victimization by peers, abuse by parents and internet using time on child aggression with Korea Welfare Panel Study data observed three times between 2006 and 2012. Since Korea Welfare Panel Study data have missing values, the missing at random is assumed. The linear mixed effect model and the restricted maximum likelihood estimation are considered.